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ABCB11
receptor: FXRTier 1
CAMIP causal chains
FXR
Disrupted receptor-mediated transactivation via the FXR/RXRα heterodimer, abolishing the critical canalicular expression of the Bile Salt Export Pump. This directly cripples the ATP-dependent rate-limiting step of hepatic bile acid elimination, precipitating toxic intracellular bile salt accumulation and rendering hepatocytes profoundly vulnerable to severe drug-induced cholestatic liver injury under medications such as bosentan and cyclosporine.
Affected substrate drugs (PharmGKB): bosentan; cyclosporine; estrogens
Scored variants near ABCB11
chr2:168,820,780..169,131,324, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr2_169031334_A_G | chr2:169031334 | 1.000 | 1.000 | 0.916 | — |
| chr2_169031340_A_G | chr2:169031340 | 1.000 | 1.000 | 0.910 | — |
| chr2_169031312_T_A | chr2:169031312 | 0.572 | 1.000 | 1.000 | — |
| chr2_169031342_T_C | chr2:169031342 | 0.808 | 0.977 | 0.713 | — |
| chr2_169031312_T_G | chr2:169031312 | 0.502 | 0.908 | 1.000 | — |
| chr2_169031317_A_G | chr2:169031317 | 0.541 | 0.718 | 0.461 | — |
| chr2_169031343_C_G | chr2:169031343 | 0.484 | 0.539 | 0.531 | — |
| chr2_169031315_T_G | chr2:169031315 | 0.461 | 0.746 | 0.663 | — |
| chr2_169031224_C_G | chr2:169031224 | -0.403 | -0.597 | -0.590 | — |
| chr2_169031254_G_T | chr2:169031254 | 0.402 | 0.481 | 0.275 | — |
| chr2_169031341_T_G | chr2:169031341 | 0.402 | 0.605 | 0.303 | — |
| chr2_169031224_C_A | chr2:169031224 | -0.398 | -0.576 | -0.632 | — |
| chr2_169031223_A_C | chr2:169031223 | -0.357 | -0.504 | -0.640 | — |
| chr2_169031326_A_T | chr2:169031326 | -0.369 | -0.542 | -0.506 | — |
| chr2_169031282_A_C | chr2:169031282 | 0.361 | 0.557 | 0.287 | — |
| chr2_169031338_G_T | chr2:169031338 | -0.353 | -0.544 | -0.393 | — |
| chr2_169031225_C_A | chr2:169031225 | -0.348 | -0.499 | -0.435 | — |
| chr2_169031223_A_T | chr2:169031223 | -0.346 | -0.469 | -0.573 | — |
| chr2_169031288_T_C | chr2:169031288 | -0.275 | -0.487 | -0.584 | — |
| chr2_169031308_T_C | chr2:169031308 | 0.339 | 0.489 | 0.303 | — |
| chr2_169031288_T_A | chr2:169031288 | -0.282 | -0.471 | -0.570 | — |
| chr2_169031290_T_C | chr2:169031290 | -0.328 | -0.640 | -0.483 | — |
| chr2_169031315_T_C | chr2:169031315 | -0.325 | -0.499 | -0.514 | — |
| chr2_169031314_T_C | chr2:169031314 | -0.312 | -0.514 | -0.433 | — |
| chr2_169031312_T_C | chr2:169031312 | 0.302 | 0.414 | 0.483 | — |
| chr2_169031295_A_T | chr2:169031295 | -0.193 | -0.320 | -0.486 | — |
| chr2_169031313_T_C | chr2:169031313 | -0.267 | -0.423 | -0.483 | — |
| chr2_169031224_C_T | chr2:169031224 | -0.280 | -0.471 | -0.461 | — |
| chr2_169031292_A_G | chr2:169031292 | 0.274 | 0.547 | 0.410 | — |
| chr2_169031294_A_T | chr2:169031294 | -0.207 | -0.484 | -0.466 | — |
| chr2_169031336_C_G | chr2:169031336 | -0.267 | -0.344 | -0.452 | — |
| chr2_169031338_G_A | chr2:169031338 | -0.265 | -0.355 | -0.253 | — |
