Home / Gene
CYP2C8
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of CYP2C8 reduces the inducible metabolic clearance of substrates such as repaglinide and paclitaxel.
Affected substrate drugs (PharmGKB): ibuprofen; tacrolimus; rosiglitazone; pioglitazone; amodiaquine; paclitaxel
Scored variants near CYP2C8
chr10:94,936,771..95,169,497, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr10_94936934_T_A | chr10:94936934 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936905_T_A | chr10:94936905 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936924_C_A | chr10:94936924 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936921_T_A | chr10:94936921 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936924_C_T | chr10:94936924 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936935_T_A | chr10:94936935 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936937_C_A | chr10:94936937 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936924_C_G | chr10:94936924 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936910_T_A | chr10:94936910 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936940_A_T | chr10:94936940 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936897_A_G | chr10:94936897 | 1.000 | 1.000 | 0.778 | — |
| chr10_94936941_A_T | chr10:94936941 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936916_A_T | chr10:94936916 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936934_T_G | chr10:94936934 | -1.000 | -1.000 | -0.936 | — |
| chr10_94936935_T_C | chr10:94936935 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936979_A_T | chr10:94936979 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936934_T_C | chr10:94936934 | -1.000 | -1.000 | -0.918 | — |
| chr10_94936912_G_C | chr10:94936912 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr10_94936940_A_G | chr10:94936940 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936939_A_G | chr10:94936939 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936906_T_A | chr10:94936906 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936913_A_G | chr10:94936913 | 1.000 | 0.907 | 0.772 | — |
| chr10_94936968_A_T | chr10:94936968 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936913_A_T | chr10:94936913 | 1.000 | 0.872 | 0.743 | — |
| chr10_94936938_G_T | chr10:94936938 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936948_A_G | chr10:94936948 | 1.000 | 0.892 | 0.830 | — |
| chr10_94936966_T_A | chr10:94936966 | -1.000 | -1.000 | -0.705 | — |
| chr10_94936898_T_C | chr10:94936898 | 1.000 | 0.846 | 0.673 | — |
| chr10_94936937_C_G | chr10:94936937 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936969_A_T | chr10:94936969 | -1.000 | -1.000 | -0.927 | — |
| chr10_94936898_T_G | chr10:94936898 | 1.000 | 0.766 | 0.655 | — |
| chr10_94936923_A_T | chr10:94936923 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936915_A_T | chr10:94936915 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936941_A_C | chr10:94936941 | -1.000 | -1.000 | -0.985 | — |
