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ALDH3A1
receptor: AhRTier 1
CAMIP causal chains
AhR
Reduced AhR-mediated induction of ALDH3A1 would lower ALDH3A1-mediated oxidation of aldophosphamide; increased retention of the active intermediate may sensitise tumour cells to cyclophosphamide.
Affected substrate drugs (PharmGKB): cyclophosphamide; doxorubicin; fluorouracil
Scored variants near ALDH3A1
chr17:19,637,984..19,848,298, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr17_19648971_C_G | chr17:19648971 | 1.000 | 0.048 | 0.247 | — |
| chr17_19648978_C_G | chr17:19648978 | 1.000 | 1.000 | 0.539 | — |
| chr17_19648930_C_A | chr17:19648930 | 1.000 | 0.320 | 0.326 | — |
| chr17_19649058_C_G | chr17:19649058 | 0.984 | 0.141 | 0.298 | 0.0046% |
| chr17_19648985_T_C | chr17:19648985 | -0.957 | -0.781 | -0.573 | — |
| chr17_19648985_T_A | chr17:19648985 | -0.941 | -0.786 | -0.640 | — |
| chr17_19648985_T_G | chr17:19648985 | -0.921 | -0.763 | -0.483 | — |
| chr17_19648862_C_G | chr17:19648862 | -0.872 | -0.479 | -0.169 | — |
| chr17_19648984_G_A | chr17:19648984 | -0.869 | -0.665 | -0.472 | — |
| chr17_19648981_G_A | chr17:19648981 | 0.862 | 0.904 | 0.303 | — |
| chr17_19648977_G_A | chr17:19648977 | -0.859 | -0.549 | -0.551 | — |
| chr17_19648984_G_T | chr17:19648984 | -0.856 | -0.610 | -0.416 | — |
| chr17_19648981_G_C | chr17:19648981 | -0.852 | -0.632 | -0.494 | — |
| chr17_19648804_G_A | chr17:19648804 | 0.820 | 0.476 | 0.270 | — |
| chr17_19648860_G_C | chr17:19648860 | 0.820 | 0.196 | 0.348 | — |
| chr17_19648977_G_T | chr17:19648977 | -0.800 | -0.642 | -0.449 | — |
| chr17_19648980_C_G | chr17:19648980 | -0.790 | -0.524 | -0.382 | — |
| chr17_19648799_A_G | chr17:19648799 | -0.780 | -0.476 | -0.090 | — |
| chr17_19649017_C_A | chr17:19649017 | 0.780 | 0.761 | 0.511 | — |
| chr17_19648982_A_G | chr17:19648982 | -0.764 | -0.572 | -0.303 | — |
| chr17_19648931_C_A | chr17:19648931 | 0.757 | 0.184 | 0.416 | — |
| chr17_19648792_G_C | chr17:19648792 | -0.754 | -0.322 | -0.146 | — |
| chr17_19648982_A_C | chr17:19648982 | -0.741 | -0.562 | -0.258 | — |
| chr17_19648980_C_A | chr17:19648980 | -0.731 | -0.496 | -0.449 | — |
| chr17_19648865_C_G | chr17:19648865 | 0.721 | 0.015 | 0.079 | — |
| chr17_19648984_G_C | chr17:19648984 | -0.711 | -0.496 | -0.348 | — |
| chr17_19648996_C_A | chr17:19648996 | 0.711 | 0.678 | 0.315 | — |
| chr17_19648820_G_C | chr17:19648820 | -0.698 | -0.171 | -0.056 | — |
| chr17_19649017_C_G | chr17:19649017 | 0.695 | 0.738 | 0.343 | — |
| chr17_19648982_A_T | chr17:19648982 | -0.679 | -0.509 | -0.292 | — |
| chr17_19648799_A_T | chr17:19648799 | -0.675 | -0.657 | -0.135 | — |
| chr17_19648923_C_A | chr17:19648923 | 0.669 | 0.403 | 0.281 | — |
| chr17_19648782_G_T | chr17:19648782 | 0.138 | 0.214 | 1.000 | — |
| chr17_19648983_A_T | chr17:19648983 | -0.652 | -0.534 | -0.270 | — |
| chr17_19648865_C_A | chr17:19648865 | 0.643 | 0.091 | 0.079 | — |
