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ABCC2
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of ABCC2 expression, diminishing canalicular efflux capacity and reducing the clearance of clearance-dependent substrates.
Affected substrate drugs (PharmGKB): tenofovir; methotrexate; mycophenolic acid; talinolol; lopinavir; tacrolimus
Scored variants near ABCC2
chr10:99,682,639..99,952,594, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr10_99732714_A_G | chr10:99732714 | 1.000 | 0.849 | 1.000 | — |
| chr10_99696002_A_T | chr10:99696002 | 1.000 | 1.000 | 1.000 | — |
| chr10_99732715_T_C | chr10:99732715 | 1.000 | 0.597 | 0.930 | — |
| chr10_99695953_T_C | chr10:99695953 | 0.681 | 0.758 | 1.000 | — |
| chr10_99732718_C_T | chr10:99732718 | 0.482 | 0.191 | 0.152 | — |
| chr10_99732709_C_A | chr10:99732709 | 0.465 | 0.229 | 0.234 | — |
| chr10_99695943_T_C | chr10:99695943 | 0.373 | 0.491 | 0.734 | — |
| chr10_99732687_T_G | chr10:99732687 | 0.389 | 0.212 | 0.456 | — |
| chr10_99696004_G_T | chr10:99696004 | 0.321 | 0.491 | 0.652 | — |
| chr10_99696019_C_G | chr10:99696019 | -0.309 | -0.433 | -0.585 | — |
| chr10_99732683_A_C | chr10:99732683 | 0.142 | 0.239 | 0.567 | — |
| chr10_99695989_A_C | chr10:99695989 | 0.255 | 0.305 | 0.550 | — |
| chr10_99695951_T_A | chr10:99695951 | 0.298 | 0.360 | 0.541 | — |
| chr10_99696019_C_A | chr10:99696019 | -0.270 | -0.360 | -0.503 | — |
| chr10_99732699_C_T | chr10:99732699 | 0.267 | 0.136 | 0.222 | — |
| chr10_99695969_A_T | chr10:99695969 | -0.193 | -0.275 | -0.459 | — |
| chr10_99732708_A_C | chr10:99732708 | -0.257 | -0.081 | -0.298 | — |
| chr10_99732727_C_G | chr10:99732727 | 0.255 | 0.106 | 0.222 | — |
| chr10_99696019_C_T | chr10:99696019 | -0.229 | -0.322 | -0.444 | — |
| chr10_99696022_G_C | chr10:99696022 | -0.196 | -0.272 | -0.433 | — |
| chr10_99732714_A_C | chr10:99732714 | 0.079 | 0.113 | 0.433 | — |
| chr10_99732725_G_C | chr10:99732725 | -0.227 | -0.121 | -0.433 | — |
| chr10_99732704_C_A | chr10:99732704 | -0.242 | -0.113 | -0.316 | — |
| chr10_99732706_A_C | chr10:99732706 | -0.238 | -0.111 | -0.205 | — |
| chr10_99732704_C_T | chr10:99732704 | -0.225 | -0.068 | -0.246 | — |
| chr10_99732626_C_T | chr10:99732626 | -0.030 | -0.103 | -0.386 | — |
| chr10_99695948_T_C | chr10:99695948 | 0.147 | 0.232 | 0.383 | — |
| chr10_99695965_G_C | chr10:99695965 | -0.166 | -0.244 | -0.383 | — |
| chr10_99695965_G_A | chr10:99695965 | -0.149 | -0.219 | -0.380 | — |
| chr10_99732703_G_C | chr10:99732703 | -0.214 | -0.128 | -0.193 | — |
| chr10_99696021_C_G | chr10:99696021 | -0.166 | -0.222 | -0.374 | — |
| chr10_99732567_A_C | chr10:99732567 | 0.172 | 0.093 | 0.374 | — |
| chr10_99695951_T_C | chr10:99695951 | 0.168 | 0.207 | 0.371 | — |
| chr10_99732704_C_G | chr10:99732704 | -0.209 | -0.073 | -0.158 | — |
| chr10_99696024_G_A | chr10:99696024 | -0.167 | -0.237 | -0.363 | — |
