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CYP1A2
receptor: AhRTier 1
CAMIP causal chains
AhR
Reduced receptor-mediated transactivation of CYP1A2 diminishes the inducibility of this major hepatic CYP; substrate clearance is correspondingly less enhanced in the induced state, which may raise exposure to narrow-therapeutic substrates.
Affected substrate drugs (PharmGKB): clozapine; caffeine; leflunomide; paroxetine; olanzapine; escitalopram
Scored variants near CYP1A2
chr15:74,648,844..74,856,607, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr15_74726000_C_A | chr15:74726000 | 36,288 | 9,504 | 43,008 | — |
| chr15_74725977_C_G | chr15:74725977 | -27,584 | -8,256 | -23,296 | — |
| chr15_74725954_T_A | chr15:74725954 | 26,048 | 9,616 | 22,528 | — |
| chr15_74725987_C_A | chr15:74725987 | -24,576 | -4,448 | 10,496 | — |
| chr15_74725954_T_C | chr15:74725954 | -23,616 | -7,328 | -18,816 | — |
| chr15_74725978_G_C | chr15:74725978 | -22,208 | -7,280 | -22,528 | — |
| chr15_74725976_G_A | chr15:74725976 | -21,824 | -8,080 | -20,480 | 6.6e-6 |
| chr15_74725997_C_G | chr15:74725997 | 21,568 | 3,344 | 35,072 | — |
| chr15_74725979_G_A | chr15:74725979 | -21,376 | -8,320 | -18,176 | — |
| chr15_74725956_C_T | chr15:74725956 | 20,672 | 5,904 | 17,664 | — |
| chr15_74725980_G_C | chr15:74725980 | -20,480 | -8,640 | -14,464 | — |
| chr15_74725976_G_T | chr15:74725976 | -19,904 | -7,456 | -19,200 | — |
| chr15_74725999_C_A | chr15:74725999 | 19,840 | 3,264 | 13,824 | — |
| chr15_74725998_T_A | chr15:74725998 | -19,712 | -8,976 | -17,408 | — |
| chr15_74725982_C_G | chr15:74725982 | -18,880 | -6,992 | -17,024 | — |
| chr15_74725978_G_T | chr15:74725978 | -18,560 | -6,112 | -19,712 | — |
| chr15_74725998_T_C | chr15:74725998 | -17,792 | -6,752 | -17,920 | — |
| chr15_74725971_C_G | chr15:74725971 | -17,408 | -4,944 | -15,232 | — |
| chr15_74725975_G_T | chr15:74725975 | -16,000 | -6,848 | -15,744 | — |
| chr15_74725975_G_C | chr15:74725975 | -15,872 | -7,104 | -16,512 | — |
| chr15_74725987_C_T | chr15:74725987 | -15,616 | -5,104 | -6,656 | — |
| chr15_74725979_G_C | chr15:74725979 | -15,296 | -7,184 | -16,512 | — |
| chr15_74725996_C_G | chr15:74725996 | -15,232 | -8,384 | -7,168 | — |
| chr15_74725993_T_A | chr15:74725993 | -15,040 | -7,328 | -9,728 | — |
| chr15_74725975_G_A | chr15:74725975 | -14,848 | -6,352 | -15,360 | 2.0e-5 |
| chr15_74725987_C_G | chr15:74725987 | -14,784 | -5,248 | -4,224 | — |
| chr15_74725905_G_C | chr15:74725905 | 13,952 | 3,560 | 13,056 | — |
| chr15_74725937_T_C | chr15:74725937 | -13,440 | -2,368 | -6,400 | — |
| chr15_74725976_G_C | chr15:74725976 | -13,440 | -4,912 | -13,312 | — |
| chr15_74725978_G_A | chr15:74725978 | -13,248 | -4,752 | -14,848 | — |
| chr15_74725974_G_C | chr15:74725974 | -12,992 | -6,368 | -16,768 | — |
| chr15_74725974_G_T | chr15:74725974 | -12,992 | -6,352 | -15,488 | — |
| chr15_74725966_G_C | chr15:74725966 | 12,928 | 2,080 | 7,296 | — |
