Home / Gene
CYP2B6
CAMIP Tier 2: reviewed literature reference panel
These records are literature references, not evidence of a receptor-bound element in this ChIP-seq panel.
PXR
Submitted decision (verbatim): 需修訂
Reviewer notes (verbatim)
CYP2B6 的誘導在 PBREM 不完全由 CAR (NR1I3) 主導（PMID: 23840296）
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Drug context
- efavirenz; bupropion; methadone; cyclophosphamide; ketamine
- Nearest peak (bp)
- 69882
- Panel context
- CYP2B6 induction is CAR (NR1I3)-DOMINATED at the PBREM, not PXR-driven. AetherXeno profiles only PXR/FXR/AhR (not CAR), so the absence of a proximal PXR peak is exactly what CAR-dominated regulation predicts — a specificity result, not a miss. CAR profiling is planned future work.
- Claim type
- clinical_reference_no_binding_claim
Scored variants near CYP2B6
chr19:40,891,281..41,118,398, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr19_40921063_C_T | chr19:40921063 | 1.000 | 1.000 | 1.000 | — |
| chr19_40921067_T_A | chr19:40921067 | 1.000 | 1.000 | 1.000 | — |
| chr19_40897405_C_G | chr19:40897405 | 1.000 | 1.000 | 1.000 | — |
| chr19_40921057_A_T | chr19:40921057 | 1.000 | 1.000 | 0.988 | — |
| chr19_40897330_T_G | chr19:40897330 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897366_T_C | chr19:40897366 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897330_T_A | chr19:40897330 | -1.000 | -1.000 | -1.000 | — |
| chr19_40921062_C_T | chr19:40921062 | 1.000 | 1.000 | 0.935 | — |
| chr19_40897304_T_G | chr19:40897304 | 1.000 | 1.000 | 1.000 | — |
| chr19_40897333_T_A | chr19:40897333 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897385_A_C | chr19:40897385 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897334_T_C | chr19:40897334 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897356_A_T | chr19:40897356 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897384_A_G | chr19:40897384 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897384_A_T | chr19:40897384 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897385_A_T | chr19:40897385 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897380_A_C | chr19:40897380 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897328_A_G | chr19:40897328 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897386_C_A | chr19:40897386 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897357_A_T | chr19:40897357 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897378_T_A | chr19:40897378 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897350_T_G | chr19:40897350 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897378_T_C | chr19:40897378 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897331_G_T | chr19:40897331 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897328_A_T | chr19:40897328 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897383_A_G | chr19:40897383 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897335_A_C | chr19:40897335 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897382_G_A | chr19:40897382 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897348_C_A | chr19:40897348 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897336_C_G | chr19:40897336 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897347_C_T | chr19:40897347 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897347_C_A | chr19:40897347 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897322_T_A | chr19:40897322 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897315_C_A | chr19:40897315 | 1.000 | 1.000 | 1.000 | — |
| chr19_40897354_C_G | chr19:40897354 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897378_T_G | chr19:40897378 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897399_T_A | chr19:40897399 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897400_G_C | chr19:40897400 | 1.000 | 1.000 | 0.488 | — |
| chr19_40897336_C_A | chr19:40897336 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897302_C_A | chr19:40897302 | 1.000 | 1.000 | 1.000 | — |
| chr19_40897323_T_A | chr19:40897323 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897303_T_G | chr19:40897303 | 1.000 | 1.000 | 1.000 | — |
| chr19_40897354_C_A | chr19:40897354 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897394_G_A | chr19:40897394 | 1.000 | 1.000 | 1.000 | — |
| chr19_40921070_T_A | chr19:40921070 | 1.000 | 1.000 | 0.688 | — |
| chr19_40897392_C_A | chr19:40897392 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897326_G_A | chr19:40897326 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897335_A_T | chr19:40897335 | -1.000 | -0.987 | -1.000 | — |
| chr19_40897355_A_C | chr19:40897355 | -1.000 | -0.987 | -1.000 | — |
| chr19_40897402_A_G | chr19:40897402 | 1.000 | 1.000 | 1.000 | — |
| chr19_40897329_A_T | chr19:40897329 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897348_C_G | chr19:40897348 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897379_G_C | chr19:40897379 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897348_C_T | chr19:40897348 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897331_G_C | chr19:40897331 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897355_A_T | chr19:40897355 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897346_A_T | chr19:40897346 | -1.000 | -1.000 | -1.000 | — |
| chr19_40920997_G_T | chr19:40920997 | 1.000 | 1.000 | 0.806 | — |
| chr19_40897303_T_A | chr19:40897303 | 1.000 | 0.792 | 0.859 | — |
| chr19_40921110_G_A | chr19:40921110 | -1.000 | -1.000 | -0.859 | — |
| chr19_40897351_G_C | chr19:40897351 | -1.000 | -0.985 | -1.000 | — |
| chr19_40897329_A_G | chr19:40897329 | -1.000 | -1.000 | -1.000 | — |
| chr19_40921057_A_C | chr19:40921057 | 1.000 | 0.916 | 0.747 | — |
| chr19_40897347_C_G | chr19:40897347 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897306_C_G | chr19:40897306 | 1.000 | 1.000 | 1.000 | — |
| chr19_40897346_A_G | chr19:40897346 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897332_T_C | chr19:40897332 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897349_T_A | chr19:40897349 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897344_T_A | chr19:40897344 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897303_T_C | chr19:40897303 | 1.000 | 1.000 | 0.976 | — |
