Home / Gene
CYP2E1
CAMIP Tier 2: reviewed literature reference panel
These records are literature references, not evidence of a receptor-bound element in this ChIP-seq panel.
PXR
Submitted decision (verbatim): 需修訂
Reviewer notes (verbatim)
CYP2E1 的誘導主要是轉譯後（PMID: 8530344）
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Drug context
- ethanol; volatile anaesthetics; acetaminophen (bioactivation)
- Nearest peak (bp)
- 197420
- Panel context
- CYP2E1 induction is largely POST-TRANSCRIPTIONAL (substrate-mediated protein stabilization), not receptor-transcriptional — so the absence of a PXR peak is mechanistically expected, not a miss.
- Claim type
- clinical_reference_no_binding_claim
Scored variants near CYP2E1
chr10:133,427,362..133,639,123, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr10_133527260_A_T | chr10:133527260 | 1.000 | 1.000 | 1.000 | — |
| chr10_133527154_G_C | chr10:133527154 | -1.000 | -1.000 | -1.000 | — |
| chr10_133527252_C_T | chr10:133527252 | 1.000 | 1.000 | 1.000 | — |
| chr10_133527235_A_C | chr10:133527235 | 1.000 | 1.000 | 0.912 | — |
| chr10_133527159_C_G | chr10:133527159 | -1.000 | -1.000 | -1.000 | 0.0033% |
| chr10_133527160_A_C | chr10:133527160 | -1.000 | -1.000 | -1.000 | — |
| chr10_133527159_C_T | chr10:133527159 | -0.925 | -1.000 | -1.000 | <0.001% |
| chr10_133527168_A_T | chr10:133527168 | -0.892 | -1.000 | -0.982 | — |
| chr10_133527153_T_G | chr10:133527153 | -0.867 | -0.962 | -0.953 | — |
| chr10_133527162_A_C | chr10:133527162 | -0.847 | -1.000 | -0.988 | — |
| chr10_133527156_T_A | chr10:133527156 | -0.814 | -0.995 | -0.953 | — |
| chr10_133527174_T_G | chr10:133527174 | 0.814 | 0.967 | 0.953 | — |
| chr10_133527162_A_G | chr10:133527162 | -0.809 | -0.992 | -0.947 | — |
| chr10_133527174_T_A | chr10:133527174 | 0.799 | 0.962 | 0.888 | — |
| chr10_133527169_C_G | chr10:133527169 | 0.777 | 0.891 | 0.635 | — |
| chr10_133527160_A_G | chr10:133527160 | -0.745 | -0.964 | -0.600 | — |
| chr10_133527157_G_C | chr10:133527157 | -0.742 | -0.939 | -0.976 | — |
| chr10_133527216_G_C | chr10:133527216 | 0.730 | 0.853 | 0.688 | — |
| chr10_133527157_G_A | chr10:133527157 | -0.720 | -0.929 | -0.941 | — |
| chr10_133527173_A_G | chr10:133527173 | 0.720 | 0.822 | 0.829 | — |
| chr10_133527175_C_G | chr10:133527175 | 0.686 | 0.822 | 0.706 | <0.001% |
| chr10_133527154_G_T | chr10:133527154 | -0.656 | -0.848 | -0.771 | <0.001% |
| chr10_133527212_C_T | chr10:133527212 | 0.621 | 0.632 | 0.506 | — |
| chr10_133527158_A_T | chr10:133527158 | -0.619 | -0.838 | -0.871 | — |
| chr10_133527155_T_C | chr10:133527155 | -0.612 | -0.736 | -0.653 | — |
| chr10_133527196_A_T | chr10:133527196 | -0.604 | -0.756 | -0.641 | — |
| chr10_133527176_C_G | chr10:133527176 | 0.602 | 0.561 | 0.565 | — |
| chr10_133527163_G_T | chr10:133527163 | -0.592 | -0.688 | -0.576 | — |
| chr10_133527172_C_T | chr10:133527172 | 0.582 | 0.693 | 0.588 | — |
| chr10_133527226_G_A | chr10:133527226 | 0.577 | 0.599 | 0.441 | — |
| chr10_133527308_G_A | chr10:133527308 | 0.438 | 0.411 | 1.000 | — |
