Home / Gene
CYP2A6
receptor: PXRTier 1
CAMIP Tier 1: peak-anchored panel
PXR
Submitted decision (verbatim): 接受
Reviewer notes (verbatim)
Blunted receptor-mediated induction of CYP2A6 decreases the hepatic oxidative metabolism and clearance of its substrates such as nicotine and coumarin.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Rifampicin
- Regulatory element
- in distal enhancer +21719 bp
- Predicted consequence
- Blunted receptor-mediated induction of CYP2A6 decreases the hepatic oxidative metabolism and clearance of its substrates such as nicotine and coumarin.
- Prior narrative
- Blunted receptor-mediated induction of CYP2A6 decreases the hepatic oxidative metabolism and clearance of its substrates such as nicotine and coumarin.
- Drug context
- nicotine; coumarin; tegafur; efavirenz; letrozole; metronidazole
Scored variants near CYP2A6
chr19:40,743,540..40,950,447, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr19_40751082_C_T | chr19:40751082 | 0.045 | -0.165 | -0.812 | — |
| chr19_40751083_G_C | chr19:40751083 | 0.068 | -0.297 | -0.612 | — |
| chr19_40751082_C_A | chr19:40751082 | 0.062 | -0.081 | -0.600 | — |
| chr19_40751082_C_G | chr19:40751082 | 0.033 | -0.074 | -0.588 | — |
| chr19_40751083_G_A | chr19:40751083 | 0.030 | -0.244 | -0.588 | — |
| chr19_40751081_C_T | chr19:40751081 | 0.000 | -0.135 | -0.553 | — |
| chr19_40751080_T_C | chr19:40751080 | 0.158 | -0.066 | -0.529 | — |
| chr19_40751080_T_A | chr19:40751080 | 0.075 | -0.048 | -0.518 | — |
| chr19_40751081_C_A | chr19:40751081 | 0.050 | -0.114 | -0.518 | — |
| chr19_40750940_A_C | chr19:40750940 | 0.166 | 0.345 | 0.506 | — |
| chr19_40751083_G_T | chr19:40751083 | -0.053 | -0.198 | -0.506 | — |
| chr19_40751079_A_T | chr19:40751079 | -0.140 | 0.127 | 0.494 | — |
| chr19_40751081_C_G | chr19:40751081 | 0.047 | -0.157 | -0.494 | — |
| chr19_40751084_G_A | chr19:40751084 | 0.025 | -0.142 | -0.494 | — |
| chr19_40751120_C_A | chr19:40751120 | -0.060 | -0.454 | -0.482 | — |
| chr19_40798060_C_A | chr19:40798060 | -0.050 | 0.150 | 0.482 | — |
| chr19_40751144_G_C | chr19:40751144 | -0.271 | -0.150 | -0.435 | — |
| chr19_40751145_C_G | chr19:40751145 | -0.261 | -0.185 | -0.365 | — |
| chr19_40751077_A_C | chr19:40751077 | -0.043 | -0.145 | -0.424 | — |
| chr19_40751080_T_G | chr19:40751080 | 0.133 | -0.069 | -0.424 | — |
| chr19_40751078_C_A | chr19:40751078 | 0.038 | -0.256 | -0.412 | — |
| chr19_40751079_A_C | chr19:40751079 | 0.146 | -0.074 | -0.400 | — |
| chr19_40750981_C_A | chr19:40750981 | -0.047 | -0.066 | -0.388 | — |
| chr19_40751146_T_G | chr19:40751146 | -0.215 | -0.104 | -0.282 | — |
| chr19_40750917_G_T | chr19:40750917 | 0.200 | -0.010 | 0.353 | — |
| chr19_40751017_A_C | chr19:40751017 | 0.037 | 0.066 | 0.353 | — |
| chr19_40750916_A_T | chr19:40750916 | 0.073 | 0.091 | 0.329 | — |
| chr19_40798087_G_T | chr19:40798087 | 0.183 | 0.175 | 0.106 | — |
| chr19_40750976_C_A | chr19:40750976 | -0.090 | -0.058 | -0.306 | — |
