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CYP2A6
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of CYP2A6 decreases the hepatic oxidative metabolism and clearance of its substrates such as nicotine and coumarin.
Affected substrate drugs (PharmGKB): nicotine; coumarin; tegafur; efavirenz; letrozole; metronidazole
Scored variants near CYP2A6
chr19:40,743,540..40,950,447, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr19_40751144_G_C | chr19:40751144 | -10,432 | -1,888 | -9,472 | — |
| chr19_40751145_C_G | chr19:40751145 | -10,048 | -2,336 | -7,936 | — |
| chr19_40751146_T_G | chr19:40751146 | -8,256 | -1,312 | -6,144 | — |
| chr19_40750917_G_T | chr19:40750917 | 7,680 | -128 | 7,680 | — |
| chr19_40798087_G_T | chr19:40798087 | 7,040 | 2,208 | 2,304 | — |
| chr19_40751061_T_A | chr19:40751061 | 6,592 | 768 | 1,536 | — |
| chr19_40750940_A_C | chr19:40750940 | 6,400 | 4,352 | 11,008 | — |
| chr19_40751063_C_A | chr19:40751063 | 6,400 | 896 | 256 | — |
| chr19_40750939_T_A | chr19:40750939 | -6,272 | -2,176 | -3,840 | — |
| chr19_40751080_T_C | chr19:40751080 | 6,080 | -832 | -11,520 | — |
| chr19_40751146_T_A | chr19:40751146 | -6,016 | -256 | -3,584 | — |
| chr19_40751145_C_A | chr19:40751145 | -5,824 | -864 | -4,608 | — |
| chr19_40751079_A_C | chr19:40751079 | 5,632 | -928 | -8,704 | — |
| chr19_40751079_A_T | chr19:40751079 | -5,376 | 1,600 | 10,752 | — |
| chr19_40750962_C_A | chr19:40750962 | 5,248 | 928 | 1,280 | — |
| chr19_40751080_T_G | chr19:40751080 | 5,120 | -864 | -9,216 | — |
| chr19_40750940_A_T | chr19:40750940 | 5,120 | 704 | 0 | — |
| chr19_40751100_C_A | chr19:40751100 | -5,056 | -1,280 | -1,792 | — |
| chr19_40798066_C_G | chr19:40798066 | 5,056 | 992 | 768 | — |
| chr19_40798076_T_A | chr19:40798076 | 5,056 | 1,664 | 1,792 | — |
| chr19_40750949_T_A | chr19:40750949 | -4,992 | -320 | -3,072 | — |
| chr19_40751144_G_T | chr19:40751144 | -4,928 | -800 | -6,400 | — |
| chr19_40798014_G_C | chr19:40798014 | -4,864 | -1,408 | -4,992 | — |
| chr19_40751101_G_C | chr19:40751101 | 4,800 | 32 | 2,304 | — |
| chr19_40750928_C_A | chr19:40750928 | -4,608 | -1,280 | -3,328 | — |
| chr19_40750999_T_A | chr19:40750999 | 4,608 | -192 | -1,280 | — |
| chr19_40750949_T_C | chr19:40750949 | -4,480 | -704 | 2,048 | — |
| chr19_40751090_T_A | chr19:40751090 | 4,480 | 960 | 3,840 | — |
| chr19_40798049_C_G | chr19:40798049 | -4,480 | -864 | -2,048 | — |
| chr19_40750921_T_A | chr19:40750921 | 4,352 | -896 | -5,888 | — |
| chr19_40750942_C_A | chr19:40750942 | -4,352 | -1,024 | -3,840 | — |
| chr19_40750954_A_T | chr19:40750954 | 4,352 | 320 | 1,280 | — |
| chr19_40751145_C_T | chr19:40751145 | -4,352 | -160 | -3,328 | — |
| chr19_40798051_A_T | chr19:40798051 | 4,288 | 2,048 | 4,608 | — |
| chr19_40798058_T_G | chr19:40798058 | 4,288 | 1,344 | 2,304 | — |