| chr15_74725981_G_T | chr15:74725981 | -12,800 | -4,096 | -12,544 | — |
| chr15_74725996_C_T | chr15:74725996 | -12,672 | -7,440 | -5,888 | 1.9e-4 |
| chr15_74725909_C_G | chr15:74725909 | 12,448 | 1,816 | 7,744 | — |
| chr15_74725977_C_T | chr15:74725977 | -12,288 | -4,336 | -9,600 | — |
| chr15_74725985_C_A | chr15:74725985 | 11,968 | 6,592 | 1,920 | — |
| chr15_74725993_T_G | chr15:74725993 | -11,840 | -5,872 | -7,936 | 1.2e-4 |
| chr15_74725912_C_A | chr15:74725912 | 11,680 | 3,560 | 7,808 | — |
| chr15_74725993_T_C | chr15:74725993 | -11,584 | -5,376 | -5,120 | — |
| chr15_74725955_A_T | chr15:74725955 | -10,816 | -3,712 | -8,192 | — |
| chr15_74725955_A_C | chr15:74725955 | -10,720 | -2,688 | -6,528 | — |
| chr15_74725988_C_A | chr15:74725988 | -10,560 | -3,536 | -5,632 | — |
| chr15_74725995_A_T | chr15:74725995 | -10,432 | -5,744 | -2,048 | — |
| chr15_74725951_G_T | chr15:74725951 | -10,368 | -4,624 | -13,696 | — |
| chr15_74725995_A_C | chr15:74725995 | -10,368 | -4,880 | -1,536 | — |
| chr15_74725959_G_T | chr15:74725959 | -10,240 | 4,288 | 36,480 | — |
| chr15_74725930_A_C | chr15:74725930 | 10,176 | 3,440 | 15,360 | — |
| chr15_74725896_G_C | chr15:74725896 | -9,632 | -2,768 | -640 | — |
| chr15_74725953_C_G | chr15:74725953 | -9,408 | -5,168 | -9,472 | — |
| chr15_74725977_C_A | chr15:74725977 | -9,408 | -3,968 | -7,552 | — |
| chr15_74725925_C_G | chr15:74725925 | -9,376 | -2,360 | -3,968 | — |
| chr15_74725982_C_A | chr15:74725982 | -9,088 | -3,776 | -11,264 | — |
| chr15_74725933_T_C | chr15:74725933 | 9,088 | 3,352 | 10,112 | — |
| chr15_74725952_C_G | chr15:74725952 | -8,992 | -2,752 | -6,016 | — |
| chr15_74725949_C_A | chr15:74725949 | -8,864 | -2,736 | -6,656 | — |
| chr15_74725973_G_C | chr15:74725973 | -8,704 | -4,016 | -7,424 | — |
| chr15_74725981_G_C | chr15:74725981 | -8,512 | -3,376 | -9,984 | — |
| chr15_74725908_C_G | chr15:74725908 | 8,352 | 2,440 | 4,992 | 1.3e-5 |
| chr15_74725942_A_C | chr15:74725942 | 8,320 | 2,184 | 10,496 | — |
| chr15_74725901_T_C | chr15:74725901 | 8,128 | 2,112 | 2,304 | — |
| chr15_74725994_G_T | chr15:74725994 | -8,064 | -4,816 | -6,656 | — |
| chr15_74725953_C_T | chr15:74725953 | -7,936 | -2,944 | -8,320 | — |
| chr15_74725973_G_T | chr15:74725973 | 7,744 | 3,520 | 10,240 | — |
| chr15_74725938_C_G | chr15:74725938 | 7,744 | 1,712 | 6,656 | — |
| chr15_74725953_C_A | chr15:74725953 | -7,680 | -2,032 | -7,168 | — |
| chr15_74725894_T_A | chr15:74725894 | 7,648 | 1,488 | 9,792 | — |
| chr15_74725952_C_A | chr15:74725952 | -7,648 | -2,112 | -6,656 | 1.6e-4 |
| chr15_74725934_G_C | chr15:74725934 | 7,552 | 3,560 | 8,320 | — |
| chr15_74725996_C_A | chr15:74725996 | -7,552 | -4,528 | -4,096 | — |
| chr15_74725920_C_G | chr15:74725920 | -7,392 | -2,648 | -896 | — |
| chr15_74725932_A_G | chr15:74725932 | 7,360 | 1,168 | 1,152 | — |
| chr15_74725894_T_G | chr15:74725894 | 7,328 | 1,944 | 9,664 | — |