| chr10_133527178_C_G | chr10:133527178 | 0.569 | 0.599 | 0.471 | — |
| chr10_133527162_A_T | chr10:133527162 | -0.556 | -0.739 | -0.676 | — |
| chr10_133527174_T_C | chr10:133527174 | 0.547 | 0.744 | 0.718 | — |
| chr10_133527155_T_G | chr10:133527155 | -0.546 | -0.698 | -0.618 | — |
| chr10_133527158_A_G | chr10:133527158 | -0.531 | -0.680 | -0.612 | — |
| chr10_133527207_G_A | chr10:133527207 | -0.531 | -0.642 | -0.706 | — |
| chr10_133527161_C_G | chr10:133527161 | -0.526 | -0.640 | -0.500 | — |
| chr10_133527160_A_T | chr10:133527160 | -0.524 | -0.728 | -0.329 | — |
| chr10_133527220_G_C | chr10:133527220 | 0.516 | 0.536 | 0.453 | — |
| chr10_133527172_C_A | chr10:133527172 | 0.509 | 0.609 | 0.506 | — |
| chr10_133527178_C_A | chr10:133527178 | 0.502 | 0.571 | 0.394 | — |
| chr10_133527196_A_G | chr10:133527196 | -0.501 | -0.548 | -0.471 | — |
| chr10_133527260_A_C | chr10:133527260 | 0.489 | 0.482 | 0.341 | — |
| chr10_133527212_C_G | chr10:133527212 | 0.483 | 0.487 | 0.429 | — |
| chr10_133527172_C_G | chr10:133527172 | 0.473 | 0.538 | 0.506 | — |
| chr10_133527177_T_G | chr10:133527177 | 0.466 | 0.520 | 0.488 | — |
| chr10_133527211_C_A | chr10:133527211 | 0.458 | 0.482 | 0.388 | — |
| chr10_133527158_A_C | chr10:133527158 | -0.441 | -0.589 | -0.535 | — |
| chr10_133527153_T_C | chr10:133527153 | -0.439 | -0.518 | -0.406 | — |
| chr10_133527153_T_A | chr10:133527153 | -0.424 | -0.487 | -0.429 | — |
| chr10_133527187_A_C | chr10:133527187 | -0.421 | -0.505 | -0.418 | — |
| chr10_133527187_A_T | chr10:133527187 | -0.419 | -0.503 | -0.459 | — |
| chr10_133527238_A_T | chr10:133527238 | 0.418 | 0.472 | 0.471 | — |
| chr10_133527207_G_C | chr10:133527207 | -0.416 | -0.447 | -0.441 | — |
| chr10_133527181_C_A | chr10:133527181 | 0.413 | 0.551 | 0.453 | — |
| chr10_133527233_A_G | chr10:133527233 | 0.411 | 0.414 | 0.359 | — |
| chr10_133527263_C_G | chr10:133527263 | -0.411 | -0.449 | -0.412 | — |
| chr10_133527183_G_A | chr10:133527183 | -0.408 | -0.515 | -0.412 | — |
| chr10_133527197_A_C | chr10:133527197 | -0.401 | -0.368 | -0.424 | — |
| chr10_133527275_G_C | chr10:133527275 | 0.399 | 0.462 | 0.494 | — |
| chr10_133527211_C_G | chr10:133527211 | 0.396 | 0.437 | 0.429 | — |
| chr10_133527173_A_C | chr10:133527173 | 0.389 | 0.538 | 0.524 | — |
| chr10_133527156_T_G | chr10:133527156 | -0.388 | -0.477 | -0.294 | — |
| chr10_133527227_C_A | chr10:133527227 | 0.381 | 0.391 | 0.259 | — |
| chr10_133527192_C_A | chr10:133527192 | -0.379 | -0.404 | -0.441 | — |
| chr10_133527186_C_A | chr10:133527186 | -0.376 | -0.520 | -0.476 | — |
| chr10_133527219_G_T | chr10:133527219 | 0.376 | 0.406 | 0.488 | — |
| chr10_133527263_C_A | chr10:133527263 | -0.374 | -0.404 | -0.429 | — |
| chr10_133527164_T_A | chr10:133527164 | -0.371 | -0.444 | -0.335 | — |
| chr10_133527186_C_T | chr10:133527186 | -0.369 | -0.416 | -0.424 | — |
| chr10_133527177_T_A | chr10:133527177 | 0.363 | 0.391 | 0.382 | — |
| chr10_133527182_A_T | chr10:133527182 | -0.351 | -0.429 | -0.394 | — |
| chr10_133527259_T_A | chr10:133527259 | -0.349 | -0.358 | -0.388 | — |
