Home / Gene
CYP8B1
receptor: FXRTier 1
CAMIP causal chains
FXR
Altered receptor-mediated feedback repression of CYP8B1, shifting the cholic acid to chenodeoxycholic acid synthesis ratio in endogenous bile acid pathways.
Affected substrate drugs (PharmGKB): none in routine clinical use, endogenous or bile acid pathway
Scored variants near CYP8B1
chr3:42,772,191..42,975,879, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr3_42804558_A_T | chr3:42804558 | 23,424 | 7,584 | 15,104 | 6.6e-6 |
| chr3_42804607_T_C | chr3:42804607 | 22,720 | -4,352 | 11,008 | — |
| chr3_42804709_G_C | chr3:42804709 | 22,336 | 4,544 | 8,960 | — |
| chr3_42804710_G_A | chr3:42804710 | 20,160 | 4,608 | 7,680 | — |
| chr3_42804609_G_A | chr3:42804609 | 19,712 | -2,464 | 12,544 | — |
| chr3_42804708_G_C | chr3:42804708 | 19,584 | 3,808 | 6,656 | — |
| chr3_42804609_G_C | chr3:42804609 | 18,688 | -3,328 | 11,776 | — |
| chr3_42804709_G_A | chr3:42804709 | 18,624 | 2,560 | 2,560 | 1.1e-4 |
| chr3_42804709_G_T | chr3:42804709 | 18,304 | 3,808 | 7,168 | — |
| chr3_42804532_A_G | chr3:42804532 | 17,984 | -2,400 | 8,448 | — |
| chr3_42804703_T_G | chr3:42804703 | 17,920 | 5,632 | 25,600 | — |
| chr3_42804708_G_A | chr3:42804708 | 17,920 | 3,680 | 3,840 | 6.6e-6 |
| chr3_42804707_G_A | chr3:42804707 | 17,472 | 4,448 | 8,192 | 2.0e-5 |
| chr3_42804625_C_A | chr3:42804625 | -17,024 | 352 | -7,168 | — |
| chr3_42804609_G_T | chr3:42804609 | 16,704 | -4,192 | 7,936 | — |
| chr3_42804707_G_C | chr3:42804707 | 16,704 | 4,992 | 11,008 | — |
| chr3_42804710_G_C | chr3:42804710 | 16,320 | 3,968 | 10,496 | — |
| chr3_42804605_A_C | chr3:42804605 | 16,256 | -4,064 | 12,288 | — |
| chr3_42804607_T_G | chr3:42804607 | 15,936 | -3,808 | 11,520 | — |
| chr3_42804576_C_G | chr3:42804576 | 15,488 | 576 | 512 | — |
| chr3_42804708_G_T | chr3:42804708 | 15,488 | 3,808 | 5,888 | — |
| chr3_42804606_T_C | chr3:42804606 | 15,360 | -3,264 | 12,288 | — |
| chr3_42804707_G_T | chr3:42804707 | 14,976 | 3,072 | 6,400 | — |
| chr3_42804611_T_A | chr3:42804611 | 13,568 | -736 | 7,936 | — |
| chr3_42804530_C_A | chr3:42804530 | 12,992 | -5,216 | 1,792 | — |
| chr3_42804635_A_G | chr3:42804635 | 12,224 | 2,848 | 3,328 | — |
| chr3_42804612_G_T | chr3:42804612 | 11,776 | -512 | 8,192 | — |
| chr3_42804531_C_T | chr3:42804531 | 11,648 | -3,360 | 4,864 | — |
| chr3_42804711_C_A | chr3:42804711 | 11,648 | 2,688 | 5,376 | — |
| chr3_42804593_A_G | chr3:42804593 | 10,880 | -1,984 | 4,608 | — |
| chr3_42804608_G_A | chr3:42804608 | 10,880 | -3,328 | 10,752 | — |
| chr3_42804687_G_C | chr3:42804687 | 10,816 | 2,080 | 1,536 | — |
| chr3_42804534_T_G | chr3:42804534 | 10,752 | -4,704 | 5,888 | — |
| chr3_42804756_T_G | chr3:42804756 | 10,688 | 3,424 | 7,680 | — |
