Home / Gene
FGF19
receptor: FXRTier 1
CAMIP Tier 1: peak-anchored panel
FXR
Submitted decision (verbatim): 需修訂
Reviewer revision (verbatim)
Blunted receptor-mediated induction of intestinal FGF19 expression may weaken gut–liver endocrine signaling, thereby attenuating feedback repression of hepatic bile acid biosynthesis.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Obeticholic acid; Experimental GW4064
- Regulatory element
- at promoter -2789 bp
- Predicted consequence
- Attenuated receptor-mediated transcriptional activation of enterocyte FGF19, disrupting the intestinal endocrine signaling cascade required for the downstream feedback repression of hepatic bile acid biosynthesis.
- Prior narrative
- Attenuated receptor-mediated transcriptional activation of enterocyte FGF19, disrupting the intestinal endocrine signaling cascade required for the downstream feedback repression of hepatic bile acid biosynthesis.
- Drug context
- none in routine clinical use, endogenous or bile acid pathway
Scored variants near FGF19
chr11:69,598,237..69,804,022, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr11_69688546_T_A | chr11:69688546 | 0.514 | 0.470 | 0.388 | — |
| chr11_69688546_T_G | chr11:69688546 | 0.481 | 0.439 | 0.371 | — |
| chr11_69641732_A_G | chr11:69641732 | -0.155 | -0.187 | -0.806 | — |
| chr11_69641747_A_G | chr11:69641747 | -0.141 | -0.077 | -0.665 | — |
| chr11_69639073_A_C | chr11:69639073 | 0.375 | 0.315 | 0.565 | — |
| chr11_69688561_T_G | chr11:69688561 | 0.339 | 0.335 | 0.265 | — |
| chr11_69641741_T_G | chr11:69641741 | -0.115 | -0.094 | -0.571 | — |
| chr11_69688555_G_T | chr11:69688555 | -0.304 | -0.338 | -0.412 | — |
| chr11_69639078_G_C | chr11:69639078 | 0.154 | 0.203 | 0.529 | — |
| chr11_69641738_G_C | chr11:69641738 | 0.073 | 0.114 | 0.529 | — |
| chr11_69641739_G_C | chr11:69641739 | 0.078 | 0.108 | 0.500 | — |
| chr11_69688548_T_G | chr11:69688548 | 0.281 | 0.371 | 0.229 | — |
| chr11_69639076_A_C | chr11:69639076 | 0.278 | 0.218 | 0.459 | — |
| chr11_69641738_G_T | chr11:69641738 | 0.097 | 0.089 | 0.482 | — |
| chr11_69641752_T_G | chr11:69641752 | -0.103 | -0.071 | -0.482 | — |
| chr11_69639062_C_G | chr11:69639062 | -0.270 | -0.160 | -0.306 | <0.001% |
| chr11_69641743_C_G | chr11:69641743 | -0.081 | -0.099 | -0.476 | — |
| chr11_69639064_G_C | chr11:69639064 | 0.002 | 0.178 | 0.471 | — |
| chr11_69639076_A_T | chr11:69639076 | 0.160 | 0.183 | 0.459 | — |
| chr11_69641738_G_A | chr11:69641738 | 0.078 | 0.113 | 0.453 | — |
| chr11_69638962_T_G | chr11:69638962 | 0.210 | 0.173 | 0.447 | — |
| chr11_69638982_T_G | chr11:69638982 | 0.253 | 0.277 | 0.424 | — |
| chr11_69641739_G_A | chr11:69641739 | 0.087 | 0.113 | 0.447 | <0.001% |
| chr11_69639077_A_C | chr11:69639077 | 0.247 | 0.122 | 0.435 | — |
| chr11_69638964_C_G | chr11:69638964 | 0.135 | 0.124 | 0.435 | — |
| chr11_69639042_A_C | chr11:69639042 | 0.181 | 0.190 | 0.435 | 0.102% |
| chr11_69641737_G_C | chr11:69641737 | 0.060 | 0.094 | 0.435 | — |
