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ABCC3
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of ABCC3 expression, weakening basolateral transport capacity for organic anions and drug conjugates such as methotrexate and morphine-glucuronide.
Affected substrate drugs (PharmGKB): cisplatin; morphine; cyclophosphamide; doxorubicin; methotrexate; vincristine
Scored variants near ABCC3
chr17:50,534,880..50,792,253, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr17_50543044_C_G | chr17:50543044 | 1.000 | 1.000 | 1.000 | — |
| chr17_50542998_A_T | chr17:50542998 | 1.000 | 0.889 | 1.000 | — |
| chr17_50543214_A_G | chr17:50543214 | 0.285 | 0.365 | 1.000 | — |
| chr17_50543035_A_T | chr17:50543035 | 1.000 | 0.937 | 1.000 | — |
| chr17_50543051_T_G | chr17:50543051 | 0.941 | 0.899 | 1.000 | — |
| chr17_50543205_C_G | chr17:50543205 | 0.834 | 0.771 | 1.000 | — |
| chr17_50543044_C_T | chr17:50543044 | 0.793 | 0.514 | 0.966 | 0.0039% |
| chr17_50543067_T_A | chr17:50543067 | -0.744 | -0.637 | -1.000 | — |
| chr17_50543067_T_G | chr17:50543067 | -0.743 | -0.615 | -1.000 | — |
| chr17_50543051_T_C | chr17:50543051 | 0.610 | 0.642 | 0.798 | — |
| chr17_50543067_T_C | chr17:50543067 | -0.607 | -0.544 | -0.972 | — |
| chr17_50543060_C_T | chr17:50543060 | 0.590 | 0.539 | 0.742 | — |
| chr17_50543195_T_C | chr17:50543195 | -0.575 | -0.443 | -0.978 | — |
| chr17_50543060_C_A | chr17:50543060 | -0.508 | -0.363 | -0.966 | — |
| chr17_50543064_T_G | chr17:50543064 | -0.559 | -0.348 | -0.826 | — |
| chr17_50543068_G_C | chr17:50543068 | -0.559 | -0.388 | -0.933 | — |
| chr17_50543035_A_C | chr17:50543035 | 0.549 | 0.494 | 0.551 | — |
| chr17_50543064_T_A | chr17:50543064 | -0.546 | -0.338 | -0.860 | — |
| chr17_50543196_C_G | chr17:50543196 | 0.541 | 0.438 | 0.742 | — |
| chr17_50542998_A_C | chr17:50542998 | 0.390 | 0.267 | 0.921 | — |
| chr17_50543031_T_C | chr17:50543031 | -0.525 | -0.398 | -0.843 | — |
| chr17_50543054_A_G | chr17:50543054 | 0.502 | 0.481 | 0.775 | — |
| chr17_50543060_C_G | chr17:50543060 | -0.475 | -0.325 | -0.843 | — |
| chr17_50543063_A_C | chr17:50543063 | -0.489 | -0.341 | -0.764 | — |
| chr17_50543052_T_G | chr17:50543052 | 0.477 | 0.431 | 0.697 | 0.0059% |
| chr17_50543065_A_T | chr17:50543065 | -0.425 | -0.300 | -0.809 | — |
| chr17_50543022_G_C | chr17:50543022 | 0.457 | 0.275 | 0.573 | — |
| chr17_50543063_A_G | chr17:50543063 | -0.454 | -0.320 | -0.713 | — |
| chr17_50543064_T_C | chr17:50543064 | -0.449 | -0.305 | -0.685 | — |
| chr17_50543070_C_G | chr17:50543070 | -0.402 | -0.272 | -0.758 | — |
| chr17_50543047_A_G | chr17:50543047 | 0.439 | 0.360 | 0.697 | — |
| chr17_50543069_A_C | chr17:50543069 | -0.372 | -0.282 | -0.753 | — |
| chr17_50543065_A_C | chr17:50543065 | -0.398 | -0.282 | -0.736 | — |
| chr17_50543055_T_G | chr17:50543055 | 0.423 | 0.469 | 0.652 | — |
| chr17_50543000_A_G | chr17:50543000 | 0.405 | 0.579 | 0.629 | — |
