Home / Gene
CES2
receptor: PXRTier 1
Prior gene annotation
Retained explanatory context, not the pharmacist's submitted wording; submitted reviews below take precedence.
Drug substrates (prior annotation)
irinotecan
refs: 17003103
CAMIP Tier 1: peak-anchored panel
PXR
Submitted decision (verbatim): 接受
Reviewer notes (verbatim)
Blunted PXR-mediated induction of CES2 may attenuate inducible prodrug bioactivation, including the hydrolysis of irinotecan to SN-38.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Rifampicin
- Regulatory element
- at promoter -111 bp
- Predicted consequence
- Blunted receptor-mediated induction of CES2 expression, impairing the hydrolytic bioactivation of key prodrugs such as irinotecan.
- Prior narrative
- Blunted receptor-mediated induction of CES2 expression, impairing the hydrolytic bioactivation of key prodrugs such as irinotecan.
- Drug context
- irinotecan
- Prior references
- 17003103
Scored variants near CES2
chr16:66,834,470..67,045,091, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr16_66934353_G_C | chr16:66934353 | 0.514 | 0.112 | 0.141 | — |
| chr16_66934236_T_A | chr16:66934236 | 0.290 | 0.173 | 0.729 | — |
| chr16_66934277_C_A | chr16:66934277 | 0.225 | 0.350 | 0.694 | — |
| chr16_66934263_G_C | chr16:66934263 | 0.150 | 0.244 | 0.600 | — |
| chr16_66934353_G_T | chr16:66934353 | 0.334 | 0.170 | 0.224 | — |
| chr16_66912684_T_A | chr16:66912684 | 0.300 | -0.067 | 0.091 | — |
| chr16_66934345_A_C | chr16:66934345 | -0.213 | -0.180 | -0.506 | — |
| chr16_66934311_G_A | chr16:66934311 | 0.276 | 0.046 | 0.059 | — |
| chr16_66934351_C_G | chr16:66934351 | 0.263 | 0.071 | 0.282 | — |
| chr16_66934257_C_G | chr16:66934257 | 0.053 | 0.061 | 0.459 | — |
| chr16_66934289_G_C | chr16:66934289 | 0.243 | 0.170 | 0.224 | — |
| chr16_66934214_G_T | chr16:66934214 | -0.095 | -0.084 | -0.424 | — |
| chr16_66934289_G_A | chr16:66934289 | 0.233 | 0.135 | 0.224 | 0.0020% |
| chr16_66934221_A_G | chr16:66934221 | 0.017 | 0.081 | 0.400 | — |
| chr16_66934238_C_A | chr16:66934238 | 0.186 | 0.089 | 0.388 | — |
| chr16_66934225_A_C | chr16:66934225 | 0.037 | 0.063 | 0.376 | — |
| chr16_66934343_C_T | chr16:66934343 | 0.213 | 0.074 | 0.176 | — |
| chr16_66934220_T_A | chr16:66934220 | 0.087 | 0.119 | 0.353 | — |
| chr16_66934233_G_T | chr16:66934233 | -0.058 | -0.048 | -0.341 | — |
| chr16_66934230_C_G | chr16:66934230 | -0.106 | -0.091 | -0.329 | — |
| chr16_66934230_C_T | chr16:66934230 | -0.106 | -0.046 | -0.329 | <0.001% |
| chr16_66934319_T_C | chr16:66934319 | -0.183 | -0.061 | -0.071 | — |
| chr16_66934227_G_T | chr16:66934227 | -0.080 | -0.063 | -0.318 | 0.054% |
| chr16_66934232_C_T | chr16:66934232 | -0.111 | -0.041 | -0.318 | — |
| chr16_66934355_C_G | chr16:66934355 | 0.097 | 0.058 | 0.318 | — |
| chr16_66934347_C_G | chr16:66934347 | -0.176 | 0.048 | -0.071 | — |
| chr16_66934349_C_G | chr16:66934349 | 0.176 | 0.028 | 0.153 | — |
| chr16_66934235_G_T | chr16:66934235 | -0.075 | -0.033 | -0.306 | — |