| chr10_99732626_C_A | chr10:99732626 | -0.010 | -0.073 | -0.363 | — |
| chr10_99732692_T_A | chr10:99732692 | -0.142 | -0.111 | -0.363 | — |
| chr10_99695969_A_C | chr10:99695969 | -0.180 | -0.257 | -0.360 | — |
| chr10_99696024_G_C | chr10:99696024 | -0.174 | -0.247 | -0.360 | — |
| chr10_99732692_T_C | chr10:99732692 | -0.204 | -0.123 | -0.281 | — |
| chr10_99695965_G_T | chr10:99695965 | -0.148 | -0.207 | -0.354 | — |
| chr10_99732686_T_G | chr10:99732686 | 0.046 | 0.121 | 0.351 | — |
| chr10_99696022_G_T | chr10:99696022 | -0.158 | -0.232 | -0.348 | — |
| chr10_99695967_C_G | chr10:99695967 | -0.151 | -0.202 | -0.339 | — |
| chr10_99732626_C_G | chr10:99732626 | -0.013 | -0.101 | -0.339 | — |
| chr10_99732707_C_A | chr10:99732707 | -0.137 | -0.071 | -0.333 | — |
| chr10_99732710_G_A | chr10:99732710 | -0.169 | -0.081 | -0.333 | — |
| chr10_99696022_G_A | chr10:99696022 | -0.168 | -0.244 | -0.330 | — |
| chr10_99695967_C_A | chr10:99695967 | -0.139 | -0.191 | -0.327 | — |
| chr10_99696021_C_A | chr10:99696021 | -0.156 | -0.209 | -0.327 | — |
| chr10_99732680_T_G | chr10:99732680 | 0.053 | 0.096 | 0.327 | — |
| chr10_99732692_T_G | chr10:99732692 | -0.185 | -0.139 | -0.298 | — |
| chr10_99732693_T_G | chr10:99732693 | 0.017 | 0.073 | 0.327 | — |
| chr10_99732566_G_A | chr10:99732566 | -0.182 | -0.086 | -0.304 | — |
| chr10_99695967_C_T | chr10:99695967 | -0.135 | -0.204 | -0.319 | — |
| chr10_99695946_T_C | chr10:99695946 | 0.176 | 0.247 | 0.316 | 0.0072% |
| chr10_99695968_A_T | chr10:99695968 | -0.118 | -0.191 | -0.316 | — |
| chr10_99732537_C_T | chr10:99732537 | -0.099 | -0.048 | -0.316 | — |
| chr10_99732555_T_A | chr10:99732555 | 0.179 | 0.020 | 0.082 | — |
| chr10_99732562_T_G | chr10:99732562 | 0.063 | 0.030 | 0.316 | — |
| chr10_99732627_G_A | chr10:99732627 | 0.179 | 0.088 | 0.012 | 0.0013% |
| chr10_99695905_A_G | chr10:99695905 | 0.142 | 0.149 | 0.310 | — |
| chr10_99732625_T_C | chr10:99732625 | 0.175 | -0.043 | -0.129 | — |
| chr10_99732713_G_C | chr10:99732713 | 0.050 | 0.076 | 0.310 | <0.001% |
| chr10_99696021_C_T | chr10:99696021 | -0.161 | -0.232 | -0.307 | 0.0026% |
| chr10_99696027_C_T | chr10:99696027 | -0.149 | -0.199 | -0.307 | — |
| chr10_99696025_T_G | chr10:99696025 | 0.151 | 0.202 | 0.301 | — |
| chr10_99696032_T_G | chr10:99696032 | 0.148 | 0.219 | 0.301 | — |
| chr10_99695916_A_G | chr10:99695916 | 0.075 | 0.219 | 0.298 | — |
| chr10_99695968_A_G | chr10:99695968 | -0.129 | -0.194 | -0.298 | — |
| chr10_99695977_C_A | chr10:99695977 | -0.113 | -0.149 | -0.298 | — |
| chr10_99732708_A_T | chr10:99732708 | -0.169 | -0.045 | -0.228 | — |
| chr10_99695963_C_A | chr10:99695963 | -0.142 | -0.189 | -0.295 | — |
| chr10_99696009_A_T | chr10:99696009 | -0.148 | -0.207 | -0.295 | — |
| chr10_99695982_T_A | chr10:99695982 | 0.166 | 0.229 | 0.272 | — |
| chr10_99696034_T_A | chr10:99696034 | -0.132 | -0.186 | -0.292 | — |
| chr10_99732577_C_G | chr10:99732577 | -0.096 | -0.010 | -0.292 | — |