| chr17_50543057_C_A | chr17:50543057 | 0.405 | 0.355 | 0.640 | — |
| chr17_50543069_A_T | chr17:50543069 | -0.339 | -0.272 | -0.691 | — |
| chr17_50543053_A_C | chr17:50543053 | 0.402 | 0.416 | 0.674 | — |
| chr17_50543070_C_A | chr17:50543070 | -0.351 | -0.254 | -0.680 | — |
| chr17_50543052_T_A | chr17:50543052 | 0.392 | 0.338 | 0.483 | — |
| chr17_50543041_G_T | chr17:50543041 | 0.389 | 0.300 | 0.545 | — |
| chr17_50542934_G_A | chr17:50542934 | 0.241 | 0.254 | 0.663 | — |
| chr17_50543061_A_G | chr17:50543061 | -0.316 | -0.259 | -0.624 | — |
| chr17_50543065_A_G | chr17:50543065 | -0.356 | -0.272 | -0.624 | — |
| chr17_50543035_A_G | chr17:50543035 | 0.361 | 0.247 | 0.382 | <0.001% |
| chr17_50543038_C_G | chr17:50543038 | -0.325 | -0.244 | -0.612 | — |
| chr17_50543047_A_C | chr17:50543047 | -0.352 | -0.307 | -0.444 | — |
| chr17_50543220_T_A | chr17:50543220 | -0.144 | -0.164 | -0.601 | — |
| chr17_50543238_T_C | chr17:50543238 | -0.031 | -0.106 | 0.601 | — |
| chr17_50543062_A_T | chr17:50543062 | -0.348 | -0.227 | -0.579 | — |
| chr17_50543066_T_A | chr17:50543066 | -0.305 | -0.196 | -0.596 | — |
| chr17_50543232_T_G | chr17:50543232 | 0.346 | 0.345 | 0.534 | — |
| chr17_50543066_T_C | chr17:50543066 | -0.308 | -0.217 | -0.590 | — |
| chr17_50543220_T_G | chr17:50543220 | -0.152 | -0.174 | -0.590 | — |
| chr17_50543222_A_C | chr17:50543222 | -0.143 | -0.169 | -0.590 | — |
| chr17_50543044_C_A | chr17:50543044 | 0.339 | 0.257 | 0.461 | — |
| chr17_50543028_A_C | chr17:50543028 | 0.300 | 0.229 | 0.573 | — |
| chr17_50543066_T_G | chr17:50543066 | -0.307 | -0.209 | -0.573 | — |
| chr17_50543063_A_T | chr17:50543063 | -0.321 | -0.196 | -0.556 | — |
| chr17_50542995_T_G | chr17:50542995 | 0.270 | 0.219 | 0.551 | — |
| chr17_50543045_C_G | chr17:50543045 | 0.292 | 0.204 | 0.551 | — |
| chr17_50543055_T_A | chr17:50543055 | 0.321 | 0.345 | 0.483 | — |
| chr17_50543062_A_C | chr17:50543062 | -0.321 | -0.204 | -0.511 | — |
| chr17_50543062_A_G | chr17:50543062 | -0.320 | -0.207 | -0.517 | — |
| chr17_50543222_A_T | chr17:50543222 | -0.123 | -0.176 | -0.545 | — |
| chr17_50543045_C_A | chr17:50543045 | 0.315 | 0.217 | 0.506 | — |
| chr17_50543053_A_G | chr17:50543053 | 0.274 | 0.275 | 0.539 | — |
| chr17_50542999_G_T | chr17:50542999 | 0.313 | 0.282 | 0.393 | — |
| chr17_50543050_T_G | chr17:50543050 | 0.303 | 0.355 | 0.494 | — |
| chr17_50543040_G_T | chr17:50543040 | 0.302 | 0.222 | 0.449 | — |
| chr17_50543215_C_A | chr17:50543215 | 0.295 | 0.222 | 0.517 | — |
| chr17_50543011_C_A | chr17:50543011 | -0.289 | -0.234 | -0.393 | <0.001% |
| chr17_50543013_G_T | chr17:50543013 | -0.264 | -0.259 | -0.494 | — |
| chr17_50543219_G_T | chr17:50543219 | -0.098 | -0.098 | -0.494 | — |
| chr17_50542996_C_G | chr17:50542996 | 0.285 | 0.237 | 0.472 | — |
| chr17_50543219_G_A | chr17:50543219 | -0.105 | -0.113 | -0.483 | — |
