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CYP2C19
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of CYP2C19 lowers antiplatelet effect of the prodrug clopidogrel, and raises exposure of voriconazole.
Affected substrate drugs (PharmGKB): clopidogrel; voriconazole; omeprazole; lansoprazole; citalopram; escitalopram
Scored variants near CYP2C19
chr10:94,662,680..94,955,547, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr10_94673779_C_A | chr10:94673779 | 0.291 | 0.330 | 0.246 | — |
| chr10_94673775_A_G | chr10:94673775 | 0.043 | 0.126 | 0.506 | — |
| chr10_94673794_C_G | chr10:94673794 | 0.220 | 0.291 | 0.497 | — |
| chr10_94673789_G_T | chr10:94673789 | 0.142 | 0.297 | 0.491 | — |
| chr10_94673789_G_A | chr10:94673789 | 0.268 | 0.332 | 0.102 | — |
| chr10_94673793_T_A | chr10:94673793 | 0.255 | 0.389 | 0.357 | — |
| chr10_94673773_T_A | chr10:94673773 | -0.227 | -0.168 | -0.433 | — |
| chr10_94673778_T_A | chr10:94673778 | 0.224 | 0.241 | 0.222 | — |
| chr10_94673794_C_T | chr10:94673794 | 0.210 | 0.306 | 0.386 | — |
| chr10_94673773_T_G | chr10:94673773 | -0.206 | -0.137 | -0.383 | — |
| chr10_94673773_T_C | chr10:94673773 | -0.198 | -0.144 | -0.368 | — |
| chr10_94673780_A_C | chr10:94673780 | -0.123 | -0.067 | -0.368 | — |
| chr10_94673793_T_G | chr10:94673793 | 0.195 | 0.314 | 0.269 | — |
| chr10_94673743_C_G | chr10:94673743 | 0.189 | 0.365 | 0.228 | — |
| chr10_94673731_C_T | chr10:94673731 | 0.183 | 0.173 | 0.292 | — |
| chr10_94673780_A_T | chr10:94673780 | -0.086 | -0.064 | -0.316 | <0.001% |
| chr10_94673774_T_C | chr10:94673774 | -0.115 | -0.093 | -0.313 | — |
| chr10_94673775_A_C | chr10:94673775 | -0.138 | -0.099 | -0.313 | — |
| chr10_94673794_C_A | chr10:94673794 | 0.156 | 0.230 | 0.228 | — |
| chr10_94673779_C_G | chr10:94673779 | -0.084 | 0.001 | -0.275 | — |
| chr10_94673782_C_G | chr10:94673782 | -0.096 | -0.084 | -0.275 | — |
| chr10_94673774_T_A | chr10:94673774 | -0.022 | -0.065 | -0.266 | — |
| chr10_94673780_A_G | chr10:94673780 | -0.075 | -0.057 | -0.246 | — |
| chr10_94673788_T_A | chr10:94673788 | -0.056 | 0.029 | -0.243 | — |
| chr10_94673792_A_C | chr10:94673792 | 0.133 | 0.189 | 0.216 | — |
| chr10_94673776_C_T | chr10:94673776 | -0.065 | -0.043 | -0.234 | — |
| chr10_94673790_A_G | chr10:94673790 | 0.132 | 0.205 | 0.076 | — |
| chr10_94673741_A_C | chr10:94673741 | 0.130 | 0.204 | 0.219 | — |
| chr10_94673686_C_T | chr10:94673686 | 0.129 | 0.142 | 0.219 | — |
| chr10_94673737_T_A | chr10:94673737 | -0.108 | -0.067 | -0.225 | 0.011% |
| chr10_94673778_T_G | chr10:94673778 | -0.047 | -0.005 | -0.222 | — |
| chr10_94673731_C_A | chr10:94673731 | 0.113 | 0.117 | 0.216 | — |
| chr10_94673742_T_A | chr10:94673742 | -0.092 | -0.037 | -0.216 | — |
| chr10_94673776_C_A | chr10:94673776 | -0.074 | -0.033 | -0.213 | — |
| chr10_94673779_C_T | chr10:94673779 | -0.104 | -0.015 | -0.213 | — |
