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ABCC3
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of ABCC3 expression, weakening basolateral transport capacity for organic anions and drug conjugates such as methotrexate and morphine-glucuronide.
Affected substrate drugs (PharmGKB): cisplatin; morphine; cyclophosphamide; doxorubicin; methotrexate; vincristine
Scored variants near ABCC3
chr17:50,534,880..50,792,253, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr17_50543044_C_G | chr17:50543044 | 84,800 | 19,072 | 52,480 | — |
| chr17_50542998_A_T | chr17:50542998 | 53,184 | 11,296 | 54,272 | — |
| chr17_50543035_A_T | chr17:50543035 | 48,704 | 11,904 | 29,952 | — |
| chr17_50543051_T_G | chr17:50543051 | 36,736 | 11,424 | 25,856 | — |
| chr17_50543205_C_G | chr17:50543205 | 32,576 | 9,792 | 28,288 | — |
| chr17_50543044_C_T | chr17:50543044 | 30,976 | 6,528 | 22,016 | 3.9e-5 |
| chr17_50543067_T_A | chr17:50543067 | -29,056 | -8,096 | -28,800 | — |
| chr17_50543067_T_G | chr17:50543067 | -28,992 | -7,808 | -27,392 | — |
| chr17_50543051_T_C | chr17:50543051 | 23,808 | 8,160 | 18,176 | — |
| chr17_50543067_T_C | chr17:50543067 | -23,680 | -6,912 | -22,144 | — |
| chr17_50543060_C_T | chr17:50543060 | 23,040 | 6,848 | 16,896 | — |
| chr17_50543195_T_C | chr17:50543195 | -22,464 | -5,632 | -22,272 | — |
| chr17_50543064_T_G | chr17:50543064 | -21,824 | -4,416 | -18,816 | — |
| chr17_50543068_G_C | chr17:50543068 | -21,824 | -4,928 | -21,248 | — |
| chr17_50543035_A_C | chr17:50543035 | 21,440 | 6,272 | 12,544 | — |
| chr17_50543064_T_A | chr17:50543064 | -21,312 | -4,288 | -19,584 | — |
| chr17_50543196_C_G | chr17:50543196 | 21,120 | 5,568 | 16,896 | — |
| chr17_50543031_T_C | chr17:50543031 | -20,480 | -5,056 | -19,200 | — |
| chr17_50543060_C_A | chr17:50543060 | -19,840 | -4,608 | -22,016 | — |
| chr17_50543054_A_G | chr17:50543054 | 19,584 | 6,112 | 17,664 | — |
| chr17_50543063_A_C | chr17:50543063 | -19,072 | -4,336 | -17,408 | — |
| chr17_50543052_T_G | chr17:50543052 | 18,624 | 5,472 | 15,872 | 5.9e-5 |
| chr17_50543060_C_G | chr17:50543060 | -18,560 | -4,128 | -19,200 | — |
| chr17_50543022_G_C | chr17:50543022 | 17,856 | 3,488 | 13,056 | — |
| chr17_50543063_A_G | chr17:50543063 | -17,728 | -4,064 | -16,256 | — |
| chr17_50543064_T_C | chr17:50543064 | -17,536 | -3,872 | -15,616 | — |
| chr17_50543047_A_G | chr17:50543047 | 17,152 | 4,576 | 15,872 | — |
| chr17_50543065_A_T | chr17:50543065 | -16,576 | -3,808 | -18,432 | — |
| chr17_50543055_T_G | chr17:50543055 | 16,512 | 5,952 | 14,848 | — |
| chr17_50543000_A_G | chr17:50543000 | 15,808 | 7,360 | 14,336 | — |
| chr17_50543057_C_A | chr17:50543057 | 15,808 | 4,512 | 14,592 | — |
| chr17_50543070_C_G | chr17:50543070 | -15,680 | -3,456 | -17,280 | — |
| chr17_50543053_A_C | chr17:50543053 | 15,680 | 5,280 | 15,360 | — |
| chr17_50543065_A_C | chr17:50543065 | -15,552 | -3,584 | -16,768 | — |