| chr17_19648980_C_T | chr17:19648980 | -0.639 | -0.413 | -0.348 | — |
| chr17_19648977_G_C | chr17:19648977 | -0.626 | -0.544 | -0.247 | — |
| chr17_19648983_A_C | chr17:19648983 | -0.616 | -0.360 | -0.281 | — |
| chr17_19649025_A_T | chr17:19649025 | -0.616 | -0.574 | -0.124 | — |
| chr17_19648946_C_G | chr17:19648946 | 0.613 | 0.199 | 0.303 | — |
| chr17_19648981_G_T | chr17:19648981 | -0.610 | -0.484 | -0.449 | — |
| chr17_19649023_C_T | chr17:19649023 | 0.600 | 0.620 | 0.253 | — |
| chr17_19649028_T_A | chr17:19649028 | -0.600 | -0.516 | -0.247 | — |
| chr17_19648877_G_A | chr17:19648877 | -0.597 | -0.360 | -0.337 | 0.0013% |
| chr17_19648877_G_T | chr17:19648877 | -0.597 | -0.567 | -0.506 | — |
| chr17_19648987_C_G | chr17:19648987 | -0.593 | -0.471 | -0.371 | — |
| chr17_19648930_C_T | chr17:19648930 | 0.580 | 0.149 | 0.157 | — |
| chr17_19648987_C_A | chr17:19648987 | -0.570 | -0.360 | -0.416 | — |
| chr17_19648923_C_G | chr17:19648923 | 0.557 | 0.219 | 0.292 | — |
| chr17_19648928_T_C | chr17:19648928 | -0.380 | -0.401 | -0.955 | — |
| chr17_19648990_C_G | chr17:19648990 | -0.557 | -0.340 | -0.449 | — |
| chr17_19649056_G_A | chr17:19649056 | -0.557 | -0.270 | -0.393 | — |
| chr17_19648859_A_G | chr17:19648859 | 0.551 | 0.297 | 0.045 | — |
| chr17_19648836_T_C | chr17:19648836 | 0.544 | 0.428 | 0.180 | 0.0046% |
| chr17_19649076_G_A | chr17:19649076 | 0.544 | 0.582 | 0.837 | — |
| chr17_19648979_T_C | chr17:19648979 | -0.541 | -0.368 | -0.281 | — |
| chr17_19648877_G_C | chr17:19648877 | -0.528 | -0.302 | -0.191 | — |
| chr17_19649025_A_G | chr17:19649025 | -0.525 | -0.521 | -0.079 | — |
| chr17_19648932_C_T | chr17:19648932 | 0.521 | 0.096 | 0.213 | — |
| chr17_19648843_T_G | chr17:19648843 | -0.518 | -0.247 | -0.011 | — |
| chr17_19648939_C_A | chr17:19648939 | 0.518 | 0.358 | 0.236 | — |
| chr17_19648930_C_G | chr17:19648930 | 0.508 | 0.179 | 0.247 | — |
| chr17_19649023_C_G | chr17:19649023 | -0.505 | -0.378 | -0.247 | — |
| chr17_19648983_A_G | chr17:19648983 | -0.502 | -0.469 | -0.191 | — |
| chr17_19648861_A_C | chr17:19648861 | 0.498 | 0.252 | 0.180 | — |
| chr17_19649024_G_C | chr17:19649024 | -0.498 | -0.438 | -0.152 | — |
| chr17_19648792_G_T | chr17:19648792 | -0.492 | -0.184 | -0.157 | — |
| chr17_19648865_C_T | chr17:19648865 | 0.492 | 0.055 | -0.067 | <0.001% |
| chr17_19648878_G_A | chr17:19648878 | -0.492 | -0.320 | -0.303 | — |
| chr17_19648925_C_T | chr17:19648925 | 0.492 | 0.217 | 0.146 | — |
| chr17_19648979_T_G | chr17:19648979 | -0.489 | -0.297 | -0.202 | <0.001% |
| chr17_19649024_G_T | chr17:19649024 | -0.489 | -0.463 | -0.298 | — |
| chr17_19648988_G_A | chr17:19648988 | 0.485 | 0.317 | 0.180 | — |
| chr17_19648987_C_T | chr17:19648987 | -0.482 | -0.370 | -0.393 | <0.001% |
| chr17_19648991_G_C | chr17:19648991 | -0.475 | -0.277 | -0.303 | — |
| chr17_19649023_C_A | chr17:19649023 | -0.472 | -0.332 | -0.298 | — |