| chr11_69688566_C_G | chr11:69688566 | -0.246 | -0.277 | -0.206 | <0.001% |
| chr11_69688561_T_C | chr11:69688561 | -0.088 | -0.284 | -0.429 | — |
| chr11_69688559_T_G | chr11:69688559 | 0.241 | 0.241 | 0.194 | — |
| chr11_69639045_T_C | chr11:69639045 | 0.195 | 0.114 | 0.424 | — |
| chr11_69639045_T_G | chr11:69639045 | 0.205 | 0.127 | 0.424 | — |
| chr11_69641735_A_G | chr11:69641735 | -0.077 | -0.085 | -0.412 | — |
| chr11_69688568_T_A | chr11:69688568 | 0.233 | 0.249 | 0.200 | — |
| chr11_69639041_A_C | chr11:69639041 | 0.077 | 0.107 | 0.400 | — |
| chr11_69639089_A_T | chr11:69639089 | 0.092 | 0.123 | 0.400 | — |
| chr11_69641739_G_T | chr11:69641739 | 0.085 | 0.089 | 0.394 | — |
| chr11_69688554_A_T | chr11:69688554 | 0.221 | 0.241 | 0.182 | — |
| chr11_69638963_T_G | chr11:69638963 | 0.112 | 0.099 | 0.388 | — |
| chr11_69639088_G_C | chr11:69639088 | 0.180 | 0.193 | 0.388 | — |
| chr11_69641737_G_A | chr11:69641737 | 0.068 | 0.085 | 0.388 | — |
| chr11_69641750_G_C | chr11:69641750 | 0.058 | 0.084 | 0.388 | — |
| chr11_69688564_A_C | chr11:69688564 | -0.220 | -0.256 | -0.159 | — |
| chr11_69641744_G_C | chr11:69641744 | 0.063 | 0.075 | 0.382 | — |
| chr11_69641750_G_A | chr11:69641750 | 0.065 | 0.079 | 0.382 | — |
| chr11_69688563_A_C | chr11:69688563 | -0.213 | -0.241 | -0.176 | — |
| chr11_69688565_A_T | chr11:69688565 | -0.213 | -0.193 | -0.112 | — |
| chr11_69639029_A_T | chr11:69639029 | 0.211 | 0.185 | -0.106 | — |
| chr11_69641750_G_T | chr11:69641750 | 0.073 | 0.072 | 0.371 | — |
| chr11_69688564_A_T | chr11:69688564 | -0.210 | -0.256 | -0.176 | — |
| chr11_69639047_G_C | chr11:69639047 | 0.161 | 0.084 | 0.365 | — |
| chr11_69639074_C_T | chr11:69639074 | 0.163 | 0.188 | 0.365 | <0.001% |
| chr11_69641734_A_G | chr11:69641734 | -0.067 | -0.086 | -0.359 | — |
| chr11_69641736_G_C | chr11:69641736 | 0.037 | 0.075 | 0.359 | — |
| chr11_69639045_T_A | chr11:69639045 | 0.095 | 0.066 | 0.353 | — |
| chr11_69639066_G_C | chr11:69639066 | 0.043 | 0.135 | 0.353 | 0.0020% |
| chr11_69641737_G_T | chr11:69641737 | 0.060 | 0.100 | 0.353 | — |
| chr11_69688563_A_T | chr11:69688563 | -0.200 | -0.213 | -0.224 | — |
| chr11_69688551_C_A | chr11:69688551 | 0.198 | 0.228 | 0.194 | — |
| chr11_69639027_C_T | chr11:69639027 | -0.197 | -0.117 | -0.271 | — |
| chr11_69639090_G_T | chr11:69639090 | 0.196 | 0.183 | 0.341 | — |
| chr11_69688562_C_T | chr11:69688562 | -0.195 | -0.213 | -0.206 | — |
| chr11_69639008_G_C | chr11:69639008 | -0.121 | -0.162 | -0.341 | — |
| chr11_69639092_T_C | chr11:69639092 | -0.032 | -0.036 | -0.341 | — |
| chr11_69641740_G_A | chr11:69641740 | 0.062 | 0.085 | 0.335 | — |
| chr11_69688562_C_A | chr11:69688562 | -0.190 | -0.216 | -0.188 | — |
| chr11_69688563_A_G | chr11:69688563 | -0.190 | -0.213 | -0.088 | — |
| chr11_69688571_C_T | chr11:69688571 | -0.188 | -0.195 | -0.206 | — |
| chr11_69638964_C_A | chr11:69638964 | 0.084 | 0.117 | 0.329 | — |
| chr11_69638965_C_G | chr11:69638965 | 0.104 | 0.150 | 0.329 | — |
