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CYP8B1
receptor: FXRTier 1
CAMIP causal chains
FXR
Altered receptor-mediated feedback repression of CYP8B1, shifting the cholic acid to chenodeoxycholic acid synthesis ratio in endogenous bile acid pathways.
Affected substrate drugs (PharmGKB): none in routine clinical use, endogenous or bile acid pathway
Scored variants near CYP8B1
chr3:42,772,191..42,975,879, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr3_42804703_T_G | chr3:42804703 | 0.479 | 0.457 | 1.000 | — |
| chr3_42804558_A_T | chr3:42804558 | 0.626 | 0.616 | 0.721 | <0.001% |
| chr3_42804607_T_C | chr3:42804607 | 0.607 | -0.353 | 0.525 | — |
| chr3_42804709_G_C | chr3:42804709 | 0.597 | 0.369 | 0.427 | — |
| chr3_42804827_G_T | chr3:42804827 | 0.099 | 0.208 | 0.977 | 0.0013% |
| chr3_42804710_G_A | chr3:42804710 | 0.538 | 0.374 | 0.366 | — |
| chr3_42804609_G_A | chr3:42804609 | 0.526 | -0.200 | 0.598 | — |
| chr3_42804708_G_C | chr3:42804708 | 0.523 | 0.309 | 0.318 | — |
| chr3_42804609_G_C | chr3:42804609 | 0.499 | -0.270 | 0.562 | — |
| chr3_42804709_G_A | chr3:42804709 | 0.497 | 0.208 | 0.122 | 0.011% |
| chr3_42804709_G_T | chr3:42804709 | 0.489 | 0.309 | 0.342 | — |
| chr3_42804532_A_G | chr3:42804532 | 0.480 | -0.195 | 0.403 | — |
| chr3_42804560_G_A | chr3:42804560 | 0.014 | 0.000 | 0.855 | <0.001% |
| chr3_42804708_G_A | chr3:42804708 | 0.479 | 0.299 | 0.183 | <0.001% |
| chr3_42804707_G_A | chr3:42804707 | 0.467 | 0.361 | 0.391 | 0.0020% |
| chr3_42804625_C_A | chr3:42804625 | -0.455 | 0.029 | -0.342 | — |
| chr3_42804609_G_T | chr3:42804609 | 0.446 | -0.340 | 0.379 | — |
| chr3_42804707_G_C | chr3:42804707 | 0.446 | 0.405 | 0.525 | — |
| chr3_42804710_G_C | chr3:42804710 | 0.436 | 0.322 | 0.501 | — |
| chr3_42804605_A_C | chr3:42804605 | 0.434 | -0.330 | 0.586 | — |
| chr3_42804607_T_G | chr3:42804607 | 0.426 | -0.309 | 0.550 | — |
| chr3_42804576_C_G | chr3:42804576 | 0.414 | 0.047 | 0.024 | — |
| chr3_42804708_G_T | chr3:42804708 | 0.414 | 0.309 | 0.281 | — |
| chr3_42804606_T_C | chr3:42804606 | 0.410 | -0.265 | 0.586 | — |
| chr3_42804707_G_T | chr3:42804707 | 0.400 | 0.249 | 0.305 | — |
| chr3_42804578_G_C | chr3:42804578 | -0.060 | -0.047 | 0.708 | — |
| chr3_42804577_G_A | chr3:42804577 | 0.191 | 0.294 | 0.684 | <0.001% |
| chr3_42804664_G_C | chr3:42804664 | 0.147 | 0.127 | 0.672 | — |
| chr3_42804611_T_A | chr3:42804611 | 0.362 | -0.060 | 0.379 | — |
| chr3_42804530_C_A | chr3:42804530 | 0.347 | -0.423 | 0.085 | — |
| chr3_42804562_G_A | chr3:42804562 | -0.209 | 0.083 | -0.586 | — |
| chr3_42804635_A_G | chr3:42804635 | 0.326 | 0.231 | 0.159 | — |
| chr3_42804559_C_G | chr3:42804559 | -0.154 | -0.184 | -0.562 | — |
| chr3_42804612_G_T | chr3:42804612 | 0.315 | -0.042 | 0.391 | — |
| chr3_42804531_C_T | chr3:42804531 | 0.311 | -0.273 | 0.232 | — |