| chr17_50543052_T_A | chr17:50543052 | 15,296 | 4,288 | 11,008 | — |
| chr17_50542998_A_C | chr17:50542998 | 15,232 | 3,392 | 20,992 | — |
| chr17_50543041_G_T | chr17:50543041 | 15,168 | 3,808 | 12,416 | — |
| chr17_50543069_A_C | chr17:50543069 | -14,528 | -3,584 | -17,152 | — |
| chr17_50543035_A_G | chr17:50543035 | 14,080 | 3,136 | 8,704 | 6.6e-6 |
| chr17_50543065_A_G | chr17:50543065 | -13,888 | -3,456 | -14,208 | — |
| chr17_50543047_A_C | chr17:50543047 | -13,760 | -3,904 | -10,112 | — |
| chr17_50543070_C_A | chr17:50543070 | -13,696 | -3,232 | -15,488 | — |
| chr17_50543062_A_T | chr17:50543062 | -13,568 | -2,880 | -13,184 | — |
| chr17_50543232_T_G | chr17:50543232 | 13,504 | 4,384 | 12,160 | — |
| chr17_50543069_A_T | chr17:50543069 | -13,248 | -3,456 | -15,744 | — |
| chr17_50543044_C_A | chr17:50543044 | 13,248 | 3,264 | 10,496 | — |
| chr17_50543038_C_G | chr17:50543038 | -12,672 | -3,104 | -13,952 | — |
| chr17_50543063_A_T | chr17:50543063 | -12,544 | -2,496 | -12,672 | — |
| chr17_50543055_T_A | chr17:50543055 | 12,544 | 4,384 | 11,008 | — |
| chr17_50543062_A_C | chr17:50543062 | -12,544 | -2,592 | -11,648 | — |
| chr17_50543062_A_G | chr17:50543062 | -12,480 | -2,624 | -11,776 | — |
| chr17_50543061_A_G | chr17:50543061 | -12,352 | -3,296 | -14,208 | — |
| chr17_50543045_C_A | chr17:50543045 | 12,288 | 2,752 | 11,520 | — |
| chr17_50542999_G_T | chr17:50542999 | 12,224 | 3,584 | 8,960 | — |
| chr17_50543066_T_C | chr17:50543066 | -12,032 | -2,752 | -13,440 | — |
| chr17_50543066_T_G | chr17:50543066 | -11,968 | -2,656 | -13,056 | — |
| chr17_50543066_T_A | chr17:50543066 | -11,904 | -2,496 | -13,568 | — |
| chr17_50543050_T_G | chr17:50543050 | 11,840 | 4,512 | 11,264 | — |
| chr17_50543040_G_T | chr17:50543040 | 11,776 | 2,816 | 10,240 | — |
| chr17_50543028_A_C | chr17:50543028 | 11,712 | 2,912 | 13,056 | — |
| chr17_50543215_C_A | chr17:50543215 | 11,520 | 2,816 | 11,776 | — |
| chr17_50543045_C_G | chr17:50543045 | 11,392 | 2,592 | 12,544 | — |
| chr17_50543011_C_A | chr17:50543011 | -11,264 | -2,976 | -8,960 | 6.6e-6 |
| chr17_50543214_A_G | chr17:50543214 | 11,136 | 4,640 | 50,688 | — |
| chr17_50542996_C_G | chr17:50542996 | 11,136 | 3,008 | 10,752 | — |
| chr17_50543015_C_G | chr17:50543015 | 10,752 | 4,832 | 7,680 | — |
| chr17_50543055_T_C | chr17:50543055 | 10,752 | 3,872 | 10,240 | — |
| chr17_50543053_A_G | chr17:50543053 | 10,688 | 3,488 | 12,288 | — |
| chr17_50542966_A_C | chr17:50542966 | 10,688 | 3,712 | 9,216 | — |
| chr17_50543206_T_G | chr17:50543206 | 10,624 | 3,072 | 10,368 | — |
| chr17_50542995_T_G | chr17:50542995 | 10,560 | 2,784 | 12,544 | — |
| chr17_50543013_G_T | chr17:50543013 | -10,304 | -3,296 | -11,264 | — |
| chr17_50543071_T_G | chr17:50543071 | -10,240 | -3,104 | -8,960 | — |
| chr17_50543030_A_T | chr17:50543030 | 10,112 | 3,232 | 8,448 | — |
| chr17_50543205_C_A | chr17:50543205 | 10,048 | 3,424 | 10,496 | — |