| chr16_66934316_G_C | chr16:66934316 | 0.173 | 0.015 | 0.212 | — |
| chr16_66934348_C_A | chr16:66934348 | 0.170 | -0.023 | 0.200 | — |
| chr16_66934348_C_G | chr16:66934348 | 0.166 | 0.058 | 0.141 | — |
| chr16_66934226_A_T | chr16:66934226 | 0.050 | 0.058 | 0.282 | — |
| chr16_66934233_G_C | chr16:66934233 | -0.040 | -0.051 | -0.282 | — |
| chr16_66934214_G_C | chr16:66934214 | -0.027 | -0.084 | -0.271 | — |
| chr16_66934234_C_T | chr16:66934234 | -0.063 | -0.058 | -0.271 | <0.001% |
| chr16_66934235_G_C | chr16:66934235 | -0.078 | -0.041 | -0.271 | — |
| chr16_66934240_T_A | chr16:66934240 | -0.053 | -0.086 | -0.271 | — |
| chr16_66934291_T_C | chr16:66934291 | -0.088 | -0.028 | -0.271 | — |
| chr16_66934334_G_T | chr16:66934334 | -0.077 | -0.008 | -0.271 | — |
| chr16_66934348_C_T | chr16:66934348 | 0.153 | 0.061 | 0.047 | — |
| chr16_66934351_C_A | chr16:66934351 | 0.153 | 0.071 | 0.129 | — |
| chr16_66936462_C_A | chr16:66936462 | -0.080 | -0.132 | -0.271 | — |
| chr16_66934357_C_G | chr16:66934357 | 0.148 | -0.010 | 0.141 | — |
| chr16_66934234_C_A | chr16:66934234 | -0.063 | -0.051 | -0.259 | — |
| chr16_66934244_T_G | chr16:66934244 | 0.060 | 0.063 | 0.259 | — |
| chr16_66934231_T_G | chr16:66934231 | -0.143 | 0.089 | 0.141 | — |
| chr16_66934345_A_G | chr16:66934345 | 0.143 | 0.013 | 0.165 | — |
| chr16_66934225_A_T | chr16:66934225 | -0.003 | 0.033 | 0.247 | — |
| chr16_66934326_C_G | chr16:66934326 | 0.140 | 0.005 | 0.153 | — |
| chr16_66934352_C_G | chr16:66934352 | 0.106 | 0.015 | 0.247 | — |
| chr16_66934232_C_A | chr16:66934232 | -0.065 | -0.074 | -0.235 | — |
| chr16_66934234_C_G | chr16:66934234 | -0.077 | -0.061 | -0.235 | — |
| chr16_66934338_G_C | chr16:66934338 | -0.077 | -0.071 | -0.235 | — |
| chr16_66934339_C_G | chr16:66934339 | 0.133 | -0.003 | 0.176 | — |
| chr16_66934354_C_T | chr16:66934354 | 0.133 | 0.043 | 0.071 | — |
| chr16_66934291_T_G | chr16:66934291 | 0.131 | 0.043 | 0.141 | — |
| chr16_66934224_G_A | chr16:66934224 | -0.002 | -0.010 | -0.224 | — |
| chr16_66934235_G_A | chr16:66934235 | -0.062 | -0.025 | -0.224 | — |
| chr16_66934340_C_G | chr16:66934340 | 0.126 | 0.020 | 0.118 | — |
| chr16_66934219_A_T | chr16:66934219 | 0.123 | 0.038 | 0.071 | — |
| chr16_66934354_C_G | chr16:66934354 | 0.123 | 0.028 | 0.176 | — |
| chr16_66934359_T_C | chr16:66934359 | -0.123 | -0.096 | -0.047 | — |
| chr16_66934214_G_A | chr16:66934214 | -0.013 | -0.048 | -0.212 | 0.0039% |
| chr16_66934227_G_A | chr16:66934227 | -0.037 | -0.010 | -0.212 | — |
| chr16_66934232_C_G | chr16:66934232 | -0.092 | -0.051 | -0.212 | — |
| chr16_66934261_T_G | chr16:66934261 | 0.028 | 0.069 | 0.212 | — |
| chr16_66934321_G_A | chr16:66934321 | 0.017 | -0.018 | -0.212 | — |
| chr16_66934358_C_A | chr16:66934358 | 0.120 | 0.081 | 0.106 | — |
| chr16_66934349_C_A | chr16:66934349 | 0.116 | 0.043 | 0.082 | — |
| chr16_66934215_G_C | chr16:66934215 | 0.040 | 0.089 | 0.200 | — |
| chr16_66934220_T_G | chr16:66934220 | 0.057 | 0.018 | 0.200 | — |