| chr3_42804711_C_A | chr3:42804711 | 0.311 | 0.218 | 0.256 | — |
| chr3_42804692_C_A | chr3:42804692 | 0.256 | 0.161 | 0.525 | — |
| chr3_42804593_A_G | chr3:42804593 | 0.291 | -0.161 | 0.220 | — |
| chr3_42804608_G_A | chr3:42804608 | 0.291 | -0.270 | 0.513 | — |
| chr3_42804687_G_C | chr3:42804687 | 0.289 | 0.169 | 0.073 | — |
| chr3_42804534_T_G | chr3:42804534 | 0.287 | -0.382 | 0.281 | — |
| chr3_42804756_T_G | chr3:42804756 | 0.285 | 0.278 | 0.366 | — |
| chr3_42804605_A_T | chr3:42804605 | 0.284 | -0.335 | 0.403 | — |
| chr3_42804847_G_A | chr3:42804847 | 0.021 | -0.091 | -0.501 | — |
| chr3_42804532_A_C | chr3:42804532 | 0.279 | -0.343 | 0.244 | — |
| chr3_42804606_T_G | chr3:42804606 | 0.275 | -0.312 | 0.427 | — |
| chr3_42804711_C_T | chr3:42804711 | 0.275 | 0.234 | 0.183 | — |
| chr3_42804606_T_A | chr3:42804606 | 0.274 | -0.371 | 0.489 | — |
| chr3_42804610_C_G | chr3:42804610 | -0.026 | -0.335 | 0.489 | — |
| chr3_42804616_C_A | chr3:42804616 | 0.250 | 0.294 | 0.489 | — |
| chr3_42804733_T_A | chr3:42804733 | 0.144 | 0.239 | 0.489 | — |
| chr3_42804757_C_G | chr3:42804757 | 0.272 | 0.332 | 0.281 | — |
| chr3_42804566_G_A | chr3:42804566 | 0.270 | -0.091 | 0.476 | 0.0013% |
| chr3_42804833_G_T | chr3:42804833 | 0.133 | -0.073 | -0.476 | — |
| chr3_42804517_A_C | chr3:42804517 | 0.265 | -0.003 | -0.012 | — |
| chr3_42804559_C_A | chr3:42804559 | -0.260 | -0.034 | -0.269 | — |
| chr3_42804578_G_T | chr3:42804578 | -0.097 | -0.023 | 0.464 | — |
| chr3_42804528_A_T | chr3:42804528 | -0.253 | -0.057 | 0.110 | — |
| chr3_42804604_G_C | chr3:42804604 | 0.251 | -0.177 | 0.379 | — |
| chr3_42804630_C_A | chr3:42804630 | 0.251 | 0.192 | 0.037 | — |
| chr3_42804706_A_T | chr3:42804706 | 0.251 | 0.182 | 0.256 | — |
| chr3_42804608_G_C | chr3:42804608 | 0.248 | -0.319 | 0.232 | — |
| chr3_42804562_G_C | chr3:42804562 | -0.026 | -0.021 | -0.440 | — |
| chr3_42804669_G_C | chr3:42804669 | -0.039 | 0.442 | 0.440 | 0.0013% |
| chr3_42804711_C_G | chr3:42804711 | 0.246 | 0.229 | 0.159 | — |
| chr3_42804628_G_A | chr3:42804628 | 0.238 | 0.255 | 0.427 | — |
| chr3_42804534_T_A | chr3:42804534 | 0.238 | -0.231 | 0.208 | — |
| chr3_42804726_C_A | chr3:42804726 | 0.238 | 0.210 | 0.256 | — |
| chr3_42804529_G_C | chr3:42804529 | -0.236 | -0.317 | -0.281 | — |
| chr3_42804530_C_G | chr3:42804530 | 0.234 | -0.208 | 0.208 | — |
| chr3_42804560_G_T | chr3:42804560 | 0.234 | 0.073 | 0.256 | — |
| chr3_42804557_G_C | chr3:42804557 | 0.007 | -0.023 | 0.415 | — |
| chr3_42804563_T_A | chr3:42804563 | -0.024 | -0.143 | -0.415 | — |
| chr3_42804563_T_G | chr3:42804563 | -0.068 | -0.091 | -0.415 | — |
| chr3_42804564_G_C | chr3:42804564 | -0.053 | -0.101 | -0.415 | — |
| chr3_42804706_A_C | chr3:42804706 | 0.232 | 0.109 | 0.183 | — |