| chr10_94936942_T_A | chr10:94936942 | -1.000 | -1.000 | -0.798 | — |
| chr10_94936889_T_A | chr10:94936889 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936903_G_T | chr10:94936903 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr10_94936936_A_C | chr10:94936936 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936937_C_T | chr10:94936937 | -1.000 | -1.000 | -0.936 | 0.069% |
| chr10_94936912_G_T | chr10:94936912 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr10_94936899_T_C | chr10:94936899 | 1.000 | 0.874 | 0.716 | — |
| chr10_94936909_T_A | chr10:94936909 | -1.000 | -1.000 | -0.924 | — |
| chr10_94936938_G_C | chr10:94936938 | -1.000 | -1.000 | -0.860 | — |
| chr10_94936968_A_G | chr10:94936968 | -1.000 | -1.000 | -0.883 | — |
| chr10_94936910_T_G | chr10:94936910 | -1.000 | -1.000 | -0.664 | — |
| chr10_94936908_T_C | chr10:94936908 | 1.000 | 0.937 | 0.708 | — |
| chr10_94936979_A_G | chr10:94936979 | -1.000 | -1.000 | -0.781 | <0.001% |
| chr10_94936966_T_G | chr10:94936966 | -0.987 | -0.887 | -0.520 | — |
| chr10_94936897_A_C | chr10:94936897 | 0.977 | 0.725 | 0.591 | — |
| chr10_94936933_A_T | chr10:94936933 | -0.972 | -1.000 | -0.813 | — |
| chr10_94936969_A_G | chr10:94936969 | -0.962 | -1.000 | -0.725 | — |
| chr10_94936969_A_C | chr10:94936969 | -0.959 | -1.000 | -0.740 | — |
| chr10_94936938_G_A | chr10:94936938 | -0.952 | -1.000 | -0.763 | 0.039% |
| chr10_94936900_A_C | chr10:94936900 | 0.947 | 0.856 | 0.585 | — |
| chr10_94936916_A_G | chr10:94936916 | -0.944 | -1.000 | -0.827 | — |
| chr10_94936950_C_T | chr10:94936950 | -0.944 | -0.874 | -0.623 | <0.001% |
| chr10_94936890_T_A | chr10:94936890 | -0.935 | -1.000 | -0.772 | — |
| chr10_94936923_A_C | chr10:94936923 | -0.935 | -1.000 | -0.766 | 0.0020% |
| chr10_94936909_T_G | chr10:94936909 | -0.927 | -1.000 | -0.743 | — |
| chr10_94936890_T_G | chr10:94936890 | -0.924 | -1.000 | -0.763 | — |
| chr10_94936970_T_A | chr10:94936970 | -0.920 | -0.907 | -0.623 | — |
| chr10_94936971_A_T | chr10:94936971 | -0.920 | -1.000 | -0.778 | — |
| chr10_94936941_A_G | chr10:94936941 | -0.918 | -1.000 | -0.772 | — |
| chr10_94936967_A_G | chr10:94936967 | -0.916 | -1.000 | -0.737 | — |
| chr10_94936950_C_A | chr10:94936950 | -0.906 | -0.804 | -0.594 | — |
| chr10_94936892_A_T | chr10:94936892 | -0.892 | -1.000 | -0.871 | — |
| chr10_94936965_G_T | chr10:94936965 | -0.892 | -0.995 | -0.696 | — |
| chr10_94936899_T_G | chr10:94936899 | 0.889 | 0.718 | 0.599 | — |
| chr10_94936965_G_A | chr10:94936965 | -0.877 | -1.000 | -0.690 | — |
| chr10_94936967_A_T | chr10:94936967 | -0.872 | -1.000 | -0.687 | — |
| chr10_94936921_T_G | chr10:94936921 | -0.863 | -1.000 | -0.658 | — |
| chr10_94936918_A_C | chr10:94936918 | 0.856 | 0.660 | 0.491 | — |
| chr10_94936920_T_A | chr10:94936920 | -0.839 | -1.000 | -0.684 | — |
| chr10_94936925_T_G | chr10:94936925 | -0.833 | -1.000 | -0.596 | — |