| chr3_42804605_A_T | chr3:42804605 | 10,624 | -4,128 | 8,448 | — |
| chr3_42804532_A_C | chr3:42804532 | 10,432 | -4,224 | 5,120 | — |
| chr3_42804606_T_G | chr3:42804606 | 10,304 | -3,840 | 8,960 | — |
| chr3_42804711_C_T | chr3:42804711 | 10,304 | 2,880 | 3,840 | — |
| chr3_42804606_T_A | chr3:42804606 | 10,240 | -4,576 | 10,240 | — |
| chr3_42804757_C_G | chr3:42804757 | 10,176 | 4,096 | 5,888 | — |
| chr3_42804566_G_A | chr3:42804566 | 10,112 | -1,120 | 9,984 | 1.3e-5 |
| chr3_42804517_A_C | chr3:42804517 | 9,920 | -32 | -256 | — |
| chr3_42804559_C_A | chr3:42804559 | -9,728 | -416 | -5,632 | — |
| chr3_42804692_C_A | chr3:42804692 | 9,600 | 1,984 | 11,008 | — |
| chr3_42804528_A_T | chr3:42804528 | -9,472 | -704 | 2,304 | — |
| chr3_42804604_G_C | chr3:42804604 | 9,408 | -2,176 | 7,936 | — |
| chr3_42804630_C_A | chr3:42804630 | 9,408 | 2,368 | 768 | — |
| chr3_42804706_A_T | chr3:42804706 | 9,408 | 2,240 | 5,376 | — |
| chr3_42804616_C_A | chr3:42804616 | 9,344 | 3,616 | 10,240 | — |
| chr3_42804608_G_C | chr3:42804608 | 9,280 | -3,936 | 4,864 | — |
| chr3_42804711_C_G | chr3:42804711 | 9,216 | 2,816 | 3,328 | — |
| chr3_42804628_G_A | chr3:42804628 | 8,896 | 3,136 | 8,960 | — |
| chr3_42804534_T_A | chr3:42804534 | 8,896 | -2,848 | 4,352 | — |
| chr3_42804726_C_A | chr3:42804726 | 8,896 | 2,592 | 5,376 | — |
| chr3_42804529_G_C | chr3:42804529 | -8,832 | -3,904 | -5,888 | — |
| chr3_42804530_C_G | chr3:42804530 | 8,768 | -2,560 | 4,352 | — |
| chr3_42804560_G_T | chr3:42804560 | 8,768 | 896 | 5,376 | — |
| chr3_42804706_A_C | chr3:42804706 | 8,704 | 1,344 | 3,840 | — |
| chr3_42804603_G_A | chr3:42804603 | 8,640 | -1,664 | 3,328 | — |
| chr3_42804621_A_G | chr3:42804621 | -8,640 | 416 | 3,328 | — |
| chr3_42804605_A_G | chr3:42804605 | 8,384 | -2,912 | 8,448 | — |
| chr3_42804516_C_G | chr3:42804516 | -8,384 | 512 | 256 | — |
| chr3_42804625_C_G | chr3:42804625 | -8,256 | 672 | -1,024 | 1.0e-3 |
| chr3_42804634_T_G | chr3:42804634 | 8,192 | 2,176 | 7,168 | — |
| chr3_42804846_T_G | chr3:42804846 | 8,128 | 736 | 8,704 | — |
| chr3_42804652_C_T | chr3:42804652 | -8,128 | 2,816 | -3,840 | — |
| chr3_42804627_G_C | chr3:42804627 | -7,936 | -224 | -6,144 | — |
| chr3_42804562_G_A | chr3:42804562 | -7,808 | 1,024 | -12,288 | — |
| chr3_42804633_C_G | chr3:42804633 | 7,680 | 544 | 1,792 | — |
| chr3_42804551_C_G | chr3:42804551 | -7,616 | -96 | 3,328 | — |
| chr3_42804660_G_A | chr3:42804660 | -7,616 | 2,240 | 3,072 | 1.3e-5 |
| chr3_42804604_G_A | chr3:42804604 | 7,552 | -3,040 | 6,912 | — |
| chr3_42804611_T_C | chr3:42804611 | 7,424 | -1,280 | 2,816 | 6.6e-6 |
| chr3_42804649_G_C | chr3:42804649 | -7,360 | 1,312 | -2,816 | — |
| chr3_42804633_C_A | chr3:42804633 | 7,296 | 1,280 | 4,096 | — |
| chr3_42804631_C_T | chr3:42804631 | 7,232 | 512 | 4,608 | — |