| chr19_40751015_G_C | chr19:40751015 | -0.017 | 0.051 | 0.306 | — |
| chr19_40751061_T_A | chr19:40751061 | 0.171 | 0.061 | 0.071 | — |
| chr19_40750988_C_G | chr19:40750988 | -0.077 | -0.018 | -0.294 | — |
| chr19_40751024_C_A | chr19:40751024 | -0.050 | -0.086 | -0.294 | — |
| chr19_40751063_C_A | chr19:40751063 | 0.166 | 0.071 | 0.012 | — |
| chr19_40751144_G_T | chr19:40751144 | -0.128 | -0.063 | -0.294 | — |
| chr19_40750939_T_A | chr19:40750939 | -0.163 | -0.173 | -0.176 | — |
| chr19_40751146_T_A | chr19:40751146 | -0.156 | -0.020 | -0.165 | — |
| chr19_40750921_T_A | chr19:40750921 | 0.113 | -0.071 | -0.271 | — |
| chr19_40751089_T_G | chr19:40751089 | -0.043 | 0.074 | 0.271 | — |
| chr19_40751144_G_A | chr19:40751144 | -0.080 | -0.033 | -0.271 | — |
| chr19_40751145_C_A | chr19:40751145 | -0.151 | -0.069 | -0.212 | — |
| chr19_40750916_A_C | chr19:40750916 | 0.073 | 0.010 | 0.259 | — |
| chr19_40750924_G_A | chr19:40750924 | 0.060 | -0.066 | -0.247 | — |
| chr19_40750938_G_A | chr19:40750938 | -0.047 | -0.117 | -0.247 | — |
| chr19_40750957_A_C | chr19:40750957 | 0.023 | 0.020 | 0.247 | — |
| chr19_40751020_C_A | chr19:40751020 | -0.040 | -0.099 | -0.247 | — |
| chr19_40751039_C_A | chr19:40751039 | -0.030 | -0.066 | -0.247 | — |
| chr19_40751084_G_T | chr19:40751084 | -0.057 | -0.063 | -0.247 | — |
| chr19_40750962_C_A | chr19:40750962 | 0.136 | 0.074 | 0.059 | — |
| chr19_40750919_A_C | chr19:40750919 | 0.003 | 0.086 | 0.235 | — |
| chr19_40750927_C_T | chr19:40750927 | 0.023 | -0.061 | -0.235 | — |
| chr19_40750940_A_T | chr19:40750940 | 0.133 | 0.056 | 0.000 | — |
| chr19_40750972_C_A | chr19:40750972 | -0.053 | -0.010 | -0.235 | — |
| chr19_40751055_C_T | chr19:40751055 | -0.060 | -0.043 | -0.235 | — |
| chr19_40751077_A_T | chr19:40751077 | 0.012 | -0.099 | -0.235 | — |
| chr19_40798072_A_C | chr19:40798072 | -0.018 | 0.114 | 0.235 | — |
| chr19_40751100_C_A | chr19:40751100 | -0.131 | -0.102 | -0.082 | — |
| chr19_40798066_C_G | chr19:40798066 | 0.131 | 0.079 | 0.035 | — |
| chr19_40798076_T_A | chr19:40798076 | 0.131 | 0.132 | 0.082 | — |
| chr19_40750949_T_A | chr19:40750949 | -0.130 | -0.025 | -0.141 | — |
| chr19_40798014_G_C | chr19:40798014 | -0.126 | -0.112 | -0.229 | — |
| chr19_40750935_A_T | chr19:40750935 | 0.100 | -0.066 | -0.224 | — |
| chr19_40750971_G_A | chr19:40750971 | 0.000 | 0.013 | -0.224 | — |
| chr19_40751069_T_A | chr19:40751069 | -0.013 | -0.051 | -0.224 | — |
| chr19_40751085_G_A | chr19:40751085 | 0.010 | -0.069 | -0.224 | — |
| chr19_40751101_G_C | chr19:40751101 | 0.125 | 0.003 | 0.106 | — |
| chr19_40750927_C_G | chr19:40750927 | -0.010 | -0.081 | -0.212 | — |
| chr19_40750928_C_A | chr19:40750928 | -0.120 | -0.102 | -0.153 | — |
| chr19_40750960_A_T | chr19:40750960 | 0.080 | 0.183 | 0.212 | — |
| chr19_40750972_C_T | chr19:40750972 | -0.023 | -0.003 | -0.212 | — |
| chr19_40750981_C_G | chr19:40750981 | -0.057 | -0.048 | -0.212 | — |
| chr19_40750987_G_T | chr19:40750987 | -0.027 | -0.028 | -0.212 | — |