| chr10_133527207_G_T | chr10:133527207 | -0.343 | -0.401 | -0.529 | — |
| chr10_133527225_A_G | chr10:133527225 | 0.338 | 0.376 | 0.341 | — |
| chr10_133527179_A_G | chr10:133527179 | 0.329 | 0.355 | 0.353 | — |
| chr10_133527192_C_G | chr10:133527192 | -0.329 | -0.259 | -0.347 | — |
| chr10_133527198_C_G | chr10:133527198 | 0.326 | 0.325 | 0.441 | — |
| chr10_133527175_C_A | chr10:133527175 | 0.323 | 0.414 | 0.447 | — |
| chr10_133527195_G_T | chr10:133527195 | 0.321 | 0.340 | 0.206 | — |
| chr10_133527167_A_C | chr10:133527167 | -0.318 | -0.383 | -0.188 | — |
| chr10_133527262_A_T | chr10:133527262 | -0.316 | -0.340 | -0.435 | — |
| chr10_133527226_G_T | chr10:133527226 | -0.314 | -0.386 | -0.418 | 0.0033% |
| chr10_133527259_T_G | chr10:133527259 | -0.314 | -0.393 | -0.341 | — |
| chr10_133527184_G_A | chr10:133527184 | -0.303 | -0.409 | -0.300 | — |
| chr10_133527192_C_T | chr10:133527192 | -0.303 | -0.312 | -0.353 | — |
| chr10_133527155_T_A | chr10:133527155 | -0.301 | -0.457 | -0.341 | — |
| chr10_133527171_C_A | chr10:133527171 | 0.301 | 0.315 | 0.324 | — |
| chr10_133527205_G_C | chr10:133527205 | 0.300 | 0.221 | 0.265 | — |
| chr10_133527187_A_G | chr10:133527187 | -0.293 | -0.338 | -0.235 | — |
| chr10_133527191_G_T | chr10:133527191 | -0.290 | -0.348 | -0.388 | — |
| chr10_133527181_C_G | chr10:133527181 | 0.288 | 0.297 | 0.318 | — |
| chr10_133527184_G_C | chr10:133527184 | -0.288 | -0.368 | -0.159 | <0.001% |
| chr10_133527260_A_G | chr10:133527260 | -0.288 | -0.358 | -0.335 | — |
| chr10_133527214_T_G | chr10:133527214 | 0.286 | 0.338 | 0.388 | — |
| chr10_133527251_G_T | chr10:133527251 | -0.285 | -0.320 | -0.376 | — |
| chr10_133527267_T_G | chr10:133527267 | 0.283 | 0.315 | 0.276 | — |
| chr10_133527255_A_G | chr10:133527255 | -0.281 | -0.368 | -0.353 | — |
| chr10_133527203_G_A | chr10:133527203 | 0.280 | 0.193 | 0.159 | — |
| chr10_133527256_T_C | chr10:133527256 | -0.278 | -0.322 | -0.253 | — |
| chr10_133527163_G_C | chr10:133527163 | -0.276 | -0.317 | -0.218 | — |
| chr10_133527170_T_G | chr10:133527170 | 0.275 | 0.310 | 0.435 | — |
| chr10_133527270_T_G | chr10:133527270 | 0.273 | 0.251 | 0.288 | — |
| chr10_133527154_G_A | chr10:133527154 | -0.271 | -0.378 | -0.376 | — |
| chr10_133527164_T_C | chr10:133527164 | -0.268 | -0.282 | -0.212 | <0.001% |
| chr10_133527236_C_A | chr10:133527236 | -0.263 | -0.251 | -0.318 | — |
| chr10_133527243_C_G | chr10:133527243 | -0.263 | -0.289 | -0.276 | — |
| chr10_133527299_T_A | chr10:133527299 | 0.261 | 0.284 | 0.218 | — |
| chr10_133527205_G_T | chr10:133527205 | 0.260 | 0.211 | 0.159 | — |
| chr10_133527308_G_C | chr10:133527308 | 0.260 | 0.226 | 0.412 | — |
| chr10_133527163_G_A | chr10:133527163 | -0.258 | -0.315 | -0.312 | — |
| chr10_133527183_G_T | chr10:133527183 | -0.258 | -0.383 | -0.259 | — |
| chr10_133527242_C_G | chr10:133527242 | -0.258 | -0.297 | -0.300 | — |
| chr10_133527169_C_T | chr10:133527169 | 0.256 | 0.246 | 0.306 | — |
| chr10_133527240_G_T | chr10:133527240 | 0.256 | 0.322 | 0.253 | — |