| chr17_50543015_C_G | chr17:50543015 | 0.275 | 0.380 | 0.337 | — |
| chr17_50543055_T_C | chr17:50543055 | 0.275 | 0.305 | 0.449 | — |
| chr17_50542966_A_C | chr17:50542966 | 0.274 | 0.292 | 0.404 | — |
| chr17_50543188_C_A | chr17:50543188 | -0.244 | -0.212 | -0.466 | — |
| chr17_50543202_C_A | chr17:50543202 | 0.169 | 0.156 | 0.466 | — |
| chr17_50543206_T_G | chr17:50543206 | 0.272 | 0.242 | 0.455 | — |
| chr17_50543205_C_A | chr17:50543205 | 0.257 | 0.270 | 0.461 | — |
| chr17_50543192_A_G | chr17:50543192 | -0.234 | -0.181 | -0.455 | — |
| chr17_50543071_T_G | chr17:50543071 | -0.262 | -0.244 | -0.393 | — |
| chr17_50543030_A_T | chr17:50543030 | 0.259 | 0.254 | 0.371 | — |
| chr17_50543222_A_G | chr17:50543222 | -0.052 | -0.149 | -0.444 | — |
| chr17_50542972_C_A | chr17:50542972 | -0.248 | -0.191 | -0.438 | — |
| chr17_50543053_A_T | chr17:50543053 | 0.223 | 0.209 | 0.438 | — |
| chr17_50543061_A_T | chr17:50543061 | -0.203 | -0.191 | -0.438 | — |
| chr17_50543223_C_G | chr17:50543223 | 0.256 | 0.204 | 0.000 | — |
| chr17_50543223_C_T | chr17:50543223 | 0.202 | 0.098 | 0.433 | 0.0020% |
| chr17_50543237_C_T | chr17:50543237 | 0.252 | 0.370 | 0.337 | — |
| chr17_50542984_G_C | chr17:50542984 | 0.216 | 0.189 | 0.427 | — |
| chr17_50543243_T_C | chr17:50543243 | -0.249 | -0.234 | -0.360 | 0.0013% |
| chr17_50542997_A_C | chr17:50542997 | 0.193 | 0.174 | 0.416 | — |
| chr17_50542999_G_A | chr17:50542999 | 0.243 | 0.292 | 0.416 | 0.0020% |
| chr17_50543014_G_C | chr17:50543014 | -0.239 | -0.184 | -0.315 | <0.001% |
| chr17_50543040_G_A | chr17:50543040 | -0.239 | -0.139 | -0.360 | — |
| chr17_50543204_C_G | chr17:50543204 | 0.211 | 0.199 | 0.410 | — |
| chr17_50543220_T_C | chr17:50543220 | -0.031 | -0.081 | -0.410 | — |
| chr17_50542983_C_G | chr17:50542983 | -0.223 | -0.035 | -0.404 | — |
| chr17_50542997_A_T | chr17:50542997 | 0.230 | 0.239 | 0.404 | — |
| chr17_50543025_T_G | chr17:50543025 | 0.193 | 0.108 | 0.404 | — |
| chr17_50543194_C_G | chr17:50543194 | -0.179 | -0.121 | -0.404 | — |
| chr17_50543243_T_A | chr17:50543243 | -0.236 | -0.217 | -0.191 | — |
| chr17_50543001_G_C | chr17:50543001 | -0.233 | -0.209 | -0.388 | — |
| chr17_50542962_A_G | chr17:50542962 | 0.195 | 0.300 | 0.393 | — |
| chr17_50543014_G_T | chr17:50543014 | -0.221 | -0.184 | -0.393 | — |
| chr17_50543054_A_T | chr17:50543054 | 0.226 | 0.174 | 0.348 | — |
| chr17_50543223_C_A | chr17:50543223 | -0.054 | -0.081 | -0.388 | — |
| chr17_50543211_T_C | chr17:50543211 | -0.223 | -0.234 | -0.365 | — |
| chr17_50542940_A_C | chr17:50542940 | 0.216 | 0.146 | 0.242 | — |
| chr17_50543034_C_A | chr17:50543034 | -0.166 | -0.128 | -0.371 | — |
| chr17_50543043_C_G | chr17:50543043 | 0.216 | 0.176 | 0.292 | — |
| chr17_50543059_G_C | chr17:50543059 | -0.195 | -0.171 | -0.371 | — |
| chr17_50543068_G_A | chr17:50543068 | -0.130 | 0.038 | -0.371 | — |
| chr17_50543003_C_A | chr17:50543003 | -0.215 | -0.186 | -0.281 | — |