| chr19_40750934_G_C | chr19:40750934 | 4,224 | 1,088 | 3,328 | — |
| chr19_40750950_G_A | chr19:40750950 | -4,224 | -256 | -256 | — |
| chr19_40750951_C_A | chr19:40750951 | -4,224 | 0 | -256 | — |
| chr19_40750951_C_G | chr19:40750951 | -4,224 | -256 | 1,024 | — |
| chr19_40751079_A_G | chr19:40751079 | 4,224 | -672 | -4,096 | — |
| chr19_40798085_G_T | chr19:40798085 | -4,224 | -1,248 | -3,328 | — |
| chr19_40751123_A_T | chr19:40751123 | -4,160 | -3,488 | -2,304 | — |
| chr19_40750939_T_G | chr19:40750939 | -4,096 | -2,240 | -2,560 | — |
| chr19_40750952_A_G | chr19:40750952 | -4,096 | -448 | 2,048 | — |
| chr19_40750961_T_C | chr19:40750961 | -4,096 | -640 | 512 | — |
| chr19_40750966_G_T | chr19:40750966 | 4,096 | 0 | -512 | — |
| chr19_40751078_C_G | chr19:40751078 | 3,968 | -2,304 | -4,096 | — |
| chr19_40750950_G_T | chr19:40750950 | -3,968 | 256 | 2,304 | — |
| chr19_40750976_C_G | chr19:40750976 | -3,968 | -416 | -2,816 | — |
| chr19_40751142_G_T | chr19:40751142 | 3,968 | -32 | 2,304 | — |
| chr19_40798082_A_C | chr19:40798082 | -3,968 | -736 | -512 | — |
| chr19_40751053_T_C | chr19:40751053 | 3,904 | -704 | -256 | — |
| chr19_40751121_C_A | chr19:40751121 | -3,904 | -2,752 | -3,072 | — |
| chr19_40750935_A_T | chr19:40750935 | 3,840 | -832 | -4,864 | — |
| chr19_40750923_C_T | chr19:40750923 | 3,840 | 640 | 1,024 | — |
| chr19_40750924_G_T | chr19:40750924 | 3,840 | -64 | -1,280 | — |
| chr19_40798057_A_T | chr19:40798057 | 3,840 | 1,120 | 1,536 | — |
| chr19_40751121_C_T | chr19:40751121 | -3,776 | -2,816 | -2,304 | — |
| chr19_40798050_T_G | chr19:40798050 | -3,776 | -896 | 256 | — |
| chr19_40750963_G_T | chr19:40750963 | 3,712 | 128 | 2,048 | — |
| chr19_40798081_A_C | chr19:40798081 | 3,712 | 1,152 | 1,280 | — |
| chr19_40751065_A_T | chr19:40751065 | -3,648 | -416 | -512 | — |
| chr19_40798057_A_C | chr19:40798057 | 3,648 | 1,152 | 3,072 | — |
| chr19_40750941_A_C | chr19:40750941 | -3,584 | -1,536 | -512 | — |
| chr19_40750960_A_C | chr19:40750960 | -3,584 | 64 | 2,560 | — |
| chr19_40751121_C_G | chr19:40751121 | -3,584 | -2,720 | -3,584 | — |
| chr19_40798033_T_G | chr19:40798033 | -3,584 | -224 | -512 | — |
| chr19_40750976_C_A | chr19:40750976 | -3,456 | -736 | -6,656 | — |
| chr19_40750918_A_C | chr19:40750918 | 3,456 | -64 | 3,840 | — |
| chr19_40750950_G_C | chr19:40750950 | -3,456 | 64 | 3,840 | — |
| chr19_40750949_T_G | chr19:40750949 | -3,456 | 960 | 1,792 | — |
| chr19_40750970_G_C | chr19:40750970 | 3,456 | 0 | 3,328 | — |
| chr19_40751088_T_A | chr19:40751088 | 3,456 | 1,088 | 3,328 | — |
| chr19_40751055_C_A | chr19:40751055 | -3,392 | 256 | -1,024 | — |
| chr19_40751146_T_C | chr19:40751146 | 3,392 | 160 | -1,280 | — |
| chr19_40798056_C_G | chr19:40798056 | -3,392 | -640 | -2,816 | — |