| chr17_50543223_C_G | chr17:50543223 | 9,984 | 2,592 | 0 | — |
| chr17_50543237_C_T | chr17:50543237 | 9,856 | 4,704 | 7,680 | — |
| chr17_50543243_T_C | chr17:50543243 | -9,728 | -2,976 | -8,192 | 1.3e-5 |
| chr17_50542972_C_A | chr17:50542972 | -9,664 | -2,432 | -9,984 | — |
| chr17_50543188_C_A | chr17:50543188 | -9,536 | -2,688 | -10,624 | — |
| chr17_50542999_G_A | chr17:50542999 | 9,472 | 3,712 | 9,472 | 2.0e-5 |
| chr17_50542934_G_A | chr17:50542934 | 9,408 | 3,232 | 15,104 | — |
| chr17_50543014_G_C | chr17:50543014 | -9,344 | -2,336 | -7,168 | 6.6e-6 |
| chr17_50543040_G_A | chr17:50543040 | -9,344 | -1,760 | -8,192 | — |
| chr17_50543243_T_A | chr17:50543243 | -9,216 | -2,752 | -4,352 | — |
| chr17_50543192_A_G | chr17:50543192 | -9,152 | -2,304 | -10,368 | — |
| chr17_50543001_G_C | chr17:50543001 | -9,088 | -2,656 | -8,832 | — |
| chr17_50542997_A_T | chr17:50542997 | 8,960 | 3,040 | 9,216 | — |
| chr17_50543054_A_T | chr17:50543054 | 8,832 | 2,208 | 7,936 | — |
| chr17_50543053_A_T | chr17:50543053 | 8,704 | 2,656 | 9,984 | — |
| chr17_50542983_C_G | chr17:50542983 | -8,704 | -448 | -9,216 | — |
| chr17_50543211_T_C | chr17:50543211 | -8,704 | -2,976 | -8,320 | — |
| chr17_50543014_G_T | chr17:50543014 | -8,640 | -2,336 | -8,960 | — |
| chr17_50542984_G_C | chr17:50542984 | 8,448 | 2,400 | 9,728 | — |
| chr17_50542940_A_C | chr17:50542940 | 8,448 | 1,856 | 5,504 | — |
| chr17_50543043_C_G | chr17:50543043 | 8,448 | 2,240 | 6,656 | — |
| chr17_50543003_C_A | chr17:50543003 | -8,384 | -2,368 | -6,400 | — |
| chr17_50543203_T_A | chr17:50543203 | 8,384 | 4,224 | 5,504 | — |
| chr17_50543204_C_G | chr17:50543204 | 8,256 | 2,528 | 9,344 | — |
| chr17_50542995_T_A | chr17:50542995 | 8,128 | 2,304 | 6,656 | — |
| chr17_50542956_G_C | chr17:50542956 | -8,000 | -1,984 | -7,936 | — |
| chr17_50543061_A_T | chr17:50543061 | -7,936 | -2,432 | -9,984 | — |
| chr17_50543223_C_T | chr17:50543223 | 7,872 | 1,248 | 9,856 | 2.0e-5 |
| chr17_50543215_C_G | chr17:50543215 | 7,872 | 1,312 | 7,936 | — |
| chr17_50543195_T_A | chr17:50543195 | -7,744 | -1,728 | -6,144 | — |
| chr17_50543030_A_G | chr17:50543030 | -7,680 | -1,920 | -6,016 | — |
| chr17_50542962_A_G | chr17:50542962 | 7,616 | 3,808 | 8,960 | — |
| chr17_50543059_G_C | chr17:50543059 | -7,616 | -2,176 | -8,448 | — |
| chr17_50542997_A_C | chr17:50542997 | 7,552 | 2,208 | 9,472 | — |
| chr17_50543025_T_G | chr17:50543025 | 7,552 | 1,376 | 9,216 | — |
| chr17_50543068_G_T | chr17:50543068 | 7,552 | 2,592 | 6,656 | — |
| chr17_50543042_G_A | chr17:50543042 | -7,488 | -1,600 | -8,320 | — |
| chr17_50543203_T_C | chr17:50543203 | -7,296 | -1,216 | -7,936 | — |
| chr17_50542987_G_T | chr17:50542987 | -7,296 | -992 | -4,096 | — |
| chr17_50543028_A_G | chr17:50543028 | -7,296 | -2,048 | -6,528 | — |
| chr17_50543029_G_A | chr17:50543029 | 7,296 | 2,496 | 6,400 | — |
| chr17_50543052_T_C | chr17:50543052 | 7,296 | 2,112 | 7,168 | — |
