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CYP1A2
receptor: AhRTier 1
CAMIP causal chains
AhR
Reduced receptor-mediated transactivation of CYP1A2 diminishes the inducibility of this major hepatic CYP; substrate clearance is correspondingly less enhanced in the induced state, which may raise exposure to narrow-therapeutic substrates.
Affected substrate drugs (PharmGKB): clozapine; caffeine; leflunomide; paroxetine; olanzapine; escitalopram
Scored variants near CYP1A2
chr15:74,648,844..74,856,607, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr15_74726000_C_A | chr15:74726000 | 0.930 | 0.748 | 1.000 | — |
| chr15_74725959_G_T | chr15:74725959 | -0.262 | 0.338 | 1.000 | — |
| chr15_74725997_C_G | chr15:74725997 | 0.552 | 0.263 | 1.000 | — |
| chr15_74725977_C_G | chr15:74725977 | -0.707 | -0.650 | -1.000 | — |
| chr15_74725954_T_A | chr15:74725954 | 0.667 | 0.757 | 0.989 | — |
| chr15_74725987_C_A | chr15:74725987 | -0.630 | -0.350 | 0.461 | — |
| chr15_74725954_T_C | chr15:74725954 | -0.605 | -0.577 | -0.826 | — |
| chr15_74725978_G_C | chr15:74725978 | -0.569 | -0.573 | -0.989 | — |
| chr15_74725976_G_A | chr15:74725976 | -0.559 | -0.636 | -0.899 | <0.001% |
| chr15_74725979_G_A | chr15:74725979 | -0.548 | -0.655 | -0.798 | — |
| chr15_74725956_C_T | chr15:74725956 | 0.530 | 0.465 | 0.775 | — |
| chr15_74725980_G_C | chr15:74725980 | -0.525 | -0.680 | -0.635 | — |
| chr15_74725976_G_T | chr15:74725976 | -0.510 | -0.587 | -0.843 | — |
| chr15_74725999_C_A | chr15:74725999 | 0.508 | 0.257 | 0.607 | — |
| chr15_74725978_G_T | chr15:74725978 | -0.475 | -0.481 | -0.865 | — |
| chr15_74725998_T_A | chr15:74725998 | -0.505 | -0.707 | -0.764 | — |
| chr15_74725982_C_G | chr15:74725982 | -0.484 | -0.550 | -0.747 | — |
| chr15_74725998_T_C | chr15:74725998 | -0.456 | -0.531 | -0.787 | — |
| chr15_74725971_C_G | chr15:74725971 | -0.446 | -0.389 | -0.669 | — |
| chr15_74725974_G_C | chr15:74725974 | -0.333 | -0.501 | -0.736 | — |
| chr15_74725975_G_C | chr15:74725975 | -0.407 | -0.559 | -0.725 | — |
| chr15_74725979_G_C | chr15:74725979 | -0.392 | -0.565 | -0.725 | — |
| chr15_74725975_G_T | chr15:74725975 | -0.410 | -0.539 | -0.691 | — |
| chr15_74725987_C_T | chr15:74725987 | -0.400 | -0.402 | -0.292 | — |
| chr15_74725974_G_T | chr15:74725974 | -0.333 | -0.500 | -0.680 | — |
| chr15_74725930_A_C | chr15:74725930 | 0.261 | 0.271 | 0.674 | — |
| chr15_74725975_G_A | chr15:74725975 | -0.380 | -0.500 | -0.674 | 0.0020% |
| chr15_74725996_C_G | chr15:74725996 | -0.390 | -0.660 | -0.315 | — |
| chr15_74725993_T_A | chr15:74725993 | -0.385 | -0.577 | -0.427 | — |
| chr15_74725978_G_A | chr15:74725978 | -0.339 | -0.374 | -0.652 | — |
| chr15_74725987_C_G | chr15:74725987 | -0.379 | -0.413 | -0.185 | — |
| chr15_74725997_C_T | chr15:74725997 | -0.087 | -0.112 | 0.618 | <0.001% |
| chr15_74725905_G_C | chr15:74725905 | 0.357 | 0.280 | 0.573 | — |
