Home / Gene
CYP3A4
receptor: PXRTier 1
CAMIP causal chains
PXR
CYP3A subfamily enzymes metabolize ~30% of clinically used drugs. Blunted receptor-mediated induction of CYP3A4 reduces its inducible metabolic capacity under PXR inducers.
Affected substrate drugs (PharmGKB): quetiapine; tacrolimus; fentanyl; cyclosporine; sufentanil; simvastatin
Scored variants near CYP3A4
chr7:99,656,966..99,884,184, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr7_99680060_C_A | chr7:99680060 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680041_G_T | chr7:99680041 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680061_C_T | chr7:99680061 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680063_A_T | chr7:99680063 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680062_A_C | chr7:99680062 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680061_C_A | chr7:99680061 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680062_A_T | chr7:99680062 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680048_C_G | chr7:99680048 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680041_G_A | chr7:99680041 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680060_C_G | chr7:99680060 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680041_G_C | chr7:99680041 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680060_C_T | chr7:99680060 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680042_G_T | chr7:99680042 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680061_C_G | chr7:99680061 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680063_A_C | chr7:99680063 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680063_A_G | chr7:99680063 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680042_G_A | chr7:99680042 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680045_G_A | chr7:99680045 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680062_A_G | chr7:99680062 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680040_A_T | chr7:99680040 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680046_G_C | chr7:99680046 | -1.000 | -1.000 | -1.000 | — |
| chr7_99671516_G_C | chr7:99671516 | 1.000 | 1.000 | 1.000 | — |
| chr7_99680066_G_T | chr7:99680066 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680081_C_G | chr7:99680081 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680040_A_C | chr7:99680040 | -1.000 | -1.000 | -0.961 | — |
| chr7_99671533_T_A | chr7:99671533 | 1.000 | 1.000 | 1.000 | — |
| chr7_99680023_T_G | chr7:99680023 | -1.000 | -0.917 | -1.000 | — |
| chr7_99680011_C_A | chr7:99680011 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680042_G_C | chr7:99680042 | -1.000 | -1.000 | -0.954 | — |
| chr7_99680064_T_A | chr7:99680064 | -1.000 | -1.000 | -0.856 | — |
| chr7_99680064_T_G | chr7:99680064 | -1.000 | -1.000 | -0.935 | — |
| chr7_99680058_A_C | chr7:99680058 | -1.000 | -1.000 | -0.837 | — |