| chr19_40750999_T_A | chr19:40750999 | 0.120 | -0.015 | -0.059 | — |
| chr19_40751015_G_T | chr19:40751015 | 0.010 | 0.018 | 0.212 | — |
| chr19_40751023_G_C | chr19:40751023 | -0.030 | 0.038 | 0.212 | — |
| chr19_40751029_C_G | chr19:40751029 | 0.012 | -0.013 | -0.212 | — |
| chr19_40751064_T_C | chr19:40751064 | -0.038 | -0.074 | 0.212 | — |
| chr19_40751110_G_C | chr19:40751110 | 0.010 | 0.053 | 0.212 | — |
| chr19_40798051_A_T | chr19:40798051 | 0.111 | 0.162 | 0.212 | — |
| chr19_40750949_T_C | chr19:40750949 | -0.116 | -0.056 | 0.094 | — |
| chr19_40751090_T_A | chr19:40751090 | 0.116 | 0.076 | 0.176 | — |
| chr19_40798049_C_G | chr19:40798049 | -0.116 | -0.069 | -0.094 | — |
| chr19_40750942_C_A | chr19:40750942 | -0.113 | -0.081 | -0.176 | — |
| chr19_40750954_A_T | chr19:40750954 | 0.113 | 0.025 | 0.059 | — |
| chr19_40750974_A_C | chr19:40750974 | 0.050 | 0.015 | 0.200 | — |
| chr19_40750981_C_T | chr19:40750981 | -0.017 | -0.048 | -0.200 | — |
| chr19_40750997_C_T | chr19:40750997 | 0.003 | -0.030 | -0.200 | — |
| chr19_40751031_A_G | chr19:40751031 | -0.040 | -0.010 | -0.200 | — |
| chr19_40751089_T_C | chr19:40751089 | -0.012 | 0.086 | 0.200 | — |
| chr19_40751145_C_T | chr19:40751145 | -0.113 | -0.013 | -0.153 | — |
| chr19_40798058_T_G | chr19:40798058 | 0.111 | 0.107 | 0.106 | — |
| chr19_40750934_G_C | chr19:40750934 | 0.110 | 0.086 | 0.153 | — |
| chr19_40750950_G_A | chr19:40750950 | -0.110 | -0.020 | -0.012 | — |
| chr19_40750951_C_A | chr19:40750951 | -0.110 | 0.000 | -0.012 | — |
| chr19_40750951_C_G | chr19:40750951 | -0.110 | -0.020 | 0.047 | — |
| chr19_40751079_A_G | chr19:40751079 | 0.110 | -0.053 | -0.188 | — |
| chr19_40798085_G_T | chr19:40798085 | -0.110 | -0.099 | -0.153 | — |
| chr19_40751123_A_T | chr19:40751123 | -0.108 | -0.277 | -0.106 | — |
| chr19_40750916_A_G | chr19:40750916 | -0.017 | 0.005 | 0.188 | — |
| chr19_40750939_T_G | chr19:40750939 | -0.106 | -0.178 | -0.118 | — |
| chr19_40750952_A_G | chr19:40750952 | -0.106 | -0.036 | 0.094 | — |
| chr19_40750961_T_C | chr19:40750961 | -0.106 | -0.051 | 0.024 | — |
| chr19_40750966_G_T | chr19:40750966 | 0.106 | 0.000 | -0.024 | — |
| chr19_40750983_C_T | chr19:40750983 | -0.017 | -0.030 | -0.188 | — |
| chr19_40750996_C_T | chr19:40750996 | -0.003 | -0.008 | -0.188 | — |
| chr19_40751032_G_T | chr19:40751032 | -0.003 | 0.005 | -0.188 | — |
| chr19_40751036_A_C | chr19:40751036 | -0.003 | 0.010 | -0.188 | — |
| chr19_40751049_C_T | chr19:40751049 | -0.050 | -0.102 | -0.188 | — |
| chr19_40751052_G_T | chr19:40751052 | -0.073 | -0.089 | -0.188 | — |
| chr19_40751077_A_G | chr19:40751077 | 0.010 | -0.124 | -0.188 | — |
| chr19_40751078_C_G | chr19:40751078 | 0.103 | -0.183 | -0.188 | — |
| chr19_40751088_T_C | chr19:40751088 | -0.042 | 0.061 | 0.188 | — |
| chr19_40751091_T_G | chr19:40751091 | 0.015 | 0.058 | 0.188 | — |
| chr19_40750950_G_T | chr19:40750950 | -0.103 | 0.020 | 0.106 | — |
| chr19_40750976_C_G | chr19:40750976 | -0.103 | -0.033 | -0.129 | — |