| chr3_42804577_G_A | chr3:42804577 | 7,168 | 3,616 | 14,336 | 6.6e-6 |
| chr3_42804520_G_T | chr3:42804520 | -7,168 | -384 | -4,352 | — |
| chr3_42804594_G_C | chr3:42804594 | 7,168 | 192 | 3,584 | — |
| chr3_42804612_G_C | chr3:42804612 | 7,168 | -992 | 4,096 | — |
| chr3_42804623_T_G | chr3:42804623 | -7,040 | 288 | -7,680 | — |
| chr3_42804594_G_T | chr3:42804594 | 7,040 | 416 | 2,560 | — |
| chr3_42804705_G_A | chr3:42804705 | 7,040 | 1,472 | 1,024 | — |
| chr3_42804568_G_C | chr3:42804568 | -6,912 | -256 | -7,936 | — |
| chr3_42804565_C_A | chr3:42804565 | 6,912 | 736 | 3,072 | — |
| chr3_42804604_G_T | chr3:42804604 | 6,912 | -2,272 | 5,888 | — |
| chr3_42804556_G_T | chr3:42804556 | -6,720 | 2,080 | 0 | — |
| chr3_42804666_C_G | chr3:42804666 | 6,720 | -512 | 1,536 | — |
| chr3_42804687_G_A | chr3:42804687 | 6,528 | 1,024 | -768 | 5.9e-4 |
| chr3_42804732_C_T | chr3:42804732 | 6,464 | 1,376 | 2,560 | — |
| chr3_42804611_T_G | chr3:42804611 | 6,400 | -2,080 | 1,024 | — |
| chr3_42804541_C_T | chr3:42804541 | 6,336 | 3,136 | 2,816 | — |
| chr3_42804575_G_T | chr3:42804575 | -6,336 | 1,056 | 512 | — |
| chr3_42804550_G_A | chr3:42804550 | 6,208 | 352 | 6,656 | — |
| chr3_42804712_T_G | chr3:42804712 | 6,208 | 896 | 6,400 | — |
| chr3_42804584_G_C | chr3:42804584 | -6,208 | -928 | -256 | — |
| chr3_42804758_C_A | chr3:42804758 | 6,208 | 3,008 | 3,072 | — |
| chr3_42804529_G_T | chr3:42804529 | -6,144 | -928 | -2,560 | — |
| chr3_42804567_T_G | chr3:42804567 | 6,144 | -1,440 | 2,560 | — |
| chr3_42804613_G_T | chr3:42804613 | 6,144 | 160 | 0 | — |
| chr3_42804698_G_C | chr3:42804698 | 6,144 | 3,040 | 5,120 | — |
| chr3_42804559_C_T | chr3:42804559 | -5,952 | -1,152 | -6,144 | — |
| chr3_42804550_G_T | chr3:42804550 | 5,952 | 1,792 | 5,376 | — |
| chr3_42804607_T_A | chr3:42804607 | 5,952 | -1,216 | 3,072 | — |
| chr3_42804618_G_T | chr3:42804618 | -5,952 | 1,344 | -4,608 | — |
| chr3_42804722_G_T | chr3:42804722 | 5,952 | 1,984 | 5,120 | — |
| chr3_42804620_G_C | chr3:42804620 | 5,888 | 32 | 8,192 | — |
| chr3_42804712_T_A | chr3:42804712 | 5,888 | 1,728 | 6,400 | — |
| chr3_42804553_A_T | chr3:42804553 | 5,888 | 1,120 | 3,584 | — |
| chr3_42804757_C_A | chr3:42804757 | 5,824 | 2,432 | 3,840 | 6.6e-6 |
| chr3_42804559_C_G | chr3:42804559 | -5,760 | -2,272 | -11,776 | — |
| chr3_42804696_C_A | chr3:42804696 | 5,760 | 2,176 | 2,304 | — |
| chr3_42804712_T_C | chr3:42804712 | 5,760 | 1,760 | 5,632 | — |
| chr3_42804537_G_T | chr3:42804537 | -5,632 | -864 | -3,072 | — |
| chr3_42804706_A_G | chr3:42804706 | -5,632 | -1,824 | -3,584 | — |
| chr3_42804745_T_A | chr3:42804745 | 5,632 | 1,760 | 2,304 | — |
| chr3_42804705_G_C | chr3:42804705 | 5,568 | 1,056 | 512 | — |