| chr3_42804846_T_G | chr3:42804846 | 0.217 | 0.060 | 0.415 | — |
| chr3_42804603_G_A | chr3:42804603 | 0.231 | -0.135 | 0.159 | — |
| chr3_42804621_A_G | chr3:42804621 | -0.231 | 0.034 | 0.159 | — |
| chr3_42804605_A_G | chr3:42804605 | 0.224 | -0.236 | 0.403 | — |
| chr3_42804660_G_C | chr3:42804660 | 0.063 | 0.073 | 0.403 | — |
| chr3_42804838_G_C | chr3:42804838 | 0.085 | 0.070 | 0.403 | — |
| chr3_42804516_C_G | chr3:42804516 | -0.224 | 0.042 | 0.012 | — |
| chr3_42804625_C_G | chr3:42804625 | -0.221 | 0.055 | -0.049 | 0.103% |
| chr3_42804578_G_A | chr3:42804578 | -0.063 | -0.052 | 0.391 | 0.0020% |
| chr3_42804580_T_G | chr3:42804580 | 0.070 | -0.003 | -0.391 | — |
| chr3_42804620_G_C | chr3:42804620 | 0.157 | 0.003 | 0.391 | — |
| chr3_42804634_T_G | chr3:42804634 | 0.219 | 0.177 | 0.342 | — |
| chr3_42804816_G_C | chr3:42804816 | 0.065 | 0.081 | 0.391 | — |
| chr3_42804652_C_T | chr3:42804652 | -0.217 | 0.229 | -0.183 | — |
| chr3_42804568_G_C | chr3:42804568 | -0.185 | -0.021 | -0.379 | — |
| chr3_42804627_G_C | chr3:42804627 | -0.212 | -0.018 | -0.293 | — |
| chr3_42804843_G_A | chr3:42804843 | 0.128 | -0.057 | -0.379 | — |
| chr3_42804623_T_G | chr3:42804623 | -0.188 | 0.023 | -0.366 | — |
| chr3_42804633_C_G | chr3:42804633 | 0.205 | 0.044 | 0.085 | — |
| chr3_42804651_A_G | chr3:42804651 | 0.091 | -0.039 | 0.366 | — |
| chr3_42804657_G_C | chr3:42804657 | 0.111 | 0.016 | 0.366 | — |
| chr3_42804663_A_T | chr3:42804663 | -0.039 | 0.213 | 0.366 | 0.030% |
| chr3_42804716_G_T | chr3:42804716 | -0.060 | -0.143 | -0.366 | — |
| chr3_42804551_C_G | chr3:42804551 | -0.203 | -0.008 | 0.159 | — |
| chr3_42804660_G_A | chr3:42804660 | -0.203 | 0.182 | 0.147 | 0.0013% |
| chr3_42804604_G_A | chr3:42804604 | 0.202 | -0.247 | 0.330 | — |
| chr3_42804557_G_T | chr3:42804557 | -0.074 | -0.010 | -0.354 | — |
| chr3_42804611_T_C | chr3:42804611 | 0.198 | -0.104 | 0.134 | <0.001% |
| chr3_42804697_G_T | chr3:42804697 | 0.108 | 0.114 | 0.354 | — |
| chr3_42804649_G_C | chr3:42804649 | -0.197 | 0.106 | -0.134 | — |
| chr3_42804633_C_A | chr3:42804633 | 0.195 | 0.104 | 0.195 | — |
| chr3_42804631_C_T | chr3:42804631 | 0.193 | 0.042 | 0.220 | — |
| chr3_42804520_G_T | chr3:42804520 | -0.191 | -0.031 | -0.208 | — |
| chr3_42804564_G_T | chr3:42804564 | 0.017 | -0.062 | -0.342 | — |
| chr3_42804594_G_C | chr3:42804594 | 0.191 | 0.016 | 0.171 | — |
| chr3_42804612_G_C | chr3:42804612 | 0.191 | -0.081 | 0.195 | — |
| chr3_42804775_C_T | chr3:42804775 | 0.068 | -0.062 | -0.342 | — |
| chr3_42804594_G_T | chr3:42804594 | 0.188 | 0.034 | 0.122 | — |
| chr3_42804705_G_A | chr3:42804705 | 0.188 | 0.119 | 0.049 | — |
| chr3_42804565_C_A | chr3:42804565 | 0.185 | 0.060 | 0.147 | — |
| chr3_42804577_G_T | chr3:42804577 | 0.079 | 0.062 | 0.330 | — |
| chr3_42804604_G_T | chr3:42804604 | 0.185 | -0.184 | 0.281 | — |
