Home / Gene
ABCC3
receptor: PXRTier 1
Prior gene annotation
Retained explanatory context, not the pharmacist's submitted wording; submitted reviews below take precedence.
Drug substrates (prior annotation)
cisplatin; morphine; cyclophosphamide; doxorubicin; methotrexate; vincristine
refs: 19593667
CAMIP Tier 1: peak-anchored panel
PXR
Submitted decision (verbatim): 接受
No revision text or notes were submitted.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Rifampicin
- Regulatory element
- at promoter -544 bp
- Predicted consequence
- Blunted receptor-mediated induction of ABCC3 expression, weakening basolateral transport capacity for organic anions and drug conjugates such as methotrexate and morphine-glucuronide.
- Prior narrative
- Blunted receptor-mediated induction of ABCC3 expression, weakening basolateral transport capacity for organic anions and drug conjugates such as methotrexate and morphine-glucuronide.
- Drug context
- cisplatin; morphine; cyclophosphamide; doxorubicin; methotrexate; vincristine
- Prior references
- 19593667
Scored variants near ABCC3
chr17:50,534,880..50,792,253, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr17_50543044_C_G | chr17:50543044 | 1.000 | 1.000 | 1.000 | — |
| chr17_50542998_A_T | chr17:50542998 | 1.000 | 0.896 | 1.000 | — |
| chr17_50543214_A_G | chr17:50543214 | 0.290 | 0.368 | 1.000 | — |
| chr17_50543035_A_T | chr17:50543035 | 1.000 | 0.944 | 1.000 | — |
| chr17_50543051_T_G | chr17:50543051 | 0.955 | 0.906 | 1.000 | — |
| chr17_50543205_C_G | chr17:50543205 | 0.847 | 0.777 | 1.000 | — |
| chr17_50543044_C_T | chr17:50543044 | 0.805 | 0.518 | 1.000 | 0.0039% |
| chr17_50543067_T_A | chr17:50543067 | -0.755 | -0.642 | -1.000 | — |
| chr17_50543067_T_G | chr17:50543067 | -0.754 | -0.619 | -1.000 | — |
| chr17_50543051_T_C | chr17:50543051 | 0.619 | 0.647 | 0.835 | — |
| chr17_50543067_T_C | chr17:50543067 | -0.616 | -0.548 | -1.000 | — |
| chr17_50543060_C_T | chr17:50543060 | 0.599 | 0.543 | 0.776 | — |
| chr17_50543195_T_C | chr17:50543195 | -0.584 | -0.447 | -1.000 | — |
| chr17_50543060_C_A | chr17:50543060 | -0.516 | -0.365 | -1.000 | — |
| chr17_50543064_T_G | chr17:50543064 | -0.567 | -0.350 | -0.865 | — |
| chr17_50543068_G_C | chr17:50543068 | -0.567 | -0.391 | -0.976 | — |
| chr17_50543035_A_C | chr17:50543035 | 0.557 | 0.497 | 0.576 | — |
| chr17_50543064_T_A | chr17:50543064 | -0.554 | -0.340 | -0.900 | — |
| chr17_50543196_C_G | chr17:50543196 | 0.549 | 0.442 | 0.776 | — |
| chr17_50542998_A_C | chr17:50542998 | 0.396 | 0.269 | 0.965 | — |
| chr17_50543031_T_C | chr17:50543031 | -0.532 | -0.401 | -0.882 | — |
| chr17_50543054_A_G | chr17:50543054 | 0.509 | 0.485 | 0.812 | — |
| chr17_50543060_C_G | chr17:50543060 | -0.483 | -0.327 | -0.882 | — |
| chr17_50543063_A_C | chr17:50543063 | -0.496 | -0.344 | -0.800 | — |
| chr17_50543052_T_G | chr17:50543052 | 0.484 | 0.434 | 0.729 | 0.0059% |
| chr17_50543065_A_T | chr17:50543065 | -0.431 | -0.302 | -0.847 | — |
| chr17_50543022_G_C | chr17:50543022 | 0.464 | 0.277 | 0.600 | — |