| chr3_42804734_C_T | chr3:42804734 | 5,568 | 2,752 | 3,328 | — |
| chr3_42804664_G_C | chr3:42804664 | 5,504 | 1,568 | 14,080 | — |
| chr3_42804690_C_A | chr3:42804690 | 5,504 | 1,440 | 1,024 | — |
| chr3_42804699_G_T | chr3:42804699 | 5,504 | 2,112 | 5,376 | — |
| chr3_42804576_C_T | chr3:42804576 | -5,440 | 1,312 | -2,816 | — |
| chr3_42804595_C_G | chr3:42804595 | -5,440 | -448 | 2,560 | — |
| chr3_42804608_G_T | chr3:42804608 | 5,440 | -3,776 | 4,864 | — |
| chr3_42804733_T_A | chr3:42804733 | 5,376 | 2,944 | 10,240 | — |
| chr3_42804734_C_G | chr3:42804734 | 5,376 | 2,592 | 5,888 | — |
| chr3_42804564_G_A | chr3:42804564 | -5,376 | 1,728 | -4,096 | — |
| chr3_42804630_C_T | chr3:42804630 | 5,312 | 1,088 | -1,280 | — |
| chr3_42804565_C_T | chr3:42804565 | 5,248 | -128 | -4,608 | — |
| chr3_42804838_G_T | chr3:42804838 | 5,248 | -64 | -3,584 | — |
| chr3_42804632_A_T | chr3:42804632 | 5,184 | 1,088 | 512 | — |
| chr3_42804749_G_C | chr3:42804749 | 5,184 | 384 | 768 | — |
| chr3_42804626_T_C | chr3:42804626 | -5,120 | 672 | -4,096 | — |
| chr3_42804833_G_T | chr3:42804833 | 4,992 | -896 | -9,984 | — |
| chr3_42804717_C_T | chr3:42804717 | -4,928 | -1,376 | -2,304 | — |
| chr3_42804843_G_A | chr3:42804843 | 4,800 | -704 | -7,936 | — |
| chr3_42804733_T_G | chr3:42804733 | 4,480 | 2,080 | 6,912 | 6.6e-6 |
| chr3_42804573_C_T | chr3:42804573 | -4,288 | 1,696 | 5,120 | — |
| chr3_42804657_G_C | chr3:42804657 | 4,160 | 192 | 7,680 | — |
| chr3_42804697_G_T | chr3:42804697 | 4,032 | 1,408 | 7,424 | — |
| chr3_42804652_C_A | chr3:42804652 | -3,840 | -352 | 6,656 | — |
| chr3_42804827_G_T | chr3:42804827 | 3,712 | 2,560 | 20,480 | 1.3e-5 |
| chr3_42804578_G_T | chr3:42804578 | -3,648 | -288 | 9,728 | — |
| chr3_42804691_G_C | chr3:42804691 | -3,648 | -544 | -6,400 | — |
| chr3_42804553_A_C | chr3:42804553 | 3,648 | 1,152 | 5,376 | — |
| chr3_42804700_C_G | chr3:42804700 | -3,520 | -1,920 | -5,120 | — |
| chr3_42804651_A_G | chr3:42804651 | 3,392 | -480 | 7,680 | — |
| chr3_42804838_G_C | chr3:42804838 | 3,200 | 864 | 8,448 | — |
| chr3_42804675_T_A | chr3:42804675 | 3,200 | 608 | 5,120 | — |
| chr3_42804556_G_A | chr3:42804556 | -3,136 | -1,312 | -5,888 | — |
| chr3_42804584_G_T | chr3:42804584 | 3,136 | -352 | 5,632 | — |
| chr3_42804700_C_A | chr3:42804700 | -3,136 | -1,632 | -5,632 | — |
| chr3_42804565_C_G | chr3:42804565 | -3,072 | -896 | -5,888 | — |
| chr3_42804734_C_A | chr3:42804734 | 3,072 | 2,560 | 5,120 | — |
| chr3_42804577_G_T | chr3:42804577 | 2,944 | 768 | 6,912 | — |
| chr3_42804667_G_T | chr3:42804667 | -2,944 | -1,056 | -5,632 | — |
| chr3_42804557_G_T | chr3:42804557 | -2,752 | -128 | -7,424 | — |
| chr3_42804580_T_G | chr3:42804580 | 2,624 | -32 | -8,192 | — |
| chr3_42804563_T_G | chr3:42804563 | -2,560 | -1,120 | -8,704 | — |