| chr10_94673774_T_G | chr10:94673774 | -0.100 | -0.136 | -0.211 | — |
| chr10_94673742_T_C | chr10:94673742 | -0.095 | -0.063 | -0.208 | — |
| chr10_94673776_C_G | chr10:94673776 | -0.064 | -0.060 | -0.208 | — |
| chr10_94673757_A_T | chr10:94673757 | -0.116 | -0.073 | -0.126 | — |
| chr10_94673744_A_C | chr10:94673744 | -0.075 | -0.048 | -0.202 | — |
| chr10_94673744_A_T | chr10:94673744 | -0.064 | -0.038 | -0.202 | — |
| chr10_94673793_T_C | chr10:94673793 | 0.114 | 0.200 | 0.076 | — |
| chr10_94673717_C_G | chr10:94673717 | 0.062 | 0.082 | 0.199 | — |
| chr10_94673731_C_G | chr10:94673731 | 0.096 | 0.110 | 0.199 | — |
| chr10_94673757_A_G | chr10:94673757 | -0.111 | -0.110 | -0.135 | — |
| chr10_94673730_T_G | chr10:94673730 | 0.050 | 0.064 | 0.196 | — |
| chr10_94673817_T_A | chr10:94673817 | 0.110 | 0.145 | 0.073 | — |
| chr10_94673795_A_C | chr10:94673795 | -0.026 | 0.028 | -0.193 | — |
| chr10_94673699_A_T | chr10:94673699 | 0.109 | 0.155 | 0.149 | — |
| chr10_94673818_T_A | chr10:94673818 | 0.013 | 0.018 | 0.190 | — |
| chr10_94673709_A_C | chr10:94673709 | 0.107 | 0.106 | 0.187 | — |
| chr10_94673766_C_A | chr10:94673766 | -0.051 | -0.058 | -0.187 | — |
| chr10_94673785_A_C | chr10:94673785 | -0.105 | -0.123 | -0.135 | — |
| chr10_94673791_C_A | chr10:94673791 | 0.105 | 0.179 | 0.096 | — |
| chr10_94673790_A_T | chr10:94673790 | 0.104 | 0.171 | 0.184 | — |
| chr10_94673808_A_G | chr10:94673808 | 0.079 | 0.081 | 0.184 | — |
| chr10_94673742_T_G | chr10:94673742 | -0.079 | -0.040 | -0.181 | — |
| chr10_94673826_A_C | chr10:94673826 | -0.044 | -0.034 | -0.181 | — |
| chr10_94673777_A_G | chr10:94673777 | -0.102 | -0.128 | -0.123 | — |
| chr10_94673738_G_C | chr10:94673738 | -0.071 | -0.025 | -0.178 | — |
| chr10_94673743_C_A | chr10:94673743 | 0.100 | 0.151 | 0.102 | — |
| chr10_94673739_A_G | chr10:94673739 | -0.084 | -0.044 | -0.173 | — |
| chr10_94673763_C_T | chr10:94673763 | -0.096 | -0.018 | 0.161 | — |
| chr10_94673772_A_T | chr10:94673772 | -0.046 | -0.020 | -0.170 | — |
| chr10_94673782_C_A | chr10:94673782 | -0.019 | -0.031 | -0.170 | — |
| chr10_94673824_T_G | chr10:94673824 | 0.095 | 0.159 | 0.094 | — |
| chr10_94673775_A_T | chr10:94673775 | 0.089 | 0.134 | 0.167 | — |
| chr10_94673802_T_G | chr10:94673802 | 0.074 | 0.084 | 0.167 | — |
| chr10_94673826_A_T | chr10:94673826 | -0.035 | -0.011 | -0.167 | — |
| chr10_94673787_A_C | chr10:94673787 | 0.092 | 0.150 | 0.020 | — |
| chr10_94673788_T_G | chr10:94673788 | 0.002 | 0.098 | -0.161 | — |
| chr10_94673825_G_T | chr10:94673825 | 0.090 | 0.116 | 0.079 | — |
| chr10_94673754_A_G | chr10:94673754 | 0.039 | 0.038 | 0.158 | — |
| chr10_94673777_A_C | chr10:94673777 | -0.084 | -0.053 | -0.158 | — |
| chr10_94673788_T_C | chr10:94673788 | -0.034 | 0.039 | -0.158 | <0.001% |
| chr10_94673813_A_G | chr10:94673813 | 0.018 | 0.019 | 0.158 | — |
| chr10_94673818_T_G | chr10:94673818 | -0.009 | 0.009 | 0.158 | — |