| chr17_50543063_A_G | chr17:50543063 | -0.461 | -0.322 | -0.747 | — |
| chr17_50543064_T_C | chr17:50543064 | -0.456 | -0.307 | -0.718 | — |
| chr17_50543070_C_G | chr17:50543070 | -0.408 | -0.274 | -0.794 | — |
| chr17_50543047_A_G | chr17:50543047 | 0.446 | 0.363 | 0.729 | — |
| chr17_50543069_A_C | chr17:50543069 | -0.378 | -0.284 | -0.788 | — |
| chr17_50543065_A_C | chr17:50543065 | -0.404 | -0.284 | -0.771 | — |
| chr17_50543055_T_G | chr17:50543055 | 0.429 | 0.472 | 0.682 | — |
| chr17_50543000_A_G | chr17:50543000 | 0.411 | 0.584 | 0.659 | — |
| chr17_50543057_C_A | chr17:50543057 | 0.411 | 0.358 | 0.671 | — |
| chr17_50543069_A_T | chr17:50543069 | -0.344 | -0.274 | -0.724 | — |
| chr17_50543053_A_C | chr17:50543053 | 0.408 | 0.419 | 0.706 | — |
| chr17_50543070_C_A | chr17:50543070 | -0.356 | -0.256 | -0.712 | — |
| chr17_50543052_T_A | chr17:50543052 | 0.398 | 0.340 | 0.506 | — |
| chr17_50543041_G_T | chr17:50543041 | 0.394 | 0.302 | 0.571 | — |
| chr17_50542934_G_A | chr17:50542934 | 0.245 | 0.256 | 0.694 | — |
| chr17_50543061_A_G | chr17:50543061 | -0.321 | -0.261 | -0.653 | — |
| chr17_50543065_A_G | chr17:50543065 | -0.361 | -0.274 | -0.653 | — |
| chr17_50543035_A_G | chr17:50543035 | 0.366 | 0.249 | 0.400 | <0.001% |
| chr17_50543038_C_G | chr17:50543038 | -0.329 | -0.246 | -0.641 | — |
| chr17_50543047_A_C | chr17:50543047 | -0.358 | -0.310 | -0.465 | — |
| chr17_50543220_T_A | chr17:50543220 | -0.146 | -0.165 | -0.629 | — |
| chr17_50543238_T_C | chr17:50543238 | -0.032 | -0.107 | 0.629 | — |
| chr17_50543062_A_T | chr17:50543062 | -0.353 | -0.228 | -0.606 | — |
| chr17_50543066_T_A | chr17:50543066 | -0.309 | -0.198 | -0.624 | — |
| chr17_50543232_T_G | chr17:50543232 | 0.351 | 0.348 | 0.559 | — |
| chr17_50543066_T_C | chr17:50543066 | -0.313 | -0.218 | -0.618 | — |
| chr17_50543220_T_G | chr17:50543220 | -0.155 | -0.175 | -0.618 | — |
| chr17_50543222_A_C | chr17:50543222 | -0.145 | -0.170 | -0.618 | — |
| chr17_50543044_C_A | chr17:50543044 | 0.344 | 0.259 | 0.482 | — |
| chr17_50543028_A_C | chr17:50543028 | 0.304 | 0.231 | 0.600 | — |
| chr17_50543066_T_G | chr17:50543066 | -0.311 | -0.211 | -0.600 | — |
| chr17_50543063_A_T | chr17:50543063 | -0.326 | -0.198 | -0.582 | — |
| chr17_50542995_T_G | chr17:50542995 | 0.275 | 0.221 | 0.576 | — |
| chr17_50543045_C_G | chr17:50543045 | 0.296 | 0.206 | 0.576 | — |
| chr17_50543055_T_A | chr17:50543055 | 0.326 | 0.348 | 0.506 | — |
| chr17_50543062_A_C | chr17:50543062 | -0.326 | -0.206 | -0.535 | — |
| chr17_50543062_A_G | chr17:50543062 | -0.324 | -0.208 | -0.541 | — |
| chr17_50543222_A_T | chr17:50543222 | -0.125 | -0.178 | -0.571 | — |
| chr17_50543045_C_A | chr17:50543045 | 0.319 | 0.218 | 0.529 | — |
| chr17_50543053_A_G | chr17:50543053 | 0.278 | 0.277 | 0.565 | — |
| chr17_50542999_G_T | chr17:50542999 | 0.318 | 0.284 | 0.412 | — |
| chr17_50543050_T_G | chr17:50543050 | 0.308 | 0.358 | 0.518 | — |
| chr17_50543040_G_T | chr17:50543040 | 0.306 | 0.223 | 0.471 | — |
