Home / Gene
CYP2C8
receptor: PXRTier 1
CAMIP Tier 1: peak-anchored panel
PXR
Submitted decision (verbatim): 需修訂
Reviewer revision (verbatim)
Blunted receptor-mediated induction of CYP2C8 reduces the inducible metabolic clearance of substrates such as repaglinide and paclitaxel.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Rifampicin
- Regulatory element
- at promoter -1846 bp
- Predicted consequence
- Blunted receptor-mediated induction of CYP2C8 reduces the inducible metabolic clearance of substrates such as repaglinide and paclitaxel.
- Prior narrative
- Blunted receptor-mediated induction of CYP2C8 reduces the inducible metabolic clearance of substrates such as repaglinide and paclitaxel.
- Drug context
- ibuprofen; tacrolimus; rosiglitazone; pioglitazone; amodiaquine; paclitaxel
Scored variants near CYP2C8
chr10:94,936,771..95,169,497, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr10_94936934_T_A | chr10:94936934 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936905_T_A | chr10:94936905 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936924_C_A | chr10:94936924 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936921_T_A | chr10:94936921 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936924_C_T | chr10:94936924 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936935_T_A | chr10:94936935 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936937_C_A | chr10:94936937 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936924_C_G | chr10:94936924 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936910_T_A | chr10:94936910 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936940_A_T | chr10:94936940 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936897_A_G | chr10:94936897 | 1.000 | 1.000 | 0.782 | — |
| chr10_94936941_A_T | chr10:94936941 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936916_A_T | chr10:94936916 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936934_T_G | chr10:94936934 | -1.000 | -1.000 | -0.941 | — |
| chr10_94936935_T_C | chr10:94936935 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936979_A_T | chr10:94936979 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936934_T_C | chr10:94936934 | -1.000 | -1.000 | -0.924 | — |
| chr10_94936912_G_C | chr10:94936912 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr10_94936940_A_G | chr10:94936940 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936939_A_G | chr10:94936939 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936906_T_A | chr10:94936906 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936913_A_G | chr10:94936913 | 1.000 | 0.914 | 0.776 | — |
| chr10_94936968_A_T | chr10:94936968 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936913_A_T | chr10:94936913 | 1.000 | 0.878 | 0.747 | — |
| chr10_94936938_G_T | chr10:94936938 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936948_A_G | chr10:94936948 | 1.000 | 0.898 | 0.835 | — |
| chr10_94936966_T_A | chr10:94936966 | -1.000 | -1.000 | -0.709 | — |
| chr10_94936898_T_C | chr10:94936898 | 1.000 | 0.853 | 0.676 | — |