| chr11_69638980_A_T | chr11:69638980 | 0.170 | 0.096 | 0.329 | — |
| chr11_69641740_G_C | chr11:69641740 | 0.053 | 0.080 | 0.329 | — |
| chr11_69641834_C_G | chr11:69641834 | 0.185 | 0.128 | 0.071 | — |
| chr11_69688568_T_C | chr11:69688568 | 0.181 | 0.129 | 0.206 | — |
| chr11_69638959_A_T | chr11:69638959 | 0.085 | 0.094 | 0.318 | — |
| chr11_69638965_C_A | chr11:69638965 | 0.067 | 0.135 | 0.318 | — |
| chr11_69639046_T_G | chr11:69639046 | 0.121 | 0.140 | 0.318 | — |
| chr11_69639075_G_A | chr11:69639075 | 0.109 | 0.142 | 0.318 | — |
| chr11_69688573_A_G | chr11:69688573 | 0.175 | 0.173 | 0.194 | — |
| chr11_69638977_C_A | chr11:69638977 | 0.118 | 0.058 | 0.306 | — |
| chr11_69638992_T_C | chr11:69638992 | -0.064 | -0.046 | -0.306 | — |
| chr11_69638995_C_G | chr11:69638995 | 0.160 | 0.020 | 0.306 | — |
| chr11_69639033_G_T | chr11:69639033 | 0.144 | 0.190 | 0.306 | — |
| chr11_69639069_A_G | chr11:69639069 | -0.004 | 0.024 | 0.306 | — |
| chr11_69639078_G_T | chr11:69639078 | 0.139 | 0.071 | 0.306 | — |
| chr11_69639089_A_C | chr11:69639089 | 0.055 | 0.041 | 0.306 | — |
| chr11_69641749_G_C | chr11:69641749 | 0.048 | 0.043 | 0.306 | — |
| chr11_69688565_A_C | chr11:69688565 | -0.173 | -0.185 | -0.029 | — |
| chr11_69641748_G_T | chr11:69641748 | 0.065 | 0.052 | 0.300 | — |
| chr11_69688544_C_A | chr11:69688544 | -0.169 | -0.180 | -0.300 | — |
| chr11_69638956_C_A | chr11:69638956 | 0.074 | 0.076 | 0.294 | — |
| chr11_69638995_C_A | chr11:69638995 | 0.154 | 0.005 | 0.294 | — |
| chr11_69639022_G_T | chr11:69639022 | -0.085 | -0.063 | -0.294 | — |
| chr11_69639082_C_A | chr11:69639082 | 0.164 | 0.190 | 0.235 | — |
| chr11_69641746_G_A | chr11:69641746 | 0.037 | 0.070 | 0.288 | — |
| chr11_69688564_A_G | chr11:69688564 | -0.163 | -0.195 | -0.118 | — |
| chr11_69688569_A_C | chr11:69688569 | -0.163 | -0.162 | -0.141 | — |
| chr11_69638956_C_T | chr11:69638956 | 0.094 | 0.089 | 0.282 | — |
| chr11_69638977_C_G | chr11:69638977 | 0.094 | 0.010 | 0.282 | — |
| chr11_69638981_A_T | chr11:69638981 | 0.108 | 0.096 | 0.282 | — |
| chr11_69638996_C_G | chr11:69638996 | 0.088 | 0.010 | 0.282 | — |
| chr11_69639044_T_G | chr11:69639044 | 0.112 | 0.071 | 0.282 | — |
| chr11_69639066_G_A | chr11:69639066 | 0.028 | 0.091 | 0.282 | — |
| chr11_69639077_A_G | chr11:69639077 | 0.146 | 0.065 | 0.282 | — |
| chr11_69641748_G_A | chr11:69641748 | 0.037 | 0.042 | 0.282 | — |
| chr11_69688565_A_G | chr11:69688565 | -0.158 | -0.160 | -0.071 | — |
| chr11_69641748_G_C | chr11:69641748 | 0.068 | 0.047 | 0.276 | — |
| chr11_69638962_T_A | chr11:69638962 | 0.097 | 0.107 | 0.271 | — |
| chr11_69638976_C_A | chr11:69638976 | 0.116 | 0.084 | 0.271 | — |
| chr11_69638998_G_C | chr11:69638998 | -0.086 | -0.028 | -0.271 | — |
| chr11_69639012_G_A | chr11:69639012 | 0.102 | 0.053 | 0.271 | — |
| chr11_69639048_C_G | chr11:69639048 | -0.124 | -0.066 | -0.271 | — |
| chr11_69639075_G_C | chr11:69639075 | 0.068 | 0.074 | 0.271 | <0.001% |
| chr11_69688558_A_G | chr11:69688558 | -0.153 | -0.175 | -0.047 | — |