| chr17_50543203_T_A | chr17:50543203 | 0.215 | 0.332 | 0.242 | — |
| chr17_50543042_G_A | chr17:50543042 | -0.192 | -0.126 | -0.365 | — |
| chr17_50543221_C_T | chr17:50543221 | -0.044 | -0.078 | -0.365 | — |
| chr17_50543057_C_G | chr17:50543057 | 0.179 | 0.171 | 0.360 | — |
| chr17_50543069_A_G | chr17:50543069 | -0.159 | -0.149 | -0.360 | — |
| chr17_50542995_T_A | chr17:50542995 | 0.208 | 0.181 | 0.292 | — |
| chr17_50542956_G_C | chr17:50542956 | -0.205 | -0.156 | -0.348 | — |
| chr17_50543203_T_C | chr17:50543203 | -0.187 | -0.096 | -0.348 | — |
| chr17_50543215_C_G | chr17:50543215 | 0.202 | 0.103 | 0.348 | — |
| chr17_50543042_G_T | chr17:50543042 | -0.154 | -0.113 | -0.343 | — |
| chr17_50543195_T_A | chr17:50543195 | -0.198 | -0.136 | -0.270 | — |
| chr17_50543030_A_G | chr17:50543030 | -0.197 | -0.151 | -0.264 | — |
| chr17_50542969_A_C | chr17:50542969 | 0.074 | 0.010 | 0.331 | — |
| chr17_50543068_G_T | chr17:50543068 | 0.193 | 0.204 | 0.292 | — |
| chr17_50543217_G_C | chr17:50543217 | -0.034 | -0.053 | -0.331 | — |
| chr17_50542998_A_G | chr17:50542998 | 0.113 | 0.096 | 0.326 | — |
| chr17_50542987_G_T | chr17:50542987 | -0.187 | -0.078 | -0.180 | — |
| chr17_50543027_G_A | chr17:50543027 | -0.169 | -0.154 | -0.320 | — |
| chr17_50543028_A_G | chr17:50543028 | -0.187 | -0.161 | -0.287 | — |
| chr17_50543029_G_A | chr17:50543029 | 0.187 | 0.196 | 0.281 | — |
| chr17_50543052_T_C | chr17:50543052 | 0.187 | 0.166 | 0.315 | — |
| chr17_50543192_A_T | chr17:50543192 | -0.164 | -0.076 | -0.320 | — |
| chr17_50543217_G_A | chr17:50543217 | -0.013 | -0.033 | -0.320 | <0.001% |
| chr17_50542987_G_A | chr17:50542987 | -0.185 | -0.063 | -0.067 | — |
| chr17_50542953_C_G | chr17:50542953 | -0.143 | -0.128 | -0.315 | — |
| chr17_50542983_C_T | chr17:50542983 | -0.175 | -0.128 | -0.315 | 0.0020% |
| chr17_50542992_A_T | chr17:50542992 | -0.167 | -0.103 | -0.315 | — |
| chr17_50543004_A_T | chr17:50543004 | -0.184 | -0.159 | -0.292 | — |
| chr17_50543033_C_A | chr17:50543033 | 0.184 | 0.202 | 0.253 | — |
| chr17_50543058_A_C | chr17:50543058 | 0.146 | 0.144 | 0.315 | — |
| chr17_50543204_C_A | chr17:50543204 | 0.184 | 0.262 | 0.264 | — |
| chr17_50543021_G_T | chr17:50543021 | 0.182 | 0.096 | 0.202 | — |
| chr17_50543025_T_A | chr17:50543025 | 0.164 | 0.116 | 0.309 | <0.001% |
| chr17_50543036_G_A | chr17:50543036 | -0.180 | -0.154 | -0.309 | — |
| chr17_50543231_G_A | chr17:50543231 | -0.128 | -0.086 | -0.309 | — |
| chr17_50543285_C_T | chr17:50543285 | 0.093 | 0.050 | 0.309 | — |
| chr17_50543210_T_C | chr17:50543210 | 0.179 | 0.146 | 0.303 | — |
| chr17_50542980_G_C | chr17:50542980 | 0.084 | 0.068 | 0.303 | — |
| chr17_50542997_A_G | chr17:50542997 | 0.138 | 0.088 | 0.303 | — |
| chr17_50543026_G_T | chr17:50543026 | -0.092 | -0.077 | -0.303 | — |
| chr17_50543051_T_A | chr17:50543051 | 0.177 | 0.244 | 0.225 | — |
