Home / Gene
CYP1B1
receptor: AhRTier 1
CAMIP Tier 1: peak-anchored panel
AhR
Submitted decision (verbatim): 需修訂
Reviewer revision (verbatim)
Impaired receptor-mediated signaling that attenuates both the basal constitutive expression and chemical inducibility of CYP1B1 in chromatin context, lowering the localized pathway of estradiol 4-hydroxylation and procarcinogen activation that underlies tissue-specific susceptibility to malignancies.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Smoking; PAHs; Experimental TCDD
- Regulatory element
- overlapping TSS
- Predicted consequence
- Impaired receptor-mediated signaling that abolishes both the basal constitutive expression and chemical inducibility of CYP1B1 in extrahepatic tissues, perturbing the localized pathway of estradiol 4-hydroxylation and procarcinogen activation that drives tissue-specific susceptibility to malignancies.
- Prior narrative
- Impaired receptor-mediated signaling that abolishes both the basal constitutive expression and chemical inducibility of CYP1B1 in extrahepatic tissues, perturbing the localized pathway of estradiol 4-hydroxylation and procarcinogen activation that drives tissue-specific susceptibility to malignancies.
- Drug context
- cyclophosphamide; doxorubicin; fluorouracil; risperidone; epirubicin; paclitaxel
Scored variants near CYP1B1
chr2:37,967,509..38,176,151, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr2_38015061_T_G | chr2:38015061 | 0.461 | 0.376 | 0.919 | — |
| chr2_38076076_G_A | chr2:38076076 | 0.326 | 0.091 | 0.259 | — |
| chr2_38075966_G_C | chr2:38075966 | 0.319 | 0.206 | 0.365 | — |
| chr2_38076022_G_C | chr2:38076022 | 0.193 | 0.096 | 0.282 | — |
| chr2_38075974_C_T | chr2:38075974 | -0.093 | -0.096 | -0.318 | <0.001% |
| chr2_38076020_T_G | chr2:38076020 | 0.173 | 0.096 | 0.141 | — |
| chr2_38015049_A_C | chr2:38015049 | 0.125 | 0.146 | 0.301 | — |
| chr2_38075971_G_T | chr2:38075971 | 0.160 | 0.056 | 0.082 | — |
| chr2_38075968_T_C | chr2:38075968 | 0.120 | 0.107 | 0.271 | — |
| chr2_38076015_G_T | chr2:38076015 | 0.146 | 0.069 | 0.094 | — |
| chr2_38076038_C_G | chr2:38076038 | 0.146 | 0.041 | 0.106 | — |
| chr2_38076122_A_T | chr2:38076122 | -0.126 | -0.132 | -0.259 | — |
| chr2_38075942_C_G | chr2:38075942 | -0.140 | -0.043 | -0.106 | — |
| chr2_38076037_C_A | chr2:38076037 | 0.136 | 0.079 | -0.141 | — |
| chr2_38075967_A_C | chr2:38075967 | 0.133 | 0.137 | 0.165 | — |
| chr2_38075969_G_C | chr2:38075969 | 0.130 | 0.081 | 0.235 | — |