| chr16_66934230_C_A | chr16:66934230 | -0.050 | -0.013 | -0.200 | — |
| chr16_66934309_A_G | chr16:66934309 | 0.012 | 0.008 | 0.200 | — |
| chr16_66934341_G_C | chr16:66934341 | -0.030 | -0.074 | -0.200 | — |
| chr16_66934228_A_C | chr16:66934228 | -0.111 | -0.094 | -0.141 | — |
| chr16_66934344_G_T | chr16:66934344 | 0.110 | 0.020 | -0.035 | 0.0020% |
| chr16_66934356_G_C | chr16:66934356 | -0.110 | -0.066 | -0.094 | — |
| chr16_66934216_C_A | chr16:66934216 | 0.007 | -0.028 | -0.188 | — |
| chr16_66934219_A_C | chr16:66934219 | 0.043 | 0.030 | 0.188 | — |
| chr16_66934226_A_C | chr16:66934226 | -0.030 | -0.010 | 0.188 | — |
| chr16_66934240_T_G | chr16:66934240 | -0.063 | -0.091 | -0.188 | <0.001% |
| chr16_66934251_G_C | chr16:66934251 | 0.033 | 0.010 | 0.188 | — |
| chr16_66934264_T_G | chr16:66934264 | 0.013 | 0.071 | 0.188 | — |
| chr16_66934273_C_G | chr16:66934273 | 0.037 | 0.066 | 0.188 | — |
| chr16_66934322_C_G | chr16:66934322 | 0.106 | 0.008 | 0.059 | — |
| chr16_66934342_C_T | chr16:66934342 | 0.106 | 0.033 | -0.012 | — |
| chr16_66934346_C_G | chr16:66934346 | 0.106 | 0.013 | 0.047 | — |
| chr16_66934248_G_A | chr16:66934248 | 0.103 | -0.025 | -0.106 | — |
| chr16_66934333_A_T | chr16:66934333 | 0.103 | 0.008 | -0.012 | — |
| chr16_66934337_C_G | chr16:66934337 | 0.103 | 0.033 | 0.082 | — |
| chr16_66934339_C_T | chr16:66934339 | 0.103 | 0.013 | 0.047 | — |
| chr16_66934351_C_T | chr16:66934351 | 0.103 | 0.063 | 0.153 | — |
| chr16_66934238_C_G | chr16:66934238 | -0.101 | -0.063 | -0.153 | — |
| chr16_66934211_A_G | chr16:66934211 | -0.013 | 0.036 | 0.176 | — |
| chr16_66934212_G_T | chr16:66934212 | 0.003 | -0.036 | -0.176 | — |
| chr16_66934220_T_C | chr16:66934220 | 0.010 | -0.043 | 0.176 | — |
| chr16_66934228_A_G | chr16:66934228 | -0.100 | -0.096 | -0.129 | — |
| chr16_66934237_G_A | chr16:66934237 | -0.002 | 0.025 | -0.176 | — |
| chr16_66934237_G_C | chr16:66934237 | -0.027 | -0.030 | -0.176 | — |
| chr16_66934241_C_G | chr16:66934241 | -0.080 | -0.051 | -0.176 | — |
| chr16_66934248_G_T | chr16:66934248 | -0.043 | -0.028 | -0.176 | <0.001% |
| chr16_66934257_C_T | chr16:66934257 | -0.023 | 0.046 | 0.176 | — |
| chr16_66934268_C_A | chr16:66934268 | 0.073 | 0.114 | 0.176 | — |
| chr16_66934274_C_G | chr16:66934274 | 0.043 | 0.033 | 0.176 | — |
| chr16_66934350_G_C | chr16:66934350 | 0.067 | 0.036 | -0.176 | — |
| chr16_66934311_G_T | chr16:66934311 | 0.097 | 0.043 | 0.035 | — |
| chr16_66934316_G_T | chr16:66934316 | 0.097 | 0.008 | 0.059 | — |
| chr16_66934341_G_T | chr16:66934341 | 0.095 | 0.033 | -0.012 | — |
| chr16_66934215_G_A | chr16:66934215 | -0.003 | -0.030 | -0.165 | <0.001% |
| chr16_66934231_T_C | chr16:66934231 | -0.025 | -0.058 | -0.165 | — |
| chr16_66934239_G_A | chr16:66934239 | 0.037 | -0.041 | -0.165 | — |
| chr16_66934252_G_C | chr16:66934252 | 0.073 | 0.030 | 0.165 | — |
| chr16_66934263_G_A | chr16:66934263 | 0.033 | -0.020 | -0.165 | — |
| chr16_66934269_C_A | chr16:66934269 | 0.007 | -0.015 | -0.165 | — |
| chr16_66934270_T_G | chr16:66934270 | 0.013 | 0.041 | 0.165 | — |