| chr10_94936915_A_C | chr10:94936915 | -0.829 | -1.000 | -0.675 | — |
| chr10_94936965_G_C | chr10:94936965 | -0.829 | -0.902 | -0.608 | — |
| chr10_94936893_T_G | chr10:94936893 | -0.821 | -1.000 | -0.649 | — |
| chr10_94936931_G_T | chr10:94936931 | -0.820 | -1.000 | -0.713 | — |
| chr10_94936948_A_C | chr10:94936948 | 0.808 | 0.589 | 0.520 | — |
| chr10_94936884_A_C | chr10:94936884 | -0.793 | -1.000 | -0.754 | — |
| chr10_94936927_G_T | chr10:94936927 | -0.793 | -0.980 | -0.673 | — |
| chr10_94936884_A_T | chr10:94936884 | -0.783 | -1.000 | -0.781 | — |
| chr10_94936887_T_G | chr10:94936887 | 0.783 | 0.748 | 0.509 | — |
| chr10_94936959_C_T | chr10:94936959 | -0.780 | -0.872 | -0.596 | — |
| chr10_94936904_T_C | chr10:94936904 | -0.767 | -0.768 | -0.614 | — |
| chr10_94936893_T_C | chr10:94936893 | 0.760 | 0.736 | 0.497 | — |
| chr10_94936918_A_G | chr10:94936918 | 0.748 | 0.438 | 0.433 | — |
| chr10_94936922_T_A | chr10:94936922 | 0.748 | 0.587 | 0.462 | — |
| chr10_94936917_T_A | chr10:94936917 | -0.747 | -0.970 | -0.611 | — |
| chr10_94936923_A_G | chr10:94936923 | -0.732 | -0.950 | -0.547 | — |
| chr10_94936968_A_C | chr10:94936968 | -0.731 | -0.831 | -0.564 | — |
| chr10_94936913_A_C | chr10:94936913 | 0.725 | 0.630 | 0.520 | — |
| chr10_94936891_A_T | chr10:94936891 | -0.705 | -1.000 | -0.655 | — |
| chr10_94937022_A_C | chr10:94937022 | 0.705 | 0.662 | 0.307 | — |
| chr10_94936972_T_A | chr10:94936972 | -0.696 | -0.887 | -0.570 | — |
| chr10_94936895_A_T | chr10:94936895 | -0.685 | -0.849 | -0.564 | — |
| chr10_94936976_T_G | chr10:94936976 | -0.681 | -0.766 | -0.488 | — |
| chr10_94936892_A_G | chr10:94936892 | -0.674 | -0.894 | -0.567 | — |
| chr10_94936839_A_G | chr10:94936839 | 0.669 | 0.698 | 0.442 | <0.001% |
| chr10_94936888_A_T | chr10:94936888 | -0.667 | -0.942 | -0.643 | — |
| chr10_94936925_T_A | chr10:94936925 | -0.659 | -0.816 | -0.474 | — |
| chr10_94936894_G_T | chr10:94936894 | -0.651 | -0.647 | -0.500 | — |
| chr10_94936883_T_A | chr10:94936883 | -0.649 | -0.907 | -0.591 | — |
| chr10_94936970_T_G | chr10:94936970 | -0.646 | -0.592 | -0.401 | — |
| chr10_94936903_G_A | chr10:94936903 | -0.642 | -0.866 | -0.629 | 0.0013% |
| chr10_94936905_T_C | chr10:94936905 | -0.639 | -0.584 | -0.459 | 0.0039% |
| chr10_94936889_T_C | chr10:94936889 | -0.623 | -0.904 | -0.494 | — |
| chr10_94936893_T_A | chr10:94936893 | -0.619 | -0.831 | -0.538 | — |
| chr10_94936971_A_G | chr10:94936971 | -0.618 | -0.700 | -0.465 | — |
| chr10_94936914_A_C | chr10:94936914 | 0.611 | 0.489 | 0.398 | — |
| chr10_94936884_A_G | chr10:94936884 | -0.609 | -0.897 | -0.553 | — |
| chr10_94936912_G_A | chr10:94936912 | -0.606 | -0.771 | -0.567 | — |
| chr10_94936960_T_G | chr10:94936960 | 0.606 | 0.431 | 0.418 | — |
| chr10_94936906_T_C | chr10:94936906 | -0.601 | -0.471 | -0.389 | — |
| chr10_94936971_A_C | chr10:94936971 | -0.599 | -0.718 | -0.462 | — |
| chr10_94936892_A_C | chr10:94936892 | -0.598 | -0.859 | -0.518 | — |