| chr17_50542987_G_A | chr17:50542987 | -7,232 | -800 | -1,536 | — |
| chr17_50543004_A_T | chr17:50543004 | -7,168 | -2,016 | -6,656 | — |
| chr17_50543033_C_A | chr17:50543033 | 7,168 | 2,560 | 5,760 | — |
| chr17_50543204_C_A | chr17:50543204 | 7,168 | 3,328 | 6,016 | — |
| chr17_50543021_G_T | chr17:50543021 | 7,104 | 1,216 | 4,608 | — |
| chr17_50543036_G_A | chr17:50543036 | -7,040 | -1,952 | -7,040 | — |
| chr17_50543194_C_G | chr17:50543194 | -6,976 | -1,536 | -9,216 | — |
| chr17_50543057_C_G | chr17:50543057 | 6,976 | 2,176 | 8,192 | — |
| chr17_50543210_T_C | chr17:50543210 | 6,976 | 1,856 | 6,912 | — |
| chr17_50543051_T_A | chr17:50543051 | 6,912 | 3,104 | 5,120 | — |
| chr17_50543211_T_G | chr17:50543211 | 6,912 | 1,312 | 3,328 | — |
| chr17_50542983_C_T | chr17:50542983 | -6,848 | -1,632 | -7,168 | 2.0e-5 |
| chr17_50543011_C_T | chr17:50543011 | 6,784 | 2,016 | 6,400 | — |
| chr17_50543243_T_G | chr17:50543243 | -6,720 | -2,720 | -4,992 | — |
| chr17_50542939_G_C | chr17:50542939 | 6,656 | 1,664 | 512 | — |
| chr17_50543001_G_T | chr17:50543001 | -6,656 | -2,048 | -6,656 | — |
| chr17_50543020_A_T | chr17:50543020 | 6,656 | 1,856 | 5,888 | — |
| chr17_50543202_C_A | chr17:50543202 | 6,592 | 1,984 | 10,624 | — |
| chr17_50543027_G_A | chr17:50543027 | -6,592 | -1,952 | -7,296 | — |
| chr17_50543061_A_C | chr17:50543061 | -6,592 | -2,144 | -6,912 | — |
| chr17_50543196_C_A | chr17:50543196 | -6,592 | -1,280 | -6,656 | — |
| chr17_50542992_A_T | chr17:50542992 | -6,528 | -1,312 | -7,168 | — |
| chr17_50543034_C_A | chr17:50543034 | -6,464 | -1,632 | -8,448 | — |
| chr17_50542988_C_A | chr17:50542988 | -6,464 | -1,216 | -4,864 | — |
| chr17_50542999_G_C | chr17:50542999 | 6,464 | 2,144 | 6,400 | — |
| chr17_50543022_G_T | chr17:50543022 | 6,464 | 1,088 | 3,328 | — |
| chr17_50543192_A_T | chr17:50543192 | -6,400 | -960 | -7,296 | — |
| chr17_50543025_T_A | chr17:50543025 | 6,400 | 1,472 | 7,040 | 6.6e-6 |
| chr17_50543189_A_T | chr17:50543189 | 6,400 | 1,312 | 6,528 | — |
| chr17_50542996_C_A | chr17:50542996 | 6,400 | 2,176 | 5,888 | — |
| chr17_50543207_T_G | chr17:50543207 | 6,400 | 1,984 | 4,224 | — |
| chr17_50543208_T_A | chr17:50543208 | -6,336 | -1,312 | -6,912 | — |
| chr17_50543016_T_G | chr17:50543016 | 6,336 | 1,472 | 6,656 | — |
| chr17_50542983_C_A | chr17:50542983 | -6,336 | -608 | -5,376 | — |
| chr17_50543014_G_A | chr17:50543014 | -6,336 | -1,472 | -5,632 | — |
| chr17_50543071_T_A | chr17:50543071 | 6,336 | 2,432 | 4,352 | — |
| chr17_50543039_T_A | chr17:50543039 | 6,272 | 1,248 | 5,120 | — |
| chr17_50543069_A_G | chr17:50543069 | -6,208 | -1,888 | -8,192 | — |
| chr17_50543203_T_G | chr17:50543203 | 6,144 | 1,536 | 5,248 | 6.6e-6 |
| chr17_50543023_C_T | chr17:50543023 | 6,080 | 1,376 | 2,560 | 6.6e-6 |
| chr17_50543042_G_T | chr17:50543042 | -6,016 | -1,440 | -7,808 | — |
| chr17_50543220_T_G | chr17:50543220 | -5,952 | -2,208 | -13,440 | — |