| chr2_38075982_G_C | chr2:38075982 | 0.100 | 0.048 | 0.235 | — |
| chr2_38075983_G_C | chr2:38075983 | 0.106 | 0.069 | 0.235 | — |
| chr2_38076030_G_C | chr2:38076030 | 0.133 | 0.089 | 0.106 | — |
| chr2_38076118_C_A | chr2:38076118 | -0.073 | -0.036 | -0.235 | — |
| chr2_38076127_T_G | chr2:38076127 | -0.133 | -0.003 | -0.082 | — |
| chr2_38076062_G_T | chr2:38076062 | 0.130 | 0.076 | 0.176 | — |
| chr2_38075966_G_A | chr2:38075966 | 0.113 | 0.117 | 0.224 | — |
| chr2_38075968_T_G | chr2:38075968 | -0.027 | 0.094 | 0.224 | — |
| chr2_38076015_G_C | chr2:38076015 | 0.126 | 0.051 | 0.094 | — |
| chr2_38076024_A_C | chr2:38076024 | 0.126 | 0.043 | 0.224 | — |
| chr2_38076087_C_G | chr2:38076087 | 0.020 | -0.025 | -0.224 | — |
| chr2_38076093_C_G | chr2:38076093 | 0.126 | 0.036 | -0.059 | — |
| chr2_38075935_G_A | chr2:38075935 | 0.123 | 0.038 | -0.012 | — |
| chr2_38076062_G_C | chr2:38076062 | 0.123 | 0.071 | 0.141 | — |
| chr2_38075966_G_T | chr2:38075966 | 0.120 | 0.112 | 0.141 | — |
| chr2_38076102_C_G | chr2:38076102 | 0.120 | 0.023 | 0.094 | — |
| chr2_38076008_C_A | chr2:38076008 | 0.116 | 0.079 | 0.094 | — |
| chr2_38076013_G_T | chr2:38076013 | 0.116 | 0.051 | 0.047 | — |
| chr2_38076113_A_C | chr2:38076113 | -0.116 | -0.066 | -0.176 | — |
| chr2_38075940_G_A | chr2:38075940 | 0.113 | 0.063 | 0.071 | 0.0039% |
| chr2_38075942_C_A | chr2:38075942 | -0.113 | -0.005 | 0.024 | — |
| chr2_38075952_A_G | chr2:38075952 | -0.113 | -0.041 | -0.082 | — |
| chr2_38075970_G_T | chr2:38075970 | 0.113 | 0.074 | 0.141 | — |
| chr2_38075986_C_A | chr2:38075986 | 0.100 | 0.084 | 0.200 | — |
| chr2_38076057_G_A | chr2:38076057 | 0.070 | 0.069 | 0.200 | 0.0026% |
| chr2_38076067_C_G | chr2:38076067 | 0.047 | 0.063 | 0.200 | — |
| chr2_38076080_C_T | chr2:38076080 | -0.113 | -0.025 | -0.082 | — |
| chr2_38076087_C_A | chr2:38076087 | 0.040 | -0.015 | -0.200 | — |
| chr2_38076063_G_C | chr2:38076063 | 0.110 | 0.081 | 0.176 | — |
| chr2_38076064_G_T | chr2:38076064 | 0.110 | 0.048 | 0.106 | — |
| chr2_38075949_A_C | chr2:38075949 | -0.106 | -0.015 | -0.024 | — |
| chr2_38075950_G_T | chr2:38075950 | -0.106 | -0.069 | -0.118 | — |
| chr2_38075963_T_C | chr2:38075963 | 0.106 | 0.071 | 0.188 | — |
| chr2_38075965_G_C | chr2:38075965 | 0.106 | 0.094 | 0.176 | — |
| chr2_38075995_C_T | chr2:38075995 | -0.010 | -0.023 | -0.188 | — |
| chr2_38076004_G_C | chr2:38076004 | -0.106 | -0.046 | -0.129 | — |
| chr2_38076014_G_T | chr2:38076014 | 0.106 | 0.038 | 0.071 | — |