| chr7_99680045_G_C | chr7:99680045 | -1.000 | -0.843 | -0.752 | — |
| chr7_99680023_T_A | chr7:99680023 | -1.000 | -0.757 | -1.000 | — |
| chr7_99671585_A_G | chr7:99671585 | 1.000 | 0.987 | 0.938 | — |
| chr7_99679979_T_A | chr7:99679979 | -1.000 | -0.738 | -0.856 | — |
| chr7_99680048_C_A | chr7:99680048 | -1.000 | -0.856 | -0.915 | — |
| chr7_99680064_T_C | chr7:99680064 | -1.000 | -0.981 | -0.784 | — |
| chr7_99680081_C_T | chr7:99680081 | -1.000 | -0.757 | -0.797 | — |
| chr7_99679973_T_A | chr7:99679973 | 1.000 | 0.233 | 1.000 | — |
| chr7_99680009_A_T | chr7:99680009 | -1.000 | -0.665 | -0.601 | — |
| chr7_99680059_G_T | chr7:99680059 | -1.000 | -0.706 | -0.673 | — |
| chr7_99680030_C_A | chr7:99680030 | -1.000 | -0.706 | -0.771 | — |
| chr7_99680047_G_C | chr7:99680047 | -1.000 | -0.601 | -0.660 | — |
| chr7_99679981_C_A | chr7:99679981 | 1.000 | 0.997 | 0.438 | — |
| chr7_99680010_G_T | chr7:99680010 | -1.000 | -0.323 | -0.614 | — |
| chr7_99680039_G_C | chr7:99680039 | -1.000 | -0.754 | -0.693 | — |
| chr7_99680059_G_C | chr7:99680059 | -1.000 | -0.677 | -0.601 | — |
| chr7_99680045_G_T | chr7:99680045 | -1.000 | -0.578 | -0.621 | — |
| chr7_99680006_C_A | chr7:99680006 | -0.977 | -0.581 | -0.614 | — |
| chr7_99680083_C_T | chr7:99680083 | -0.975 | -0.748 | -0.699 | — |
| chr7_99671585_A_T | chr7:99671585 | 0.973 | 0.706 | 0.683 | — |
| chr7_99679970_G_T | chr7:99679970 | -0.973 | -0.409 | -0.562 | — |
| chr7_99679971_C_T | chr7:99679971 | -0.973 | -0.345 | -0.693 | — |
| chr7_99680046_G_A | chr7:99680046 | -0.965 | -0.722 | -0.660 | — |
| chr7_99680046_G_T | chr7:99680046 | -0.955 | -0.700 | -0.660 | — |
| chr7_99679995_G_T | chr7:99679995 | -0.953 | -0.419 | -0.569 | — |
| chr7_99679997_A_T | chr7:99679997 | -0.932 | -0.642 | -0.425 | — |
| chr7_99679971_C_A | chr7:99679971 | -0.924 | -0.272 | -0.595 | — |
| chr7_99680006_C_T | chr7:99680006 | -0.895 | -0.460 | -0.562 | — |
| chr7_99680043_C_A | chr7:99680043 | -0.895 | -0.629 | -0.614 | — |
| chr7_99679970_G_C | chr7:99679970 | -0.891 | -0.380 | -0.529 | — |
| chr7_99680071_G_C | chr7:99680071 | 0.876 | 0.524 | 0.366 | — |
| chr7_99680007_C_A | chr7:99680007 | -0.866 | -0.412 | -0.536 | — |
| chr7_99680038_G_T | chr7:99680038 | -0.864 | -0.665 | -0.608 | — |
| chr7_99680043_C_G | chr7:99680043 | -0.864 | -0.601 | -0.549 | — |
| chr7_99671516_G_T | chr7:99671516 | 0.858 | 0.923 | 0.690 | — |
| chr7_99679972_C_A | chr7:99679972 | -0.841 | -0.217 | -0.556 | — |
| chr7_99679973_T_C | chr7:99679973 | 0.841 | 0.150 | 0.882 | — |
| chr7_99680043_C_T | chr7:99680043 | -0.835 | -0.540 | -0.542 | — |
| chr7_99680058_A_T | chr7:99680058 | -0.835 | -0.754 | -0.536 | — |
| chr7_99671593_A_T | chr7:99671593 | 0.831 | 0.875 | 0.712 | — |
| chr7_99671577_C_T | chr7:99671577 | 0.829 | 0.655 | 0.614 | — |
| chr7_99679964_C_G | chr7:99679964 | -0.808 | -0.252 | -0.588 | — |