| chr17_50543215_C_A | chr17:50543215 | 0.300 | 0.223 | 0.541 | — |
| chr17_50543011_C_A | chr17:50543011 | -0.293 | -0.236 | -0.412 | <0.001% |
| chr17_50543013_G_T | chr17:50543013 | -0.268 | -0.261 | -0.518 | — |
| chr17_50543219_G_T | chr17:50543219 | -0.100 | -0.099 | -0.518 | — |
| chr17_50542996_C_G | chr17:50542996 | 0.290 | 0.239 | 0.494 | — |
| chr17_50543219_G_A | chr17:50543219 | -0.106 | -0.114 | -0.506 | — |
| chr17_50543015_C_G | chr17:50543015 | 0.280 | 0.383 | 0.353 | — |
| chr17_50543055_T_C | chr17:50543055 | 0.280 | 0.307 | 0.471 | — |
| chr17_50542966_A_C | chr17:50542966 | 0.278 | 0.294 | 0.424 | — |
| chr17_50543188_C_A | chr17:50543188 | -0.248 | -0.213 | -0.488 | — |
| chr17_50543202_C_A | chr17:50543202 | 0.171 | 0.157 | 0.488 | — |
| chr17_50543206_T_G | chr17:50543206 | 0.276 | 0.244 | 0.476 | — |
| chr17_50543205_C_A | chr17:50543205 | 0.261 | 0.272 | 0.482 | — |
| chr17_50543192_A_G | chr17:50543192 | -0.238 | -0.183 | -0.476 | — |
| chr17_50543071_T_G | chr17:50543071 | -0.266 | -0.246 | -0.412 | — |
| chr17_50543030_A_T | chr17:50543030 | 0.263 | 0.256 | 0.388 | — |
| chr17_50543222_A_G | chr17:50543222 | -0.053 | -0.150 | -0.465 | — |
| chr17_50542972_C_A | chr17:50542972 | -0.251 | -0.193 | -0.459 | — |
| chr17_50543053_A_T | chr17:50543053 | 0.226 | 0.211 | 0.459 | — |
| chr17_50543061_A_T | chr17:50543061 | -0.206 | -0.193 | -0.459 | — |
| chr17_50543223_C_G | chr17:50543223 | 0.260 | 0.206 | 0.000 | — |
| chr17_50543223_C_T | chr17:50543223 | 0.205 | 0.099 | 0.453 | 0.0020% |
| chr17_50543237_C_T | chr17:50543237 | 0.256 | 0.373 | 0.353 | — |
| chr17_50542984_G_C | chr17:50542984 | 0.220 | 0.190 | 0.447 | — |
| chr17_50543243_T_C | chr17:50543243 | -0.253 | -0.236 | -0.376 | 0.0013% |
| chr17_50542997_A_C | chr17:50542997 | 0.196 | 0.175 | 0.435 | — |
| chr17_50542999_G_A | chr17:50542999 | 0.246 | 0.294 | 0.435 | 0.0020% |
| chr17_50543014_G_C | chr17:50543014 | -0.243 | -0.185 | -0.329 | <0.001% |
| chr17_50543040_G_A | chr17:50543040 | -0.243 | -0.140 | -0.376 | — |
| chr17_50543204_C_G | chr17:50543204 | 0.215 | 0.201 | 0.429 | — |
| chr17_50543220_T_C | chr17:50543220 | -0.032 | -0.081 | -0.429 | — |
| chr17_50542983_C_G | chr17:50542983 | -0.226 | -0.036 | -0.424 | — |
| chr17_50542997_A_T | chr17:50542997 | 0.233 | 0.241 | 0.424 | — |
| chr17_50543025_T_G | chr17:50543025 | 0.196 | 0.109 | 0.424 | — |
| chr17_50543194_C_G | chr17:50543194 | -0.181 | -0.122 | -0.424 | — |
| chr17_50543243_T_A | chr17:50543243 | -0.240 | -0.218 | -0.200 | — |
| chr17_50543001_G_C | chr17:50543001 | -0.236 | -0.211 | -0.406 | — |
| chr17_50542962_A_G | chr17:50542962 | 0.198 | 0.302 | 0.412 | — |
| chr17_50543014_G_T | chr17:50543014 | -0.225 | -0.185 | -0.412 | — |
| chr17_50543054_A_T | chr17:50543054 | 0.230 | 0.175 | 0.365 | — |
| chr17_50543223_C_A | chr17:50543223 | -0.055 | -0.081 | -0.406 | — |
| chr17_50543211_T_C | chr17:50543211 | -0.226 | -0.236 | -0.382 | — |
| chr17_50542940_A_C | chr17:50542940 | 0.220 | 0.147 | 0.253 | — |
| chr17_50543034_C_A | chr17:50543034 | -0.168 | -0.129 | -0.388 | — |