| chr10_133527255_A_C | chr10:133527255 | -0.256 | -0.345 | -0.341 | — |
| chr10_133527169_C_A | chr10:133527169 | 0.253 | 0.310 | 0.224 | — |
| chr10_133527238_A_C | chr10:133527238 | 0.253 | 0.335 | 0.447 | — |
| chr10_133527171_C_G | chr10:133527171 | 0.251 | 0.254 | 0.288 | — |
| chr10_133527214_T_C | chr10:133527214 | 0.251 | 0.320 | 0.347 | — |
| chr10_133527249_C_T | chr10:133527249 | 0.251 | 0.277 | 0.212 | <0.001% |
| chr10_133527209_C_A | chr10:133527209 | 0.250 | 0.297 | 0.235 | — |
| chr10_133527251_G_C | chr10:133527251 | -0.250 | -0.325 | -0.329 | — |
| chr10_133527259_T_C | chr10:133527259 | -0.250 | -0.320 | -0.288 | — |
| chr10_133527185_T_C | chr10:133527185 | -0.248 | -0.332 | -0.159 | — |
| chr10_133527244_A_C | chr10:133527244 | -0.248 | -0.246 | -0.241 | — |
| chr10_133527261_A_C | chr10:133527261 | -0.245 | -0.287 | -0.335 | — |
| chr10_133527224_C_T | chr10:133527224 | 0.243 | 0.261 | 0.229 | — |
| chr10_133527263_C_T | chr10:133527263 | -0.243 | -0.218 | -0.300 | — |
| chr10_133527185_T_A | chr10:133527185 | -0.241 | -0.292 | -0.235 | — |
| chr10_133527268_A_G | chr10:133527268 | 0.240 | 0.244 | 0.271 | — |
| chr10_133527261_A_T | chr10:133527261 | -0.238 | -0.299 | -0.353 | — |
| chr10_133527173_A_T | chr10:133527173 | 0.231 | 0.345 | 0.271 | — |
| chr10_133527255_A_T | chr10:133527255 | -0.231 | -0.272 | -0.253 | — |
| chr10_133527152_G_A | chr10:133527152 | 0.230 | 0.188 | 0.153 | <0.001% |
| chr10_133527274_G_C | chr10:133527274 | 0.230 | 0.246 | 0.376 | — |
| chr10_133527157_G_T | chr10:133527157 | 0.228 | 0.343 | 0.194 | — |
| chr10_133527168_A_C | chr10:133527168 | -0.226 | -0.188 | -0.135 | — |
| chr10_133527231_T_A | chr10:133527231 | -0.226 | -0.302 | -0.259 | — |
| chr10_133527231_T_C | chr10:133527231 | -0.226 | -0.317 | -0.247 | — |
| chr10_133527236_C_G | chr10:133527236 | -0.225 | -0.228 | -0.276 | — |
| chr10_133527276_A_C | chr10:133527276 | 0.223 | 0.195 | 0.300 | — |
| chr10_133527167_A_G | chr10:133527167 | -0.221 | -0.307 | -0.124 | — |
| chr10_133527227_C_T | chr10:133527227 | -0.221 | -0.239 | -0.318 | — |
| chr10_133527175_C_T | chr10:133527175 | 0.220 | 0.325 | 0.335 | 0.0053% |
| chr10_133527184_G_T | chr10:133527184 | -0.220 | -0.292 | -0.200 | — |
| chr10_133527201_C_T | chr10:133527201 | -0.218 | -0.269 | -0.288 | — |
| chr10_133527214_T_A | chr10:133527214 | 0.216 | 0.244 | 0.229 | — |
| chr10_133527272_T_A | chr10:133527272 | -0.216 | -0.155 | -0.088 | — |
| chr10_133527206_G_T | chr10:133527206 | -0.213 | -0.269 | -0.329 | — |
| chr10_133527277_T_C | chr10:133527277 | 0.211 | 0.221 | 0.353 | — |
| chr10_133527182_A_G | chr10:133527182 | 0.206 | 0.201 | 0.218 | — |
| chr10_133527244_A_T | chr10:133527244 | -0.206 | -0.195 | -0.206 | — |
| chr10_133527254_A_C | chr10:133527254 | -0.203 | -0.261 | -0.294 | — |
| chr10_133527254_A_G | chr10:133527254 | -0.188 | -0.246 | -0.359 | — |
| chr10_133527262_A_G | chr10:133527262 | -0.203 | -0.244 | -0.271 | — |
| chr10_133527229_T_A | chr10:133527229 | -0.201 | -0.259 | -0.288 | — |