| chr19_40897389_G_A | chr19:40897389 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897350_T_C | chr19:40897350 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897294_C_G | chr19:40897294 | -1.000 | -1.000 | -1.000 | — |
| chr19_40897357_A_G | chr19:40897357 | -0.998 | -1.000 | -1.000 | — |
| chr19_40921059_G_A | chr19:40921059 | 0.998 | 0.629 | 0.565 | — |
| chr19_40897351_G_T | chr19:40897351 | -0.986 | -0.855 | -1.000 | — |
| chr19_40897382_G_C | chr19:40897382 | -0.986 | -1.000 | -1.000 | — |
| chr19_40897325_T_A | chr19:40897325 | -0.983 | -1.000 | -1.000 | — |
| chr19_40921111_G_C | chr19:40921111 | 0.982 | 0.777 | 0.447 | — |
| chr19_40897339_C_A | chr19:40897339 | 0.978 | 0.766 | 0.600 | — |
| chr19_40897385_A_G | chr19:40897385 | -0.874 | -1.000 | -1.000 | — |
| chr19_40921058_G_T | chr19:40921058 | 0.978 | 0.942 | 0.476 | — |
| chr19_40897359_A_C | chr19:40897359 | -0.973 | -1.000 | -1.000 | — |
| chr19_40897332_T_G | chr19:40897332 | -0.970 | -1.000 | -1.000 | — |
| chr19_40897405_C_T | chr19:40897405 | 0.961 | 0.835 | 0.912 | — |
| chr19_40897346_A_C | chr19:40897346 | -0.959 | -1.000 | -1.000 | — |
| chr19_40897349_T_G | chr19:40897349 | -0.951 | -1.000 | -0.982 | — |
| chr19_40897392_C_G | chr19:40897392 | -0.949 | -0.817 | -0.382 | — |
| chr19_40897381_T_G | chr19:40897381 | -0.945 | -1.000 | -1.000 | — |
| chr19_40897301_C_G | chr19:40897301 | 0.940 | 0.942 | 0.976 | — |
| chr19_40921080_A_T | chr19:40921080 | 0.928 | 0.477 | 0.459 | — |
| chr19_40897345_G_A | chr19:40897345 | -0.928 | -1.000 | -1.000 | — |
| chr19_40897302_C_G | chr19:40897302 | 0.926 | 1.000 | 1.000 | — |
| chr19_40897345_G_T | chr19:40897345 | -0.925 | -1.000 | -1.000 | — |
| chr19_40897390_T_C | chr19:40897390 | -0.915 | -0.947 | -0.729 | — |
| chr19_40897318_G_T | chr19:40897318 | -0.913 | -1.000 | -1.000 | — |
| chr19_40897381_T_A | chr19:40897381 | -0.882 | -1.000 | -1.000 | — |
| chr19_40897302_C_T | chr19:40897302 | 0.913 | 1.000 | 0.929 | — |
| chr19_40897334_T_A | chr19:40897334 | -0.908 | -0.967 | -1.000 | — |
| chr19_40897403_G_C | chr19:40897403 | 0.901 | 0.848 | 0.435 | — |
| chr19_40897328_A_C | chr19:40897328 | -0.897 | -1.000 | -1.000 | — |
| chr19_40897336_C_T | chr19:40897336 | -0.897 | -1.000 | -1.000 | — |
| chr19_40897352_T_C | chr19:40897352 | -0.895 | -1.000 | -1.000 | — |
| chr19_40921102_C_A | chr19:40921102 | -0.889 | -0.797 | -0.776 | — |
| chr19_40897356_A_G | chr19:40897356 | -0.879 | -0.982 | -1.000 | — |
| chr19_40897399_T_G | chr19:40897399 | -0.865 | -0.871 | -0.682 | — |
| chr19_40897386_C_G | chr19:40897386 | -0.857 | -0.982 | -1.000 | — |
| chr19_40921079_A_C | chr19:40921079 | 0.852 | 0.731 | 0.506 | — |
| chr19_40897304_T_A | chr19:40897304 | 0.848 | 1.000 | 0.847 | — |
| chr19_40897411_T_C | chr19:40897411 | 0.841 | 0.934 | 0.806 | — |
| chr19_40897358_C_A | chr19:40897358 | -0.839 | -0.827 | -1.000 | — |
| chr19_40897379_G_A | chr19:40897379 | -0.536 | -0.673 | -1.000 | — |