| chr17_50543043_C_G | chr17:50543043 | 0.220 | 0.178 | 0.306 | — |
| chr17_50543059_G_C | chr17:50543059 | -0.198 | -0.173 | -0.388 | — |
| chr17_50543068_G_A | chr17:50543068 | -0.131 | 0.038 | -0.388 | — |
| chr17_50543003_C_A | chr17:50543003 | -0.218 | -0.188 | -0.294 | — |
| chr17_50543203_T_A | chr17:50543203 | 0.218 | 0.335 | 0.253 | — |
| chr17_50543042_G_A | chr17:50543042 | -0.195 | -0.127 | -0.382 | — |
| chr17_50543221_C_T | chr17:50543221 | -0.045 | -0.079 | -0.382 | — |
| chr17_50543057_C_G | chr17:50543057 | 0.181 | 0.173 | 0.376 | — |
| chr17_50543069_A_G | chr17:50543069 | -0.161 | -0.150 | -0.376 | — |
| chr17_50542995_T_A | chr17:50542995 | 0.211 | 0.183 | 0.306 | — |
| chr17_50542956_G_C | chr17:50542956 | -0.208 | -0.157 | -0.365 | — |
| chr17_50543203_T_C | chr17:50543203 | -0.190 | -0.096 | -0.365 | — |
| chr17_50543215_C_G | chr17:50543215 | 0.205 | 0.104 | 0.365 | — |
| chr17_50543042_G_T | chr17:50543042 | -0.156 | -0.114 | -0.359 | — |
| chr17_50543195_T_A | chr17:50543195 | -0.201 | -0.137 | -0.282 | — |
| chr17_50543030_A_G | chr17:50543030 | -0.200 | -0.152 | -0.276 | — |
| chr17_50542969_A_C | chr17:50542969 | 0.075 | 0.010 | 0.347 | — |
| chr17_50543068_G_T | chr17:50543068 | 0.196 | 0.206 | 0.306 | — |
| chr17_50543217_G_C | chr17:50543217 | -0.035 | -0.053 | -0.347 | — |
| chr17_50542998_A_G | chr17:50542998 | 0.115 | 0.096 | 0.341 | — |
| chr17_50542987_G_T | chr17:50542987 | -0.190 | -0.079 | -0.188 | — |
| chr17_50543027_G_A | chr17:50543027 | -0.171 | -0.155 | -0.335 | — |
| chr17_50543028_A_G | chr17:50543028 | -0.190 | -0.162 | -0.300 | — |
| chr17_50543029_G_A | chr17:50543029 | 0.190 | 0.198 | 0.294 | — |
| chr17_50543052_T_C | chr17:50543052 | 0.190 | 0.168 | 0.329 | — |
| chr17_50543192_A_T | chr17:50543192 | -0.166 | -0.076 | -0.335 | — |
| chr17_50543217_G_A | chr17:50543217 | -0.013 | -0.033 | -0.335 | <0.001% |
| chr17_50542987_G_A | chr17:50542987 | -0.188 | -0.063 | -0.071 | — |
| chr17_50542953_C_G | chr17:50542953 | -0.145 | -0.129 | -0.329 | — |
| chr17_50542983_C_T | chr17:50542983 | -0.178 | -0.129 | -0.329 | 0.0020% |
| chr17_50542992_A_T | chr17:50542992 | -0.170 | -0.104 | -0.329 | — |
| chr17_50543004_A_T | chr17:50543004 | -0.186 | -0.160 | -0.306 | — |
| chr17_50543033_C_A | chr17:50543033 | 0.186 | 0.203 | 0.265 | — |
| chr17_50543058_A_C | chr17:50543058 | 0.148 | 0.145 | 0.329 | — |
| chr17_50543204_C_A | chr17:50543204 | 0.186 | 0.264 | 0.276 | — |
| chr17_50543021_G_T | chr17:50543021 | 0.185 | 0.096 | 0.212 | — |
| chr17_50543025_T_A | chr17:50543025 | 0.166 | 0.117 | 0.324 | <0.001% |
| chr17_50543036_G_A | chr17:50543036 | -0.183 | -0.155 | -0.324 | — |
| chr17_50543231_G_A | chr17:50543231 | -0.130 | -0.086 | -0.324 | — |
| chr17_50543285_C_T | chr17:50543285 | 0.095 | 0.051 | 0.324 | — |
| chr17_50543210_T_C | chr17:50543210 | 0.181 | 0.147 | 0.318 | — |
| chr17_50542980_G_C | chr17:50542980 | 0.085 | 0.069 | 0.318 | — |
| chr17_50542997_A_G | chr17:50542997 | 0.140 | 0.089 | 0.318 | — |