| chr15_74725951_G_T | chr15:74725951 | -0.266 | -0.364 | -0.601 | — |
| chr15_74725937_T_C | chr15:74725937 | -0.344 | -0.186 | -0.281 | — |
| chr15_74725976_G_C | chr15:74725976 | -0.344 | -0.387 | -0.584 | — |
| chr15_74725966_G_C | chr15:74725966 | 0.331 | 0.164 | 0.320 | — |
| chr15_74725981_G_T | chr15:74725981 | -0.328 | -0.322 | -0.551 | — |
| chr15_74725996_C_T | chr15:74725996 | -0.325 | -0.586 | -0.258 | 0.019% |
| chr15_74725909_C_G | chr15:74725909 | 0.319 | 0.143 | 0.340 | — |
| chr15_74725977_C_T | chr15:74725977 | -0.315 | -0.341 | -0.421 | — |
| chr15_74725985_C_A | chr15:74725985 | 0.307 | 0.519 | 0.084 | — |
| chr15_74725993_T_G | chr15:74725993 | -0.303 | -0.462 | -0.348 | 0.012% |
| chr15_74725912_C_A | chr15:74725912 | 0.299 | 0.280 | 0.343 | — |
| chr15_74725993_T_C | chr15:74725993 | -0.297 | -0.423 | -0.225 | — |
| chr15_74725982_C_A | chr15:74725982 | -0.233 | -0.297 | -0.494 | — |
| chr15_74725955_A_T | chr15:74725955 | -0.277 | -0.292 | -0.360 | — |
| chr15_74725955_A_C | chr15:74725955 | -0.275 | -0.212 | -0.287 | — |
| chr15_74725988_C_A | chr15:74725988 | -0.270 | -0.278 | -0.247 | — |
| chr15_74725942_A_C | chr15:74725942 | 0.213 | 0.172 | 0.461 | — |
| chr15_74725995_A_T | chr15:74725995 | -0.267 | -0.452 | -0.090 | — |
| chr15_74725995_A_C | chr15:74725995 | -0.266 | -0.384 | -0.067 | — |
| chr15_74725973_G_T | chr15:74725973 | 0.198 | 0.277 | 0.449 | — |
| chr15_74725871_T_C | chr15:74725871 | 0.078 | 0.158 | 0.444 | — |
| chr15_74725933_T_C | chr15:74725933 | 0.233 | 0.264 | 0.444 | — |
| chr15_74725981_G_C | chr15:74725981 | -0.218 | -0.266 | -0.438 | — |
| chr15_74725958_A_T | chr15:74725958 | -0.126 | -0.173 | -0.433 | — |
| chr15_74725894_T_A | chr15:74725894 | 0.196 | 0.117 | 0.430 | — |
| chr15_74725894_T_G | chr15:74725894 | 0.188 | 0.153 | 0.424 | — |
| chr15_74725896_G_C | chr15:74725896 | -0.247 | -0.218 | -0.028 | — |
| chr15_74725950_A_C | chr15:74725950 | 0.096 | 0.134 | 0.416 | — |
| chr15_74725953_C_G | chr15:74725953 | -0.241 | -0.407 | -0.416 | — |
| chr15_74725977_C_A | chr15:74725977 | -0.241 | -0.312 | -0.331 | — |
| chr15_74725925_C_G | chr15:74725925 | -0.240 | -0.186 | -0.174 | — |
| chr15_74725971_C_T | chr15:74725971 | -0.118 | -0.238 | -0.404 | — |
| chr15_74725952_C_G | chr15:74725952 | -0.230 | -0.217 | -0.264 | — |
| chr15_74725936_C_A | chr15:74725936 | -0.165 | -0.226 | -0.393 | — |
| chr15_74725984_G_T | chr15:74725984 | 0.085 | 0.026 | 0.393 | — |
| chr15_74725949_C_A | chr15:74725949 | -0.227 | -0.215 | -0.292 | — |
| chr15_74725918_C_T | chr15:74725918 | -0.048 | 0.075 | 0.388 | <0.001% |
| chr15_74725943_G_T | chr15:74725943 | -0.143 | -0.164 | -0.388 | — |
| chr15_74725980_G_T | chr15:74725980 | -0.174 | -0.341 | -0.388 | — |
| chr15_74725905_G_A | chr15:74725905 | 0.175 | 0.147 | 0.382 | — |
| chr15_74725931_G_C | chr15:74725931 | 0.109 | 0.200 | 0.382 | — |
| chr15_74725973_G_C | chr15:74725973 | -0.223 | -0.316 | -0.326 | — |