| chr10_94936937_C_G | chr10:94936937 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936969_A_T | chr10:94936969 | -1.000 | -1.000 | -0.932 | — |
| chr10_94936898_T_G | chr10:94936898 | 1.000 | 0.772 | 0.659 | — |
| chr10_94936923_A_T | chr10:94936923 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936915_A_T | chr10:94936915 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936941_A_C | chr10:94936941 | -1.000 | -1.000 | -0.991 | — |
| chr10_94936942_T_A | chr10:94936942 | -1.000 | -1.000 | -0.803 | — |
| chr10_94936889_T_A | chr10:94936889 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936903_G_T | chr10:94936903 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr10_94936936_A_C | chr10:94936936 | -1.000 | -1.000 | -1.000 | — |
| chr10_94936937_C_T | chr10:94936937 | -1.000 | -1.000 | -0.941 | 0.069% |
| chr10_94936912_G_T | chr10:94936912 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr10_94936899_T_C | chr10:94936899 | 1.000 | 0.881 | 0.721 | — |
| chr10_94936909_T_A | chr10:94936909 | -1.000 | -1.000 | -0.929 | — |
| chr10_94936938_G_C | chr10:94936938 | -1.000 | -1.000 | -0.865 | — |
| chr10_94936968_A_G | chr10:94936968 | -1.000 | -1.000 | -0.888 | — |
| chr10_94936910_T_G | chr10:94936910 | -1.000 | -1.000 | -0.668 | — |
| chr10_94936908_T_C | chr10:94936908 | 1.000 | 0.944 | 0.712 | — |
| chr10_94936979_A_G | chr10:94936979 | -1.000 | -1.000 | -0.785 | <0.001% |
| chr10_94936966_T_G | chr10:94936966 | -0.992 | -0.893 | -0.524 | — |
| chr10_94936897_A_C | chr10:94936897 | 0.982 | 0.731 | 0.594 | — |
| chr10_94936933_A_T | chr10:94936933 | -0.977 | -1.000 | -0.818 | — |
| chr10_94936969_A_G | chr10:94936969 | -0.967 | -1.000 | -0.729 | — |
| chr10_94936969_A_C | chr10:94936969 | -0.963 | -1.000 | -0.744 | — |
| chr10_94936938_G_A | chr10:94936938 | -0.957 | -1.000 | -0.768 | 0.039% |
| chr10_94936900_A_C | chr10:94936900 | 0.952 | 0.863 | 0.588 | — |
| chr10_94936916_A_G | chr10:94936916 | -0.948 | -1.000 | -0.832 | — |
| chr10_94936950_C_T | chr10:94936950 | -0.948 | -0.881 | -0.626 | <0.001% |
| chr10_94936890_T_A | chr10:94936890 | -0.940 | -1.000 | -0.776 | — |
| chr10_94936923_A_C | chr10:94936923 | -0.940 | -1.000 | -0.771 | 0.0020% |
| chr10_94936909_T_G | chr10:94936909 | -0.932 | -1.000 | -0.747 | — |
| chr10_94936890_T_G | chr10:94936890 | -0.928 | -1.000 | -0.768 | — |
| chr10_94936970_T_A | chr10:94936970 | -0.924 | -0.914 | -0.626 | — |
| chr10_94936971_A_T | chr10:94936971 | -0.924 | -1.000 | -0.782 | — |
| chr10_94936941_A_G | chr10:94936941 | -0.923 | -1.000 | -0.776 | — |
| chr10_94936967_A_G | chr10:94936967 | -0.920 | -1.000 | -0.741 | — |
| chr10_94936950_C_A | chr10:94936950 | -0.910 | -0.810 | -0.597 | — |
| chr10_94936892_A_T | chr10:94936892 | -0.897 | -1.000 | -0.876 | — |
| chr10_94936965_G_T | chr10:94936965 | -0.897 | -1.000 | -0.700 | — |
| chr10_94936899_T_G | chr10:94936899 | 0.894 | 0.723 | 0.603 | — |
| chr10_94936965_G_A | chr10:94936965 | -0.881 | -1.000 | -0.694 | — |
| chr10_94936967_A_T | chr10:94936967 | -0.876 | -1.000 | -0.691 | — |