| chr10_94936883_T_G | chr10:94936883 | -0.593 | -0.854 | -0.529 | — |
| chr10_94936916_A_C | chr10:94936916 | -0.593 | -0.725 | -0.436 | — |
| chr10_94936883_T_C | chr10:94936883 | -0.589 | -0.826 | -0.503 | — |
| chr10_94936984_A_C | chr10:94936984 | -0.589 | -0.615 | -0.398 | — |
| chr10_94936897_A_T | chr10:94936897 | 0.586 | 0.403 | 0.322 | — |
| chr10_94936890_T_C | chr10:94936890 | -0.584 | -0.804 | -0.406 | — |
| chr10_94936886_T_G | chr10:94936886 | -0.578 | -0.738 | -0.409 | — |
| chr10_94937038_T_C | chr10:94937038 | 0.576 | 0.521 | 0.269 | — |
| chr10_94936973_T_C | chr10:94936973 | -0.561 | -0.579 | -0.377 | — |
| chr10_94936888_A_C | chr10:94936888 | -0.560 | -0.856 | -0.538 | — |
| chr10_94936821_C_G | chr10:94936821 | 0.558 | 0.481 | 0.333 | — |
| chr10_94936974_G_T | chr10:94936974 | 0.555 | 0.355 | 0.287 | — |
| chr10_94936885_A_G | chr10:94936885 | -0.553 | -0.819 | -0.439 | — |
| chr10_94936891_A_C | chr10:94936891 | -0.551 | -0.856 | -0.482 | — |
| chr10_94936881_T_C | chr10:94936881 | -0.545 | -0.751 | -0.395 | — |
| chr10_94936983_A_C | chr10:94936983 | -0.545 | -0.579 | -0.357 | — |
| chr10_94936894_G_A | chr10:94936894 | -0.543 | -0.599 | -0.447 | — |
| chr10_94936931_G_A | chr10:94936931 | -0.542 | -0.657 | -0.456 | — |
| chr10_94936904_T_G | chr10:94936904 | -0.541 | -0.406 | -0.401 | — |
| chr10_94936929_C_T | chr10:94936929 | -0.540 | -0.635 | -0.418 | 0.0013% |
| chr10_94936951_A_T | chr10:94936951 | 0.536 | 0.650 | 0.310 | — |
| chr10_94936895_A_C | chr10:94936895 | -0.535 | -0.670 | -0.342 | — |
| chr10_94936957_C_T | chr10:94936957 | -0.533 | -0.662 | -0.421 | — |
| chr10_94936917_T_C | chr10:94936917 | -0.528 | -0.748 | -0.357 | 1.56% |
| chr10_94936926_A_G | chr10:94936926 | -0.526 | -0.537 | -0.310 | — |
| chr10_94937011_A_T | chr10:94937011 | 0.526 | 0.610 | 0.251 | — |
| chr10_94936915_A_G | chr10:94936915 | -0.525 | -0.660 | -0.380 | — |
| chr10_94936889_T_G | chr10:94936889 | -0.522 | -0.668 | -0.404 | — |
| chr10_94936901_A_C | chr10:94936901 | 0.520 | 0.484 | 0.345 | — |
| chr10_94936887_T_C | chr10:94936887 | 0.518 | 0.587 | 0.386 | — |
| chr10_94936838_T_C | chr10:94936838 | 0.510 | 0.494 | 0.240 | — |
| chr10_94936900_A_G | chr10:94936900 | 0.500 | 0.479 | 0.339 | — |
| chr10_94936858_C_A | chr10:94936858 | -0.498 | -0.582 | -0.363 | — |
| chr10_94936902_T_C | chr10:94936902 | -0.497 | -0.282 | -0.281 | — |
| chr10_94936877_G_A | chr10:94936877 | -0.492 | -0.554 | -0.371 | — |
| chr10_94936882_G_T | chr10:94936882 | 0.492 | 0.408 | 0.275 | <0.001% |
| chr10_94937035_G_C | chr10:94937035 | 0.490 | 0.481 | 0.354 | — |
| chr10_94936946_G_A | chr10:94936946 | -0.480 | -0.388 | -0.319 | — |
| chr10_94936854_T_A | chr10:94936854 | -0.478 | -0.486 | -0.310 | <0.001% |
| chr10_94936911_T_C | chr10:94936911 | -0.478 | -0.474 | -0.301 | — |
| chr10_94937039_T_A | chr10:94937039 | 0.478 | 0.526 | 0.228 | — |
| chr10_94936929_C_A | chr10:94936929 | -0.474 | -0.519 | -0.348 | — |