| chr17_50543026_G_T | chr17:50543026 | -0.093 | -0.077 | -0.318 | — |
| chr17_50543051_T_A | chr17:50543051 | 0.180 | 0.246 | 0.235 | — |
| chr17_50543061_A_C | chr17:50543061 | -0.171 | -0.170 | -0.318 | — |
| chr17_50543208_T_A | chr17:50543208 | -0.165 | -0.104 | -0.318 | — |
| chr17_50543211_T_G | chr17:50543211 | 0.180 | 0.104 | 0.153 | — |
| chr17_50543215_C_T | chr17:50543215 | -0.053 | -0.084 | -0.318 | — |
| chr17_50543011_C_T | chr17:50543011 | 0.176 | 0.160 | 0.294 | — |
| chr17_50543194_C_A | chr17:50543194 | -0.141 | -0.079 | -0.312 | — |
| chr17_50543216_T_G | chr17:50543216 | -0.030 | -0.058 | -0.312 | — |
| chr17_50543235_C_A | chr17:50543235 | -0.151 | -0.114 | -0.312 | <0.001% |
| chr17_50543243_T_G | chr17:50543243 | -0.175 | -0.216 | -0.229 | — |
| chr17_50542939_G_C | chr17:50542939 | 0.173 | 0.132 | 0.024 | — |
| chr17_50543001_G_T | chr17:50543001 | -0.173 | -0.162 | -0.306 | — |
| chr17_50543016_T_G | chr17:50543016 | 0.165 | 0.117 | 0.306 | — |
| chr17_50543020_A_T | chr17:50543020 | 0.173 | 0.147 | 0.271 | — |
| chr17_50543196_C_A | chr17:50543196 | -0.171 | -0.102 | -0.306 | — |
| chr17_50543225_T_G | chr17:50543225 | 0.072 | 0.013 | 0.306 | — |
| chr17_50543189_A_T | chr17:50543189 | 0.166 | 0.104 | 0.300 | — |
| chr17_50543202_C_G | chr17:50543202 | -0.097 | -0.051 | -0.300 | — |
| chr17_50543209_G_A | chr17:50543209 | -0.130 | -0.102 | -0.300 | — |
| chr17_50542988_C_A | chr17:50542988 | -0.168 | -0.096 | -0.224 | — |
| chr17_50542999_G_C | chr17:50542999 | 0.168 | 0.170 | 0.294 | — |
| chr17_50543022_G_T | chr17:50543022 | 0.168 | 0.086 | 0.153 | — |
| chr17_50542986_G_A | chr17:50542986 | 0.113 | 0.124 | 0.294 | — |
| chr17_50542996_C_A | chr17:50542996 | 0.166 | 0.173 | 0.271 | — |
| chr17_50543207_T_G | chr17:50543207 | 0.166 | 0.157 | 0.194 | — |
| chr17_50542983_C_A | chr17:50542983 | -0.165 | -0.048 | -0.247 | — |
| chr17_50543014_G_A | chr17:50543014 | -0.165 | -0.117 | -0.259 | — |
| chr17_50543071_T_A | chr17:50543071 | 0.165 | 0.193 | 0.200 | — |
| chr17_50543039_T_A | chr17:50543039 | 0.163 | 0.099 | 0.235 | — |
| chr17_50543189_A_G | chr17:50543189 | 0.093 | 0.046 | 0.288 | — |
| chr17_50543239_G_C | chr17:50543239 | -0.155 | -0.162 | -0.288 | — |
| chr17_50549487_G_C | chr17:50549487 | 0.000 | 0.099 | 0.288 | — |
| chr17_50549489_T_G | chr17:50549489 | 0.017 | 0.131 | 0.288 | — |
| chr17_50542981_G_T | chr17:50542981 | 0.115 | 0.135 | 0.282 | — |
| chr17_50542989_T_C | chr17:50542989 | 0.083 | 0.076 | 0.282 | — |
| chr17_50543000_A_C | chr17:50543000 | 0.136 | 0.094 | 0.282 | — |
| chr17_50543013_G_A | chr17:50543013 | -0.155 | -0.137 | -0.282 | — |
| chr17_50543203_T_G | chr17:50543203 | 0.160 | 0.122 | 0.241 | <0.001% |
| chr17_50543023_C_T | chr17:50543023 | 0.158 | 0.109 | 0.118 | <0.001% |
| chr17_50543034_C_T | chr17:50543034 | -0.113 | -0.074 | -0.276 | <0.001% |
| chr17_50543189_A_C | chr17:50543189 | 0.131 | 0.089 | 0.276 | — |
| chr17_50543193_G_A | chr17:50543193 | 0.078 | 0.053 | 0.276 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.