| chr10_94936921_T_G | chr10:94936921 | -0.867 | -1.000 | -0.662 | — |
| chr10_94936918_A_C | chr10:94936918 | 0.860 | 0.665 | 0.494 | — |
| chr10_94936920_T_A | chr10:94936920 | -0.844 | -1.000 | -0.688 | — |
| chr10_94936925_T_G | chr10:94936925 | -0.837 | -1.000 | -0.600 | — |
| chr10_94936915_A_C | chr10:94936915 | -0.834 | -1.000 | -0.679 | — |
| chr10_94936965_G_C | chr10:94936965 | -0.833 | -0.909 | -0.612 | — |
| chr10_94936893_T_G | chr10:94936893 | -0.825 | -1.000 | -0.653 | — |
| chr10_94936931_G_T | chr10:94936931 | -0.824 | -1.000 | -0.718 | — |
| chr10_94936948_A_C | chr10:94936948 | 0.812 | 0.594 | 0.524 | — |
| chr10_94936884_A_C | chr10:94936884 | -0.797 | -1.000 | -0.759 | — |
| chr10_94936927_G_T | chr10:94936927 | -0.797 | -0.987 | -0.676 | — |
| chr10_94936884_A_T | chr10:94936884 | -0.787 | -1.000 | -0.785 | — |
| chr10_94936887_T_G | chr10:94936887 | 0.787 | 0.754 | 0.512 | — |
| chr10_94936959_C_T | chr10:94936959 | -0.784 | -0.878 | -0.600 | — |
| chr10_94936904_T_C | chr10:94936904 | -0.770 | -0.774 | -0.618 | — |
| chr10_94936893_T_C | chr10:94936893 | 0.764 | 0.741 | 0.500 | — |
| chr10_94936918_A_G | chr10:94936918 | 0.752 | 0.442 | 0.435 | — |
| chr10_94936922_T_A | chr10:94936922 | 0.752 | 0.591 | 0.465 | — |
| chr10_94936917_T_A | chr10:94936917 | -0.750 | -0.977 | -0.615 | — |
| chr10_94936923_A_G | chr10:94936923 | -0.735 | -0.957 | -0.550 | — |
| chr10_94936968_A_C | chr10:94936968 | -0.735 | -0.838 | -0.568 | — |
| chr10_94936913_A_C | chr10:94936913 | 0.729 | 0.635 | 0.524 | — |
| chr10_94936891_A_T | chr10:94936891 | -0.709 | -1.000 | -0.659 | — |
| chr10_94937022_A_C | chr10:94937022 | 0.709 | 0.668 | 0.309 | — |
| chr10_94936972_T_A | chr10:94936972 | -0.700 | -0.893 | -0.574 | — |
| chr10_94936895_A_T | chr10:94936895 | -0.689 | -0.855 | -0.568 | — |
| chr10_94936976_T_G | chr10:94936976 | -0.685 | -0.772 | -0.491 | — |
| chr10_94936892_A_G | chr10:94936892 | -0.677 | -0.901 | -0.571 | — |
| chr10_94936839_A_G | chr10:94936839 | 0.672 | 0.703 | 0.444 | <0.001% |
| chr10_94936888_A_T | chr10:94936888 | -0.671 | -0.949 | -0.647 | — |
| chr10_94936925_T_A | chr10:94936925 | -0.662 | -0.822 | -0.476 | — |
| chr10_94936894_G_T | chr10:94936894 | -0.654 | -0.652 | -0.503 | — |
| chr10_94936883_T_A | chr10:94936883 | -0.652 | -0.914 | -0.594 | — |
| chr10_94936970_T_G | chr10:94936970 | -0.649 | -0.596 | -0.403 | — |
| chr10_94936903_G_A | chr10:94936903 | -0.646 | -0.873 | -0.632 | 0.0013% |
| chr10_94936905_T_C | chr10:94936905 | -0.642 | -0.589 | -0.462 | 0.0039% |
| chr10_94936889_T_C | chr10:94936889 | -0.626 | -0.911 | -0.497 | — |
| chr10_94936893_T_A | chr10:94936893 | -0.622 | -0.838 | -0.541 | — |
| chr10_94936971_A_G | chr10:94936971 | -0.621 | -0.706 | -0.468 | — |
| chr10_94936914_A_C | chr10:94936914 | 0.614 | 0.492 | 0.400 | — |
| chr10_94936884_A_G | chr10:94936884 | -0.612 | -0.904 | -0.556 | — |
| chr10_94936912_G_A | chr10:94936912 | -0.609 | -0.777 | -0.571 | — |
| chr10_94936960_T_G | chr10:94936960 | 0.609 | 0.434 | 0.421 | — |
| chr10_94936906_T_C | chr10:94936906 | -0.604 | -0.475 | -0.391 | — |