| chr15_74725984_G_C | chr15:74725984 | -7,104 | -2,672 | -5,120 | — |
| chr15_74725994_G_C | chr15:74725994 | -7,104 | -2,560 | -768 | — |
| chr15_74725995_A_G | chr15:74725995 | -6,976 | -4,160 | 1,024 | — |
| chr15_74725905_G_A | chr15:74725905 | 6,848 | 1,864 | 8,704 | — |
| chr15_74725980_G_T | chr15:74725980 | -6,784 | -4,336 | -8,832 | — |
| chr15_74725972_G_T | chr15:74725972 | -6,784 | -1,824 | -4,864 | 6.6e-6 |
| chr15_74725981_G_A | chr15:74725981 | -6,720 | -1,552 | -8,064 | — |
| chr15_74725879_C_G | chr15:74725879 | 6,688 | 3,040 | 5,952 | — |
| chr15_74725952_C_T | chr15:74725952 | -6,528 | -2,256 | -7,296 | — |
| chr15_74725909_C_T | chr15:74725909 | 6,496 | 1,368 | 384 | — |
| chr15_74725936_C_A | chr15:74725936 | -6,432 | -2,872 | -8,960 | — |
| chr15_74725988_C_G | chr15:74725988 | -6,400 | -2,512 | -3,584 | 6.6e-6 |
| chr15_74725954_T_G | chr15:74725954 | -6,240 | -1,536 | -3,712 | — |
| chr15_74725968_A_G | chr15:74725968 | -6,016 | -2,560 | -5,888 | — |
| chr15_74725904_T_G | chr15:74725904 | 5,888 | 1,232 | 7,680 | — |
| chr15_74725908_C_A | chr15:74725908 | 5,728 | 2,168 | 2,944 | — |
| chr15_74725943_G_T | chr15:74725943 | -5,568 | -2,080 | -8,832 | — |
| chr15_74725972_G_C | chr15:74725972 | -5,568 | -2,320 | -4,608 | — |
| chr15_74725979_G_T | chr15:74725979 | -5,568 | -1,856 | -3,840 | — |
| chr15_74725926_G_A | chr15:74725926 | -5,536 | -1,408 | -3,456 | — |
| chr15_74725911_A_G | chr15:74725911 | 5,504 | 752 | 2,560 | — |
| chr15_74725992_G_A | chr15:74725992 | 5,504 | 2,272 | 1,024 | — |
| chr15_74725933_T_G | chr15:74725933 | 5,472 | 1,640 | 3,200 | — |
| chr15_74725862_G_T | chr15:74725862 | 5,376 | 496 | 192 | — |
| chr15_74725912_C_G | chr15:74725912 | 5,344 | 1,552 | 2,944 | — |
| chr15_74725956_C_A | chr15:74725956 | -5,312 | -1,504 | -6,144 | — |
| chr15_74725937_T_A | chr15:74725937 | -5,312 | -1,992 | -3,840 | — |
| chr15_74725910_C_A | chr15:74725910 | 5,280 | 864 | 896 | — |
| chr15_74725940_C_G | chr15:74725940 | 5,216 | 632 | 3,072 | — |
| chr15_74725902_T_A | chr15:74725902 | 5,120 | 1,480 | 3,072 | — |
| chr15_74725903_T_C | chr15:74725903 | 5,120 | 920 | 1,984 | — |
| chr15_74725944_C_G | chr15:74725944 | -5,120 | -224 | -640 | — |
| chr15_74725967_C_G | chr15:74725967 | -5,120 | -1,680 | -4,736 | — |
| chr15_74725970_G_C | chr15:74725970 | 5,120 | 1,952 | 3,200 | — |
| chr15_74725917_A_G | chr15:74725917 | 5,088 | 1,232 | 1,664 | — |
| chr15_74725948_A_T | chr15:74725948 | 5,056 | 2,608 | 6,400 | — |
| chr15_74725967_C_T | chr15:74725967 | -4,992 | -1,680 | -2,432 | — |
| chr15_74725958_A_T | chr15:74725958 | -4,928 | -2,200 | -9,856 | — |
| chr15_74725912_C_T | chr15:74725912 | 4,864 | 1,256 | 2,048 | — |
| chr15_74725941_C_T | chr15:74725941 | 4,864 | 1,088 | 3,200 | — |
| chr15_74725966_G_T | chr15:74725966 | 4,864 | 1,440 | 3,584 | — |
| chr15_74725869_C_G | chr15:74725869 | 4,832 | 1,608 | 6,976 | — |