| chr17_50543239_G_C | chr17:50543239 | -5,952 | -2,048 | -6,272 | — |
| chr17_50543013_G_A | chr17:50543013 | -5,952 | -1,728 | -6,144 | — |
| chr17_50543235_C_A | chr17:50543235 | -5,824 | -1,440 | -6,784 | 6.6e-6 |
| chr17_50543058_A_C | chr17:50543058 | 5,696 | 1,824 | 7,168 | — |
| chr17_50543220_T_A | chr17:50543220 | -5,632 | -2,080 | -13,696 | — |
| chr17_50543222_A_C | chr17:50543222 | -5,568 | -2,144 | -13,440 | — |
| chr17_50542953_C_G | chr17:50542953 | -5,568 | -1,632 | -7,168 | — |
| chr17_50543194_C_A | chr17:50543194 | -5,440 | -992 | -6,784 | — |
| chr17_50542997_A_G | chr17:50542997 | 5,376 | 1,120 | 6,912 | — |
| chr17_50543000_A_C | chr17:50543000 | 5,248 | 1,184 | 6,144 | — |
| chr17_50543068_G_A | chr17:50543068 | -5,056 | 480 | -8,448 | — |
| chr17_50543189_A_C | chr17:50543189 | 5,056 | 1,120 | 6,016 | — |
| chr17_50543231_G_A | chr17:50543231 | -4,992 | -1,088 | -7,040 | — |
| chr17_50543209_G_A | chr17:50543209 | -4,992 | -1,280 | -6,528 | — |
| chr17_50543222_A_T | chr17:50543222 | -4,800 | -2,240 | -12,416 | — |
| chr17_50542998_A_G | chr17:50542998 | 4,416 | 1,216 | 7,424 | — |
| chr17_50542981_G_T | chr17:50542981 | 4,416 | 1,696 | 6,144 | — |
| chr17_50542986_G_A | chr17:50542986 | 4,352 | 1,568 | 6,400 | — |
| chr17_50543034_C_T | chr17:50543034 | -4,352 | -928 | -6,016 | 6.6e-6 |
| chr17_50543219_G_A | chr17:50543219 | -4,096 | -1,440 | -11,008 | — |
| chr17_50543219_G_T | chr17:50543219 | -3,840 | -1,248 | -11,264 | — |
| chr17_50543202_C_G | chr17:50543202 | -3,712 | -640 | -6,528 | — |
| chr17_50543285_C_T | chr17:50543285 | 3,648 | 640 | 7,040 | — |
| chr17_50543026_G_T | chr17:50543026 | -3,584 | -976 | -6,912 | — |
| chr17_50543189_A_G | chr17:50543189 | 3,584 | 576 | 6,272 | — |
| chr17_50542980_G_C | chr17:50542980 | 3,264 | 864 | 6,912 | — |
| chr17_50542989_T_C | chr17:50542989 | 3,200 | 960 | 6,144 | — |
| chr17_50543193_G_A | chr17:50543193 | 3,008 | 672 | 6,016 | — |
| chr17_50542969_A_C | chr17:50542969 | 2,880 | 128 | 7,552 | — |
| chr17_50543225_T_G | chr17:50543225 | 2,752 | 160 | 6,656 | — |
| chr17_50543223_C_A | chr17:50543223 | -2,112 | -1,024 | -8,832 | — |
| chr17_50543222_A_G | chr17:50543222 | -2,048 | -1,888 | -10,112 | — |
| chr17_50543215_C_T | chr17:50543215 | -2,048 | -1,056 | -6,912 | — |
| chr17_50543221_C_T | chr17:50543221 | -1,728 | -992 | -8,320 | — |
| chr17_50543217_G_C | chr17:50543217 | -1,344 | -672 | -7,552 | — |
| chr17_50543238_T_C | chr17:50543238 | -1,216 | -1,344 | 13,696 | — |
| chr17_50543220_T_C | chr17:50543220 | -1,216 | -1,024 | -9,344 | — |
| chr17_50543216_T_G | chr17:50543216 | -1,152 | -736 | -6,784 | — |
| chr17_50549489_T_G | chr17:50549489 | 640 | 1,648 | 6,272 | — |
| chr17_50543217_G_A | chr17:50543217 | -512 | -416 | -7,296 | 6.6e-6 |
| chr17_50549487_G_C | chr17:50549487 | 0 | 1,248 | 6,272 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.