| chr10_94936971_A_C | chr10:94936971 | -0.601 | -0.723 | -0.465 | — |
| chr10_94936892_A_C | chr10:94936892 | -0.601 | -0.865 | -0.521 | — |
| chr10_94936883_T_G | chr10:94936883 | -0.596 | -0.860 | -0.532 | — |
| chr10_94936916_A_C | chr10:94936916 | -0.596 | -0.731 | -0.438 | — |
| chr10_94936883_T_C | chr10:94936883 | -0.592 | -0.832 | -0.506 | — |
| chr10_94936984_A_C | chr10:94936984 | -0.592 | -0.619 | -0.400 | — |
| chr10_94936897_A_T | chr10:94936897 | 0.589 | 0.406 | 0.324 | — |
| chr10_94936890_T_C | chr10:94936890 | -0.587 | -0.810 | -0.409 | — |
| chr10_94936886_T_G | chr10:94936886 | -0.581 | -0.744 | -0.412 | — |
| chr10_94937038_T_C | chr10:94937038 | 0.579 | 0.525 | 0.271 | — |
| chr10_94936973_T_C | chr10:94936973 | -0.564 | -0.584 | -0.379 | — |
| chr10_94936888_A_C | chr10:94936888 | -0.562 | -0.863 | -0.541 | — |
| chr10_94936821_C_G | chr10:94936821 | 0.561 | 0.485 | 0.335 | — |
| chr10_94936974_G_T | chr10:94936974 | 0.557 | 0.358 | 0.288 | — |
| chr10_94936885_A_G | chr10:94936885 | -0.556 | -0.825 | -0.441 | — |
| chr10_94936891_A_C | chr10:94936891 | -0.554 | -0.863 | -0.485 | — |
| chr10_94936881_T_C | chr10:94936881 | -0.547 | -0.756 | -0.397 | — |
| chr10_94936983_A_C | chr10:94936983 | -0.547 | -0.584 | -0.359 | — |
| chr10_94936894_G_A | chr10:94936894 | -0.546 | -0.604 | -0.450 | — |
| chr10_94936931_G_A | chr10:94936931 | -0.545 | -0.662 | -0.459 | — |
| chr10_94936904_T_G | chr10:94936904 | -0.544 | -0.409 | -0.403 | — |
| chr10_94936929_C_T | chr10:94936929 | -0.542 | -0.640 | -0.421 | 0.0013% |
| chr10_94936951_A_T | chr10:94936951 | 0.539 | 0.655 | 0.312 | — |
| chr10_94936895_A_C | chr10:94936895 | -0.537 | -0.675 | -0.344 | — |
| chr10_94936957_C_T | chr10:94936957 | -0.536 | -0.668 | -0.424 | — |
| chr10_94936917_T_C | chr10:94936917 | -0.531 | -0.754 | -0.359 | 1.56% |
| chr10_94936926_A_G | chr10:94936926 | -0.529 | -0.541 | -0.312 | — |
| chr10_94937011_A_T | chr10:94937011 | 0.529 | 0.614 | 0.253 | — |
| chr10_94936915_A_G | chr10:94936915 | -0.527 | -0.665 | -0.382 | — |
| chr10_94936889_T_G | chr10:94936889 | -0.524 | -0.673 | -0.406 | — |
| chr10_94936901_A_C | chr10:94936901 | 0.522 | 0.487 | 0.347 | — |
| chr10_94936887_T_C | chr10:94936887 | 0.521 | 0.591 | 0.388 | — |
| chr10_94936838_T_C | chr10:94936838 | 0.512 | 0.497 | 0.241 | — |
| chr10_94936900_A_G | chr10:94936900 | 0.502 | 0.482 | 0.341 | — |
| chr10_94936858_C_A | chr10:94936858 | -0.501 | -0.586 | -0.365 | — |
| chr10_94936902_T_C | chr10:94936902 | -0.499 | -0.284 | -0.282 | — |
| chr10_94936877_G_A | chr10:94936877 | -0.494 | -0.558 | -0.374 | — |
| chr10_94936882_G_T | chr10:94936882 | 0.494 | 0.411 | 0.276 | <0.001% |
| chr10_94937035_G_C | chr10:94937035 | 0.493 | 0.485 | 0.356 | — |
| chr10_94936946_G_A | chr10:94936946 | -0.483 | -0.391 | -0.321 | — |
| chr10_94936854_T_A | chr10:94936854 | -0.481 | -0.490 | -0.312 | <0.001% |
| chr10_94936911_T_C | chr10:94936911 | -0.481 | -0.477 | -0.303 | — |
| chr10_94937039_T_A | chr10:94937039 | 0.481 | 0.530 | 0.229 | — |