| chr19_40751122_A_T | chr19:40751122 | -3,328 | -1,120 | 0 | — |
| chr19_40751123_A_C | chr19:40751123 | -3,264 | -2,912 | -256 | — |
| chr19_40751100_C_G | chr19:40751100 | -3,200 | -640 | -3,328 | — |
| chr19_40750954_A_C | chr19:40750954 | 3,200 | 256 | -1,024 | — |
| chr19_40750995_G_A | chr19:40750995 | 3,200 | 384 | -2,816 | — |
| chr19_40751047_G_T | chr19:40751047 | 3,200 | 896 | 2,560 | — |
| chr19_40751048_A_C | chr19:40751048 | -3,200 | -96 | 1,024 | — |
| chr19_40751136_T_G | chr19:40751136 | 3,200 | 96 | -256 | — |
| chr19_40798039_C_G | chr19:40798039 | -3,200 | -544 | -256 | — |
| chr19_40798080_C_G | chr19:40798080 | -3,200 | -1,024 | -2,048 | — |
| chr19_40798082_A_T | chr19:40798082 | -3,200 | -800 | -2,304 | — |
| chr19_40751060_T_A | chr19:40751060 | 3,136 | 64 | -2,048 | — |
| chr19_40798017_C_T | chr19:40798017 | 3,136 | 768 | 0 | — |
| chr19_40798075_C_G | chr19:40798075 | -3,136 | -864 | -768 | — |
| chr19_40798078_G_C | chr19:40798078 | -3,136 | -1,088 | -256 | — |
| chr19_40751144_G_A | chr19:40751144 | -3,072 | -416 | -5,888 | — |
| chr19_40750960_A_T | chr19:40750960 | 3,072 | 2,304 | 4,608 | — |
| chr19_40750988_C_G | chr19:40750988 | -2,944 | -224 | -6,400 | — |
| chr19_40751080_T_A | chr19:40751080 | 2,880 | -608 | -11,264 | — |
| chr19_40750916_A_T | chr19:40750916 | 2,816 | 1,152 | 7,168 | — |
| chr19_40750916_A_C | chr19:40750916 | 2,816 | 128 | 5,632 | — |
| chr19_40751052_G_T | chr19:40751052 | -2,816 | -1,120 | -4,096 | — |
| chr19_40750942_C_G | chr19:40750942 | -2,816 | -2,176 | -3,840 | — |
| chr19_40751104_C_T | chr19:40751104 | -2,688 | -960 | -3,584 | — |
| chr19_40750994_G_C | chr19:40750994 | 2,688 | 512 | 3,328 | — |
| chr19_40751083_G_C | chr19:40751083 | 2,624 | -3,744 | -13,312 | — |
| chr19_40798078_G_T | chr19:40798078 | -2,496 | -992 | -3,840 | — |
| chr19_40751030_G_A | chr19:40751030 | 2,432 | 992 | 3,328 | — |
| chr19_40751082_C_A | chr19:40751082 | 2,368 | -1,024 | -13,056 | — |
| chr19_40751120_C_A | chr19:40751120 | -2,304 | -5,728 | -10,496 | — |
| chr19_40750924_G_A | chr19:40750924 | 2,304 | -832 | -5,376 | — |
| chr19_40751055_C_T | chr19:40751055 | -2,304 | -544 | -5,120 | — |
| chr19_40751084_G_T | chr19:40751084 | -2,176 | -800 | -5,376 | — |
| chr19_40750981_C_G | chr19:40750981 | -2,176 | -608 | -4,608 | — |
| chr19_40750999_T_G | chr19:40750999 | 2,176 | -96 | 3,840 | — |
| chr19_40751083_G_T | chr19:40751083 | -2,048 | -2,496 | -11,008 | — |
| chr19_40750972_C_A | chr19:40750972 | -2,048 | -128 | -5,120 | — |
| chr19_40751081_C_A | chr19:40751081 | 1,920 | -1,440 | -11,264 | — |
| chr19_40798060_C_A | chr19:40798060 | -1,920 | 1,888 | 10,496 | — |
| chr19_40751024_C_A | chr19:40751024 | -1,920 | -1,088 | -6,400 | — |
| chr19_40750974_A_C | chr19:40750974 | 1,920 | 192 | 4,352 | — |
