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ABCC2
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of ABCC2 expression, diminishing canalicular efflux capacity and reducing the clearance of clearance-dependent substrates.
Affected substrate drugs (PharmGKB): tenofovir; methotrexate; mycophenolic acid; talinolol; lopinavir; tacrolimus
Scored variants near ABCC2
chr10:99,682,639..99,952,594, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr10_99732714_A_G | chr10:99732714 | 60,736 | 10,784 | 25,216 | — |
| chr10_99732715_T_C | chr10:99732715 | 44,544 | 7,584 | 20,352 | — |
| chr10_99696002_A_T | chr10:99696002 | 44,288 | 18,720 | 46,656 | — |
| chr10_99695953_T_C | chr10:99695953 | 26,336 | 9,632 | 22,848 | — |
| chr10_99732718_C_T | chr10:99732718 | 18,624 | 2,432 | 3,328 | — |
| chr10_99732709_C_A | chr10:99732709 | 17,984 | 2,912 | 5,120 | — |
| chr10_99732687_T_G | chr10:99732687 | 15,040 | 2,688 | 9,984 | — |
| chr10_99695943_T_C | chr10:99695943 | 14,400 | 6,240 | 16,064 | — |
| chr10_99696004_G_T | chr10:99696004 | 12,416 | 6,240 | 14,272 | — |
| chr10_99696019_C_G | chr10:99696019 | -11,936 | -5,504 | -12,800 | — |
| chr10_99695951_T_A | chr10:99695951 | 11,520 | 4,576 | 11,840 | — |
| chr10_99696019_C_A | chr10:99696019 | -10,432 | -4,576 | -11,008 | — |
| chr10_99732699_C_T | chr10:99732699 | 10,304 | 1,728 | 4,864 | — |
| chr10_99732708_A_C | chr10:99732708 | -9,920 | -1,024 | -6,528 | — |
| chr10_99695989_A_C | chr10:99695989 | 9,856 | 3,872 | 12,032 | — |
| chr10_99732727_C_G | chr10:99732727 | 9,856 | 1,344 | 4,864 | — |
| chr10_99732704_C_A | chr10:99732704 | -9,344 | -1,440 | -6,912 | — |
| chr10_99732706_A_C | chr10:99732706 | -9,216 | -1,408 | -4,480 | — |
| chr10_99696019_C_T | chr10:99696019 | -8,864 | -4,096 | -9,728 | — |
| chr10_99732725_G_C | chr10:99732725 | -8,768 | -1,536 | -9,472 | — |
| chr10_99732704_C_T | chr10:99732704 | -8,704 | -864 | -5,376 | — |
| chr10_99732703_G_C | chr10:99732703 | -8,256 | -1,632 | -4,224 | — |
| chr10_99732704_C_G | chr10:99732704 | -8,064 | -928 | -3,456 | — |
| chr10_99732692_T_C | chr10:99732692 | -7,872 | -1,568 | -6,144 | — |
| chr10_99696022_G_C | chr10:99696022 | -7,584 | -3,456 | -9,472 | — |
| chr10_99695969_A_T | chr10:99695969 | -7,456 | -3,488 | -10,048 | — |
| chr10_99732692_T_G | chr10:99732692 | -7,168 | -1,760 | -6,528 | — |
| chr10_99732566_G_A | chr10:99732566 | -7,040 | -1,088 | -6,656 | — |
| chr10_99695969_A_C | chr10:99695969 | -6,976 | -3,264 | -7,872 | — |
| chr10_99732555_T_A | chr10:99732555 | 6,912 | 256 | 1,792 | — |
| chr10_99732627_G_A | chr10:99732627 | 6,912 | 1,120 | 256 | 1.3e-5 |
| chr10_99695946_T_C | chr10:99695946 | 6,816 | 3,136 | 6,912 | 7.2e-5 |
| chr10_99732625_T_C | chr10:99732625 | 6,784 | -544 | -2,816 | — |
| chr10_99696024_G_C | chr10:99696024 | -6,720 | -3,136 | -7,872 | — |
| chr10_99732567_A_C | chr10:99732567 | 6,656 | 1,184 | 8,192 | — |