| chr2_38076030_G_A | chr2:38076030 | -0.106 | -0.010 | 0.012 | — |
| chr2_38076078_G_A | chr2:38076078 | -0.067 | -0.043 | -0.188 | — |
| chr2_38076078_G_C | chr2:38076078 | -0.106 | -0.005 | -0.035 | — |
| chr2_38076125_G_C | chr2:38076125 | -0.106 | -0.038 | 0.035 | — |
| chr2_38075949_A_G | chr2:38075949 | -0.100 | -0.056 | -0.047 | — |
| chr2_38075995_C_A | chr2:38075995 | -0.023 | -0.028 | -0.176 | — |
| chr2_38076016_G_A | chr2:38076016 | 0.100 | 0.028 | 0.094 | — |
| chr2_38076016_G_T | chr2:38076016 | 0.100 | -0.005 | -0.059 | — |
| chr2_38076028_T_C | chr2:38076028 | 0.047 | 0.048 | 0.176 | — |
| chr2_38076063_G_A | chr2:38076063 | 0.090 | 0.053 | 0.176 | — |
| chr2_38076097_C_G | chr2:38076097 | -0.100 | -0.003 | -0.047 | — |
| chr2_38075961_A_G | chr2:38075961 | -0.097 | -0.028 | -0.118 | <0.001% |
| chr2_38076127_T_C | chr2:38076127 | -0.097 | -0.015 | -0.024 | — |
| chr2_38075950_G_C | chr2:38075950 | -0.093 | -0.048 | -0.059 | — |
| chr2_38075952_A_C | chr2:38075952 | -0.093 | -0.013 | -0.035 | — |
| chr2_38075970_G_A | chr2:38075970 | 0.093 | 0.061 | 0.094 | — |
| chr2_38075971_G_C | chr2:38075971 | 0.093 | 0.053 | 0.094 | — |
| chr2_38076015_G_A | chr2:38076015 | 0.093 | 0.038 | 0.000 | — |
| chr2_38076031_A_C | chr2:38076031 | -0.020 | 0.015 | 0.165 | <0.001% |
| chr2_38076038_C_A | chr2:38076038 | 0.093 | 0.041 | 0.024 | — |
| chr2_38076066_T_G | chr2:38076066 | 0.027 | 0.041 | 0.165 | — |
| chr2_38076075_G_T | chr2:38076075 | 0.093 | 0.043 | 0.071 | — |
| chr2_38076077_C_G | chr2:38076077 | -0.093 | 0.036 | 0.059 | — |
| chr2_38076086_C_T | chr2:38076086 | -0.060 | -0.033 | -0.165 | — |
| chr2_38076108_A_G | chr2:38076108 | 0.040 | 0.028 | 0.165 | 0.0013% |
| chr2_38076111_G_T | chr2:38076111 | -0.090 | -0.030 | -0.024 | — |
| chr2_38075935_G_T | chr2:38075935 | 0.087 | 0.010 | -0.047 | — |
| chr2_38075943_A_G | chr2:38075943 | -0.077 | -0.023 | -0.153 | <0.001% |
| chr2_38075946_G_A | chr2:38075946 | -0.053 | -0.051 | -0.153 | — |
| chr2_38075968_T_A | chr2:38075968 | 0.007 | 0.036 | 0.153 | <0.001% |
| chr2_38075979_A_C | chr2:38075979 | 0.047 | 0.020 | 0.153 | — |
| chr2_38075983_G_A | chr2:38075983 | -0.030 | -0.061 | -0.153 | — |
| chr2_38075987_C_A | chr2:38075987 | -0.040 | -0.048 | -0.153 | — |
| chr2_38076003_C_A | chr2:38076003 | 0.087 | 0.036 | 0.059 | — |
| chr2_38076004_G_T | chr2:38076004 | -0.063 | -0.051 | -0.153 | — |
| chr2_38076057_G_C | chr2:38076057 | 0.037 | 0.018 | 0.153 | — |
| chr2_38076061_G_A | chr2:38076061 | 0.027 | 0.023 | 0.153 | — |