| chr7_99680005_G_A | chr7:99680005 | -0.796 | -0.259 | -0.510 | — |
| chr7_99671485_A_G | chr7:99671485 | 0.792 | 0.751 | 0.565 | — |
| chr7_99671575_T_G | chr7:99671575 | 0.788 | 0.802 | 0.801 | — |
| chr7_99680026_T_G | chr7:99680026 | -0.773 | -0.505 | -0.634 | — |
| chr7_99680076_G_C | chr7:99680076 | -0.773 | -0.495 | -0.693 | — |
| chr7_99680066_G_C | chr7:99680066 | -0.769 | -0.671 | -0.621 | — |
| chr7_99680038_G_C | chr7:99680038 | -0.767 | -0.649 | -0.477 | — |
| chr7_99680007_C_T | chr7:99680007 | -0.746 | -0.435 | -0.425 | — |
| chr7_99671569_A_G | chr7:99671569 | 0.738 | 0.703 | 0.637 | — |
| chr7_99680005_G_C | chr7:99680005 | -0.738 | -0.211 | -0.556 | — |
| chr7_99680005_G_T | chr7:99680005 | -0.734 | -0.288 | -0.444 | — |
| chr7_99680081_C_A | chr7:99680081 | -0.734 | -0.527 | -0.556 | — |
| chr7_99679996_C_A | chr7:99679996 | -0.722 | -0.291 | -0.490 | — |
| chr7_99680080_A_C | chr7:99680080 | -0.715 | -0.435 | -0.608 | — |
| chr7_99680008_A_C | chr7:99680008 | -0.705 | -0.489 | -0.464 | — |
| chr7_99680003_C_A | chr7:99680003 | -0.680 | -0.403 | -0.458 | — |
| chr7_99679972_C_G | chr7:99679972 | -0.676 | -0.201 | -0.392 | — |
| chr7_99680079_C_T | chr7:99680079 | -0.668 | -0.438 | -0.490 | — |
| chr7_99680084_C_T | chr7:99680084 | -0.666 | -0.578 | -0.444 | — |
| chr7_99671575_T_A | chr7:99671575 | 0.662 | 0.581 | 0.592 | — |
| chr7_99679963_G_T | chr7:99679963 | -0.660 | -0.188 | -0.477 | — |
| chr7_99679981_C_G | chr7:99679981 | 0.647 | 0.422 | 0.379 | — |
| chr7_99680079_C_G | chr7:99680079 | -0.645 | -0.409 | -0.490 | — |
| chr7_99680007_C_G | chr7:99680007 | -0.639 | -0.256 | -0.216 | — |
| chr7_99679978_C_T | chr7:99679978 | 0.635 | 0.358 | 0.346 | — |
| chr7_99680054_C_A | chr7:99680054 | -0.633 | -0.396 | -0.458 | — |
| chr7_99679972_C_T | chr7:99679972 | -0.627 | -0.144 | -0.484 | — |
| chr7_99680006_C_G | chr7:99680006 | -0.627 | -0.387 | -0.373 | — |
| chr7_99680048_C_T | chr7:99680048 | -0.627 | -0.399 | -0.516 | — |
| chr7_99679963_G_C | chr7:99679963 | -0.623 | -0.246 | -0.399 | — |
| chr7_99680047_G_T | chr7:99680047 | -0.623 | -0.307 | -0.490 | — |
| chr7_99680027_G_T | chr7:99680027 | 0.606 | 0.521 | 0.248 | — |
| chr7_99671574_A_G | chr7:99671574 | 0.600 | 0.530 | 0.507 | — |
| chr7_99671553_T_G | chr7:99671553 | -0.588 | -0.617 | -0.572 | — |
| chr7_99679969_T_A | chr7:99679969 | -0.581 | -0.176 | -0.399 | — |
| chr7_99680085_C_A | chr7:99680085 | -0.571 | -0.399 | -0.405 | — |
| chr7_99679963_G_A | chr7:99679963 | -0.565 | -0.147 | -0.477 | — |
| chr7_99671553_T_A | chr7:99671553 | -0.563 | -0.591 | -0.552 | — |
| chr7_99679964_C_T | chr7:99679964 | -0.561 | -0.121 | -0.451 | — |
| chr7_99680059_G_A | chr7:99680059 | -0.561 | -0.316 | -0.340 | — |
| chr7_99679983_C_G | chr7:99679983 | 0.557 | 0.578 | 0.516 | — |
| chr7_99680080_A_T | chr7:99680080 | -0.555 | -0.319 | -0.497 | — |