| chr10_99732710_G_A | chr10:99732710 | -6,528 | -1,024 | -7,296 | — |
| chr10_99732708_A_T | chr10:99732708 | -6,528 | -576 | -4,992 | — |
| chr10_99695951_T_C | chr10:99695951 | 6,496 | 2,624 | 8,128 | — |
| chr10_99696022_G_A | chr10:99696022 | -6,496 | -3,104 | -7,232 | — |
| chr10_99696024_G_A | chr10:99696024 | -6,464 | -3,008 | -7,936 | — |
| chr10_99695965_G_C | chr10:99695965 | -6,400 | -3,104 | -8,384 | — |
| chr10_99696021_C_G | chr10:99696021 | -6,400 | -2,816 | -8,192 | — |
| chr10_99695982_T_A | chr10:99695982 | 6,400 | 2,912 | 5,952 | — |
| chr10_99732711_A_G | chr10:99732711 | 6,400 | 1,120 | 4,352 | — |
| chr10_99732718_C_G | chr10:99732718 | -6,400 | -1,056 | -2,944 | — |
| chr10_99696021_C_T | chr10:99696021 | -6,208 | -2,944 | -6,720 | 2.6e-5 |
| chr10_99732712_G_A | chr10:99732712 | -6,208 | -672 | -5,888 | — |
| chr10_99732674_G_C | chr10:99732674 | 6,144 | 1,856 | 5,120 | — |
| chr10_99732706_A_T | chr10:99732706 | -6,144 | -704 | -3,072 | — |
| chr10_99696022_G_T | chr10:99696022 | -6,112 | -2,944 | -7,616 | — |
| chr10_99696021_C_A | chr10:99696021 | -6,016 | -2,656 | -7,168 | — |
| chr10_99732708_A_G | chr10:99732708 | -6,016 | -320 | -2,688 | — |
| chr10_99696020_A_G | chr10:99696020 | -5,984 | -3,104 | -6,336 | — |
| chr10_99695967_C_G | chr10:99695967 | -5,856 | -2,560 | -7,424 | — |
| chr10_99696025_T_G | chr10:99696025 | 5,824 | 2,560 | 6,592 | — |
| chr10_99696023_T_C | chr10:99696023 | -5,824 | -2,784 | -4,224 | 6.6e-6 |
| chr10_99695965_G_A | chr10:99695965 | -5,760 | -2,784 | -8,320 | — |
| chr10_99696027_C_T | chr10:99696027 | -5,760 | -2,528 | -6,720 | — |
| chr10_99695965_G_T | chr10:99695965 | -5,728 | -2,624 | -7,744 | — |
| chr10_99696032_T_G | chr10:99696032 | 5,728 | 2,784 | 6,592 | — |
| chr10_99696009_A_T | chr10:99696009 | -5,728 | -2,624 | -6,464 | — |
| chr10_99695981_C_G | chr10:99695981 | -5,728 | -1,632 | -3,776 | — |
| chr10_99695948_T_C | chr10:99695948 | 5,696 | 2,944 | 8,384 | — |
| chr10_99732705_C_A | chr10:99732705 | -5,696 | -832 | -4,224 | — |
| chr10_99695973_C_G | chr10:99695973 | -5,664 | -2,656 | -6,208 | — |
| chr10_99732689_A_T | chr10:99732689 | -5,632 | -1,792 | -4,864 | — |
| chr10_99732701_T_A | chr10:99732701 | -5,568 | -992 | -4,736 | — |
| chr10_99732683_A_C | chr10:99732683 | 5,504 | 3,040 | 12,416 | — |
| chr10_99732692_T_A | chr10:99732692 | -5,504 | -1,408 | -7,936 | — |
| chr10_99695963_C_A | chr10:99695963 | -5,504 | -2,400 | -6,464 | — |
| chr10_99732727_C_A | chr10:99732727 | 5,504 | 864 | 1,920 | — |
| chr10_99695905_A_G | chr10:99695905 | 5,472 | 1,888 | 6,784 | — |
| chr10_99732684_G_T | chr10:99732684 | -5,440 | -1,376 | -6,144 | — |
| chr10_99732710_G_C | chr10:99732710 | -5,440 | -320 | -4,608 | — |
| chr10_99695967_C_A | chr10:99695967 | -5,376 | -2,432 | -7,168 | — |
| chr10_99696011_A_C | chr10:99696011 | -5,376 | -2,400 | -5,248 | — |