| chr2_38076068_G_T | chr2:38076068 | -0.020 | -0.051 | -0.153 | <0.001% |
| chr2_38076079_T_C | chr2:38076079 | -0.087 | 0.000 | 0.000 | — |
| chr2_38076097_C_A | chr2:38076097 | -0.087 | -0.036 | -0.106 | 0.0033% |
| chr2_38076107_A_C | chr2:38076107 | 0.087 | 0.018 | 0.141 | — |
| chr2_38075969_G_T | chr2:38075969 | 0.083 | 0.030 | 0.035 | — |
| chr2_38076061_G_C | chr2:38076061 | 0.083 | 0.043 | 0.094 | 0.0013% |
| chr2_38075938_T_C | chr2:38075938 | -0.080 | -0.013 | 0.047 | — |
| chr2_38075948_C_A | chr2:38075948 | -0.080 | -0.038 | -0.106 | — |
| chr2_38075951_G_C | chr2:38075951 | 0.080 | 0.051 | 0.129 | — |
| chr2_38075980_A_T | chr2:38075980 | -0.013 | -0.048 | -0.141 | — |
| chr2_38075983_G_T | chr2:38075983 | 0.080 | 0.051 | 0.082 | — |
| chr2_38075984_T_G | chr2:38075984 | -0.080 | -0.043 | -0.047 | — |
| chr2_38075985_G_A | chr2:38075985 | -0.033 | -0.028 | -0.141 | — |
| chr2_38076014_G_C | chr2:38076014 | 0.080 | 0.038 | 0.141 | — |
| chr2_38076019_C_G | chr2:38076019 | 0.050 | 0.018 | 0.141 | — |
| chr2_38076026_A_G | chr2:38076026 | 0.007 | 0.003 | 0.141 | — |
| chr2_38076032_G_T | chr2:38076032 | 0.080 | 0.030 | 0.047 | — |
| chr2_38076042_C_A | chr2:38076042 | -0.080 | -0.018 | -0.141 | — |
| chr2_38076053_T_G | chr2:38076053 | 0.030 | 0.036 | 0.141 | — |
| chr2_38076054_T_C | chr2:38076054 | 0.077 | 0.048 | 0.141 | — |
| chr2_38076062_G_A | chr2:38076062 | 0.070 | 0.038 | 0.141 | — |
| chr2_38076069_G_A | chr2:38076069 | 0.040 | -0.033 | -0.141 | — |
| chr2_38076073_G_T | chr2:38076073 | 0.020 | -0.048 | -0.141 | — |
| chr2_38076086_C_A | chr2:38076086 | -0.007 | -0.015 | -0.141 | — |
| chr2_38076102_C_T | chr2:38076102 | 0.073 | 0.063 | 0.141 | — |
| chr2_38076104_C_G | chr2:38076104 | 0.080 | 0.025 | 0.106 | — |
| chr2_38076120_G_T | chr2:38076120 | 0.017 | 0.036 | 0.141 | — |
| chr2_38075936_C_T | chr2:38075936 | 0.077 | 0.025 | 0.000 | <0.001% |
| chr2_38075961_A_C | chr2:38075961 | 0.077 | 0.043 | 0.059 | — |
| chr2_38076121_A_C | chr2:38076121 | 0.077 | 0.020 | 0.082 | — |
| chr2_38076121_A_T | chr2:38076121 | 0.077 | 0.025 | 0.082 | — |
| chr2_38075936_C_G | chr2:38075936 | -0.073 | -0.036 | 0.024 | — |
| chr2_38075946_G_C | chr2:38075946 | -0.073 | -0.041 | -0.035 | — |
| chr2_38075955_G_T | chr2:38075955 | 0.073 | 0.010 | -0.082 | — |
| chr2_38075958_T_A | chr2:38075958 | -0.073 | -0.015 | 0.012 | — |
| chr2_38075964_G_C | chr2:38075964 | 0.073 | 0.053 | 0.129 | — |
| chr2_38075975_G_T | chr2:38075975 | 0.073 | 0.023 | -0.024 | — |