| chr2_169031291_C_T | chr2:169031291 | -0.222 | -0.426 | -0.449 | — |
| chr2_169031289_T_A | chr2:169031289 | -0.215 | -0.458 | -0.441 | — |
| chr2_169031302_C_G | chr2:169031302 | 0.257 | 0.509 | 0.399 | — |
| chr2_169031336_C_A | chr2:169031336 | -0.220 | -0.225 | -0.427 | — |
| chr2_169031262_G_C | chr2:169031262 | 0.243 | 0.270 | 0.225 | — |
| chr2_169031223_A_G | chr2:169031223 | -0.241 | -0.348 | -0.379 | — |
| chr2_169031194_G_C | chr2:169031194 | 0.239 | 0.254 | 0.149 | — |
| chr2_169031308_T_G | chr2:169031308 | 0.239 | 0.443 | 0.388 | — |
| chr2_169031340_A_T | chr2:169031340 | 0.239 | 0.280 | 0.275 | — |
| chr2_169031296_C_A | chr2:169031296 | -0.148 | -0.306 | -0.407 | — |
| chr2_169031254_G_C | chr2:169031254 | 0.236 | 0.275 | 0.169 | — |
| chr2_169031334_A_T | chr2:169031334 | -0.231 | -0.320 | -0.275 | — |
| chr2_169031293_C_G | chr2:169031293 | -0.164 | -0.428 | -0.393 | — |
| chr2_169031294_A_G | chr2:169031294 | -0.135 | -0.358 | -0.393 | — |
| chr2_169031333_G_T | chr2:169031333 | -0.227 | -0.325 | -0.281 | — |
| chr2_169031291_C_G | chr2:169031291 | -0.175 | -0.378 | -0.388 | — |
| chr2_169031325_A_T | chr2:169031325 | -0.225 | -0.297 | -0.309 | — |
| chr2_169031317_A_T | chr2:169031317 | -0.225 | -0.312 | -0.315 | — |
| chr2_169031288_T_G | chr2:169031288 | -0.137 | -0.271 | -0.379 | — |
| chr2_169031306_C_T | chr2:169031306 | -0.216 | -0.353 | -0.301 | — |
| chr2_169031331_C_A | chr2:169031331 | -0.196 | -0.262 | -0.365 | — |
| chr2_169031309_C_T | chr2:169031309 | -0.211 | -0.319 | -0.264 | — |
| chr2_169031226_T_C | chr2:169031226 | -0.210 | -0.270 | -0.202 | — |
| chr2_169031226_T_A | chr2:169031226 | -0.208 | -0.295 | -0.174 | — |
| chr2_169031329_C_A | chr2:169031329 | -0.208 | -0.262 | -0.216 | — |
| chr2_169031225_C_T | chr2:169031225 | -0.207 | -0.302 | -0.174 | — |
| chr2_169031341_T_A | chr2:169031341 | 0.207 | 0.144 | 0.225 | — |
| chr2_169031324_T_C | chr2:169031324 | 0.199 | 0.295 | 0.129 | — |
| chr2_169031198_T_G | chr2:169031198 | -0.192 | -0.217 | -0.146 | — |
| chr2_169031290_T_G | chr2:169031290 | 0.190 | 0.244 | 0.191 | — |
| chr2_169031291_C_A | chr2:169031291 | -0.151 | -0.348 | -0.326 | — |
| chr2_169031336_C_T | chr2:169031336 | -0.189 | -0.236 | -0.289 | — |
| chr2_169031343_C_A | chr2:169031343 | -0.184 | -0.190 | -0.239 | — |
| chr2_169031322_T_A | chr2:169031322 | 0.181 | 0.222 | 0.180 | — |
| chr2_169031184_A_C | chr2:169031184 | 0.180 | 0.174 | 0.253 | — |
| chr2_169031270_C_T | chr2:169031270 | -0.180 | -0.237 | -0.124 | — |
| chr2_169031292_A_T | chr2:169031292 | -0.175 | -0.330 | -0.309 | — |
| chr2_169031289_T_C | chr2:169031289 | -0.106 | -0.282 | -0.306 | — |
| chr2_169031342_T_A | chr2:169031342 | 0.179 | 0.209 | 0.197 | — |
| chr2_169031304_A_C | chr2:169031304 | -0.177 | -0.248 | -0.242 | — |
| chr2_169031320_A_C | chr2:169031320 | -0.167 | -0.297 | -0.301 | — |
| chr2_169031294_A_C | chr2:169031294 | -0.123 | -0.345 | -0.298 | — |