| chr19_40897373_G_A | chr19:40897373 | -0.829 | -0.881 | -1.000 | — |
| chr19_40897389_G_C | chr19:40897389 | -0.819 | -0.902 | -0.765 | — |
| chr19_40897293_T_A | chr19:40897293 | 0.816 | 1.000 | 0.988 | — |
| chr19_40921092_G_C | chr19:40921092 | -0.809 | -0.792 | -0.753 | — |
| chr19_40897398_G_A | chr19:40897398 | -0.803 | -0.865 | -0.606 | — |
| chr19_40897390_T_A | chr19:40897390 | -0.800 | -1.000 | -1.000 | — |
| chr19_40897377_A_T | chr19:40897377 | -0.671 | -0.789 | -1.000 | — |
| chr19_40897357_A_C | chr19:40897357 | -0.795 | -0.815 | -1.000 | — |
| chr19_40897341_C_A | chr19:40897341 | -0.791 | -0.987 | -1.000 | — |
| chr19_40897359_A_T | chr19:40897359 | -0.791 | -0.657 | -0.465 | — |
| chr19_40897360_G_T | chr19:40897360 | -0.791 | -0.896 | -1.000 | — |
| chr19_40897333_T_G | chr19:40897333 | -0.782 | -0.751 | -1.000 | — |
| chr19_40921094_C_T | chr19:40921094 | -0.782 | -0.820 | -0.776 | — |
| chr19_40897333_T_C | chr19:40897333 | -0.781 | -0.736 | -1.000 | — |
| chr19_40897370_T_C | chr19:40897370 | -0.778 | -0.906 | -0.776 | — |
| chr19_40921059_G_C | chr19:40921059 | 0.772 | 0.401 | 0.500 | — |
| chr19_40921065_G_T | chr19:40921065 | 0.765 | 0.830 | 0.541 | — |
| chr19_40897352_T_A | chr19:40897352 | -0.765 | -0.901 | -1.000 | — |
| chr19_40897321_T_A | chr19:40897321 | 0.764 | 0.840 | 1.000 | — |
| chr19_40897322_T_G | chr19:40897322 | -0.758 | -0.934 | -0.976 | — |
| chr19_40897389_G_T | chr19:40897389 | -0.753 | -0.803 | -0.471 | — |
| chr19_40921108_C_T | chr19:40921108 | 0.742 | 0.635 | 0.435 | — |
| chr19_40897337_A_G | chr19:40897337 | -0.734 | -0.820 | -0.835 | — |
| chr19_40897258_A_T | chr19:40897258 | -0.723 | -0.871 | -0.924 | — |
| chr19_40921073_G_A | chr19:40921073 | -0.722 | -1.000 | -0.300 | — |
| chr19_40897383_A_C | chr19:40897383 | 0.479 | 0.794 | 1.000 | — |
| chr19_40897392_C_T | chr19:40897392 | -0.719 | -0.931 | -0.771 | — |
| chr19_40897380_A_G | chr19:40897380 | -0.611 | -0.744 | -1.000 | — |
| chr19_40897341_C_T | chr19:40897341 | -0.715 | -0.944 | -0.994 | — |
| chr19_40897359_A_G | chr19:40897359 | -0.710 | -0.655 | -0.853 | — |
| chr19_40897326_G_C | chr19:40897326 | 0.704 | 0.355 | 0.012 | — |
| chr19_40897289_A_G | chr19:40897289 | 0.701 | 0.728 | 0.782 | — |
| chr19_40921073_G_C | chr19:40921073 | 0.699 | 0.162 | 1.000 | — |
| chr19_40921076_C_A | chr19:40921076 | -0.699 | -0.820 | -0.329 | — |
| chr19_40897355_A_G | chr19:40897355 | -0.694 | -0.607 | -0.888 | — |
| chr19_40897329_A_C | chr19:40897329 | -0.693 | -0.789 | -0.888 | — |
| chr19_40897345_G_C | chr19:40897345 | -0.689 | -0.868 | -0.976 | — |
| chr19_40921102_C_G | chr19:40921102 | -0.689 | -0.569 | -0.553 | — |
| chr19_40921108_C_A | chr19:40921108 | -0.689 | -0.665 | -0.494 | — |
| chr19_40897352_T_G | chr19:40897352 | -0.688 | -0.807 | -0.947 | — |
| chr19_40897382_G_T | chr19:40897382 | -0.601 | -0.871 | -1.000 | — |
| chr19_40897403_G_A | chr19:40897403 | 0.680 | 0.657 | 0.347 | — |
| chr19_40897350_T_A | chr19:40897350 | -0.679 | -0.723 | -0.676 | — |
| chr19_40897376_G_A | chr19:40897376 | -0.409 | -0.513 | -1.000 | — |