| chr19_40751142_G_T | chr19:40751142 | 0.103 | -0.003 | 0.106 | — |
| chr19_40798082_A_C | chr19:40798082 | -0.103 | -0.058 | -0.024 | — |
| chr19_40751053_T_C | chr19:40751053 | 0.101 | -0.056 | -0.012 | — |
| chr19_40751121_C_A | chr19:40751121 | -0.101 | -0.218 | -0.141 | — |
| chr19_40750918_A_C | chr19:40750918 | 0.090 | -0.005 | 0.176 | — |
| chr19_40750923_C_T | chr19:40750923 | 0.100 | 0.051 | 0.047 | — |
| chr19_40750924_G_T | chr19:40750924 | 0.100 | -0.005 | -0.059 | — |
| chr19_40750932_C_A | chr19:40750932 | 0.023 | -0.066 | -0.176 | — |
| chr19_40750933_G_C | chr19:40750933 | 0.027 | 0.020 | 0.176 | — |
| chr19_40750942_C_G | chr19:40750942 | -0.073 | -0.173 | -0.176 | — |
| chr19_40750950_G_C | chr19:40750950 | -0.090 | 0.005 | 0.176 | — |
| chr19_40750975_G_A | chr19:40750975 | -0.027 | -0.015 | -0.176 | — |
| chr19_40750987_G_A | chr19:40750987 | -0.040 | -0.020 | -0.176 | — |
| chr19_40750988_C_A | chr19:40750988 | -0.017 | -0.008 | -0.176 | — |
| chr19_40750999_T_G | chr19:40750999 | 0.057 | -0.008 | 0.176 | — |
| chr19_40751035_C_A | chr19:40751035 | 0.012 | 0.008 | -0.176 | — |
| chr19_40751035_C_G | chr19:40751035 | -0.015 | -0.003 | -0.176 | — |
| chr19_40751064_T_G | chr19:40751064 | -0.025 | 0.043 | 0.176 | — |
| chr19_40751085_G_C | chr19:40751085 | 0.025 | -0.074 | -0.176 | — |
| chr19_40751092_C_G | chr19:40751092 | 0.002 | 0.036 | 0.176 | — |
| chr19_40751118_G_C | chr19:40751118 | 0.045 | 0.046 | 0.176 | — |
| chr19_40751139_A_T | chr19:40751139 | 0.028 | -0.030 | 0.176 | — |
| chr19_40798057_A_T | chr19:40798057 | 0.100 | 0.089 | 0.071 | — |
| chr19_40798078_G_T | chr19:40798078 | -0.065 | -0.079 | -0.176 | — |
| chr19_40751121_C_T | chr19:40751121 | -0.098 | -0.223 | -0.106 | — |
| chr19_40798050_T_G | chr19:40798050 | -0.098 | -0.071 | 0.012 | — |
| chr19_40750963_G_T | chr19:40750963 | 0.097 | 0.010 | 0.094 | — |
| chr19_40798081_A_C | chr19:40798081 | 0.097 | 0.091 | 0.059 | — |
| chr19_40751065_A_T | chr19:40751065 | -0.095 | -0.033 | -0.024 | — |
| chr19_40798057_A_C | chr19:40798057 | 0.095 | 0.091 | 0.141 | — |
| chr19_40750917_G_C | chr19:40750917 | 0.003 | 0.015 | 0.165 | — |
| chr19_40750918_A_G | chr19:40750918 | -0.017 | -0.015 | 0.165 | — |
| chr19_40750938_G_C | chr19:40750938 | -0.027 | -0.152 | -0.165 | — |
| chr19_40750941_A_C | chr19:40750941 | -0.093 | -0.122 | -0.024 | — |
| chr19_40750953_A_C | chr19:40750953 | 0.033 | 0.036 | 0.165 | — |
| chr19_40750960_A_C | chr19:40750960 | -0.093 | 0.005 | 0.118 | — |
| chr19_40750975_G_T | chr19:40750975 | 0.010 | -0.023 | -0.165 | — |
| chr19_40750983_C_A | chr19:40750983 | -0.050 | -0.043 | -0.165 | — |
| chr19_40750986_G_A | chr19:40750986 | 0.020 | 0.000 | -0.165 | — |
| chr19_40750986_G_T | chr19:40750986 | -0.013 | 0.008 | -0.165 | — |
| chr19_40751015_G_A | chr19:40751015 | -0.043 | -0.008 | -0.165 | — |
| chr19_40751020_C_T | chr19:40751020 | -0.032 | -0.051 | -0.165 | — |
| chr19_40751051_T_G | chr19:40751051 | -0.048 | -0.119 | -0.165 | — |