| chr2_169031321_T_A | chr2:169031321 | -0.166 | -0.327 | -0.289 | — |
| chr2_169031260_A_T | chr2:169031260 | 0.166 | 0.136 | 0.135 | — |
| chr2_169031296_C_G | chr2:169031296 | -0.108 | -0.191 | -0.281 | — |
| chr2_169031313_T_A | chr2:169031313 | -0.144 | -0.227 | -0.278 | — |
| chr2_169031314_T_A | chr2:169031314 | -0.055 | -0.277 | -0.278 | — |
| chr2_169031309_C_A | chr2:169031309 | -0.160 | -0.297 | -0.185 | — |
| chr2_169031289_T_G | chr2:169031289 | -0.131 | -0.315 | -0.272 | — |
| chr2_169031225_C_G | chr2:169031225 | -0.156 | -0.222 | -0.037 | — |
| chr2_169031323_C_A | chr2:169031323 | -0.143 | -0.247 | -0.267 | — |
| chr2_169031339_A_G | chr2:169031339 | 0.155 | 0.189 | 0.185 | — |
| chr2_169031290_T_A | chr2:169031290 | 0.151 | 0.166 | 0.174 | — |
| chr2_169031293_C_A | chr2:169031293 | -0.134 | -0.290 | -0.258 | — |
| chr2_169031327_A_T | chr2:169031327 | -0.135 | -0.149 | -0.258 | — |
| chr2_169031176_T_A | chr2:169031176 | 0.149 | 0.131 | 0.098 | — |
| chr2_169031267_C_G | chr2:169031267 | 0.149 | 0.217 | 0.247 | — |
| chr2_169031178_A_C | chr2:169031178 | 0.148 | 0.166 | 0.115 | — |
| chr2_169031226_T_G | chr2:169031226 | -0.148 | -0.166 | -0.135 | — |
| chr2_169031295_A_C | chr2:169031295 | -0.121 | -0.252 | -0.253 | — |
| chr2_169031327_A_G | chr2:169031327 | -0.148 | -0.150 | -0.211 | — |
| chr2_169031329_C_G | chr2:169031329 | -0.148 | -0.184 | -0.171 | — |
| chr2_169031332_T_A | chr2:169031332 | -0.123 | -0.270 | -0.253 | — |
| chr2_169031310_G_A | chr2:169031310 | -0.147 | -0.229 | -0.169 | — |
| chr2_169031278_A_G | chr2:169031278 | 0.143 | 0.174 | 0.202 | — |
| chr2_169031324_T_G | chr2:169031324 | 0.139 | 0.249 | 0.219 | — |
| chr2_169031279_G_C | chr2:169031279 | -0.138 | -0.154 | -0.177 | — |
| chr2_169031292_A_C | chr2:169031292 | -0.138 | -0.307 | -0.230 | — |
| chr2_169031197_T_C | chr2:169031197 | -0.134 | -0.060 | 0.087 | — |
| chr2_169031305_A_T | chr2:169031305 | -0.134 | -0.204 | -0.219 | — |
| chr2_169031308_T_A | chr2:169031308 | 0.121 | 0.159 | 0.230 | — |
| chr2_169031264_A_C | chr2:169031264 | -0.134 | -0.151 | -0.022 | — |
| chr2_169031316_C_A | chr2:169031316 | 0.131 | 0.028 | 0.073 | — |
| chr2_169031332_T_G | chr2:169031332 | -0.125 | -0.234 | -0.225 | — |
| chr2_169031311_G_A | chr2:169031311 | -0.130 | -0.139 | -0.157 | — |
| chr2_169031306_C_A | chr2:169031306 | -0.129 | -0.234 | -0.157 | — |
| chr2_169031222_T_G | chr2:169031222 | -0.116 | -0.257 | -0.219 | — |
| chr2_169031316_C_T | chr2:169031316 | -0.075 | -0.254 | -0.219 | — |
| chr2_169031335_A_C | chr2:169031335 | 0.125 | 0.207 | 0.185 | — |
| chr2_169031171_A_C | chr2:169031171 | 0.125 | 0.101 | 0.110 | — |
| chr2_169031315_T_A | chr2:169031315 | 0.125 | 0.169 | 0.112 | — |
| chr2_169031337_A_C | chr2:169031337 | 0.125 | 0.164 | 0.062 | — |
| chr2_169031179_A_C | chr2:169031179 | 0.123 | 0.063 | 0.076 | — |
| chr2_169031335_A_T | chr2:169031335 | -0.123 | -0.189 | -0.191 | — |