| chr19_40921072_G_C | chr19:40921072 | -0.672 | -0.825 | -0.388 | — |
| chr19_40897308_T_C | chr19:40897308 | 0.668 | 0.787 | 0.671 | — |
| chr19_40897326_G_T | chr19:40897326 | -0.667 | -0.825 | -0.941 | — |
| chr19_40897321_T_C | chr19:40897321 | 0.662 | 0.906 | 0.906 | — |
| chr19_40897327_T_A | chr19:40897327 | -0.661 | -0.734 | -0.835 | — |
| chr19_40897266_T_C | chr19:40897266 | 0.660 | 0.744 | 0.612 | — |
| chr19_40897269_G_A | chr19:40897269 | 0.659 | 0.675 | 0.665 | — |
| chr19_40921103_A_G | chr19:40921103 | -0.659 | -0.523 | -0.476 | — |
| chr19_40897262_T_C | chr19:40897262 | -0.657 | -0.810 | -0.735 | — |
| chr19_40921071_T_A | chr19:40921071 | 0.656 | 0.848 | 0.335 | — |
| chr19_40921078_G_T | chr19:40921078 | -0.656 | -0.475 | -0.371 | — |
| chr19_40897393_A_T | chr19:40897393 | -0.654 | -0.652 | -0.476 | — |
| chr19_40897354_C_T | chr19:40897354 | -0.653 | -0.807 | -0.712 | — |
| chr19_40897330_T_C | chr19:40897330 | -0.652 | -0.690 | -0.771 | — |
| chr19_40897390_T_G | chr19:40897390 | 0.651 | 0.782 | 0.412 | — |
| chr19_40897402_A_C | chr19:40897402 | 0.644 | -0.063 | 0.871 | — |
| chr19_40921112_A_C | chr19:40921112 | 0.639 | 0.487 | 0.482 | — |
| chr19_40897373_G_T | chr19:40897373 | -0.636 | -0.756 | -0.865 | — |
| chr19_40921094_C_G | chr19:40921094 | -0.636 | -0.571 | -0.576 | — |
| chr19_40897255_T_G | chr19:40897255 | 0.635 | 0.701 | 0.641 | — |
| chr19_40897263_T_A | chr19:40897263 | -0.631 | -0.678 | -0.671 | — |
| chr19_40921065_G_C | chr19:40921065 | -0.629 | -0.576 | -0.312 | — |
| chr19_40897287_G_C | chr19:40897287 | 0.626 | 0.693 | 0.700 | — |
| chr19_40897373_G_C | chr19:40897373 | -0.625 | -0.730 | -0.882 | — |
| chr19_40897409_C_G | chr19:40897409 | 0.625 | 0.670 | 0.553 | — |
| chr19_40897351_G_A | chr19:40897351 | -0.622 | -0.772 | -0.559 | — |
| chr19_40921084_T_A | chr19:40921084 | -0.622 | -0.602 | -0.447 | — |
| chr19_40921092_G_T | chr19:40921092 | -0.622 | -0.632 | -0.665 | — |
| chr19_40921101_C_T | chr19:40921101 | -0.619 | -0.538 | -0.524 | — |
| chr19_40897338_A_T | chr19:40897338 | -0.618 | -0.736 | -0.776 | — |
| chr19_40897325_T_C | chr19:40897325 | 0.617 | 0.865 | 1.000 | — |
| chr19_40897384_A_C | chr19:40897384 | -0.385 | -0.629 | -1.000 | — |
| chr19_40897324_A_C | chr19:40897324 | -0.613 | -0.860 | -0.918 | — |
| chr19_40897324_A_T | chr19:40897324 | -0.611 | -0.845 | -1.000 | — |
| chr19_40897262_T_A | chr19:40897262 | -0.608 | -0.693 | -0.653 | — |
| chr19_40897280_G_T | chr19:40897280 | 0.602 | 0.736 | 0.600 | — |
| chr19_40921092_G_A | chr19:40921092 | -0.602 | -0.609 | -0.647 | — |
| chr19_40897339_C_G | chr19:40897339 | 0.597 | 0.617 | 0.500 | — |
| chr19_40921106_G_C | chr19:40921106 | -0.596 | -0.609 | -0.447 | — |
| chr19_40921000_C_A | chr19:40921000 | 0.594 | 0.076 | 0.512 | — |
| chr19_40897321_T_G | chr19:40897321 | 0.590 | 0.736 | 0.976 | — |
| chr19_40897361_C_G | chr19:40897361 | -0.587 | -0.528 | -0.859 | — |
| chr19_40921059_G_T | chr19:40921059 | 0.586 | 0.274 | 0.294 | — |
| chr19_40897379_G_T | chr19:40897379 | 0.582 | 0.338 | -0.200 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.