| chr15_74725964_C_T | chr15:74725964 | -4,800 | -2,656 | -6,784 | — |
| chr15_74725929_C_T | chr15:74725929 | 4,768 | 1,552 | 3,712 | — |
| chr15_74725957_C_A | chr15:74725957 | -4,736 | -1,376 | -1,536 | — |
| chr15_74725970_G_A | chr15:74725970 | 4,736 | 1,120 | 1,024 | 6.6e-6 |
| chr15_74725971_C_T | chr15:74725971 | -4,608 | -3,024 | -9,216 | — |
| chr15_74725980_G_A | chr15:74725980 | 4,608 | 2,464 | 5,120 | — |
| chr15_74725967_C_A | chr15:74725967 | -4,608 | -1,616 | -4,480 | — |
| chr15_74725986_C_T | chr15:74725986 | -4,608 | -3,040 | -2,048 | — |
| chr15_74725929_C_A | chr15:74725929 | -4,576 | -1,520 | -6,784 | — |
| chr15_74725962_C_T | chr15:74725962 | -4,480 | -1,456 | -3,456 | — |
| chr15_74725983_T_G | chr15:74725983 | -4,480 | -1,984 | -3,456 | — |
| chr15_74725904_T_A | chr15:74725904 | 4,416 | 1,256 | 5,760 | — |
| chr15_74725860_G_C | chr15:74725860 | -4,288 | 0 | -960 | 6.6e-6 |
| chr15_74725911_A_C | chr15:74725911 | -4,288 | -504 | -1,792 | — |
| chr15_74725932_A_C | chr15:74725932 | 4,288 | 712 | 3,584 | — |
| chr15_74725931_G_C | chr15:74725931 | 4,256 | 2,536 | 8,704 | — |
| chr15_74725888_T_G | chr15:74725888 | 4,256 | 1,624 | 5,632 | — |
| chr15_74725891_T_C | chr15:74725891 | 4,256 | 1,664 | 2,048 | — |
| chr15_74725941_C_G | chr15:74725941 | 4,224 | 688 | 3,840 | — |
| chr15_74725951_G_C | chr15:74725951 | -4,224 | -608 | 384 | — |
| chr15_74725896_G_A | chr15:74725896 | -4,192 | -1,320 | -6,144 | — |
| chr15_74725928_G_C | chr15:74725928 | -4,160 | -1,656 | -3,072 | — |
| chr15_74725896_G_T | chr15:74725896 | -4,032 | -920 | -7,424 | — |
| chr15_74725991_G_A | chr15:74725991 | 4,032 | 2,368 | 2,048 | 6.6e-6 |
| chr15_74725881_C_G | chr15:74725881 | -4,000 | 152 | 0 | — |
| chr15_74725936_C_T | chr15:74725936 | -4,000 | -1,544 | -3,072 | — |
| chr15_74725921_T_G | chr15:74725921 | -3,968 | -1,376 | 640 | — |
| chr15_74725903_T_G | chr15:74725903 | 3,936 | 664 | 128 | — |
| chr15_74725923_G_C | chr15:74725923 | 3,904 | -880 | -896 | — |
| chr15_74725983_T_A | chr15:74725983 | -3,904 | -1,856 | -1,664 | — |
| chr15_74725904_T_C | chr15:74725904 | 3,808 | 712 | 4,224 | — |
| chr15_74725932_A_T | chr15:74725932 | 3,808 | 1,800 | 3,712 | — |
| chr15_74725950_A_C | chr15:74725950 | 3,744 | 1,704 | 9,472 | — |
| chr15_74725869_C_T | chr15:74725869 | 3,744 | 976 | 3,584 | — |
| chr15_74725891_T_G | chr15:74725891 | 3,648 | 1,648 | 6,208 | — |
| chr15_74725997_C_A | chr15:74725997 | -3,456 | -3,968 | 2,560 | — |
| chr15_74725997_C_T | chr15:74725997 | -3,392 | -1,424 | 14,080 | 6.6e-6 |
| chr15_74725989_G_C | chr15:74725989 | 3,392 | 2,064 | -3,840 | — |
| chr15_74725949_C_T | chr15:74725949 | -3,360 | -1,840 | -4,608 | — |
| chr15_74725984_G_T | chr15:74725984 | 3,328 | 336 | 8,960 | — |
| chr15_74725989_G_A | chr15:74725989 | -3,264 | -640 | -4,864 | 3.3e-2 |
| chr15_74725884_G_C | chr15:74725884 | 3,232 | 808 | 3,840 | — |