| chr10_99732711_A_G | chr10:99732711 | 0.166 | 0.088 | 0.199 | — |
| chr10_99732718_C_G | chr10:99732718 | -0.166 | -0.083 | -0.135 | — |
| chr10_99696020_A_G | chr10:99696020 | -0.155 | -0.244 | -0.289 | — |
| chr10_99695966_C_T | chr10:99695966 | -0.118 | -0.176 | -0.287 | — |
| chr10_99695998_T_G | chr10:99695998 | 0.088 | 0.146 | 0.287 | — |
| chr10_99695973_C_G | chr10:99695973 | -0.147 | -0.209 | -0.284 | — |
| chr10_99732712_G_A | chr10:99732712 | -0.161 | -0.053 | -0.269 | — |
| chr10_99732674_G_C | chr10:99732674 | 0.159 | 0.146 | 0.234 | — |
| chr10_99732684_G_T | chr10:99732684 | -0.141 | -0.108 | -0.281 | — |
| chr10_99732706_A_T | chr10:99732706 | -0.159 | -0.055 | -0.140 | — |
| chr10_99732708_A_G | chr10:99732708 | -0.156 | -0.025 | -0.123 | — |
| chr10_99696020_A_C | chr10:99696020 | -0.122 | -0.202 | -0.272 | — |
| chr10_99695966_C_A | chr10:99695966 | -0.115 | -0.169 | -0.269 | — |
| chr10_99696023_T_C | chr10:99696023 | -0.151 | -0.219 | -0.193 | <0.001% |
| chr10_99695981_C_T | chr10:99695981 | -0.123 | -0.151 | -0.263 | — |
| chr10_99695981_C_G | chr10:99695981 | -0.148 | -0.128 | -0.173 | — |
| chr10_99696006_G_A | chr10:99696006 | -0.091 | -0.134 | -0.260 | — |
| chr10_99732705_C_A | chr10:99732705 | -0.147 | -0.065 | -0.193 | — |
| chr10_99695972_T_C | chr10:99695972 | -0.124 | -0.169 | -0.257 | — |
| chr10_99732660_C_A | chr10:99732660 | -0.022 | -0.063 | -0.257 | — |
| chr10_99732664_G_C | chr10:99732664 | -0.038 | -0.058 | -0.257 | — |
| chr10_99732689_A_T | chr10:99732689 | -0.146 | -0.141 | -0.222 | — |
| chr10_99695980_G_T | chr10:99695980 | -0.084 | -0.118 | -0.254 | — |
| chr10_99732701_T_A | chr10:99732701 | -0.144 | -0.078 | -0.216 | — |
| chr10_99732727_C_A | chr10:99732727 | 0.142 | 0.068 | 0.088 | — |
| chr10_99696020_A_T | chr10:99696020 | -0.110 | -0.179 | -0.249 | — |
| chr10_99696023_T_G | chr10:99696023 | -0.136 | -0.184 | -0.249 | <0.001% |
| chr10_99732710_G_C | chr10:99732710 | -0.141 | -0.025 | -0.211 | — |
| chr10_99695980_G_C | chr10:99695980 | -0.093 | -0.131 | -0.246 | — |
| chr10_99696003_T_C | chr10:99696003 | 0.111 | 0.156 | 0.246 | — |
| chr10_99696011_A_C | chr10:99696011 | -0.139 | -0.189 | -0.240 | — |
| chr10_99732604_G_A | chr10:99732604 | 0.089 | 0.131 | 0.246 | — |
| chr10_99732629_G_A | chr10:99732629 | 0.139 | 0.106 | 0.117 | — |
| chr10_99732665_T_C | chr10:99732665 | 0.078 | 0.149 | 0.246 | — |
| chr10_99696009_A_C | chr10:99696009 | -0.116 | -0.171 | -0.243 | — |
| chr10_99696018_A_T | chr10:99696018 | 0.110 | 0.159 | 0.243 | — |
| chr10_99696025_T_A | chr10:99696025 | 0.099 | 0.154 | 0.243 | — |
| chr10_99732717_C_G | chr10:99732717 | -0.137 | 0.000 | -0.006 | — |
| chr10_99695981_C_A | chr10:99695981 | -0.137 | -0.149 | -0.237 | — |
| chr10_99695964_T_C | chr10:99695964 | -0.126 | -0.161 | -0.240 | — |
| chr10_99695968_A_C | chr10:99695968 | -0.108 | -0.169 | -0.240 | — |