| chr15_74725908_C_G | chr15:74725908 | 0.214 | 0.192 | 0.219 | 0.0013% |
| chr15_74725934_G_C | chr15:74725934 | 0.193 | 0.280 | 0.365 | — |
| chr15_74725953_C_T | chr15:74725953 | -0.203 | -0.232 | -0.365 | — |
| chr15_74725901_T_C | chr15:74725901 | 0.208 | 0.166 | 0.101 | — |
| chr15_74725981_G_A | chr15:74725981 | -0.172 | -0.122 | -0.354 | — |
| chr15_74725994_G_T | chr15:74725994 | -0.207 | -0.379 | -0.292 | — |
| chr15_74725938_C_G | chr15:74725938 | 0.198 | 0.135 | 0.292 | — |
| chr15_74725904_T_G | chr15:74725904 | 0.151 | 0.097 | 0.337 | — |
| chr15_74725953_C_A | chr15:74725953 | -0.197 | -0.160 | -0.315 | — |
| chr15_74725952_C_A | chr15:74725952 | -0.196 | -0.166 | -0.292 | 0.016% |
| chr15_74725996_C_A | chr15:74725996 | -0.193 | -0.356 | -0.180 | — |
| chr15_74725896_G_T | chr15:74725896 | -0.103 | -0.072 | -0.326 | — |
| chr15_74725920_C_G | chr15:74725920 | -0.189 | -0.208 | -0.039 | — |
| chr15_74725932_A_G | chr15:74725932 | 0.189 | 0.092 | 0.051 | — |
| chr15_74725913_T_G | chr15:74725913 | 0.048 | 0.020 | 0.320 | — |
| chr15_74725952_C_T | chr15:74725952 | -0.167 | -0.178 | -0.320 | — |
| chr15_74725991_G_C | chr15:74725991 | 0.059 | 0.105 | -0.315 | — |
| chr15_74725984_G_C | chr15:74725984 | -0.182 | -0.210 | -0.225 | — |
| chr15_74725994_G_C | chr15:74725994 | -0.182 | -0.202 | -0.034 | — |
| chr15_74725869_C_G | chr15:74725869 | 0.124 | 0.127 | 0.306 | — |
| chr15_74725995_A_G | chr15:74725995 | -0.179 | -0.327 | 0.045 | — |
| chr15_74725905_G_T | chr15:74725905 | 0.067 | 0.145 | 0.303 | — |
| chr15_74725926_G_C | chr15:74725926 | -0.036 | -0.118 | -0.303 | 0.0013% |
| chr15_74725929_C_A | chr15:74725929 | -0.117 | -0.120 | -0.298 | — |
| chr15_74725964_C_T | chr15:74725964 | -0.123 | -0.209 | -0.298 | — |
| chr15_74725972_G_T | chr15:74725972 | -0.174 | -0.144 | -0.213 | <0.001% |
| chr15_74725879_C_G | chr15:74725879 | 0.171 | 0.239 | 0.261 | — |
| chr15_74725909_C_T | chr15:74725909 | 0.166 | 0.108 | 0.017 | — |
| chr15_74725924_G_A | chr15:74725924 | -0.065 | -0.051 | -0.281 | — |
| chr15_74725948_A_T | chr15:74725948 | 0.130 | 0.205 | 0.281 | — |
| chr15_74725988_C_G | chr15:74725988 | -0.164 | -0.198 | -0.157 | <0.001% |
| chr15_74725908_C_T | chr15:74725908 | 0.045 | -0.055 | -0.275 | — |
| chr15_74725965_G_T | chr15:74725965 | -0.082 | -0.011 | -0.275 | <0.001% |
| chr15_74725954_T_G | chr15:74725954 | -0.160 | -0.121 | -0.163 | — |
| chr15_74725891_T_G | chr15:74725891 | 0.093 | 0.130 | 0.272 | — |
| chr15_74725896_G_A | chr15:74725896 | -0.107 | -0.104 | -0.270 | — |
| chr15_74725955_A_G | chr15:74725955 | 0.072 | -0.003 | 0.270 | — |
| chr15_74725956_C_A | chr15:74725956 | -0.136 | -0.118 | -0.270 | — |
| chr15_74725968_A_G | chr15:74725968 | -0.154 | -0.202 | -0.258 | — |
| chr15_74725989_G_T | chr15:74725989 | 0.000 | 0.125 | -0.264 | 0.0013% |
| chr15_74725904_T_A | chr15:74725904 | 0.113 | 0.099 | 0.253 | — |
| chr15_74725908_C_A | chr15:74725908 | 0.147 | 0.171 | 0.129 | — |