| chr10_94673716_A_C | chr10:94673716 | -0.078 | -0.076 | -0.155 | — |
| chr10_94673746_C_A | chr10:94673746 | -0.071 | -0.065 | -0.155 | — |
| chr10_94673791_C_G | chr10:94673791 | 0.088 | 0.108 | 0.129 | — |
| chr10_94673828_T_G | chr10:94673828 | 0.035 | -0.060 | 0.155 | — |
| chr10_94673791_C_T | chr10:94673791 | 0.085 | 0.115 | 0.050 | — |
| chr10_94673717_C_A | chr10:94673717 | 0.062 | 0.065 | 0.146 | — |
| chr10_94673739_A_C | chr10:94673739 | -0.065 | -0.028 | -0.146 | — |
| chr10_94673740_C_A | chr10:94673740 | -0.065 | -0.009 | -0.146 | — |
| chr10_94673781_C_A | chr10:94673781 | -0.034 | -0.010 | -0.146 | — |
| chr10_94673814_T_A | chr10:94673814 | -0.010 | 0.014 | 0.146 | 0.0053% |
| chr10_94673831_A_T | chr10:94673831 | -0.043 | -0.039 | -0.146 | — |
| chr10_94673722_A_T | chr10:94673722 | 0.068 | 0.094 | 0.140 | — |
| chr10_94673787_A_T | chr10:94673787 | 0.002 | 0.063 | -0.140 | — |
| chr10_94673725_C_G | chr10:94673725 | -0.078 | -0.093 | -0.111 | — |
| chr10_94673737_T_G | chr10:94673737 | -0.054 | 0.003 | -0.135 | — |
| chr10_94673795_A_T | chr10:94673795 | 0.023 | 0.076 | -0.135 | — |
| chr10_94673738_G_T | chr10:94673738 | 0.059 | 0.107 | 0.132 | — |
| chr10_94673741_A_G | chr10:94673741 | 0.063 | -0.024 | 0.132 | — |
| chr10_94673797_T_C | chr10:94673797 | 0.019 | 0.014 | 0.132 | — |
| chr10_94673809_C_T | chr10:94673809 | 0.075 | 0.042 | 0.099 | — |
| chr10_94673755_G_T | chr10:94673755 | -0.074 | -0.084 | -0.123 | — |
| chr10_94673681_A_C | chr10:94673681 | -0.058 | -0.059 | -0.129 | — |
| chr10_94673765_G_C | chr10:94673765 | -0.061 | -0.037 | -0.129 | — |
| chr10_94673745_C_T | chr10:94673745 | 0.065 | 0.029 | 0.126 | <0.001% |
| chr10_94673753_C_A | chr10:94673753 | -0.071 | -0.077 | -0.114 | — |
| chr10_94673831_A_C | chr10:94673831 | -0.057 | -0.074 | -0.126 | — |
| chr10_94673762_A_G | chr10:94673762 | -0.070 | -0.084 | -0.079 | — |
| chr10_94673767_T_G | chr10:94673767 | -0.070 | -0.058 | -0.099 | — |
| chr10_94673797_T_G | chr10:94673797 | -0.070 | -0.059 | -0.114 | — |
| chr10_94673748_T_C | chr10:94673748 | 0.003 | -0.009 | 0.123 | — |
| chr10_94673783_T_C | chr10:94673783 | 0.038 | 0.025 | 0.123 | — |
| chr10_94673789_G_C | chr10:94673789 | 0.031 | 0.106 | -0.123 | — |
| chr10_94673714_A_G | chr10:94673714 | -0.068 | -0.082 | -0.091 | — |
| chr10_94673673_G_T | chr10:94673673 | 0.054 | 0.071 | 0.120 | — |
| chr10_94673737_T_C | chr10:94673737 | -0.058 | -0.031 | -0.120 | <0.001% |
| chr10_94673743_C_T | chr10:94673743 | -0.038 | 0.020 | -0.120 | — |
| chr10_94673765_G_T | chr10:94673765 | -0.048 | -0.031 | -0.120 | — |
| chr10_94673836_T_C | chr10:94673836 | 0.067 | 0.034 | 0.070 | — |
| chr10_94673716_A_G | chr10:94673716 | -0.067 | -0.081 | -0.064 | — |
| chr10_94673701_G_C | chr10:94673701 | -0.046 | -0.055 | -0.117 | — |
| chr10_94673746_C_G | chr10:94673746 | -0.058 | -0.055 | -0.117 | — |