| chr2_38075979_A_G | chr2:38075979 | 0.067 | 0.036 | 0.129 | — |
| chr2_38075981_G_C | chr2:38075981 | 0.060 | 0.028 | 0.129 | 0.070% |
| chr2_38075990_G_T | chr2:38075990 | -0.003 | -0.003 | -0.129 | — |
| chr2_38075992_T_C | chr2:38075992 | -0.073 | -0.018 | -0.035 | — |
| chr2_38075992_T_G | chr2:38075992 | -0.073 | -0.018 | -0.012 | — |
| chr2_38075999_G_A | chr2:38075999 | -0.007 | -0.010 | -0.129 | 0.0013% |
| chr2_38076026_A_C | chr2:38076026 | -0.047 | -0.056 | -0.129 | — |
| chr2_38076029_C_A | chr2:38076029 | -0.073 | 0.000 | -0.047 | — |
| chr2_38076039_T_A | chr2:38076039 | 0.073 | 0.013 | 0.024 | — |
| chr2_38076064_G_A | chr2:38076064 | 0.050 | 0.053 | 0.129 | 0.042% |
| chr2_38076065_G_A | chr2:38076065 | 0.050 | 0.038 | 0.129 | — |
| chr2_38076081_A_T | chr2:38076081 | -0.073 | -0.003 | -0.024 | — |
| chr2_38076093_C_A | chr2:38076093 | 0.073 | -0.008 | -0.094 | 0.0020% |
| chr2_38076096_G_C | chr2:38076096 | 0.073 | 0.071 | 0.035 | — |
| chr2_38076108_A_T | chr2:38076108 | -0.073 | -0.043 | -0.071 | — |
| chr2_38076112_G_C | chr2:38076112 | 0.033 | 0.025 | 0.129 | — |
| chr2_38075934_G_A | chr2:38075934 | -0.070 | -0.013 | 0.059 | — |
| chr2_38075949_A_T | chr2:38075949 | -0.070 | -0.056 | -0.047 | — |
| chr2_38075973_A_T | chr2:38075973 | 0.070 | 0.003 | -0.035 | — |
| chr2_38075985_G_C | chr2:38075985 | -0.070 | -0.043 | -0.094 | — |
| chr2_38076001_C_T | chr2:38076001 | 0.070 | 0.028 | 0.000 | — |
| chr2_38076040_C_A | chr2:38076040 | -0.070 | 0.023 | -0.012 | — |
| chr2_38076071_G_T | chr2:38076071 | 0.070 | -0.018 | -0.047 | — |
| chr2_38075942_C_T | chr2:38075942 | -0.067 | -0.023 | -0.035 | 0.0026% |
| chr2_38075945_T_G | chr2:38075945 | -0.067 | -0.038 | 0.024 | 0.0013% |
| chr2_38075947_C_T | chr2:38075947 | -0.047 | -0.038 | -0.118 | — |
| chr2_38075953_G_T | chr2:38075953 | 0.067 | 0.013 | 0.024 | — |
| chr2_38075959_G_C | chr2:38075959 | 0.067 | 0.033 | 0.071 | — |
| chr2_38075961_A_T | chr2:38075961 | -0.067 | -0.020 | -0.118 | — |
| chr2_38075964_G_T | chr2:38075964 | 0.067 | 0.046 | 0.059 | — |
| chr2_38075970_G_C | chr2:38075970 | 0.047 | 0.043 | 0.118 | <0.001% |
| chr2_38075972_G_T | chr2:38075972 | 0.067 | 0.020 | -0.012 | — |
| chr2_38075973_A_G | chr2:38075973 | 0.037 | 0.071 | 0.118 | — |
| chr2_38075977_A_T | chr2:38075977 | 0.067 | 0.008 | 0.000 | — |
| chr2_38075978_G_T | chr2:38075978 | 0.047 | -0.018 | -0.118 | — |
| chr2_38076002_C_T | chr2:38076002 | 0.067 | 0.028 | 0.035 | — |
| chr2_38076003_C_T | chr2:38076003 | 0.067 | 0.025 | 0.024 | — |