| chr10_94936929_C_A | chr10:94936929 | -0.476 | -0.523 | -0.350 | — |
| chr10_94936855_G_C | chr10:94936855 | -0.468 | -0.541 | -0.359 | — |
| chr10_94936902_T_G | chr10:94936902 | -0.464 | -0.244 | -0.276 | — |
| chr10_94936888_A_G | chr10:94936888 | -0.463 | -0.711 | -0.418 | — |
| chr10_94936903_G_C | chr10:94936903 | -0.463 | -0.477 | -0.362 | — |
| chr10_94936967_A_C | chr10:94936967 | -0.460 | -0.569 | -0.344 | — |
| chr10_94936914_A_T | chr10:94936914 | 0.458 | 0.299 | 0.294 | — |
| chr10_94936946_G_C | chr10:94936946 | -0.456 | -0.378 | -0.324 | — |
| chr10_94936854_T_G | chr10:94936854 | -0.453 | -0.437 | -0.276 | — |
| chr10_94936882_G_C | chr10:94936882 | -0.451 | -0.475 | -0.294 | — |
| chr10_94936858_C_T | chr10:94936858 | -0.441 | -0.477 | -0.312 | — |
| chr10_94936882_G_A | chr10:94936882 | -0.439 | -0.541 | -0.321 | — |
| chr10_94936964_A_C | chr10:94936964 | -0.438 | -0.482 | -0.324 | — |
| chr10_94936947_A_T | chr10:94936947 | -0.437 | -0.482 | -0.362 | — |
| chr10_94936907_A_T | chr10:94936907 | -0.436 | -0.363 | -0.371 | — |
| chr10_94936911_T_A | chr10:94936911 | 0.434 | 0.487 | 0.282 | — |
| chr10_94936954_G_T | chr10:94936954 | -0.431 | -0.371 | -0.259 | <0.001% |
| chr10_94936885_A_T | chr10:94936885 | -0.429 | -0.708 | -0.347 | — |
| chr10_94936896_A_G | chr10:94936896 | 0.429 | 0.426 | 0.306 | — |
| chr10_94936977_G_T | chr10:94936977 | 0.419 | 0.320 | 0.197 | — |
| chr10_94936886_T_C | chr10:94936886 | -0.418 | -0.528 | -0.247 | — |
| chr10_94936899_T_A | chr10:94936899 | 0.416 | 0.297 | 0.265 | — |
| chr10_94936998_T_A | chr10:94936998 | -0.416 | -0.482 | -0.253 | — |
| chr10_94936996_G_C | chr10:94936996 | -0.414 | -0.482 | -0.291 | — |
| chr10_94937045_C_G | chr10:94937045 | 0.414 | 0.414 | 0.235 | — |
| chr10_94936920_T_C | chr10:94936920 | -0.411 | -0.617 | -0.291 | — |
| chr10_94936874_C_A | chr10:94936874 | -0.409 | -0.429 | -0.282 | — |
| chr10_94936946_G_T | chr10:94936946 | -0.408 | -0.317 | -0.274 | — |
| chr10_94936974_G_C | chr10:94936974 | -0.408 | -0.343 | -0.212 | — |
| chr10_94937041_T_G | chr10:94937041 | -0.406 | -0.523 | -0.244 | — |
| chr10_94936931_G_C | chr10:94936931 | -0.403 | -0.454 | -0.321 | — |
| chr10_94936963_C_T | chr10:94936963 | -0.403 | -0.426 | -0.282 | — |
| chr10_94936879_G_T | chr10:94936879 | 0.399 | 0.437 | 0.285 | — |
| chr10_94937012_A_G | chr10:94937012 | 0.398 | 0.459 | 0.200 | — |
| chr10_94936947_A_C | chr10:94936947 | -0.397 | -0.409 | -0.315 | — |
| chr10_94936887_T_A | chr10:94936887 | -0.396 | -0.449 | -0.326 | — |
| chr10_94936817_T_C | chr10:94936817 | 0.394 | 0.404 | 0.241 | — |
| chr10_94936874_C_T | chr10:94936874 | -0.394 | -0.437 | -0.265 | <0.001% |
| chr10_94936910_T_C | chr10:94936910 | 0.394 | 0.376 | 0.265 | — |
| chr10_94936961_A_C | chr10:94936961 | 0.393 | 0.282 | 0.229 | — |
| chr10_94936979_A_C | chr10:94936979 | -0.391 | -0.398 | -0.238 | — |
| chr10_94936904_T_A | chr10:94936904 | -0.389 | -0.305 | -0.297 | — |
| chr10_94936954_G_A | chr10:94936954 | -0.386 | -0.312 | -0.235 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.