| chr7_99680082_A_C | chr7:99680082 | -0.544 | -0.457 | -0.516 | — |
| chr7_99679974_G_T | chr7:99679974 | -0.540 | -0.182 | -0.418 | — |
| chr7_99671570_A_T | chr7:99671570 | 0.532 | 0.406 | 0.402 | — |
| chr7_99680009_A_C | chr7:99680009 | -0.532 | -0.272 | -0.131 | — |
| chr7_99679999_T_A | chr7:99679999 | 0.528 | 0.355 | 0.314 | — |
| chr7_99680021_A_G | chr7:99680021 | 0.528 | 0.425 | 0.046 | — |
| chr7_99671533_T_G | chr7:99671533 | 0.526 | 0.543 | 0.477 | — |
| chr7_99679985_G_T | chr7:99679985 | -0.520 | -0.304 | -0.216 | — |
| chr7_99680027_G_C | chr7:99680027 | 0.520 | 0.399 | 0.007 | — |
| chr7_99680023_T_C | chr7:99680023 | -0.513 | -0.278 | -0.510 | — |
| chr7_99680058_A_G | chr7:99680058 | -0.511 | -0.482 | -0.333 | — |
| chr7_99679989_T_G | chr7:99679989 | 0.507 | 0.115 | 0.412 | — |
| chr7_99671568_T_G | chr7:99671568 | 0.501 | 0.572 | 0.451 | — |
| chr7_99671569_A_C | chr7:99671569 | 0.501 | 0.518 | 0.438 | — |
| chr7_99680067_C_T | chr7:99680067 | -0.499 | -0.316 | -0.353 | — |
| chr7_99680085_C_T | chr7:99680085 | -0.497 | -0.297 | -0.327 | — |
| chr7_99679969_T_G | chr7:99679969 | -0.495 | -0.121 | -0.386 | — |
| chr7_99671485_A_T | chr7:99671485 | 0.493 | 0.473 | 0.353 | — |
| chr7_99671577_C_G | chr7:99671577 | -0.493 | -0.473 | -0.487 | — |
| chr7_99671593_A_C | chr7:99671593 | 0.491 | 0.447 | 0.428 | — |
| chr7_99679970_G_A | chr7:99679970 | -0.487 | 0.109 | -0.301 | — |
| chr7_99679974_G_C | chr7:99679974 | -0.487 | -0.188 | -0.170 | — |
| chr7_99679964_C_A | chr7:99679964 | -0.482 | -0.147 | -0.418 | — |
| chr7_99679982_C_G | chr7:99679982 | 0.482 | 0.383 | 0.294 | — |
| chr7_99680052_A_C | chr7:99680052 | 0.480 | 0.182 | 0.261 | — |
| chr7_99679969_T_C | chr7:99679969 | -0.478 | -0.160 | -0.209 | — |
| chr7_99671516_G_A | chr7:99671516 | 0.476 | 0.537 | 0.382 | — |
| chr7_99680085_C_G | chr7:99680085 | -0.468 | -0.387 | -0.183 | — |
| chr7_99680020_G_A | chr7:99680020 | -0.462 | -0.281 | -0.477 | — |
| chr7_99671577_C_A | chr7:99671577 | -0.458 | -0.431 | -0.467 | — |
| chr7_99680029_G_T | chr7:99680029 | -0.458 | -0.198 | -0.327 | — |
| chr7_99680037_A_T | chr7:99680037 | -0.454 | -0.259 | -0.340 | — |
| chr7_99680039_G_A | chr7:99680039 | -0.454 | -0.265 | -0.379 | — |
| chr7_99671520_A_C | chr7:99671520 | 0.449 | 0.489 | 0.458 | — |
| chr7_99679971_C_G | chr7:99679971 | -0.449 | -0.073 | -0.307 | — |
| chr7_99679986_C_A | chr7:99679986 | 0.445 | 0.393 | 0.118 | — |
| chr7_99679988_C_G | chr7:99679988 | 0.412 | 0.288 | 0.699 | — |
| chr7_99680008_A_G | chr7:99680008 | -0.441 | -0.214 | -0.124 | — |
| chr7_99680057_C_A | chr7:99680057 | -0.439 | -0.332 | -0.353 | — |
| chr7_99680031_T_A | chr7:99680031 | -0.433 | -0.252 | -0.333 | — |
| chr7_99680079_C_A | chr7:99680079 | -0.433 | -0.281 | -0.373 | — |
| chr7_99679977_G_A | chr7:99679977 | 0.429 | 0.230 | 0.275 | — |