| chr10_99695994_G_T | chr10:99695994 | 0.132 | 0.144 | 0.240 | — |
| chr10_99732640_C_A | chr10:99732640 | 0.136 | 0.267 | 0.222 | — |
| chr10_99732699_C_A | chr10:99732699 | 0.136 | 0.058 | 0.088 | — |
| chr10_99732705_C_G | chr10:99732705 | -0.136 | -0.073 | -0.193 | — |
| chr10_99696032_T_A | chr10:99696032 | 0.135 | 0.194 | 0.225 | — |
| chr10_99696010_C_G | chr10:99696010 | -0.121 | -0.164 | -0.237 | — |
| chr10_99696024_G_T | chr10:99696024 | -0.134 | -0.184 | -0.228 | — |
| chr10_99696027_C_G | chr10:99696027 | -0.134 | -0.176 | -0.225 | — |
| chr10_99732703_G_T | chr10:99732703 | -0.134 | -0.098 | -0.216 | <0.001% |
| chr10_99696009_A_G | chr10:99696009 | -0.116 | -0.171 | -0.234 | — |
| chr10_99732558_A_T | chr10:99732558 | 0.132 | 0.065 | 0.222 | — |
| chr10_99732627_G_T | chr10:99732627 | -0.007 | -0.078 | -0.234 | — |
| chr10_99732661_C_T | chr10:99732661 | -0.063 | -0.081 | -0.234 | — |
| chr10_99732707_C_G | chr10:99732707 | -0.103 | -0.073 | -0.234 | — |
| chr10_99732709_C_G | chr10:99732709 | -0.132 | -0.060 | -0.199 | — |
| chr10_99732688_C_A | chr10:99732688 | -0.131 | -0.078 | -0.164 | — |
| chr10_99695989_A_T | chr10:99695989 | -0.100 | -0.121 | -0.228 | — |
| chr10_99732711_A_T | chr10:99732711 | -0.035 | 0.053 | 0.228 | — |
| chr10_99732724_C_T | chr10:99732724 | -0.129 | -0.058 | -0.129 | <0.001% |
| chr10_99732725_G_A | chr10:99732725 | -0.065 | -0.035 | -0.228 | — |
| chr10_99695911_C_A | chr10:99695911 | 0.033 | 0.184 | 0.225 | — |
| chr10_99695976_G_T | chr10:99695976 | -0.096 | -0.139 | -0.225 | — |
| chr10_99695979_G_T | chr10:99695979 | -0.114 | -0.139 | -0.225 | — |
| chr10_99696033_T_A | chr10:99696033 | -0.108 | -0.141 | -0.225 | — |
| chr10_99732710_G_T | chr10:99732710 | -0.127 | -0.018 | -0.205 | — |
| chr10_99695962_G_A | chr10:99695962 | -0.089 | -0.121 | -0.222 | — |
| chr10_99695977_C_G | chr10:99695977 | -0.099 | -0.121 | -0.222 | — |
| chr10_99732567_A_T | chr10:99732567 | 0.126 | 0.091 | 0.164 | — |
| chr10_99732622_G_T | chr10:99732622 | -0.026 | -0.053 | -0.222 | — |
| chr10_99732623_G_A | chr10:99732623 | 0.043 | -0.071 | -0.222 | — |
| chr10_99732680_T_C | chr10:99732680 | -0.017 | 0.010 | 0.222 | — |
| chr10_99732712_G_C | chr10:99732712 | -0.126 | 0.000 | -0.094 | — |
| chr10_99732714_A_T | chr10:99732714 | -0.013 | 0.063 | 0.222 | — |
| chr10_99695957_A_T | chr10:99695957 | 0.123 | 0.141 | 0.149 | — |
| chr10_99695953_T_G | chr10:99695953 | 0.064 | 0.078 | 0.216 | — |
| chr10_99732693_T_C | chr10:99732693 | -0.075 | -0.060 | -0.216 | — |
| chr10_99696002_A_C | chr10:99696002 | 0.067 | 0.058 | 0.213 | — |
| chr10_99696005_T_G | chr10:99696005 | -0.088 | -0.144 | -0.211 | — |
| chr10_99732563_G_A | chr10:99732563 | 0.036 | 0.020 | -0.211 | — |
| chr10_99732583_G_T | chr10:99732583 | 0.116 | 0.055 | 0.211 | — |
| chr10_99732619_C_A | chr10:99732619 | 0.119 | 0.053 | 0.012 | — |