| chr17_19648942_G_T | chr17:19648942 | 0.469 | 0.214 | 0.169 | — |
| chr17_19648921_C_A | chr17:19648921 | -0.466 | -0.496 | -0.270 | — |
| chr17_19648785_C_T | chr17:19648785 | -0.462 | -0.433 | -0.225 | — |
| chr17_19648881_G_A | chr17:19648881 | -0.462 | -0.302 | -0.202 | — |
| chr17_19648922_T_C | chr17:19648922 | -0.239 | -0.164 | -0.787 | — |
| chr17_19648988_G_T | chr17:19648988 | -0.456 | -0.388 | -0.337 | — |
| chr17_19648839_T_G | chr17:19648839 | -0.452 | -0.176 | 0.034 | — |
| chr17_19648863_A_C | chr17:19648863 | -0.452 | -0.196 | 0.000 | — |
| chr17_19648878_G_C | chr17:19648878 | -0.452 | -0.262 | -0.315 | — |
| chr17_19648784_A_T | chr17:19648784 | -0.449 | -0.123 | -0.202 | — |
| chr17_19648876_A_T | chr17:19648876 | -0.449 | -0.272 | -0.191 | — |
| chr17_19649027_C_T | chr17:19649027 | -0.449 | -0.388 | -0.247 | — |
| chr17_19648880_G_T | chr17:19648880 | -0.443 | -0.257 | -0.202 | — |
| chr17_19648920_C_A | chr17:19648920 | -0.436 | -0.280 | -0.124 | — |
| chr17_19648777_C_A | chr17:19648777 | -0.433 | -0.149 | 0.000 | — |
| chr17_19648904_A_C | chr17:19648904 | -0.433 | -0.317 | -0.157 | — |
| chr17_19648908_G_C | chr17:19648908 | -0.433 | -0.443 | -0.169 | — |
| chr17_19648988_G_C | chr17:19648988 | -0.430 | -0.428 | -0.258 | 0.0013% |
| chr17_19649085_G_T | chr17:19649085 | 0.430 | -0.169 | 0.146 | — |
| chr17_19648829_G_C | chr17:19648829 | 0.426 | 0.332 | 0.157 | — |
| chr17_19648853_C_G | chr17:19648853 | 0.426 | 0.267 | 0.202 | — |
| chr17_19648880_G_C | chr17:19648880 | -0.426 | -0.270 | -0.157 | — |
| chr17_19648986_C_G | chr17:19648986 | -0.426 | -0.285 | -0.169 | — |
| chr17_19648878_G_T | chr17:19648878 | -0.420 | -0.212 | -0.303 | — |
| chr17_19648919_G_T | chr17:19648919 | 0.413 | 0.176 | 0.000 | — |
| chr17_19648925_C_G | chr17:19648925 | 0.410 | 0.091 | 0.135 | — |
| chr17_19648880_G_A | chr17:19648880 | -0.407 | -0.254 | -0.247 | — |
| chr17_19648892_G_T | chr17:19648892 | -0.403 | -0.325 | -0.427 | — |
| chr17_19649024_G_A | chr17:19649024 | -0.403 | -0.360 | -0.292 | — |
| chr17_19649028_T_G | chr17:19649028 | -0.403 | -0.423 | -0.107 | — |
| chr17_19648862_C_T | chr17:19648862 | -0.400 | -0.227 | -0.090 | — |
| chr17_19648931_C_G | chr17:19648931 | 0.400 | 0.088 | 0.225 | — |
| chr17_19648793_G_A | chr17:19648793 | -0.397 | -0.131 | 0.000 | <0.001% |
| chr17_19648794_C_A | chr17:19648794 | -0.397 | -0.058 | -0.247 | — |
| chr17_19648881_G_T | chr17:19648881 | -0.397 | -0.239 | -0.135 | — |
| chr17_19649022_G_C | chr17:19649022 | -0.397 | -0.277 | -0.292 | — |
| chr17_19649028_T_C | chr17:19649028 | -0.397 | -0.171 | -0.124 | — |
| chr17_19649026_C_T | chr17:19649026 | -0.393 | -0.398 | -0.169 | — |
| chr17_19648986_C_A | chr17:19648986 | -0.390 | -0.259 | -0.292 | — |
| chr17_19648791_G_C | chr17:19648791 | -0.387 | -0.267 | -0.191 | <0.001% |
| chr17_19648795_G_A | chr17:19648795 | -0.387 | -0.065 | 0.034 | <0.001% |