| chr3_42804775_C_T | chr3:42804775 | 2,560 | -768 | -7,168 | — |
| chr3_42804629_C_T | chr3:42804629 | 2,496 | -1,984 | -5,376 | — |
| chr3_42804816_G_C | chr3:42804816 | 2,432 | 992 | 8,192 | — |
| chr3_42804660_G_C | chr3:42804660 | 2,368 | 896 | 8,448 | — |
| chr3_42804578_G_A | chr3:42804578 | -2,368 | -640 | 8,192 | 2.0e-5 |
| chr3_42804703_T_A | chr3:42804703 | 2,304 | 96 | 5,120 | — |
| chr3_42804578_G_C | chr3:42804578 | -2,240 | -576 | 14,848 | — |
| chr3_42804716_G_T | chr3:42804716 | -2,240 | -1,760 | -7,680 | — |
| chr3_42804658_G_C | chr3:42804658 | 2,048 | 1,344 | 5,376 | — |
| chr3_42804564_G_C | chr3:42804564 | -1,984 | -1,248 | -8,704 | — |
| chr3_42804839_A_C | chr3:42804839 | 1,920 | 736 | 5,888 | — |
| chr3_42804786_A_C | chr3:42804786 | 1,664 | -640 | 5,376 | — |
| chr3_42804643_T_C | chr3:42804643 | -1,600 | 416 | 6,400 | — |
| chr3_42804825_C_G | chr3:42804825 | -1,600 | -384 | -5,632 | — |
| chr3_42804646_A_T | chr3:42804646 | 1,536 | 2,496 | 5,120 | — |
| chr3_42804824_A_T | chr3:42804824 | -1,536 | -320 | -5,120 | — |
| chr3_42804669_G_C | chr3:42804669 | -1,472 | 5,440 | 9,216 | 1.3e-5 |
| chr3_42804663_A_T | chr3:42804663 | -1,472 | 2,624 | 7,680 | 3.0e-4 |
| chr3_42804840_T_C | chr3:42804840 | 1,152 | 736 | 5,120 | — |
| chr3_42804610_C_G | chr3:42804610 | -960 | -4,128 | 10,240 | — |
| chr3_42804562_G_C | chr3:42804562 | -960 | -256 | -9,216 | — |
| chr3_42804563_T_A | chr3:42804563 | -896 | -1,760 | -8,704 | — |
| chr3_42804580_T_C | chr3:42804580 | -896 | -1,376 | -6,400 | — |
| chr3_42804811_C_G | chr3:42804811 | 832 | -192 | 6,912 | — |
| chr3_42804819_G_T | chr3:42804819 | -832 | -320 | -6,400 | — |
| chr3_42804658_G_T | chr3:42804658 | -832 | 1,504 | 5,632 | — |
| chr3_42804847_G_A | chr3:42804847 | 768 | -1,120 | -10,496 | — |
| chr3_42804664_G_T | chr3:42804664 | -704 | 1,888 | 6,144 | — |
| chr3_42804751_C_A | chr3:42804751 | 704 | -1,376 | -6,144 | — |
| chr3_42804821_C_G | chr3:42804821 | 704 | 704 | 6,144 | 1.3e-5 |
| chr3_42804564_G_T | chr3:42804564 | 640 | -768 | -7,168 | — |
| chr3_42804702_C_A | chr3:42804702 | 640 | -576 | -5,120 | — |
| chr3_42804561_C_A | chr3:42804561 | 576 | 256 | -5,376 | — |
| chr3_42804560_G_A | chr3:42804560 | 512 | 0 | 17,920 | 6.6e-6 |
| chr3_42804793_T_G | chr3:42804793 | 448 | -768 | -6,144 | — |
| chr3_42804840_T_G | chr3:42804840 | -320 | 512 | 5,376 | — |
| chr3_42804557_G_C | chr3:42804557 | 256 | -288 | 8,704 | — |
| chr3_42804752_C_G | chr3:42804752 | 192 | -1,184 | -5,888 | — |
| chr3_42804816_G_T | chr3:42804816 | 192 | 1,056 | 5,632 | — |
| chr3_42804771_G_T | chr3:42804771 | -64 | 928 | 5,120 | — |
| chr3_42804815_G_A | chr3:42804815 | 64 | -160 | -5,120 | 9.9e-5 |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.