| chr15_74725965_G_T | chr15:74725965 | -3,200 | -144 | -6,272 | 6.6e-6 |
| chr15_74725871_T_C | chr15:74725871 | 3,040 | 2,008 | 10,112 | — |
| chr15_74725929_C_G | chr15:74725929 | 2,976 | 696 | 4,096 | — |
| chr15_74725892_C_A | chr15:74725892 | 2,848 | 1,744 | 4,480 | — |
| chr15_74725916_A_C | chr15:74725916 | -2,848 | -1,360 | 4,224 | — |
| chr15_74725955_A_G | chr15:74725955 | 2,816 | -32 | 6,144 | — |
| chr15_74725984_G_A | chr15:74725984 | 2,816 | 768 | 5,632 | — |
| chr15_74725895_C_A | chr15:74725895 | 2,784 | 1,416 | 3,776 | — |
| chr15_74725905_G_T | chr15:74725905 | 2,624 | 1,840 | 6,912 | — |
| chr15_74725866_C_G | chr15:74725866 | 2,592 | 1,128 | 3,776 | — |
| chr15_74725960_G_C | chr15:74725960 | 2,560 | 1,232 | 5,504 | — |
| chr15_74725921_T_C | chr15:74725921 | -2,560 | -1,472 | -5,376 | — |
| chr15_74725924_G_A | chr15:74725924 | -2,528 | -648 | -6,400 | — |
| chr15_74725870_A_C | chr15:74725870 | 2,368 | 2,056 | 5,312 | — |
| chr15_74725926_G_T | chr15:74725926 | -2,368 | -904 | -3,840 | — |
| chr15_74725991_G_C | chr15:74725991 | 2,304 | 1,328 | -7,168 | — |
| chr15_74725988_C_T | chr15:74725988 | -2,240 | 80 | -4,352 | — |
| chr15_74725924_G_T | chr15:74725924 | -2,144 | -1,264 | -5,248 | — |
| chr15_74725867_T_G | chr15:74725867 | 2,016 | 1,016 | 4,928 | — |
| chr15_74725966_G_A | chr15:74725966 | 1,984 | 80 | -4,864 | 1.3e-5 |
| chr15_74725918_C_T | chr15:74725918 | -1,888 | 952 | 8,832 | 6.6e-6 |
| chr15_74725891_T_A | chr15:74725891 | 1,888 | 1,088 | 4,800 | — |
| chr15_74725913_T_G | chr15:74725913 | 1,856 | 248 | 7,296 | — |
| chr15_74725893_T_C | chr15:74725893 | 1,824 | 752 | 4,352 | — |
| chr15_74725908_C_T | chr15:74725908 | 1,760 | -696 | -6,272 | — |
| chr15_74725982_C_T | chr15:74725982 | -1,728 | -224 | -5,632 | — |
| chr15_74725959_G_C | chr15:74725959 | 1,728 | 896 | 5,376 | — |
| chr15_74725825_G_T | chr15:74725825 | -1,664 | -1,120 | -4,096 | — |
| chr15_74725854_G_T | chr15:74725854 | -1,632 | -1,112 | -4,672 | — |
| chr15_74725870_A_G | chr15:74725870 | 1,504 | 976 | 4,416 | — |
| chr15_74725961_A_C | chr15:74725961 | -1,472 | -1,312 | -4,096 | — |
| chr15_74725871_T_G | chr15:74725871 | 1,440 | 1,016 | 5,376 | — |
| chr15_74725815_G_C | chr15:74725815 | 1,440 | 424 | 3,712 | — |
| chr15_74725926_G_C | chr15:74725926 | -1,408 | -1,504 | -6,912 | 1.3e-5 |
| chr15_74725948_A_C | chr15:74725948 | 1,280 | 1,088 | 4,480 | — |
| chr15_74725870_A_T | chr15:74725870 | 1,184 | 1,456 | 4,800 | 6.6e-6 |
| chr15_74725872_C_G | chr15:74725872 | 928 | 840 | 4,736 | 1.3e-5 |
| chr15_74725873_C_T | chr15:74725873 | -832 | 192 | 3,776 | — |
| chr15_74725913_T_A | chr15:74725913 | 800 | 0 | 3,840 | — |
| chr15_74725931_G_A | chr15:74725931 | 672 | 1,528 | 3,840 | — |
| chr15_74725998_T_G | chr15:74725998 | -640 | -2,272 | 5,376 | 6.6e-6 |
| chr15_74725989_G_T | chr15:74725989 | 0 | 1,584 | -6,016 | 1.3e-5 |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.