| chr2_169031188_G_T | chr2:169031188 | -0.110 | -0.123 | -0.208 | — |
| chr2_169031313_T_G | chr2:169031313 | -0.085 | -0.176 | -0.208 | — |
| chr2_169031318_T_C | chr2:169031318 | -0.121 | -0.217 | -0.118 | — |
| chr2_169031311_G_C | chr2:169031311 | -0.120 | -0.173 | -0.169 | — |
| chr2_169031307_C_T | chr2:169031307 | -0.099 | -0.174 | -0.205 | — |
| chr2_169031295_A_G | chr2:169031295 | -0.034 | -0.161 | -0.202 | — |
| chr2_169031339_A_C | chr2:169031339 | 0.118 | 0.179 | 0.051 | — |
| chr2_169031326_A_G | chr2:169031326 | 0.117 | 0.154 | 0.101 | — |
| chr2_169031326_A_C | chr2:169031326 | 0.116 | 0.156 | 0.146 | — |
| chr2_169031260_A_C | chr2:169031260 | 0.115 | 0.093 | 0.118 | — |
| chr2_169031227_G_C | chr2:169031227 | -0.113 | -0.128 | -0.112 | — |
| chr2_169031266_T_C | chr2:169031266 | -0.113 | -0.176 | -0.096 | — |
| chr2_169008089_G_T | chr2:169008089 | -0.112 | 0.040 | 0.110 | — |
| chr2_169031287_G_T | chr2:169031287 | -0.034 | -0.108 | -0.191 | — |
| chr2_169031317_A_C | chr2:169031317 | -0.111 | -0.222 | -0.152 | — |
| chr2_169031172_A_C | chr2:169031172 | 0.110 | 0.093 | 0.107 | — |
| chr2_169031241_G_T | chr2:169031241 | 0.110 | 0.111 | 0.143 | — |
| chr2_169031276_A_T | chr2:169031276 | -0.110 | -0.184 | 0.039 | — |
| chr2_169008129_G_C | chr2:169008129 | 0.057 | -0.045 | -0.187 | — |
| chr2_169031258_T_C | chr2:169031258 | -0.108 | -0.091 | 0.006 | — |
| chr2_169031263_G_C | chr2:169031263 | 0.090 | 0.141 | 0.185 | — |
| chr2_169031302_C_T | chr2:169031302 | -0.107 | -0.121 | -0.135 | — |
| chr2_169031304_A_T | chr2:169031304 | -0.106 | -0.168 | -0.135 | — |
| chr2_169031323_C_T | chr2:169031323 | -0.106 | -0.146 | -0.132 | — |
| chr2_169031194_G_T | chr2:169031194 | 0.105 | 0.108 | 0.039 | — |
| chr2_169031307_C_G | chr2:169031307 | -0.068 | -0.083 | -0.180 | — |
| chr2_169031232_T_G | chr2:169031232 | -0.084 | -0.106 | -0.177 | — |
| chr2_169031337_A_T | chr2:169031337 | 0.102 | 0.126 | 0.079 | — |
| chr2_169031299_T_C | chr2:169031299 | -0.100 | -0.161 | -0.174 | — |
| chr2_169031330_A_G | chr2:169031330 | 0.102 | 0.141 | 0.073 | — |
| chr2_169031247_G_T | chr2:169031247 | 0.100 | 0.118 | 0.048 | — |
| chr2_169031301_T_C | chr2:169031301 | 0.100 | 0.174 | 0.140 | — |
| chr2_169031307_C_A | chr2:169031307 | -0.095 | -0.154 | -0.171 | — |
| chr2_169031245_A_C | chr2:169031245 | 0.098 | 0.118 | 0.087 | — |
| chr2_169031267_C_A | chr2:169031267 | 0.098 | 0.083 | 0.118 | — |
| chr2_169031333_G_C | chr2:169031333 | -0.076 | -0.123 | -0.169 | — |
| chr2_169008119_T_A | chr2:169008119 | 0.098 | 0.063 | -0.006 | — |
| chr2_169031311_G_T | chr2:169031311 | -0.098 | -0.110 | -0.138 | — |
| chr2_169031216_G_T | chr2:169031216 | 0.097 | 0.113 | 0.104 | — |
| chr2_169031298_T_C | chr2:169031298 | -0.096 | -0.139 | -0.056 | — |
| chr2_169031194_G_A | chr2:169031194 | 0.095 | 0.101 | -0.003 | — |
| chr2_169031231_A_C | chr2:169031231 | -0.095 | -0.086 | -0.039 | — |