| chr17_19648798_G_A | chr17:19648798 | 0.387 | 0.645 | -0.045 | — |
| chr17_19648989_G_C | chr17:19648989 | 0.387 | 0.322 | 0.135 | — |
| chr17_19649026_C_G | chr17:19649026 | -0.387 | -0.401 | -0.017 | — |
| chr17_19648904_A_T | chr17:19648904 | -0.384 | -0.416 | -0.191 | — |
| chr17_19648979_T_A | chr17:19648979 | -0.384 | -0.217 | -0.067 | — |
| chr17_19648995_C_G | chr17:19648995 | 0.384 | 0.325 | 0.079 | — |
| chr17_19648792_G_A | chr17:19648792 | -0.380 | -0.156 | -0.337 | — |
| chr17_19648788_A_C | chr17:19648788 | -0.377 | -0.229 | -0.090 | — |
| chr17_19649011_T_A | chr17:19649011 | 0.377 | 0.388 | 0.079 | — |
| chr17_19648920_C_T | chr17:19648920 | -0.374 | -0.237 | -0.022 | — |
| chr17_19648924_C_T | chr17:19648924 | 0.374 | 0.154 | 0.124 | — |
| chr17_19648925_C_A | chr17:19648925 | 0.374 | 0.159 | 0.112 | — |
| chr17_19649030_T_C | chr17:19649030 | -0.374 | -0.244 | -0.124 | — |
| chr17_19649027_C_G | chr17:19649027 | -0.370 | -0.373 | 0.011 | — |
| chr17_19649030_T_A | chr17:19649030 | -0.370 | -0.186 | -0.135 | — |
| chr17_19648926_A_G | chr17:19648926 | 0.367 | 0.091 | 0.101 | — |
| chr17_19648936_G_C | chr17:19648936 | 0.367 | 0.209 | -0.169 | — |
| chr17_19648976_A_T | chr17:19648976 | -0.367 | -0.264 | -0.213 | — |
| chr17_19648986_C_T | chr17:19648986 | -0.367 | -0.116 | -0.270 | — |
| chr17_19648907_T_G | chr17:19648907 | -0.361 | -0.353 | -0.101 | — |
| chr17_19648945_C_G | chr17:19648945 | 0.361 | 0.237 | 0.112 | — |
| chr17_19649021_C_A | chr17:19649021 | 0.361 | -0.050 | 0.096 | — |
| chr17_19649026_C_A | chr17:19649026 | -0.361 | -0.335 | -0.180 | — |
| chr17_19649065_A_G | chr17:19649065 | 0.357 | 0.348 | 0.180 | — |
| chr17_19648777_C_T | chr17:19648777 | -0.354 | -0.058 | 0.000 | — |
| chr17_19648896_A_T | chr17:19648896 | 0.354 | 0.222 | 0.169 | — |
| chr17_19648960_C_A | chr17:19648960 | -0.354 | -0.194 | -0.124 | — |
| chr17_19649049_G_C | chr17:19649049 | -0.354 | -0.058 | -0.281 | — |
| chr17_19649054_A_G | chr17:19649054 | -0.354 | -0.106 | -0.287 | — |
| chr17_19648899_C_G | chr17:19648899 | -0.351 | -0.108 | -0.337 | — |
| chr17_19649031_G_T | chr17:19649031 | -0.351 | -0.224 | -0.157 | — |
| chr17_19648817_C_G | chr17:19648817 | -0.348 | -0.232 | 0.090 | <0.001% |
| chr17_19648843_T_A | chr17:19648843 | -0.348 | -0.116 | 0.079 | — |
| chr17_19648845_T_G | chr17:19648845 | -0.348 | -0.136 | -0.045 | — |
| chr17_19648847_G_C | chr17:19648847 | 0.348 | 0.151 | 0.056 | — |
| chr17_19648868_C_A | chr17:19648868 | -0.348 | -0.285 | -0.124 | <0.001% |
| chr17_19648938_C_A | chr17:19648938 | 0.348 | 0.171 | 0.124 | — |
| chr17_19649068_A_G | chr17:19649068 | 0.348 | 0.355 | 0.348 | — |
| chr17_19648956_T_A | chr17:19648956 | 0.344 | 0.264 | 0.292 | — |
| chr17_19648828_C_T | chr17:19648828 | -0.341 | -0.156 | -0.213 | — |
| chr17_19648901_T_G | chr17:19648901 | -0.338 | -0.174 | -0.213 | — |
| chr17_19648798_G_C | chr17:19648798 | 0.334 | 0.108 | -0.090 | — |