| chr19_40751084_G_C | chr19:40751084 | 0.000 | -0.038 | -0.165 | — |
| chr19_40751088_T_G | chr19:40751088 | -0.003 | 0.058 | 0.165 | — |
| chr19_40751089_T_A | chr19:40751089 | -0.002 | 0.079 | 0.165 | — |
| chr19_40751104_C_G | chr19:40751104 | -0.043 | -0.079 | -0.165 | — |
| chr19_40751104_C_T | chr19:40751104 | -0.070 | -0.076 | -0.165 | — |
| chr19_40751110_G_T | chr19:40751110 | -0.008 | 0.056 | 0.165 | — |
| chr19_40751119_G_T | chr19:40751119 | -0.048 | -0.132 | -0.165 | — |
| chr19_40751121_C_G | chr19:40751121 | -0.093 | -0.216 | -0.165 | — |
| chr19_40797999_A_C | chr19:40797999 | 0.037 | 0.043 | 0.165 | — |
| chr19_40798033_T_G | chr19:40798033 | -0.093 | -0.018 | -0.024 | — |
| chr19_40750949_T_G | chr19:40750949 | -0.090 | 0.076 | 0.082 | — |
| chr19_40750970_G_C | chr19:40750970 | 0.090 | 0.000 | 0.153 | — |
| chr19_40751088_T_A | chr19:40751088 | 0.090 | 0.086 | 0.153 | — |
| chr19_40751055_C_A | chr19:40751055 | -0.088 | 0.020 | -0.047 | — |
| chr19_40751146_T_C | chr19:40751146 | 0.088 | 0.013 | -0.059 | — |
| chr19_40798056_C_G | chr19:40798056 | -0.088 | -0.051 | -0.129 | — |
| chr19_40750958_C_A | chr19:40750958 | 0.010 | 0.015 | -0.153 | — |
| chr19_40750964_G_A | chr19:40750964 | 0.003 | 0.020 | 0.153 | — |
| chr19_40750994_G_C | chr19:40750994 | 0.070 | 0.041 | 0.153 | — |
| chr19_40751018_A_C | chr19:40751018 | 0.013 | 0.038 | 0.153 | — |
| chr19_40751030_G_A | chr19:40751030 | 0.063 | 0.079 | 0.153 | — |
| chr19_40751050_C_T | chr19:40751050 | -0.035 | -0.015 | -0.153 | — |
| chr19_40751086_T_A | chr19:40751086 | -0.008 | -0.076 | -0.153 | — |
| chr19_40751091_T_C | chr19:40751091 | -0.008 | -0.030 | 0.153 | — |
| chr19_40751097_G_T | chr19:40751097 | -0.028 | 0.104 | 0.153 | — |
| chr19_40751100_C_G | chr19:40751100 | -0.083 | -0.051 | -0.153 | — |
| chr19_40751122_A_T | chr19:40751122 | -0.087 | -0.089 | 0.000 | — |
| chr19_40751132_G_T | chr19:40751132 | -0.002 | -0.036 | -0.153 | — |
| chr19_40798031_G_T | chr19:40798031 | -0.045 | -0.053 | -0.153 | — |
| chr19_40751123_A_C | chr19:40751123 | -0.085 | -0.231 | -0.012 | — |
| chr19_40750954_A_C | chr19:40750954 | 0.083 | 0.020 | -0.047 | — |
| chr19_40750995_G_A | chr19:40750995 | 0.083 | 0.030 | -0.129 | — |
| chr19_40751047_G_T | chr19:40751047 | 0.083 | 0.071 | 0.118 | — |
| chr19_40751048_A_C | chr19:40751048 | -0.083 | -0.008 | 0.047 | — |
| chr19_40751136_T_G | chr19:40751136 | 0.083 | 0.008 | -0.012 | — |
| chr19_40798039_C_G | chr19:40798039 | -0.083 | -0.043 | -0.012 | — |
| chr19_40798080_C_G | chr19:40798080 | -0.083 | -0.081 | -0.094 | — |
| chr19_40798082_A_T | chr19:40798082 | -0.083 | -0.063 | -0.106 | — |
| chr19_40751060_T_A | chr19:40751060 | 0.082 | 0.005 | -0.094 | — |
| chr19_40798017_C_T | chr19:40798017 | 0.082 | 0.061 | 0.000 | — |
| chr19_40798075_C_G | chr19:40798075 | -0.082 | -0.069 | -0.035 | — |
| chr19_40798078_G_C | chr19:40798078 | -0.082 | -0.086 | -0.012 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.