| chr10_94673747_T_C | chr10:94673747 | 0.011 | -0.020 | 0.117 | — |
| chr10_94673772_A_C | chr10:94673772 | -0.048 | -0.038 | -0.117 | — |
| chr10_94673778_T_C | chr10:94673778 | 0.066 | 0.078 | -0.018 | — |
| chr10_94673824_T_A | chr10:94673824 | -0.021 | 0.006 | -0.117 | — |
| chr10_94673707_A_G | chr10:94673707 | 0.048 | 0.062 | 0.114 | — |
| chr10_94673797_T_A | chr10:94673797 | -0.058 | -0.039 | -0.114 | — |
| chr10_94673827_C_A | chr10:94673827 | -0.024 | 0.019 | -0.114 | — |
| chr10_94673810_C_G | chr10:94673810 | -0.064 | -0.055 | -0.070 | — |
| chr10_94673790_A_C | chr10:94673790 | 0.063 | 0.122 | -0.023 | — |
| chr10_94673817_T_G | chr10:94673817 | 0.041 | 0.059 | 0.111 | — |
| chr10_94673832_C_A | chr10:94673832 | -0.015 | 0.006 | -0.111 | — |
| chr10_94673804_C_G | chr10:94673804 | -0.062 | -0.034 | -0.056 | — |
| chr10_94673808_A_T | chr10:94673808 | 0.062 | 0.069 | 0.099 | — |
| chr10_94673714_A_C | chr10:94673714 | -0.062 | -0.081 | -0.091 | — |
| chr10_94673723_T_C | chr10:94673723 | 0.061 | 0.082 | 0.096 | — |
| chr10_94673785_A_T | chr10:94673785 | -0.061 | -0.067 | -0.038 | — |
| chr10_94673826_A_G | chr10:94673826 | -0.023 | 0.003 | -0.108 | — |
| chr10_94673675_A_T | chr10:94673675 | 0.060 | 0.071 | 0.053 | — |
| chr10_94673624_C_T | chr10:94673624 | 0.056 | 0.082 | 0.105 | — |
| chr10_94673749_G_T | chr10:94673749 | 0.042 | 0.072 | 0.105 | — |
| chr10_94673762_A_T | chr10:94673762 | -0.055 | -0.064 | -0.105 | — |
| chr10_94673792_A_T | chr10:94673792 | 0.033 | 0.093 | 0.105 | — |
| chr10_94673813_A_T | chr10:94673813 | 0.037 | 0.053 | 0.105 | — |
| chr10_94673729_A_C | chr10:94673729 | -0.059 | -0.057 | -0.041 | — |
| chr10_94673693_A_C | chr10:94673693 | 0.059 | 0.059 | 0.102 | — |
| chr10_94673806_A_G | chr10:94673806 | 0.059 | 0.065 | 0.073 | — |
| chr10_94673782_C_T | chr10:94673782 | -0.013 | -0.021 | -0.102 | <0.001% |
| chr10_94673801_G_A | chr10:94673801 | -0.033 | -0.045 | -0.102 | — |
| chr10_94673795_A_G | chr10:94673795 | 0.057 | 0.086 | -0.015 | — |
| chr10_94673836_T_G | chr10:94673836 | 0.057 | 0.040 | 0.067 | — |
| chr10_94673657_C_A | chr10:94673657 | 0.057 | 0.074 | 0.099 | — |
| chr10_94673719_A_G | chr10:94673719 | 0.023 | 0.030 | 0.099 | — |
| chr10_94673728_C_G | chr10:94673728 | 0.049 | 0.055 | 0.099 | — |
| chr10_94673745_C_G | chr10:94673745 | 0.031 | 0.040 | 0.099 | — |
| chr10_94673812_A_C | chr10:94673812 | -0.055 | -0.042 | -0.073 | — |
| chr10_94673679_C_A | chr10:94673679 | 0.035 | 0.039 | 0.096 | — |
| chr10_94673710_A_T | chr10:94673710 | -0.022 | -0.030 | -0.096 | — |
| chr10_94673730_T_C | chr10:94673730 | 0.011 | 0.021 | 0.096 | — |
| chr10_94673740_C_T | chr10:94673740 | -0.012 | 0.015 | -0.096 | — |
| chr10_94673768_G_T | chr10:94673768 | -0.031 | -0.026 | -0.096 | — |
| chr10_94673796_C_T | chr10:94673796 | 0.025 | 0.016 | 0.096 | <0.001% |
| chr10_94673811_T_C | chr10:94673811 | -0.054 | -0.052 | -0.096 | — |