| chr3_42804733_T_G | chr3:42804733 | 0.120 | 0.169 | 0.330 | <0.001% |
| chr3_42804811_C_G | chr3:42804811 | 0.022 | -0.016 | 0.330 | — |
| chr3_42804556_G_T | chr3:42804556 | -0.179 | 0.169 | 0.000 | — |
| chr3_42804666_C_G | chr3:42804666 | 0.179 | -0.042 | 0.073 | — |
| chr3_42804550_G_A | chr3:42804550 | 0.166 | 0.029 | 0.318 | — |
| chr3_42804652_C_A | chr3:42804652 | -0.103 | -0.029 | 0.318 | — |
| chr3_42804687_G_A | chr3:42804687 | 0.174 | 0.083 | -0.037 | 0.059% |
| chr3_42804732_C_T | chr3:42804732 | 0.173 | 0.112 | 0.122 | — |
| chr3_42804580_T_C | chr3:42804580 | -0.024 | -0.112 | -0.305 | — |
| chr3_42804611_T_G | chr3:42804611 | 0.171 | -0.169 | 0.049 | — |
| chr3_42804643_T_C | chr3:42804643 | -0.043 | 0.034 | 0.305 | — |
| chr3_42804691_G_C | chr3:42804691 | -0.097 | -0.044 | -0.305 | — |
| chr3_42804712_T_A | chr3:42804712 | 0.157 | 0.140 | 0.305 | — |
| chr3_42804712_T_G | chr3:42804712 | 0.166 | 0.073 | 0.305 | — |
| chr3_42804819_G_T | chr3:42804819 | -0.022 | -0.026 | -0.305 | — |
| chr3_42804541_C_T | chr3:42804541 | 0.169 | 0.255 | 0.134 | — |
| chr3_42804575_G_T | chr3:42804575 | -0.169 | 0.086 | 0.024 | — |
| chr3_42804584_G_C | chr3:42804584 | -0.166 | -0.075 | -0.012 | — |
| chr3_42804758_C_A | chr3:42804758 | 0.166 | 0.244 | 0.147 | — |
| chr3_42804529_G_T | chr3:42804529 | -0.164 | -0.075 | -0.122 | — |
| chr3_42804559_C_T | chr3:42804559 | -0.159 | -0.094 | -0.293 | — |
| chr3_42804567_T_G | chr3:42804567 | 0.164 | -0.117 | 0.122 | — |
| chr3_42804613_G_T | chr3:42804613 | 0.164 | 0.013 | 0.000 | — |
| chr3_42804664_G_T | chr3:42804664 | -0.019 | 0.153 | 0.293 | — |
| chr3_42804698_G_C | chr3:42804698 | 0.164 | 0.247 | 0.244 | — |
| chr3_42804751_C_A | chr3:42804751 | 0.019 | -0.112 | -0.293 | — |
| chr3_42804793_T_G | chr3:42804793 | 0.012 | -0.062 | -0.293 | — |
| chr3_42804821_C_G | chr3:42804821 | 0.019 | 0.057 | 0.293 | 0.0013% |
| chr3_42804550_G_T | chr3:42804550 | 0.159 | 0.145 | 0.256 | — |
| chr3_42804607_T_A | chr3:42804607 | 0.159 | -0.099 | 0.147 | — |
| chr3_42804618_G_T | chr3:42804618 | -0.159 | 0.109 | -0.220 | — |
| chr3_42804722_G_T | chr3:42804722 | 0.159 | 0.161 | 0.244 | — |
| chr3_42804553_A_T | chr3:42804553 | 0.157 | 0.091 | 0.171 | — |
| chr3_42804556_G_A | chr3:42804556 | -0.084 | -0.106 | -0.281 | — |
| chr3_42804565_C_G | chr3:42804565 | -0.082 | -0.073 | -0.281 | — |
| chr3_42804734_C_G | chr3:42804734 | 0.144 | 0.210 | 0.281 | — |
| chr3_42804752_C_G | chr3:42804752 | 0.005 | -0.096 | -0.281 | — |
| chr3_42804839_A_C | chr3:42804839 | 0.051 | 0.060 | 0.281 | — |
| chr3_42804757_C_A | chr3:42804757 | 0.156 | 0.197 | 0.183 | <0.001% |
| chr3_42804696_C_A | chr3:42804696 | 0.154 | 0.177 | 0.110 | — |
| chr3_42804712_T_C | chr3:42804712 | 0.154 | 0.143 | 0.269 | — |