| chr17_50543061_A_C | chr17:50543061 | -0.169 | -0.169 | -0.303 | — |
| chr17_50543208_T_A | chr17:50543208 | -0.162 | -0.103 | -0.303 | — |
| chr17_50543211_T_G | chr17:50543211 | 0.177 | 0.103 | 0.146 | — |
| chr17_50543215_C_T | chr17:50543215 | -0.052 | -0.083 | -0.303 | — |
| chr17_50543011_C_T | chr17:50543011 | 0.174 | 0.159 | 0.281 | — |
| chr17_50543194_C_A | chr17:50543194 | -0.139 | -0.078 | -0.298 | — |
| chr17_50543216_T_G | chr17:50543216 | -0.030 | -0.058 | -0.298 | — |
| chr17_50543235_C_A | chr17:50543235 | -0.149 | -0.113 | -0.298 | <0.001% |
| chr17_50543243_T_G | chr17:50543243 | -0.172 | -0.214 | -0.219 | — |
| chr17_50542939_G_C | chr17:50542939 | 0.170 | 0.131 | 0.022 | — |
| chr17_50543001_G_T | chr17:50543001 | -0.170 | -0.161 | -0.292 | — |
| chr17_50543016_T_G | chr17:50543016 | 0.162 | 0.116 | 0.292 | — |
| chr17_50543020_A_T | chr17:50543020 | 0.170 | 0.146 | 0.258 | — |
| chr17_50543196_C_A | chr17:50543196 | -0.169 | -0.101 | -0.292 | — |
| chr17_50543225_T_G | chr17:50543225 | 0.070 | 0.013 | 0.292 | — |
| chr17_50543189_A_T | chr17:50543189 | 0.164 | 0.103 | 0.287 | — |
| chr17_50543202_C_G | chr17:50543202 | -0.095 | -0.050 | -0.287 | — |
| chr17_50543209_G_A | chr17:50543209 | -0.128 | -0.101 | -0.287 | — |
| chr17_50542988_C_A | chr17:50542988 | -0.166 | -0.096 | -0.213 | — |
| chr17_50542999_G_C | chr17:50542999 | 0.166 | 0.169 | 0.281 | — |
| chr17_50543022_G_T | chr17:50543022 | 0.166 | 0.086 | 0.146 | — |
| chr17_50542986_G_A | chr17:50542986 | 0.111 | 0.123 | 0.281 | — |
| chr17_50542996_C_A | chr17:50542996 | 0.164 | 0.171 | 0.258 | — |
| chr17_50543207_T_G | chr17:50543207 | 0.164 | 0.156 | 0.185 | — |
| chr17_50542983_C_A | chr17:50542983 | -0.162 | -0.048 | -0.236 | — |
| chr17_50543014_G_A | chr17:50543014 | -0.162 | -0.116 | -0.247 | — |
| chr17_50543071_T_A | chr17:50543071 | 0.162 | 0.191 | 0.191 | — |
| chr17_50543039_T_A | chr17:50543039 | 0.161 | 0.098 | 0.225 | — |
| chr17_50543189_A_G | chr17:50543189 | 0.092 | 0.045 | 0.275 | — |
| chr17_50543239_G_C | chr17:50543239 | -0.152 | -0.161 | -0.275 | — |
| chr17_50549487_G_C | chr17:50549487 | 0.000 | 0.098 | 0.275 | — |
| chr17_50549489_T_G | chr17:50549489 | 0.016 | 0.130 | 0.275 | — |
| chr17_50542981_G_T | chr17:50542981 | 0.113 | 0.134 | 0.270 | — |
| chr17_50542989_T_C | chr17:50542989 | 0.082 | 0.076 | 0.270 | — |
| chr17_50543000_A_C | chr17:50543000 | 0.134 | 0.093 | 0.270 | — |
| chr17_50543013_G_A | chr17:50543013 | -0.152 | -0.136 | -0.270 | — |
| chr17_50543203_T_G | chr17:50543203 | 0.157 | 0.121 | 0.230 | <0.001% |
| chr17_50543023_C_T | chr17:50543023 | 0.156 | 0.108 | 0.112 | <0.001% |
| chr17_50543034_C_T | chr17:50543034 | -0.111 | -0.073 | -0.264 | <0.001% |
| chr17_50543189_A_C | chr17:50543189 | 0.130 | 0.088 | 0.264 | — |
| chr17_50543193_G_A | chr17:50543193 | 0.077 | 0.053 | 0.264 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.