| chr7_99680052_A_T | chr7:99680052 | 0.427 | 0.236 | 0.248 | — |
| chr7_99680076_G_T | chr7:99680076 | -0.427 | -0.220 | -0.379 | — |
| chr7_99671564_C_T | chr7:99671564 | 0.419 | 0.540 | 0.363 | — |
| chr7_99679999_T_G | chr7:99679999 | 0.416 | 0.256 | 0.569 | — |
| chr7_99671549_A_C | chr7:99671549 | -0.406 | -0.431 | -0.386 | — |
| chr7_99680044_A_C | chr7:99680044 | -0.406 | -0.240 | -0.294 | — |
| chr7_99679995_G_A | chr7:99679995 | -0.404 | -0.198 | -0.255 | — |
| chr7_99679974_G_A | chr7:99679974 | 0.400 | 0.297 | 0.033 | — |
| chr7_99680050_A_T | chr7:99680050 | 0.400 | 0.284 | 0.366 | — |
| chr7_99680051_T_G | chr7:99680051 | 0.400 | 0.182 | 0.255 | — |
| chr7_99671481_T_G | chr7:99671481 | 0.398 | 0.310 | 0.284 | — |
| chr7_99671547_T_A | chr7:99671547 | -0.398 | -0.422 | -0.441 | — |
| chr7_99680001_T_G | chr7:99680001 | 0.396 | 0.163 | 0.510 | — |
| chr7_99679984_T_C | chr7:99679984 | -0.392 | -0.387 | -0.039 | — |
| chr7_99671547_T_G | chr7:99671547 | -0.390 | -0.428 | -0.408 | — |
| chr7_99671555_G_C | chr7:99671555 | -0.386 | -0.406 | -0.412 | — |
| chr7_99680034_A_C | chr7:99680034 | 0.384 | 0.153 | 0.366 | — |
| chr7_99680019_A_G | chr7:99680019 | -0.379 | -0.240 | -0.373 | — |
| chr7_99680024_T_A | chr7:99680024 | 0.379 | 0.316 | 0.163 | — |
| chr7_99671553_T_C | chr7:99671553 | -0.377 | -0.399 | -0.395 | — |
| chr7_99671581_T_A | chr7:99671581 | -0.377 | -0.371 | -0.350 | — |
| chr7_99671555_G_A | chr7:99671555 | -0.375 | -0.396 | -0.415 | — |
| chr7_99680068_A_T | chr7:99680068 | -0.373 | -0.406 | -0.301 | — |
| chr7_99680019_A_T | chr7:99680019 | 0.371 | 0.358 | 0.288 | — |
| chr7_99671549_A_T | chr7:99671549 | -0.369 | -0.409 | -0.379 | — |
| chr7_99671570_A_G | chr7:99671570 | 0.369 | 0.339 | 0.297 | — |
| chr7_99671555_G_T | chr7:99671555 | -0.367 | -0.390 | -0.412 | — |
| chr7_99680010_G_C | chr7:99680010 | -0.367 | 0.051 | -0.275 | — |
| chr7_99680012_T_A | chr7:99680012 | -0.363 | -0.220 | -0.268 | — |
| chr7_99680016_G_T | chr7:99680016 | -0.363 | -0.198 | -0.392 | — |
| chr7_99671579_A_T | chr7:99671579 | -0.361 | -0.380 | -0.363 | — |
| chr7_99680080_A_G | chr7:99680080 | -0.359 | -0.214 | -0.222 | — |
| chr7_99671579_A_G | chr7:99671579 | -0.355 | -0.367 | -0.359 | — |
| chr7_99680011_C_G | chr7:99680011 | 0.355 | -0.246 | -0.248 | — |
| chr7_99680055_T_A | chr7:99680055 | 0.355 | 0.236 | 0.216 | — |
| chr7_99671570_A_C | chr7:99671570 | 0.351 | 0.297 | 0.275 | — |
| chr7_99671501_T_G | chr7:99671501 | 0.348 | 0.454 | 0.363 | — |
| chr7_99671554_T_G | chr7:99671554 | -0.346 | -0.358 | -0.369 | — |
| chr7_99679996_C_G | chr7:99679996 | -0.346 | -0.144 | -0.346 | — |
| chr7_99679997_A_G | chr7:99679997 | 0.346 | 0.166 | 0.288 | — |
| chr7_99680004_A_T | chr7:99680004 | 0.346 | 0.150 | 0.222 | — |
| chr7_99671495_T_A | chr7:99671495 | 0.344 | 0.387 | 0.291 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.