| chr2_38076007_G_A | chr2:38076007 | -0.030 | -0.025 | -0.118 | — |
| chr2_38076009_C_T | chr2:38076009 | 0.013 | -0.003 | -0.118 | — |
| chr2_38076016_G_C | chr2:38076016 | 0.067 | 0.015 | 0.071 | — |
| chr2_38076023_C_G | chr2:38076023 | -0.067 | -0.023 | -0.012 | — |
| chr2_38076042_C_G | chr2:38076042 | -0.040 | -0.013 | -0.118 | — |
| chr2_38076044_G_A | chr2:38076044 | -0.067 | -0.003 | -0.071 | — |
| chr2_38076048_T_C | chr2:38076048 | -0.067 | -0.008 | -0.082 | — |
| chr2_38076056_A_C | chr2:38076056 | 0.033 | 0.025 | 0.118 | — |
| chr2_38076057_G_T | chr2:38076057 | 0.067 | 0.015 | -0.012 | — |
| chr2_38076059_C_T | chr2:38076059 | -0.040 | -0.025 | -0.118 | — |
| chr2_38076060_T_A | chr2:38076060 | 0.067 | 0.046 | 0.094 | — |
| chr2_38076066_T_A | chr2:38076066 | -0.067 | -0.013 | 0.082 | — |
| chr2_38076089_T_C | chr2:38076089 | -0.020 | 0.005 | 0.118 | — |
| chr2_38076091_C_A | chr2:38076091 | -0.067 | -0.030 | -0.035 | — |
| chr2_38076110_T_G | chr2:38076110 | 0.013 | 0.038 | 0.118 | — |
| chr2_38076111_G_A | chr2:38076111 | -0.067 | -0.005 | 0.012 | — |
| chr2_38076113_A_G | chr2:38076113 | -0.067 | -0.018 | 0.094 | — |
| chr2_38076123_G_C | chr2:38076123 | -0.067 | -0.046 | -0.094 | — |
| chr2_38076127_T_A | chr2:38076127 | -0.067 | -0.023 | -0.024 | — |
| chr2_38075934_G_T | chr2:38075934 | -0.063 | -0.018 | 0.024 | — |
| chr2_38075969_G_A | chr2:38075969 | 0.063 | 0.046 | 0.094 | 0.0046% |
| chr2_38076013_G_C | chr2:38076013 | 0.063 | 0.030 | 0.106 | — |
| chr2_38076054_T_A | chr2:38076054 | 0.063 | 0.010 | 0.000 | — |
| chr2_38076065_G_C | chr2:38076065 | 0.063 | 0.053 | 0.094 | — |
| chr2_38015052_G_C | chr2:38015052 | 0.061 | 0.072 | 0.110 | — |
| chr2_38075937_G_C | chr2:38075937 | -0.043 | -0.003 | 0.106 | — |
| chr2_38075939_C_A | chr2:38075939 | 0.030 | 0.033 | 0.106 | — |
| chr2_38075939_C_G | chr2:38075939 | -0.033 | 0.015 | 0.106 | — |
| chr2_38075941_T_G | chr2:38075941 | -0.060 | 0.010 | 0.012 | — |
| chr2_38075945_T_C | chr2:38075945 | -0.007 | -0.005 | 0.106 | — |
| chr2_38075954_C_G | chr2:38075954 | -0.060 | -0.036 | -0.012 | — |
| chr2_38075967_A_T | chr2:38075967 | 0.060 | 0.091 | 0.012 | — |
| chr2_38075976_G_C | chr2:38075976 | 0.040 | 0.020 | 0.106 | 0.0039% |
| chr2_38075991_C_G | chr2:38075991 | -0.013 | -0.020 | -0.106 | — |
| chr2_38075994_G_C | chr2:38075994 | -0.047 | -0.048 | -0.106 | — |
| chr2_38075994_G_T | chr2:38075994 | 0.007 | -0.018 | -0.106 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.