| chr11_69639029_A_C | chr11:69639029 | 0.151 | 0.117 | 0.035 | — |
| chr11_69641740_G_T | chr11:69641740 | 0.042 | 0.079 | 0.265 | — |
| chr11_69641830_T_G | chr11:69641830 | -0.078 | -0.027 | -0.265 | — |
| chr11_69688560_T_A | chr11:69688560 | -0.150 | -0.236 | -0.159 | — |
| chr11_69638993_C_T | chr11:69638993 | 0.072 | 0.018 | 0.259 | — |
| chr11_69638994_C_A | chr11:69638994 | 0.132 | 0.046 | 0.259 | — |
| chr11_69639006_C_G | chr11:69639006 | -0.012 | 0.079 | 0.259 | — |
| chr11_69639040_C_A | chr11:69639040 | -0.109 | -0.102 | -0.259 | — |
| chr11_69639040_C_G | chr11:69639040 | 0.015 | -0.091 | -0.259 | — |
| chr11_69639041_A_T | chr11:69639041 | 0.047 | 0.015 | 0.259 | — |
| chr11_69639046_T_C | chr11:69639046 | 0.091 | 0.074 | 0.259 | — |
| chr11_69639084_A_G | chr11:69639084 | 0.008 | 0.108 | 0.259 | — |
| chr11_69639093_C_G | chr11:69639093 | -0.111 | -0.091 | -0.259 | 0.0020% |
| chr11_69639093_C_T | chr11:69639093 | -0.005 | 0.009 | -0.259 | — |
| chr11_69641749_G_A | chr11:69641749 | 0.035 | 0.033 | 0.259 | 0.0020% |
| chr11_69641749_G_T | chr11:69641749 | 0.052 | 0.046 | 0.259 | — |
| chr11_69639074_C_A | chr11:69639074 | -0.141 | -0.072 | -0.176 | <0.001% |
| chr11_69639010_A_C | chr11:69639010 | 0.141 | 0.094 | 0.188 | — |
| chr11_69638959_A_C | chr11:69638959 | 0.037 | 0.071 | 0.247 | — |
| chr11_69638968_C_A | chr11:69638968 | -0.069 | -0.038 | -0.247 | — |
| chr11_69638979_A_T | chr11:69638979 | 0.081 | 0.076 | 0.247 | — |
| chr11_69638986_A_C | chr11:69638986 | 0.012 | 0.056 | 0.247 | — |
| chr11_69638994_C_T | chr11:69638994 | 0.128 | 0.010 | 0.247 | — |
| chr11_69639002_G_A | chr11:69639002 | -0.041 | -0.094 | -0.247 | — |
| chr11_69639039_G_T | chr11:69639039 | -0.011 | 0.076 | 0.247 | — |
| chr11_69639044_T_A | chr11:69639044 | 0.128 | 0.094 | 0.247 | — |
| chr11_69639084_A_C | chr11:69639084 | -0.086 | -0.109 | -0.247 | — |
| chr11_69688547_T_C | chr11:69688547 | -0.140 | -0.127 | -0.171 | <0.001% |
| chr11_69688559_T_C | chr11:69688559 | -0.138 | -0.129 | -0.071 | — |
| chr11_69641736_G_A | chr11:69641736 | 0.030 | 0.049 | 0.241 | — |
| chr11_69641745_G_C | chr11:69641745 | 0.030 | 0.043 | 0.241 | — |
| chr11_69688570_C_G | chr11:69688570 | 0.135 | 0.145 | 0.200 | — |
| chr11_69638961_A_T | chr11:69638961 | 0.113 | 0.091 | 0.235 | — |
| chr11_69638962_T_C | chr11:69638962 | 0.067 | 0.036 | 0.235 | — |
| chr11_69638964_C_T | chr11:69638964 | 0.012 | 0.099 | 0.235 | — |
| chr11_69638981_A_G | chr11:69638981 | 0.128 | 0.076 | 0.235 | — |
| chr11_69638983_T_G | chr11:69638983 | 0.077 | 0.056 | 0.235 | — |
| chr11_69638999_C_G | chr11:69638999 | -0.114 | -0.074 | -0.235 | — |
| chr11_69639053_G_A | chr11:69639053 | -0.087 | -0.114 | -0.235 | — |
| chr11_69639079_T_C | chr11:69639079 | 0.129 | -0.008 | 0.235 | — |
| chr11_69639080_T_G | chr11:69639080 | 0.096 | 0.053 | 0.235 | — |
| chr11_69639083_T_A | chr11:69639083 | -0.042 | -0.084 | -0.235 | — |
| chr11_69641745_G_T | chr11:69641745 | 0.048 | 0.056 | 0.235 | — |