| chr17_19648834_A_C | chr17:19648834 | 0.334 | 0.106 | 0.011 | — |
| chr17_19648848_G_T | chr17:19648848 | 0.334 | 0.146 | -0.135 | 0.0013% |
| chr17_19648860_G_A | chr17:19648860 | 0.334 | 0.091 | 0.022 | — |
| chr17_19648884_G_C | chr17:19648884 | 0.334 | 0.134 | 0.292 | — |
| chr17_19648907_T_C | chr17:19648907 | -0.334 | -0.370 | -0.112 | <0.001% |
| chr17_19648926_A_C | chr17:19648926 | -0.059 | -0.106 | -0.573 | — |
| chr17_19649022_G_A | chr17:19649022 | 0.334 | 0.332 | 0.129 | — |
| chr17_19648883_G_A | chr17:19648883 | -0.331 | -0.121 | -0.191 | — |
| chr17_19649030_T_G | chr17:19649030 | -0.331 | -0.186 | -0.045 | — |
| chr17_19648784_A_C | chr17:19648784 | 0.328 | 0.038 | 0.225 | — |
| chr17_19648804_G_C | chr17:19648804 | -0.328 | -0.259 | -0.112 | — |
| chr17_19648860_G_T | chr17:19648860 | 0.328 | 0.207 | 0.225 | — |
| chr17_19648901_T_C | chr17:19648901 | -0.328 | -0.214 | -0.202 | — |
| chr17_19649031_G_C | chr17:19649031 | -0.328 | -0.224 | -0.096 | — |
| chr17_19648774_T_G | chr17:19648774 | -0.325 | -0.050 | -0.101 | — |
| chr17_19648923_C_T | chr17:19648923 | 0.325 | 0.171 | 0.090 | 0.0013% |
| chr17_19649079_G_T | chr17:19649079 | 0.325 | 0.028 | 0.225 | — |
| chr17_19648803_C_G | chr17:19648803 | -0.321 | -0.398 | 0.124 | — |
| chr17_19648847_G_T | chr17:19648847 | 0.321 | 0.166 | 0.000 | — |
| chr17_19648927_C_A | chr17:19648927 | 0.321 | 0.191 | 0.180 | — |
| chr17_19648908_G_A | chr17:19648908 | -0.318 | -0.310 | -0.101 | — |
| chr17_19648997_G_C | chr17:19648997 | -0.318 | -0.310 | -0.219 | — |
| chr17_19648779_G_C | chr17:19648779 | 0.315 | 0.179 | 0.191 | — |
| chr17_19648780_T_G | chr17:19648780 | -0.315 | -0.018 | 0.000 | <0.001% |
| chr17_19648832_T_G | chr17:19648832 | -0.315 | -0.196 | 0.045 | — |
| chr17_19648908_G_T | chr17:19648908 | -0.315 | -0.330 | -0.225 | — |
| chr17_19648962_G_T | chr17:19648962 | 0.315 | 0.222 | 0.157 | — |
| chr17_19648897_G_T | chr17:19648897 | -0.311 | -0.184 | -0.281 | — |
| chr17_19648943_G_T | chr17:19648943 | 0.311 | 0.033 | 0.135 | — |
| chr17_19648809_T_G | chr17:19648809 | -0.308 | -0.227 | 0.135 | — |
| chr17_19648895_G_A | chr17:19648895 | -0.308 | -0.202 | -0.169 | — |
| chr17_19648905_C_A | chr17:19648905 | -0.308 | -0.416 | -0.292 | — |
| chr17_19648773_C_G | chr17:19648773 | -0.305 | -0.111 | -0.011 | — |
| chr17_19648881_G_C | chr17:19648881 | -0.305 | -0.219 | -0.090 | <0.001% |
| chr17_19648892_G_A | chr17:19648892 | -0.305 | -0.169 | -0.315 | — |
| chr17_19649015_G_C | chr17:19649015 | 0.305 | 0.257 | 0.191 | — |
| chr17_19648797_G_A | chr17:19648797 | 0.302 | 0.453 | 0.067 | — |
| chr17_19648833_G_C | chr17:19648833 | 0.302 | 0.151 | 0.180 | — |
| chr17_19648866_C_G | chr17:19648866 | 0.302 | -0.088 | 0.112 | — |
| chr17_19648943_G_C | chr17:19648943 | 0.302 | 0.164 | 0.169 | — |
| chr17_19648963_G_C | chr17:19648963 | 0.302 | 0.222 | 0.079 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.