| chr10_94936855_G_C | chr10:94936855 | -0.465 | -0.537 | -0.357 | — |
| chr10_94936902_T_G | chr10:94936902 | -0.462 | -0.242 | -0.275 | — |
| chr10_94936888_A_G | chr10:94936888 | -0.460 | -0.705 | -0.415 | — |
| chr10_94936903_G_C | chr10:94936903 | -0.460 | -0.474 | -0.360 | — |
| chr10_94936967_A_C | chr10:94936967 | -0.458 | -0.564 | -0.342 | — |
| chr10_94936914_A_T | chr10:94936914 | 0.455 | 0.297 | 0.292 | — |
| chr10_94936946_G_C | chr10:94936946 | -0.454 | -0.375 | -0.322 | — |
| chr10_94936854_T_G | chr10:94936854 | -0.450 | -0.433 | -0.275 | — |
| chr10_94936882_G_C | chr10:94936882 | -0.449 | -0.471 | -0.292 | — |
| chr10_94936858_C_T | chr10:94936858 | -0.439 | -0.474 | -0.310 | — |
| chr10_94936882_G_A | chr10:94936882 | -0.437 | -0.537 | -0.319 | — |
| chr10_94936964_A_C | chr10:94936964 | -0.436 | -0.479 | -0.322 | — |
| chr10_94936947_A_T | chr10:94936947 | -0.435 | -0.479 | -0.360 | — |
| chr10_94936907_A_T | chr10:94936907 | -0.434 | -0.360 | -0.368 | — |
| chr10_94936911_T_A | chr10:94936911 | 0.432 | 0.484 | 0.281 | — |
| chr10_94936954_G_T | chr10:94936954 | -0.429 | -0.368 | -0.257 | <0.001% |
| chr10_94936885_A_T | chr10:94936885 | -0.427 | -0.703 | -0.345 | — |
| chr10_94936896_A_G | chr10:94936896 | 0.427 | 0.423 | 0.304 | — |
| chr10_94936977_G_T | chr10:94936977 | 0.417 | 0.317 | 0.196 | — |
| chr10_94936886_T_C | chr10:94936886 | -0.416 | -0.524 | -0.246 | — |
| chr10_94936899_T_A | chr10:94936899 | 0.414 | 0.295 | 0.263 | — |
| chr10_94936998_T_A | chr10:94936998 | -0.414 | -0.479 | -0.251 | — |
| chr10_94936996_G_C | chr10:94936996 | -0.412 | -0.479 | -0.289 | — |
| chr10_94937045_C_G | chr10:94937045 | 0.412 | 0.411 | 0.234 | — |
| chr10_94936920_T_C | chr10:94936920 | -0.409 | -0.612 | -0.289 | — |
| chr10_94936874_C_A | chr10:94936874 | -0.407 | -0.426 | -0.281 | — |
| chr10_94936946_G_T | chr10:94936946 | -0.406 | -0.315 | -0.272 | — |
| chr10_94936974_G_C | chr10:94936974 | -0.406 | -0.340 | -0.211 | — |
| chr10_94937041_T_G | chr10:94937041 | -0.404 | -0.519 | -0.243 | — |
| chr10_94936931_G_C | chr10:94936931 | -0.401 | -0.451 | -0.319 | — |
| chr10_94936963_C_T | chr10:94936963 | -0.401 | -0.423 | -0.281 | — |
| chr10_94936879_G_T | chr10:94936879 | 0.397 | 0.433 | 0.284 | — |
| chr10_94937012_A_G | chr10:94937012 | 0.396 | 0.456 | 0.199 | — |
| chr10_94936947_A_C | chr10:94936947 | -0.395 | -0.406 | -0.313 | — |
| chr10_94936887_T_A | chr10:94936887 | -0.394 | -0.446 | -0.325 | — |
| chr10_94936817_T_C | chr10:94936817 | 0.392 | 0.401 | 0.240 | — |
| chr10_94936874_C_T | chr10:94936874 | -0.392 | -0.433 | -0.263 | <0.001% |
| chr10_94936910_T_C | chr10:94936910 | 0.392 | 0.373 | 0.263 | — |
| chr10_94936961_A_C | chr10:94936961 | 0.391 | 0.280 | 0.228 | — |
| chr10_94936979_A_C | chr10:94936979 | -0.389 | -0.395 | -0.237 | — |
| chr10_94936904_T_A | chr10:94936904 | -0.387 | -0.302 | -0.295 | — |
| chr10_94936954_G_A | chr10:94936954 | -0.384 | -0.310 | -0.234 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.