| chr15_74725888_T_G | chr15:74725888 | 0.109 | 0.128 | 0.247 | — |
| chr15_74725982_C_T | chr15:74725982 | -0.044 | -0.018 | -0.247 | — |
| chr15_74725984_G_A | chr15:74725984 | 0.072 | 0.060 | 0.247 | — |
| chr15_74725972_G_C | chr15:74725972 | -0.143 | -0.183 | -0.202 | — |
| chr15_74725979_G_T | chr15:74725979 | -0.143 | -0.146 | -0.169 | — |
| chr15_74725926_G_A | chr15:74725926 | -0.142 | -0.111 | -0.152 | — |
| chr15_74725911_A_G | chr15:74725911 | 0.141 | 0.059 | 0.112 | — |
| chr15_74725960_G_C | chr15:74725960 | 0.066 | 0.097 | 0.242 | — |
| chr15_74725992_G_A | chr15:74725992 | 0.141 | 0.179 | 0.045 | — |
| chr15_74725933_T_G | chr15:74725933 | 0.140 | 0.129 | 0.140 | — |
| chr15_74725862_G_T | chr15:74725862 | 0.138 | 0.039 | 0.008 | — |
| chr15_74725871_T_G | chr15:74725871 | 0.037 | 0.080 | 0.236 | — |
| chr15_74725921_T_C | chr15:74725921 | -0.066 | -0.116 | -0.236 | — |
| chr15_74725959_G_C | chr15:74725959 | 0.044 | 0.071 | 0.236 | — |
| chr15_74725998_T_G | chr15:74725998 | -0.016 | -0.179 | 0.236 | <0.001% |
| chr15_74725912_C_G | chr15:74725912 | 0.137 | 0.122 | 0.129 | — |
| chr15_74725870_A_C | chr15:74725870 | 0.061 | 0.162 | 0.233 | — |
| chr15_74725937_T_A | chr15:74725937 | -0.136 | -0.157 | -0.169 | — |
| chr15_74725910_C_A | chr15:74725910 | 0.135 | 0.068 | 0.039 | — |
| chr15_74725924_G_T | chr15:74725924 | -0.055 | -0.099 | -0.230 | — |
| chr15_74725940_C_G | chr15:74725940 | 0.134 | 0.050 | 0.135 | — |
| chr15_74725902_T_A | chr15:74725902 | 0.131 | 0.116 | 0.135 | — |
| chr15_74725903_T_C | chr15:74725903 | 0.131 | 0.072 | 0.087 | — |
| chr15_74725944_C_G | chr15:74725944 | -0.131 | -0.018 | -0.028 | — |
| chr15_74725967_C_G | chr15:74725967 | -0.131 | -0.132 | -0.208 | — |
| chr15_74725970_G_C | chr15:74725970 | 0.131 | 0.154 | 0.140 | — |
| chr15_74725980_G_A | chr15:74725980 | 0.118 | 0.194 | 0.225 | — |
| chr15_74725917_A_G | chr15:74725917 | 0.130 | 0.097 | 0.073 | — |
| chr15_74725967_C_T | chr15:74725967 | -0.128 | -0.132 | -0.107 | — |
| chr15_74725867_T_G | chr15:74725867 | 0.052 | 0.080 | 0.216 | — |
| chr15_74725912_C_T | chr15:74725912 | 0.125 | 0.099 | 0.090 | — |
| chr15_74725941_C_T | chr15:74725941 | 0.125 | 0.086 | 0.140 | — |
| chr15_74725966_G_A | chr15:74725966 | 0.051 | 0.006 | -0.213 | 0.0013% |
| chr15_74725966_G_T | chr15:74725966 | 0.125 | 0.113 | 0.157 | — |
| chr15_74725989_G_A | chr15:74725989 | -0.084 | -0.050 | -0.213 | 3.31% |
| chr15_74725870_A_T | chr15:74725870 | 0.030 | 0.115 | 0.211 | <0.001% |
| chr15_74725891_T_A | chr15:74725891 | 0.048 | 0.086 | 0.211 | — |
| chr15_74725929_C_T | chr15:74725929 | 0.122 | 0.122 | 0.163 | — |
| chr15_74725872_C_G | chr15:74725872 | 0.024 | 0.066 | 0.208 | 0.0013% |
| chr15_74725957_C_A | chr15:74725957 | -0.121 | -0.108 | -0.067 | — |
| chr15_74725970_G_A | chr15:74725970 | 0.121 | 0.088 | 0.045 | <0.001% |
| chr15_74725854_G_T | chr15:74725854 | -0.042 | -0.088 | -0.205 | — |