| chr10_99732628_A_G | chr10:99732628 | -0.030 | -0.101 | -0.211 | — |
| chr10_99732633_C_G | chr10:99732633 | -0.043 | -0.055 | -0.211 | — |
| chr10_99732639_C_G | chr10:99732639 | 0.023 | 0.078 | 0.211 | — |
| chr10_99695962_G_T | chr10:99695962 | -0.075 | -0.111 | -0.208 | — |
| chr10_99695998_T_A | chr10:99695998 | 0.102 | 0.156 | 0.208 | — |
| chr10_99696018_A_C | chr10:99696018 | 0.079 | 0.121 | 0.208 | — |
| chr10_99695932_T_G | chr10:99695932 | 0.110 | 0.123 | 0.205 | — |
| chr10_99695976_G_A | chr10:99695976 | -0.069 | -0.106 | -0.205 | 0.0013% |
| chr10_99696008_A_T | chr10:99696008 | -0.051 | -0.088 | -0.205 | — |
| chr10_99696016_G_T | chr10:99696016 | -0.105 | -0.151 | -0.205 | — |
| chr10_99732707_C_T | chr10:99732707 | -0.113 | -0.035 | -0.205 | 0.026% |
| chr10_99732719_A_G | chr10:99732719 | -0.116 | -0.096 | -0.099 | <0.001% |
| chr10_99732723_C_A | chr10:99732723 | -0.060 | -0.028 | -0.205 | — |
| chr10_99696034_T_C | chr10:99696034 | -0.084 | -0.131 | -0.199 | — |
| chr10_99732536_A_G | chr10:99732536 | 0.113 | -0.005 | 0.105 | <0.001% |
| chr10_99732562_T_C | chr10:99732562 | -0.040 | -0.038 | 0.199 | — |
| chr10_99732564_T_C | chr10:99732564 | 0.000 | 0.071 | 0.199 | — |
| chr10_99732593_T_G | chr10:99732593 | -0.113 | -0.043 | 0.012 | — |
| chr10_99732596_C_G | chr10:99732596 | -0.026 | -0.020 | -0.199 | — |
| chr10_99732624_T_G | chr10:99732624 | 0.113 | -0.025 | -0.187 | — |
| chr10_99732625_T_A | chr10:99732625 | 0.033 | -0.053 | -0.199 | — |
| chr10_99732625_T_G | chr10:99732625 | -0.036 | -0.121 | -0.199 | — |
| chr10_99732635_G_C | chr10:99732635 | -0.033 | -0.018 | 0.199 | — |
| chr10_99732691_G_C | chr10:99732691 | -0.073 | -0.045 | -0.199 | — |
| chr10_99695945_T_A | chr10:99695945 | 0.093 | 0.101 | 0.196 | — |
| chr10_99695954_A_G | chr10:99695954 | 0.080 | 0.111 | 0.196 | — |
| chr10_99695971_A_C | chr10:99695971 | -0.111 | -0.144 | -0.161 | — |
| chr10_99695985_G_A | chr10:99695985 | -0.089 | -0.081 | -0.196 | — |
| chr10_99696006_G_T | chr10:99696006 | -0.071 | -0.086 | -0.193 | — |
| chr10_99732573_A_G | chr10:99732573 | -0.109 | -0.098 | -0.175 | — |
| chr10_99732715_T_G | chr10:99732715 | -0.012 | 0.020 | 0.193 | — |
| chr10_99732717_C_T | chr10:99732717 | -0.109 | -0.030 | -0.140 | 0.0026% |
| chr10_99695964_T_G | chr10:99695964 | -0.098 | -0.126 | -0.190 | — |
| chr10_99695966_C_G | chr10:99695966 | -0.089 | -0.134 | -0.190 | — |
| chr10_99695971_A_T | chr10:99695971 | 0.053 | 0.086 | 0.190 | — |
| chr10_99695973_C_A | chr10:99695973 | -0.072 | -0.106 | -0.190 | — |
| chr10_99732690_C_T | chr10:99732690 | -0.108 | -0.071 | -0.105 | — |
| chr10_99696017_A_C | chr10:99696017 | -0.106 | -0.169 | -0.178 | — |
| chr10_99696027_C_A | chr10:99696027 | -0.106 | -0.123 | -0.152 | — |
| chr10_99732544_T_C | chr10:99732544 | 0.043 | 0.045 | 0.187 | — |
| chr10_99732558_A_G | chr10:99732558 | 0.073 | 0.033 | 0.187 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.