| chr16_66934277_C_G | chr16:66934277 | 0.012 | 0.061 | 0.165 | — |
| chr16_66934278_C_A | chr16:66934278 | -0.007 | -0.041 | -0.165 | — |
| chr16_66934310_T_G | chr16:66934310 | -0.003 | 0.028 | 0.165 | — |
| chr16_66936480_C_G | chr16:66936480 | 0.093 | 0.084 | 0.094 | — |
| chr16_66934319_T_A | chr16:66934319 | -0.090 | -0.041 | 0.000 | — |
| chr16_66934320_G_C | chr16:66934320 | -0.090 | -0.036 | -0.024 | — |
| chr16_66934226_A_G | chr16:66934226 | -0.088 | -0.066 | -0.118 | — |
| chr16_66934353_G_A | chr16:66934353 | 0.088 | 0.023 | 0.000 | — |
| chr16_66936479_C_A | chr16:66936479 | 0.088 | 0.091 | 0.047 | — |
| chr16_66912608_G_C | chr16:66912608 | 0.034 | -0.004 | 0.153 | — |
| chr16_66934213_C_A | chr16:66934213 | -0.067 | -0.030 | -0.153 | — |
| chr16_66934213_C_T | chr16:66934213 | -0.035 | -0.041 | -0.153 | — |
| chr16_66934217_G_T | chr16:66934217 | 0.030 | -0.046 | -0.153 | — |
| chr16_66934222_T_G | chr16:66934222 | 0.020 | -0.005 | 0.153 | — |
| chr16_66934227_G_C | chr16:66934227 | -0.008 | -0.030 | -0.153 | — |
| chr16_66934242_G_T | chr16:66934242 | -0.013 | -0.015 | -0.153 | — |
| chr16_66934243_A_G | chr16:66934243 | 0.007 | 0.013 | 0.153 | — |
| chr16_66934279_G_A | chr16:66934279 | 0.000 | -0.023 | -0.153 | — |
| chr16_66934281_C_T | chr16:66934281 | 0.035 | -0.038 | -0.153 | — |
| chr16_66934285_G_T | chr16:66934285 | -0.042 | 0.010 | -0.153 | <0.001% |
| chr16_66934299_G_T | chr16:66934299 | -0.033 | -0.048 | -0.153 | — |
| chr16_66934309_A_C | chr16:66934309 | 0.023 | 0.036 | 0.153 | — |
| chr16_66934310_T_C | chr16:66934310 | 0.023 | 0.018 | 0.153 | 0.0020% |
| chr16_66934319_T_G | chr16:66934319 | -0.087 | -0.046 | 0.082 | — |
| chr16_66934340_C_A | chr16:66934340 | 0.087 | 0.000 | 0.035 | — |
| chr16_66934344_G_C | chr16:66934344 | 0.003 | -0.089 | -0.153 | — |
| chr16_66934352_C_T | chr16:66934352 | 0.087 | 0.008 | 0.129 | 0.0033% |
| chr16_66934358_C_G | chr16:66934358 | 0.087 | 0.053 | 0.153 | — |
| chr16_66936478_T_G | chr16:66936478 | 0.085 | 0.094 | 0.153 | — |
| chr16_66936489_C_G | chr16:66936489 | 0.087 | 0.074 | 0.012 | — |
| chr16_66936492_T_G | chr16:66936492 | 0.087 | 0.036 | 0.118 | — |
| chr16_66934231_T_A | chr16:66934231 | -0.083 | -0.005 | -0.024 | — |
| chr16_66934337_C_A | chr16:66934337 | 0.083 | 0.015 | 0.047 | — |
| chr16_66934352_C_A | chr16:66934352 | 0.083 | -0.005 | 0.047 | — |
| chr16_66936464_G_A | chr16:66936464 | 0.083 | 0.056 | 0.059 | — |
| chr16_66936491_C_G | chr16:66936491 | 0.083 | 0.058 | 0.047 | — |
| chr16_66936479_C_G | chr16:66936479 | 0.082 | 0.076 | 0.094 | — |
| chr16_66934217_G_A | chr16:66934217 | 0.023 | -0.033 | -0.141 | 0.0013% |
| chr16_66934236_T_C | chr16:66934236 | -0.080 | -0.018 | 0.012 | — |
| chr16_66934245_G_A | chr16:66934245 | 0.002 | -0.023 | -0.141 | — |
| chr16_66934306_T_C | chr16:66934306 | 0.040 | 0.058 | 0.141 | — |
| chr16_66934313_G_T | chr16:66934313 | -0.028 | -0.038 | -0.141 | — |
| chr16_66934327_T_G | chr16:66934327 | 0.077 | 0.030 | 0.141 | — |