| chr10_99732629_G_A | chr10:99732629 | 5,376 | 1,344 | 2,560 | — |
| chr10_99732707_C_A | chr10:99732707 | -5,312 | -896 | -7,296 | — |
| chr10_99732717_C_G | chr10:99732717 | -5,312 | 0 | -128 | — |
| chr10_99695981_C_A | chr10:99695981 | -5,280 | -1,888 | -5,184 | — |
| chr10_99696023_T_G | chr10:99696023 | -5,248 | -2,336 | -5,440 | 6.6e-6 |
| chr10_99732640_C_A | chr10:99732640 | 5,248 | 3,392 | 4,864 | — |
| chr10_99732699_C_A | chr10:99732699 | 5,248 | 736 | 1,920 | — |
| chr10_99732705_C_G | chr10:99732705 | -5,248 | -928 | -4,224 | — |
| chr10_99695967_C_T | chr10:99695967 | -5,216 | -2,592 | -6,976 | — |
| chr10_99696032_T_A | chr10:99696032 | 5,216 | 2,464 | 4,928 | — |
| chr10_99696024_G_T | chr10:99696024 | -5,184 | -2,336 | -4,992 | — |
| chr10_99696027_C_G | chr10:99696027 | -5,184 | -2,240 | -4,928 | — |
| chr10_99732703_G_T | chr10:99732703 | -5,184 | -1,248 | -4,736 | 6.6e-6 |
| chr10_99695994_G_T | chr10:99695994 | 5,120 | 1,824 | 5,248 | — |
| chr10_99732558_A_T | chr10:99732558 | 5,120 | 832 | 4,864 | — |
| chr10_99732709_C_G | chr10:99732709 | -5,120 | -768 | -4,352 | — |
| chr10_99696034_T_A | chr10:99696034 | -5,088 | -2,368 | -6,400 | — |
| chr10_99732688_C_A | chr10:99732688 | -5,056 | -992 | -3,584 | — |
| chr10_99695968_A_G | chr10:99695968 | -4,992 | -2,464 | -6,528 | — |
| chr10_99732724_C_T | chr10:99732724 | -4,992 | -736 | -2,816 | 6.6e-6 |
| chr10_99732710_G_T | chr10:99732710 | -4,928 | -224 | -4,480 | — |
| chr10_99695964_T_C | chr10:99695964 | -4,864 | -2,048 | -5,248 | — |
| chr10_99732567_A_T | chr10:99732567 | 4,864 | 1,152 | 3,584 | — |
| chr10_99732712_G_C | chr10:99732712 | -4,864 | 0 | -2,048 | — |
| chr10_99695972_T_C | chr10:99695972 | -4,800 | -2,144 | -5,632 | — |
| chr10_99695957_A_T | chr10:99695957 | 4,768 | 1,792 | 3,264 | — |
| chr10_99695981_C_T | chr10:99695981 | -4,736 | -1,920 | -5,760 | — |
| chr10_99696020_A_C | chr10:99696020 | -4,704 | -2,560 | -5,952 | — |
| chr10_99696010_C_G | chr10:99696010 | -4,672 | -2,080 | -5,184 | — |
| chr10_99732619_C_A | chr10:99732619 | 4,608 | 672 | 256 | — |
| chr10_99695968_A_T | chr10:99695968 | -4,576 | -2,432 | -6,912 | — |
| chr10_99695966_C_T | chr10:99695966 | -4,544 | -2,240 | -6,272 | — |
| chr10_99696009_A_C | chr10:99696009 | -4,480 | -2,176 | -5,312 | — |
| chr10_99696009_A_G | chr10:99696009 | -4,480 | -2,176 | -5,120 | — |
| chr10_99732583_G_T | chr10:99732583 | 4,480 | 704 | 4,608 | — |
| chr10_99732719_A_G | chr10:99732719 | -4,480 | -1,216 | -2,176 | 6.6e-6 |
| chr10_99695966_C_A | chr10:99695966 | -4,448 | -2,144 | -5,888 | — |
| chr10_99695979_G_T | chr10:99695979 | -4,416 | -1,760 | -4,928 | — |
| chr10_99695977_C_A | chr10:99695977 | -4,384 | -1,888 | -6,528 | — |
| chr10_99732707_C_T | chr10:99732707 | -4,352 | -448 | -4,480 | 2.6e-4 |
| chr10_99732536_A_G | chr10:99732536 | 4,352 | -64 | 2,304 | 6.6e-6 |