| chr10_94673815_C_T | chr10:94673815 | 0.036 | 0.057 | 0.096 | — |
| chr10_94673752_C_A | chr10:94673752 | 0.054 | 0.050 | 0.035 | — |
| chr10_94673724_C_G | chr10:94673724 | -0.038 | -0.057 | -0.094 | — |
| chr10_94673754_A_C | chr10:94673754 | 0.032 | 0.026 | 0.094 | — |
| chr10_94673765_G_A | chr10:94673765 | -0.026 | -0.031 | -0.094 | — |
| chr10_94673824_T_C | chr10:94673824 | -0.026 | -0.015 | -0.094 | <0.001% |
| chr10_94673827_C_T | chr10:94673827 | -0.031 | 0.000 | -0.094 | — |
| chr10_94673834_C_A | chr10:94673834 | -0.026 | -0.024 | -0.094 | — |
| chr10_94673729_A_G | chr10:94673729 | 0.017 | 0.034 | 0.091 | — |
| chr10_94673750_G_C | chr10:94673750 | -0.030 | -0.010 | 0.091 | — |
| chr10_94673762_A_C | chr10:94673762 | -0.051 | -0.060 | -0.050 | — |
| chr10_94673766_C_T | chr10:94673766 | -0.012 | -0.018 | -0.091 | — |
| chr10_94673817_T_C | chr10:94673817 | 0.027 | 0.040 | 0.091 | 0.0013% |
| chr10_94673827_C_G | chr10:94673827 | -0.026 | -0.003 | -0.091 | — |
| chr10_94707948_A_C | chr10:94707948 | 0.035 | 0.050 | 0.091 | <0.001% |
| chr10_94673686_C_G | chr10:94673686 | 0.050 | 0.047 | 0.064 | — |
| chr10_94673697_G_A | chr10:94673697 | -0.033 | -0.052 | -0.088 | — |
| chr10_94673727_A_C | chr10:94673727 | -0.050 | -0.053 | -0.088 | — |
| chr10_94673733_C_G | chr10:94673733 | 0.009 | 0.018 | 0.088 | — |
| chr10_94673747_T_G | chr10:94673747 | -0.007 | -0.043 | 0.088 | — |
| chr10_94673771_G_T | chr10:94673771 | -0.050 | -0.024 | -0.067 | — |
| chr10_94673783_T_G | chr10:94673783 | -0.032 | -0.053 | -0.088 | — |
| chr10_94673786_G_A | chr10:94673786 | -0.046 | -0.020 | -0.088 | — |
| chr10_94673786_G_T | chr10:94673786 | -0.027 | -0.018 | -0.088 | — |
| chr10_94673833_C_G | chr10:94673833 | -0.047 | -0.034 | -0.088 | — |
| chr10_94673755_G_C | chr10:94673755 | -0.049 | -0.049 | 0.044 | — |
| chr10_94673663_T_G | chr10:94673663 | 0.048 | 0.049 | 0.082 | — |
| chr10_94673681_A_T | chr10:94673681 | -0.046 | -0.043 | -0.085 | — |
| chr10_94673714_A_T | chr10:94673714 | -0.038 | -0.045 | -0.085 | — |
| chr10_94673802_T_A | chr10:94673802 | -0.048 | -0.037 | -0.056 | — |
| chr10_94673825_G_A | chr10:94673825 | 0.047 | 0.097 | -0.056 | — |
| chr10_94673623_G_T | chr10:94673623 | -0.007 | -0.013 | -0.082 | — |
| chr10_94673679_C_T | chr10:94673679 | 0.036 | 0.035 | 0.082 | — |
| chr10_94673825_G_C | chr10:94673825 | 0.009 | 0.050 | -0.082 | — |
| chr10_94673705_T_C | chr10:94673705 | -0.046 | -0.055 | -0.079 | — |
| chr10_94673771_G_A | chr10:94673771 | -0.046 | 0.015 | -0.003 | — |
| chr10_94673747_T_A | chr10:94673747 | -0.045 | -0.076 | -0.018 | — |
| chr10_94673643_G_A | chr10:94673643 | -0.022 | -0.026 | -0.079 | 0.0026% |
| chr10_94673669_A_G | chr10:94673669 | 0.005 | 0.018 | 0.079 | — |
| chr10_94673674_A_C | chr10:94673674 | 0.011 | 0.024 | 0.079 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.