| chr16_66934329_C_A | chr16:66934329 | -0.080 | -0.018 | -0.141 | — |
| chr16_66934331_G_A | chr16:66934331 | -0.023 | -0.003 | -0.141 | 0.0020% |
| chr16_66934336_C_T | chr16:66934336 | -0.080 | 0.008 | 0.024 | — |
| chr16_66934228_A_T | chr16:66934228 | -0.077 | 0.005 | -0.024 | — |
| chr16_66934292_C_T | chr16:66934292 | -0.077 | -0.038 | -0.118 | — |
| chr16_66934327_T_C | chr16:66934327 | 0.077 | 0.028 | 0.047 | — |
| chr16_66936476_C_A | chr16:66936476 | 0.077 | 0.107 | 0.118 | — |
| chr16_66936476_C_G | chr16:66936476 | 0.077 | 0.147 | 0.118 | — |
| chr16_66934217_G_C | chr16:66934217 | 0.027 | -0.063 | -0.129 | — |
| chr16_66934218_G_T | chr16:66934218 | 0.023 | -0.020 | -0.129 | — |
| chr16_66934233_G_A | chr16:66934233 | 0.028 | -0.020 | -0.129 | — |
| chr16_66934242_G_A | chr16:66934242 | -0.050 | 0.013 | -0.129 | — |
| chr16_66934264_T_C | chr16:66934264 | 0.050 | 0.071 | 0.129 | — |
| chr16_66934265_C_G | chr16:66934265 | 0.060 | 0.041 | 0.129 | — |
| chr16_66934266_C_A | chr16:66934266 | -0.060 | 0.089 | 0.129 | — |
| chr16_66934276_G_A | chr16:66934276 | 0.003 | -0.018 | -0.129 | — |
| chr16_66934284_A_T | chr16:66934284 | 0.047 | 0.023 | 0.129 | — |
| chr16_66934308_G_T | chr16:66934308 | 0.073 | 0.033 | 0.082 | — |
| chr16_66934316_G_A | chr16:66934316 | 0.073 | 0.028 | 0.106 | — |
| chr16_66934334_G_A | chr16:66934334 | 0.017 | 0.091 | -0.129 | <0.001% |
| chr16_66934349_C_T | chr16:66934349 | 0.067 | 0.053 | 0.129 | — |
| chr16_66936458_G_C | chr16:66936458 | 0.073 | 0.084 | 0.012 | — |
| chr16_66934317_G_C | chr16:66934317 | -0.072 | -0.018 | 0.047 | <0.001% |
| chr16_66934321_G_C | chr16:66934321 | -0.072 | -0.028 | -0.059 | — |
| chr16_66936478_T_A | chr16:66936478 | 0.072 | 0.076 | 0.106 | — |
| chr16_66934252_G_A | chr16:66934252 | 0.070 | 0.018 | 0.024 | 0.0013% |
| chr16_66934306_T_A | chr16:66934306 | -0.070 | -0.033 | -0.082 | — |
| chr16_66934334_G_C | chr16:66934334 | -0.070 | 0.018 | -0.082 | — |
| chr16_66934343_C_G | chr16:66934343 | 0.070 | -0.033 | 0.094 | — |
| chr16_66934354_C_A | chr16:66934354 | 0.070 | 0.043 | 0.035 | — |
| chr16_66936474_T_C | chr16:66936474 | 0.070 | 0.053 | 0.059 | — |
| chr16_66934215_G_T | chr16:66934215 | 0.050 | -0.038 | -0.118 | — |
| chr16_66934216_C_T | chr16:66934216 | -0.053 | -0.056 | -0.118 | — |
| chr16_66934223_C_G | chr16:66934223 | 0.007 | 0.023 | 0.118 | — |
| chr16_66934224_G_C | chr16:66934224 | -0.067 | -0.043 | -0.118 | — |
| chr16_66934224_G_T | chr16:66934224 | 0.003 | 0.013 | -0.118 | — |
| chr16_66934237_G_T | chr16:66934237 | 0.037 | 0.005 | -0.118 | — |
| chr16_66934243_A_C | chr16:66934243 | 0.000 | 0.015 | 0.118 | — |
| chr16_66934244_T_C | chr16:66934244 | 0.067 | 0.074 | 0.106 | — |
| chr16_66934246_C_T | chr16:66934246 | -0.007 | -0.015 | -0.118 | 0.0013% |
| chr16_66934251_G_A | chr16:66934251 | -0.013 | -0.010 | -0.118 | — |
| chr16_66934253_G_A | chr16:66934253 | 0.067 | 0.036 | 0.047 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.