| chr10_99732593_T_G | chr10:99732593 | -4,352 | -544 | 256 | — |
| chr10_99732624_T_G | chr10:99732624 | 4,352 | -320 | -4,096 | — |
| chr10_99696003_T_C | chr10:99696003 | 4,288 | 1,984 | 5,376 | — |
| chr10_99695971_A_C | chr10:99695971 | -4,288 | -1,824 | -3,520 | — |
| chr10_99696020_A_T | chr10:99696020 | -4,256 | -2,272 | -5,440 | — |
| chr10_99696018_A_T | chr10:99696018 | 4,256 | 2,016 | 5,312 | — |
| chr10_99695932_T_G | chr10:99695932 | 4,256 | 1,568 | 4,480 | — |
| chr10_99732573_A_G | chr10:99732573 | -4,224 | -1,248 | -3,840 | — |
| chr10_99732717_C_T | chr10:99732717 | -4,224 | -384 | -3,072 | 2.6e-5 |
| chr10_99696033_T_A | chr10:99696033 | -4,192 | -1,792 | -4,928 | — |
| chr10_99695968_A_C | chr10:99695968 | -4,160 | -2,144 | -5,248 | — |
| chr10_99732690_C_T | chr10:99732690 | -4,160 | -896 | -2,304 | — |
| chr10_99696017_A_C | chr10:99696017 | -4,096 | -2,144 | -3,904 | — |
| chr10_99696027_C_A | chr10:99696027 | -4,096 | -1,568 | -3,328 | — |
| chr10_99696016_G_T | chr10:99696016 | -4,064 | -1,920 | -4,480 | — |
| chr10_99732707_C_G | chr10:99732707 | -3,968 | -928 | -5,120 | — |
| chr10_99695998_T_A | chr10:99695998 | 3,936 | 1,984 | 4,544 | — |
| chr10_99695989_A_T | chr10:99695989 | -3,872 | -1,536 | -4,992 | — |
| chr10_99732537_C_T | chr10:99732537 | -3,840 | -608 | -6,912 | — |
| chr10_99696025_T_A | chr10:99696025 | 3,840 | 1,952 | 5,312 | — |
| chr10_99695977_C_G | chr10:99695977 | -3,808 | -1,536 | -4,864 | — |
| chr10_99695964_T_G | chr10:99695964 | -3,776 | -1,600 | -4,160 | — |
| chr10_99732577_C_G | chr10:99732577 | -3,712 | -128 | -6,400 | — |
| chr10_99695976_G_T | chr10:99695976 | -3,712 | -1,760 | -4,928 | — |
| chr10_99695980_G_C | chr10:99695980 | -3,584 | -1,664 | -5,376 | — |
| chr10_99695945_T_A | chr10:99695945 | 3,584 | 1,280 | 4,288 | — |
| chr10_99696006_G_A | chr10:99696006 | -3,520 | -1,696 | -5,696 | — |
| chr10_99732604_G_A | chr10:99732604 | 3,456 | 1,664 | 5,376 | — |
| chr10_99695962_G_A | chr10:99695962 | -3,456 | -1,536 | -4,864 | — |
| chr10_99695985_G_A | chr10:99695985 | -3,456 | -1,024 | -4,288 | — |
| chr10_99695966_C_G | chr10:99695966 | -3,456 | -1,696 | -4,160 | — |
| chr10_99695998_T_G | chr10:99695998 | 3,392 | 1,856 | 6,272 | — |
| chr10_99696005_T_G | chr10:99696005 | -3,392 | -1,824 | -4,608 | — |
| chr10_99695980_G_T | chr10:99695980 | -3,264 | -1,504 | -5,568 | — |
| chr10_99696034_T_C | chr10:99696034 | -3,232 | -1,664 | -4,352 | — |
| chr10_99695954_A_G | chr10:99695954 | 3,104 | 1,408 | 4,288 | — |
| chr10_99732714_A_C | chr10:99732714 | 3,072 | 1,440 | 9,472 | — |
| chr10_99696018_A_C | chr10:99696018 | 3,040 | 1,536 | 4,544 | — |
| chr10_99732665_T_C | chr10:99732665 | 3,008 | 1,888 | 5,376 | — |
| chr10_99695916_A_G | chr10:99695916 | 2,912 | 2,784 | 6,528 | — |
| chr10_99695962_G_T | chr10:99695962 | -2,912 | -1,408 | -4,544 | — |