| chr15_74725949_C_T | chr15:74725949 | -0.086 | -0.145 | -0.202 | — |
| chr15_74725967_C_A | chr15:74725967 | -0.118 | -0.127 | -0.197 | — |
| chr15_74725986_C_T | chr15:74725986 | -0.118 | -0.239 | -0.090 | — |
| chr15_74725892_C_A | chr15:74725892 | 0.073 | 0.137 | 0.197 | — |
| chr15_74725948_A_C | chr15:74725948 | 0.033 | 0.086 | 0.197 | — |
| chr15_74725962_C_T | chr15:74725962 | -0.115 | -0.115 | -0.152 | — |
| chr15_74725983_T_G | chr15:74725983 | -0.115 | -0.156 | -0.152 | — |
| chr15_74725870_A_G | chr15:74725870 | 0.039 | 0.077 | 0.194 | — |
| chr15_74725893_T_C | chr15:74725893 | 0.047 | 0.059 | 0.191 | — |
| chr15_74725988_C_T | chr15:74725988 | -0.057 | 0.006 | -0.191 | — |
| chr15_74725860_G_C | chr15:74725860 | -0.110 | 0.000 | -0.042 | <0.001% |
| chr15_74725911_A_C | chr15:74725911 | -0.110 | -0.040 | -0.079 | — |
| chr15_74725932_A_C | chr15:74725932 | 0.110 | 0.056 | 0.157 | — |
| chr15_74725891_T_C | chr15:74725891 | 0.109 | 0.131 | 0.090 | — |
| chr15_74725904_T_C | chr15:74725904 | 0.098 | 0.056 | 0.185 | — |
| chr15_74725916_A_C | chr15:74725916 | -0.073 | -0.107 | 0.185 | — |
| chr15_74725941_C_G | chr15:74725941 | 0.108 | 0.054 | 0.169 | — |
| chr15_74725951_G_C | chr15:74725951 | -0.108 | -0.048 | 0.017 | — |
| chr15_74725928_G_C | chr15:74725928 | -0.107 | -0.130 | -0.135 | — |
| chr15_74725825_G_T | chr15:74725825 | -0.043 | -0.088 | -0.180 | — |
| chr15_74725929_C_G | chr15:74725929 | 0.076 | 0.055 | 0.180 | — |
| chr15_74725961_A_C | chr15:74725961 | -0.038 | -0.103 | -0.180 | — |
| chr15_74725991_G_A | chr15:74725991 | 0.103 | 0.186 | 0.090 | <0.001% |
| chr15_74725881_C_G | chr15:74725881 | -0.102 | 0.012 | 0.000 | — |
| chr15_74725936_C_T | chr15:74725936 | -0.102 | -0.122 | -0.135 | — |
| chr15_74725921_T_G | chr15:74725921 | -0.102 | -0.108 | 0.028 | — |
| chr15_74725997_C_A | chr15:74725997 | -0.089 | -0.312 | 0.112 | — |
| chr15_74725903_T_G | chr15:74725903 | 0.101 | 0.052 | 0.006 | — |
| chr15_74725923_G_C | chr15:74725923 | 0.100 | -0.069 | -0.039 | — |
| chr15_74725983_T_A | chr15:74725983 | -0.100 | -0.146 | -0.073 | — |
| chr15_74725884_G_C | chr15:74725884 | 0.083 | 0.064 | 0.169 | — |
| chr15_74725913_T_A | chr15:74725913 | 0.020 | 0.000 | 0.169 | — |
| chr15_74725926_G_T | chr15:74725926 | -0.061 | -0.071 | -0.169 | — |
| chr15_74725931_G_A | chr15:74725931 | 0.017 | 0.120 | 0.169 | — |
| chr15_74725989_G_C | chr15:74725989 | 0.087 | 0.162 | -0.169 | — |
| chr15_74725932_A_T | chr15:74725932 | 0.098 | 0.142 | 0.163 | — |
| chr15_74725866_C_G | chr15:74725866 | 0.066 | 0.089 | 0.166 | — |
| chr15_74725873_C_T | chr15:74725873 | -0.021 | 0.015 | 0.166 | — |
| chr15_74725895_C_A | chr15:74725895 | 0.071 | 0.111 | 0.166 | — |
| chr15_74725869_C_T | chr15:74725869 | 0.096 | 0.077 | 0.157 | — |
| chr15_74725815_G_C | chr15:74725815 | 0.037 | 0.033 | 0.163 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.