| chr19_40751049_C_T | chr19:40751049 | -1,920 | -1,280 | -4,096 | — |
| chr19_40750983_C_A | chr19:40750983 | -1,920 | -544 | -3,584 | — |
| chr19_40751051_T_G | chr19:40751051 | -1,856 | -1,504 | -3,584 | — |
| chr19_40751119_G_T | chr19:40751119 | -1,856 | -1,664 | -3,584 | — |
| chr19_40751081_C_G | chr19:40751081 | 1,792 | -1,984 | -10,752 | — |
| chr19_40750981_C_A | chr19:40750981 | -1,792 | -832 | -8,448 | — |
| chr19_40750938_G_A | chr19:40750938 | -1,792 | -1,472 | -5,376 | — |
| chr19_40751082_C_T | chr19:40751082 | 1,728 | -2,080 | -17,664 | — |
| chr19_40751118_G_C | chr19:40751118 | 1,728 | 576 | 3,840 | — |
| chr19_40798031_G_T | chr19:40798031 | -1,728 | -672 | -3,328 | — |
| chr19_40751077_A_C | chr19:40751077 | -1,664 | -1,824 | -9,216 | — |
| chr19_40751089_T_G | chr19:40751089 | -1,664 | 928 | 5,888 | — |
| chr19_40751015_G_A | chr19:40751015 | -1,664 | -96 | -3,584 | — |
| chr19_40751104_C_G | chr19:40751104 | -1,664 | -992 | -3,584 | — |
| chr19_40751088_T_C | chr19:40751088 | -1,600 | 768 | 4,096 | — |
| chr19_40751020_C_A | chr19:40751020 | -1,536 | -1,248 | -5,376 | — |
| chr19_40751031_A_G | chr19:40751031 | -1,536 | -128 | -4,352 | — |
| chr19_40750987_G_A | chr19:40750987 | -1,536 | -256 | -3,840 | — |
| chr19_40751078_C_A | chr19:40751078 | 1,472 | -3,232 | -8,960 | — |
| chr19_40751064_T_C | chr19:40751064 | -1,472 | -928 | 4,608 | — |
| chr19_40751017_A_C | chr19:40751017 | 1,408 | 832 | 7,680 | — |
| chr19_40797999_A_C | chr19:40797999 | 1,408 | 544 | 3,584 | — |
| chr19_40751050_C_T | chr19:40751050 | -1,344 | -192 | -3,328 | — |
| chr19_40751082_C_G | chr19:40751082 | 1,280 | -928 | -12,800 | — |
| chr19_40750953_A_C | chr19:40750953 | 1,280 | 448 | 3,584 | — |
| chr19_40751020_C_T | chr19:40751020 | -1,216 | -640 | -3,584 | — |
| chr19_40751083_G_A | chr19:40751083 | 1,152 | -3,072 | -12,800 | — |
| chr19_40751039_C_A | chr19:40751039 | -1,152 | -832 | -5,376 | — |
| chr19_40751023_G_C | chr19:40751023 | -1,152 | 480 | 4,608 | — |
| chr19_40751139_A_T | chr19:40751139 | 1,088 | -384 | 3,840 | — |
| chr19_40751097_G_T | chr19:40751097 | -1,088 | 1,312 | 3,328 | — |
| chr19_40750987_G_T | chr19:40750987 | -1,024 | -352 | -4,608 | — |
| chr19_40750933_G_C | chr19:40750933 | 1,024 | 256 | 3,840 | — |
| chr19_40750975_G_A | chr19:40750975 | -1,024 | -192 | -3,840 | — |
| chr19_40750938_G_C | chr19:40750938 | -1,024 | -1,920 | -3,584 | — |
| chr19_40751084_G_A | chr19:40751084 | 960 | -1,792 | -10,752 | — |
| chr19_40751064_T_G | chr19:40751064 | -960 | 544 | 3,840 | — |
| chr19_40751085_G_C | chr19:40751085 | 960 | -928 | -3,840 | — |
| chr19_40750957_A_C | chr19:40750957 | 896 | 256 | 5,376 | — |
| chr19_40750927_C_T | chr19:40750927 | 896 | -768 | -5,120 | — |
| chr19_40750972_C_T | chr19:40750972 | -896 | -32 | -4,608 | — |