| chr10_99732693_T_C | chr10:99732693 | -2,880 | -768 | -4,736 | — |
| chr10_99732691_G_C | chr10:99732691 | -2,816 | -576 | -4,352 | — |
| chr10_99732558_A_G | chr10:99732558 | 2,816 | 416 | 4,096 | — |
| chr10_99695973_C_A | chr10:99695973 | -2,784 | -1,344 | -4,160 | — |
| chr10_99696006_G_T | chr10:99696006 | -2,752 | -1,088 | -4,224 | — |
| chr10_99695976_G_A | chr10:99695976 | -2,656 | -1,344 | -4,480 | 1.3e-5 |
| chr10_99696002_A_C | chr10:99696002 | 2,592 | 736 | 4,672 | — |
| chr10_99732725_G_A | chr10:99732725 | -2,496 | -448 | -4,992 | — |
| chr10_99695953_T_G | chr10:99695953 | 2,464 | 992 | 4,736 | — |
| chr10_99732562_T_G | chr10:99732562 | 2,432 | 384 | 6,912 | — |
| chr10_99732661_C_T | chr10:99732661 | -2,432 | -1,024 | -5,120 | — |
| chr10_99732723_C_A | chr10:99732723 | -2,304 | -352 | -4,480 | — |
| chr10_99732680_T_G | chr10:99732680 | 2,048 | 1,216 | 7,168 | — |
| chr10_99695971_A_T | chr10:99695971 | 2,048 | 1,088 | 4,160 | — |
| chr10_99696008_A_T | chr10:99696008 | -1,984 | -1,120 | -4,480 | — |
| chr10_99732713_G_C | chr10:99732713 | 1,920 | 960 | 6,784 | 6.6e-6 |
| chr10_99732686_T_G | chr10:99732686 | 1,792 | 1,536 | 7,680 | — |
| chr10_99732623_G_A | chr10:99732623 | 1,664 | -896 | -4,864 | — |
| chr10_99732633_C_G | chr10:99732633 | -1,664 | -704 | -4,608 | — |
| chr10_99732544_T_C | chr10:99732544 | 1,664 | 576 | 4,096 | — |
| chr10_99732562_T_C | chr10:99732562 | -1,536 | -480 | 4,352 | — |
| chr10_99732664_G_C | chr10:99732664 | -1,472 | -736 | -5,632 | — |
| chr10_99732563_G_A | chr10:99732563 | 1,408 | 256 | -4,608 | — |
| chr10_99732625_T_G | chr10:99732625 | -1,408 | -1,536 | -4,352 | — |
| chr10_99732711_A_T | chr10:99732711 | -1,344 | 672 | 4,992 | — |
| chr10_99695911_C_A | chr10:99695911 | 1,280 | 2,336 | 4,928 | — |
| chr10_99732625_T_A | chr10:99732625 | 1,280 | -672 | -4,352 | — |
| chr10_99732635_G_C | chr10:99732635 | -1,280 | -224 | 4,352 | — |
| chr10_99732626_C_T | chr10:99732626 | -1,152 | -1,312 | -8,448 | — |
| chr10_99732628_A_G | chr10:99732628 | -1,152 | -1,280 | -4,608 | — |
| chr10_99732622_G_T | chr10:99732622 | -1,024 | -672 | -4,864 | — |
| chr10_99732596_C_G | chr10:99732596 | -1,024 | -256 | -4,352 | — |
| chr10_99732639_C_G | chr10:99732639 | 896 | 992 | 4,608 | — |
| chr10_99732660_C_A | chr10:99732660 | -832 | -800 | -5,632 | — |
| chr10_99732693_T_G | chr10:99732693 | 640 | 928 | 7,168 | — |
| chr10_99732680_T_C | chr10:99732680 | -640 | 128 | 4,864 | — |
| chr10_99732626_C_G | chr10:99732626 | -512 | -1,280 | -7,424 | — |
| chr10_99732714_A_T | chr10:99732714 | -512 | 800 | 4,864 | — |
| chr10_99732715_T_G | chr10:99732715 | -448 | 256 | 4,224 | — |
| chr10_99732626_C_A | chr10:99732626 | -384 | -928 | -7,936 | — |
| chr10_99732627_G_T | chr10:99732627 | -256 | -992 | -5,120 | — |
| chr10_99732564_T_C | chr10:99732564 | 0 | 896 | 4,352 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.