| chr10_133527168_A_G | chr10:133527168 | -0.198 | -0.259 | -0.012 | — |
| chr10_133527156_T_C | chr10:133527156 | -0.196 | -0.345 | -0.147 | — |
| chr10_133527176_C_A | chr10:133527176 | 0.196 | 0.140 | 0.147 | — |
| chr10_133527223_T_A | chr10:133527223 | 0.196 | 0.259 | 0.241 | — |
| chr10_133527198_C_T | chr10:133527198 | 0.195 | 0.132 | 0.176 | — |
| chr10_133527190_G_T | chr10:133527190 | -0.193 | -0.221 | -0.271 | — |
| chr10_133527217_C_G | chr10:133527217 | -0.193 | -0.185 | -0.265 | <0.001% |
| chr10_133527229_T_G | chr10:133527229 | -0.193 | -0.251 | -0.282 | — |
| chr10_133527254_A_T | chr10:133527254 | -0.193 | -0.249 | -0.294 | — |
| chr10_133527232_G_A | chr10:133527232 | -0.191 | -0.231 | -0.247 | — |
| chr10_133527239_T_C | chr10:133527239 | 0.190 | 0.234 | 0.235 | — |
| chr10_133527245_A_C | chr10:133527245 | -0.190 | -0.216 | -0.259 | — |
| chr10_133527269_A_C | chr10:133527269 | 0.188 | 0.198 | 0.241 | — |
| chr10_133527228_C_A | chr10:133527228 | -0.186 | -0.228 | -0.135 | — |
| chr10_133527239_T_A | chr10:133527239 | 0.186 | 0.264 | 0.212 | — |
| chr10_133527243_C_T | chr10:133527243 | -0.186 | -0.175 | -0.165 | — |
| chr10_133527234_A_C | chr10:133527234 | 0.183 | 0.137 | 0.194 | — |
| chr10_133527236_C_T | chr10:133527236 | -0.183 | -0.175 | -0.224 | — |
| chr10_133527274_G_A | chr10:133527274 | 0.050 | 0.203 | 0.324 | — |
| chr10_133527176_C_T | chr10:133527176 | -0.180 | -0.244 | -0.212 | — |
| chr10_133527202_T_G | chr10:133527202 | -0.180 | -0.137 | -0.159 | — |
| chr10_133527213_A_T | chr10:133527213 | 0.180 | 0.211 | 0.200 | — |
| chr10_133527266_G_T | chr10:133527266 | -0.180 | -0.178 | -0.224 | — |
| chr10_133527270_T_C | chr10:133527270 | 0.180 | 0.195 | 0.265 | — |
| chr10_133527165_C_T | chr10:133527165 | 0.178 | 0.157 | 0.118 | — |
| chr10_133527251_G_A | chr10:133527251 | -0.176 | -0.216 | -0.259 | — |
| chr10_133527293_G_T | chr10:133527293 | -0.176 | -0.175 | -0.218 | — |
| chr10_133527183_G_C | chr10:133527183 | 0.175 | -0.046 | 0.235 | — |
| chr10_133527186_C_G | chr10:133527186 | -0.175 | -0.211 | -0.165 | — |
| chr10_133527256_T_G | chr10:133527256 | -0.173 | -0.223 | -0.129 | — |
| chr10_133527193_T_C | chr10:133527193 | 0.171 | 0.180 | 0.200 | — |
| chr10_133527221_A_G | chr10:133527221 | -0.171 | -0.185 | -0.206 | — |
| chr10_133527151_G_T | chr10:133527151 | 0.170 | 0.175 | 0.165 | — |
| chr10_133527185_T_G | chr10:133527185 | -0.170 | -0.239 | -0.065 | — |
| chr10_133527244_A_G | chr10:133527244 | -0.168 | -0.203 | -0.194 | — |
| chr10_133527195_G_C | chr10:133527195 | 0.166 | 0.173 | 0.171 | — |
| chr10_133527213_A_C | chr10:133527213 | 0.166 | 0.211 | 0.294 | — |
| chr10_133527274_G_T | chr10:133527274 | 0.166 | 0.188 | 0.241 | — |
| chr10_133527228_C_G | chr10:133527228 | -0.165 | -0.195 | -0.118 | — |
| chr10_133527262_A_C | chr10:133527262 | -0.165 | -0.193 | -0.147 | — |
| chr10_133527208_C_G | chr10:133527208 | -0.161 | -0.142 | -0.129 | — |
| chr10_133527199_C_G | chr10:133527199 | 0.151 | 0.145 | 0.282 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.