| chr19_40750932_C_A | chr19:40750932 | 896 | -832 | -3,840 | — |
| chr19_40750986_G_A | chr19:40750986 | 768 | 0 | -3,584 | — |
| chr19_40798072_A_C | chr19:40798072 | -704 | 1,440 | 5,120 | — |
| chr19_40751015_G_C | chr19:40751015 | -640 | 640 | 6,656 | — |
| chr19_40750981_C_T | chr19:40750981 | -640 | -608 | -4,352 | — |
| chr19_40750916_A_G | chr19:40750916 | -640 | 64 | 4,096 | — |
| chr19_40750983_C_T | chr19:40750983 | -640 | -384 | -4,096 | — |
| chr19_40750988_C_A | chr19:40750988 | -640 | -96 | -3,840 | — |
| chr19_40750918_A_G | chr19:40750918 | -640 | -192 | 3,584 | — |
| chr19_40751091_T_G | chr19:40751091 | 576 | 736 | 4,096 | — |
| chr19_40751035_C_G | chr19:40751035 | -576 | -32 | -3,840 | — |
| chr19_40751069_T_A | chr19:40751069 | -512 | -640 | -4,864 | — |
| chr19_40750986_G_T | chr19:40750986 | -512 | 96 | -3,584 | — |
| chr19_40751018_A_C | chr19:40751018 | 512 | 480 | 3,328 | — |
| chr19_40751077_A_T | chr19:40751077 | 448 | -1,248 | -5,120 | — |
| chr19_40751029_C_G | chr19:40751029 | 448 | -160 | -4,608 | — |
| chr19_40751089_T_C | chr19:40751089 | -448 | 1,088 | 4,352 | — |
| chr19_40751035_C_A | chr19:40751035 | 448 | 96 | -3,840 | — |
| chr19_40751085_G_A | chr19:40751085 | 384 | -864 | -4,864 | — |
| chr19_40750927_C_G | chr19:40750927 | -384 | -1,024 | -4,608 | — |
| chr19_40751015_G_T | chr19:40751015 | 384 | 224 | 4,608 | — |
| chr19_40751110_G_C | chr19:40751110 | 384 | 672 | 4,608 | — |
| chr19_40751077_A_G | chr19:40751077 | 384 | -1,568 | -4,096 | — |
| chr19_40750975_G_T | chr19:40750975 | 384 | -288 | -3,584 | — |
| chr19_40750958_C_A | chr19:40750958 | 384 | 192 | -3,328 | — |
| chr19_40751110_G_T | chr19:40751110 | -320 | 704 | 3,584 | — |
| chr19_40751086_T_A | chr19:40751086 | -320 | -960 | -3,328 | — |
| chr19_40751091_T_C | chr19:40751091 | -320 | -384 | 3,328 | — |
| chr19_40750919_A_C | chr19:40750919 | 128 | 1,088 | 5,120 | — |
| chr19_40750997_C_T | chr19:40750997 | 128 | -384 | -4,352 | — |
| chr19_40750996_C_T | chr19:40750996 | -128 | -96 | -4,096 | — |
| chr19_40751032_G_T | chr19:40751032 | -128 | 64 | -4,096 | — |
| chr19_40751036_A_C | chr19:40751036 | -128 | 128 | -4,096 | — |
| chr19_40750917_G_C | chr19:40750917 | 128 | 192 | 3,584 | — |
| chr19_40751088_T_G | chr19:40751088 | -128 | 736 | 3,584 | — |
| chr19_40750964_G_A | chr19:40750964 | 128 | 256 | 3,328 | — |
| chr19_40751092_C_G | chr19:40751092 | 64 | 448 | 3,840 | — |
| chr19_40751089_T_A | chr19:40751089 | -64 | 992 | 3,584 | — |
| chr19_40751132_G_T | chr19:40751132 | -64 | -448 | -3,328 | — |
| chr19_40751081_C_T | chr19:40751081 | 0 | -1,696 | -12,032 | — |
| chr19_40750971_G_A | chr19:40750971 | 0 | 160 | -4,864 | — |
| chr19_40751084_G_C | chr19:40751084 | 0 | -480 | -3,584 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.