| chr2_169031259_A_G | chr2:169031259 | -0.095 | -0.141 | -0.076 | — |
| chr2_169031280_T_A | chr2:169031280 | -0.033 | -0.118 | -0.163 | — |
| chr2_169031284_A_G | chr2:169031284 | -0.084 | -0.101 | -0.163 | — |
| chr2_169031330_A_C | chr2:169031330 | 0.094 | 0.209 | 0.163 | — |
| chr2_169031186_G_C | chr2:169031186 | 0.093 | 0.071 | 0.062 | — |
| chr2_169031298_T_A | chr2:169031298 | -0.093 | -0.161 | -0.107 | — |
| chr2_169031325_A_G | chr2:169031325 | 0.093 | 0.146 | 0.107 | — |
| chr2_169031227_G_T | chr2:169031227 | -0.092 | -0.071 | -0.096 | — |
| chr2_169031235_G_T | chr2:169031235 | 0.092 | 0.103 | 0.090 | — |
| chr2_169031241_G_C | chr2:169031241 | 0.092 | 0.151 | 0.132 | — |
| chr2_169031252_A_C | chr2:169031252 | -0.092 | -0.144 | -0.079 | — |
| chr2_169031263_G_T | chr2:169031263 | 0.085 | 0.156 | 0.157 | — |
| chr2_169031278_A_C | chr2:169031278 | -0.092 | -0.118 | -0.017 | — |
| chr2_169031173_G_A | chr2:169031173 | 0.090 | 0.128 | 0.006 | — |
| chr2_169031227_G_A | chr2:169031227 | -0.090 | -0.093 | -0.076 | — |
| chr2_169031244_G_A | chr2:169031244 | 0.090 | 0.088 | 0.079 | — |
| chr2_169031244_G_C | chr2:169031244 | 0.090 | 0.106 | 0.112 | — |
| chr2_169031176_T_G | chr2:169031176 | 0.089 | 0.083 | 0.090 | — |
| chr2_169031180_A_T | chr2:169031180 | -0.089 | -0.113 | -0.079 | — |
| chr2_169031287_G_A | chr2:169031287 | 0.089 | 0.194 | 0.152 | — |
| chr2_169031293_C_T | chr2:169031293 | -0.043 | -0.108 | -0.152 | — |
| chr2_169008140_T_G | chr2:169008140 | -0.087 | 0.005 | -0.004 | — |
| chr2_169031239_T_C | chr2:169031239 | 0.087 | 0.123 | 0.059 | — |
| chr2_169031299_T_G | chr2:169031299 | 0.087 | 0.023 | 0.067 | — |
| chr2_169008089_G_A | chr2:169008089 | -0.085 | 0.018 | 0.045 | — |
| chr2_169031318_T_G | chr2:169031318 | -0.084 | -0.136 | -0.118 | — |
| chr2_169031174_A_C | chr2:169031174 | 0.084 | 0.053 | 0.090 | — |
| chr2_169031251_G_T | chr2:169031251 | -0.070 | -0.113 | -0.143 | — |
| chr2_169031283_A_T | chr2:169031283 | -0.084 | -0.121 | -0.129 | — |
| chr2_169008120_C_T | chr2:169008120 | 0.083 | 0.015 | -0.074 | — |
| chr2_169008090_A_T | chr2:169008090 | -0.082 | 0.010 | 0.079 | — |
| chr2_169031177_T_G | chr2:169031177 | 0.082 | 0.068 | 0.093 | — |
| chr2_169031200_G_T | chr2:169031200 | 0.082 | 0.065 | -0.031 | — |
| chr2_169031220_C_A | chr2:169031220 | -0.082 | -0.164 | -0.017 | — |
| chr2_169031220_C_T | chr2:169031220 | 0.038 | 0.010 | 0.140 | — |
| chr2_169031236_A_C | chr2:169031236 | 0.011 | 0.045 | 0.140 | — |
| chr2_169031304_A_G | chr2:169031304 | 0.082 | 0.191 | 0.104 | — |
| chr2_169031167_A_C | chr2:169031167 | 0.080 | 0.043 | 0.096 | — |
| chr2_169031173_G_C | chr2:169031173 | 0.080 | 0.060 | 0.039 | — |
| chr2_169031278_A_T | chr2:169031278 | -0.080 | -0.081 | -0.051 | — |
| chr2_169031320_A_G | chr2:169031320 | -0.047 | -0.121 | -0.138 | — |
| chr2_169031303_C_T | chr2:169031303 | 0.080 | 0.121 | 0.084 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.