| chr3_42804537_G_T | chr3:42804537 | -0.150 | -0.070 | -0.147 | — |
| chr3_42804584_G_T | chr3:42804584 | 0.084 | -0.029 | 0.269 | — |
| chr3_42804658_G_T | chr3:42804658 | -0.022 | 0.122 | 0.269 | — |
| chr3_42804667_G_T | chr3:42804667 | -0.079 | -0.086 | -0.269 | — |
| chr3_42804700_C_A | chr3:42804700 | -0.084 | -0.132 | -0.269 | — |
| chr3_42804706_A_G | chr3:42804706 | -0.150 | -0.148 | -0.171 | — |
| chr3_42804745_T_A | chr3:42804745 | 0.150 | 0.143 | 0.110 | — |
| chr3_42804816_G_T | chr3:42804816 | 0.005 | 0.086 | 0.269 | — |
| chr3_42804825_C_G | chr3:42804825 | -0.043 | -0.031 | -0.269 | — |
| chr3_42804705_G_C | chr3:42804705 | 0.149 | 0.086 | 0.024 | — |
| chr3_42804734_C_T | chr3:42804734 | 0.149 | 0.223 | 0.159 | — |
| chr3_42804690_C_A | chr3:42804690 | 0.147 | 0.117 | 0.049 | — |
| chr3_42804699_G_T | chr3:42804699 | 0.147 | 0.171 | 0.256 | — |
| chr3_42804576_C_T | chr3:42804576 | -0.145 | 0.106 | -0.134 | — |
| chr3_42804595_C_G | chr3:42804595 | -0.145 | -0.036 | 0.122 | — |
| chr3_42804608_G_T | chr3:42804608 | 0.145 | -0.306 | 0.232 | — |
| chr3_42804553_A_C | chr3:42804553 | 0.097 | 0.094 | 0.256 | — |
| chr3_42804561_C_A | chr3:42804561 | 0.015 | 0.021 | -0.256 | — |
| chr3_42804564_G_A | chr3:42804564 | -0.144 | 0.140 | -0.195 | — |
| chr3_42804629_C_T | chr3:42804629 | 0.067 | -0.161 | -0.256 | — |
| chr3_42804658_G_C | chr3:42804658 | 0.055 | 0.109 | 0.256 | — |
| chr3_42804786_A_C | chr3:42804786 | 0.044 | -0.052 | 0.256 | — |
| chr3_42804840_T_G | chr3:42804840 | -0.009 | 0.042 | 0.256 | — |
| chr3_42804630_C_T | chr3:42804630 | 0.142 | 0.088 | -0.061 | — |
| chr3_42804565_C_T | chr3:42804565 | 0.140 | -0.010 | -0.220 | — |
| chr3_42804838_G_T | chr3:42804838 | 0.140 | -0.005 | -0.171 | — |
| chr3_42804632_A_T | chr3:42804632 | 0.138 | 0.088 | 0.024 | — |
| chr3_42804749_G_C | chr3:42804749 | 0.138 | 0.031 | 0.037 | — |
| chr3_42804573_C_T | chr3:42804573 | -0.115 | 0.138 | 0.244 | — |
| chr3_42804626_T_C | chr3:42804626 | -0.137 | 0.055 | -0.195 | — |
| chr3_42804646_A_T | chr3:42804646 | 0.041 | 0.203 | 0.244 | — |
| chr3_42804675_T_A | chr3:42804675 | 0.085 | 0.049 | 0.244 | — |
| chr3_42804700_C_G | chr3:42804700 | -0.094 | -0.156 | -0.244 | — |
| chr3_42804702_C_A | chr3:42804702 | 0.017 | -0.047 | -0.244 | — |
| chr3_42804703_T_A | chr3:42804703 | 0.062 | 0.008 | 0.244 | — |
| chr3_42804734_C_A | chr3:42804734 | 0.082 | 0.208 | 0.244 | — |
| chr3_42804771_G_T | chr3:42804771 | -0.002 | 0.075 | 0.244 | — |
| chr3_42804815_G_A | chr3:42804815 | 0.002 | -0.013 | -0.244 | 0.0099% |
| chr3_42804824_A_T | chr3:42804824 | -0.041 | -0.026 | -0.244 | — |
| chr3_42804840_T_C | chr3:42804840 | 0.031 | 0.060 | 0.244 | — |
| chr3_42804717_C_T | chr3:42804717 | -0.132 | -0.112 | -0.110 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.