| chr11_69641855_T_C | chr11:69641855 | -0.040 | -0.037 | -0.235 | — |
| chr11_69641802_C_G | chr11:69641802 | -0.060 | -0.005 | -0.229 | — |
| chr11_69688556_A_T | chr11:69688556 | -0.105 | -0.056 | -0.229 | — |
| chr11_69638984_C_G | chr11:69638984 | 0.129 | 0.079 | 0.212 | — |
| chr11_69639062_C_A | chr11:69639062 | -0.129 | -0.036 | -0.141 | — |
| chr11_69638963_T_C | chr11:69638963 | 0.128 | 0.089 | 0.176 | — |
| chr11_69638956_C_G | chr11:69638956 | 0.056 | 0.063 | 0.224 | — |
| chr11_69638960_A_T | chr11:69638960 | 0.107 | 0.061 | 0.224 | — |
| chr11_69638979_A_C | chr11:69638979 | 0.062 | 0.079 | 0.224 | — |
| chr11_69639042_A_G | chr11:69639042 | 0.107 | 0.061 | 0.224 | — |
| chr11_69639071_C_G | chr11:69639071 | 0.027 | 0.020 | 0.224 | — |
| chr11_69639091_A_C | chr11:69639091 | 0.069 | 0.070 | 0.224 | — |
| chr11_69688574_A_G | chr11:69688574 | 0.126 | 0.132 | 0.118 | — |
| chr11_69688577_G_A | chr11:69688577 | -0.126 | -0.150 | -0.212 | — |
| chr11_69638976_C_T | chr11:69638976 | 0.123 | 0.079 | 0.153 | — |
| chr11_69638991_C_A | chr11:69638991 | -0.123 | -0.109 | -0.094 | — |
| chr11_69641736_G_T | chr11:69641736 | 0.035 | 0.048 | 0.218 | — |
| chr11_69688574_A_C | chr11:69688574 | 0.060 | 0.089 | 0.218 | <0.001% |
| chr11_69638944_T_C | chr11:69638944 | -0.037 | -0.038 | -0.212 | — |
| chr11_69638957_C_A | chr11:69638957 | 0.035 | 0.025 | 0.212 | — |
| chr11_69638966_A_C | chr11:69638966 | -0.022 | 0.066 | 0.212 | — |
| chr11_69638995_C_T | chr11:69638995 | 0.107 | 0.008 | 0.212 | — |
| chr11_69639007_T_G | chr11:69639007 | 0.031 | 0.099 | 0.212 | — |
| chr11_69639023_C_G | chr11:69639023 | 0.111 | 0.145 | 0.212 | — |
| chr11_69639035_G_A | chr11:69639035 | 0.091 | 0.114 | 0.212 | — |
| chr11_69639079_T_A | chr11:69639079 | -0.010 | -0.088 | -0.212 | — |
| chr11_69639090_G_A | chr11:69639090 | -0.092 | -0.033 | -0.212 | — |
| chr11_69639099_G_C | chr11:69639099 | -0.032 | -0.057 | -0.212 | — |
| chr11_69641762_A_G | chr11:69641762 | -0.063 | -0.036 | -0.212 | — |
| chr11_69688550_A_T | chr11:69688550 | -0.118 | -0.122 | -0.147 | — |
| chr11_69639050_C_G | chr11:69639050 | -0.116 | -0.107 | -0.165 | — |
| chr11_69641746_G_C | chr11:69641746 | 0.042 | 0.037 | 0.206 | — |
| chr11_69641847_A_G | chr11:69641847 | -0.022 | -0.028 | -0.206 | — |
| chr11_69688567_A_C | chr11:69688567 | -0.116 | -0.112 | -0.041 | — |
| chr11_69639011_C_G | chr11:69639011 | -0.116 | -0.048 | -0.188 | — |
| chr11_69638955_C_A | chr11:69638955 | 0.059 | 0.096 | 0.200 | — |
| chr11_69638975_C_T | chr11:69638975 | 0.071 | 0.091 | 0.200 | — |
| chr11_69638981_A_C | chr11:69638981 | 0.101 | 0.043 | 0.200 | — |
| chr11_69639026_G_A | chr11:69639026 | -0.023 | -0.008 | -0.200 | — |
| chr11_69639029_A_G | chr11:69639029 | 0.070 | 0.079 | 0.200 | — |
| chr11_69639043_T_A | chr11:69639043 | 0.050 | 0.071 | 0.200 | — |
| chr11_69639066_G_T | chr11:69639066 | -0.034 | 0.051 | 0.200 | — |
| chr11_69639079_T_G | chr11:69639079 | 0.091 | 0.041 | 0.200 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.