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FMO3

CAMIP Tier 2: reviewed literature reference panel

These records are literature references, not evidence of a receptor-bound element in this ChIP-seq panel.

PXR

Submitted decision (verbatim): 需修訂

Reviewer notes (verbatim)

FMO3 expression is induced by dietary bile acids by a mechanism that involves the farnesoid X receptor (FXR), a bile acid-activated nuclear receptor（PMID: 23312283）.

Prior explanatory context

Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.

Drug context: benzydamine; trimethylamine; some tertiary amines
Nearest peak (bp): 115526
Panel context: FMO3 is mainly developmentally/constitutively regulated rather than xenobiotic-induced; nearest peak distal (116 kb) — no proximal PXR peak.
Claim type: clinical_reference_no_binding_claim

Scored variants near FMO3

chr1:170,990,904..171,217,819, gene body plus 100 kb. Showing the strongest 200 by effect size.

Variant	Position	PXR	FXR	AhR	AF
chr1_171206469_C_T	chr1:171206469	0.176	0.140	0.444	—
chr1_171206536_T_C	chr1:171206536	-0.140	-0.075	0.021	—
chr1_171206546_A_T	chr1:171206546	0.090	0.020	0.056	—
chr1_171206548_A_C	chr1:171206548	-0.086	-0.018	-0.035	—
chr1_171206472_T_G	chr1:171206472	0.085	0.015	0.038	—
chr1_171206498_A_C	chr1:171206498	-0.085	-0.028	-0.032	—
chr1_171206548_A_T	chr1:171206548	-0.077	-0.020	-0.041	—
chr1_171206546_A_C	chr1:171206546	0.077	0.018	0.076	—
chr1_171206472_T_C	chr1:171206472	0.076	0.000	0.038	—
chr1_171206472_T_A	chr1:171206472	0.074	0.028	0.115	—
chr1_171206450_T_A	chr1:171206450	0.027	0.051	0.124	—
chr1_171206475_C_A	chr1:171206475	-0.070	0.018	-0.009	—
chr1_171206447_G_T	chr1:171206447	-0.069	-0.013	-0.091	—
chr1_171206477_C_A	chr1:171206477	0.067	0.003	0.026	—
chr1_171206454_G_T	chr1:171206454	0.005	0.077	0.118	—
chr1_171206523_A_T	chr1:171206523	-0.067	-0.033	-0.062	—
chr1_171206434_G_C	chr1:171206434	0.039	0.008	0.112	—
chr1_171206539_A_C	chr1:171206539	0.063	0.013	0.088	—
chr1_171206466_G_A	chr1:171206466	0.061	0.036	-0.079	—
chr1_171206508_T_A	chr1:171206508	0.060	0.018	0.047	—
chr1_171206448_T_A	chr1:171206448	-0.059	0.013	0.009	—
chr1_171206505_A_T	chr1:171206505	0.056	0.028	0.076	—
chr1_171206540_A_G	chr1:171206540	0.056	0.008	0.062	—
chr1_171206471_A_G	chr1:171206471	0.052	-0.013	0.041	—
chr1_171206489_G_T	chr1:171206489	-0.052	0.003	-0.026	—
chr1_171206448_T_G	chr1:171206448	-0.051	-0.025	-0.003	—
chr1_171206477_C_G	chr1:171206477	0.051	0.003	0.047	—
chr1_171206476_T_G	chr1:171206476	0.050	-0.015	0.062	—
chr1_171206496_G_T	chr1:171206496	-0.050	-0.003	0.009	—
chr1_171206549_T_G	chr1:171206549	-0.050	-0.023	-0.032	—
chr1_171206471_A_C	chr1:171206471	0.048	-0.010	0.024	—
chr1_171206473_T_G	chr1:171206473	0.047	-0.013	0.018	—
chr1_171206476_T_A	chr1:171206476	0.047	0.003	0.047	—
chr1_171206464_A_G	chr1:171206464	0.046	-0.010	0.053	—
chr1_171206493_A_T	chr1:171206493	-0.045	0.000	0.000	—
chr1_171206448_T_C	chr1:171206448	-0.044	0.005	0.024	—
chr1_171206466_G_T	chr1:171206466	0.044	0.025	-0.003	—
chr1_171206541_A_G	chr1:171206541	0.044	0.000	0.068	—
chr1_171206522_T_C	chr1:171206522	-0.042	-0.030	-0.003	—
chr1_171206541_A_C	chr1:171206541	0.042	0.008	0.062	—
chr1_171206431_A_C	chr1:171206431	0.011	-0.020	0.074	—
chr1_171206432_T_G	chr1:171206432	0.028	-0.023	0.074	—
chr1_171206539_A_T	chr1:171206539	0.042	0.005	0.021	—
chr1_171206548_A_G	chr1:171206548	-0.042	-0.010	-0.006	—
chr1_171206432_T_A	chr1:171206432	0.029	-0.028	0.071	—
chr1_171206455_C_T	chr1:171206455	0.040	0.003	0.015	—
chr1_171206476_T_C	chr1:171206476	0.040	-0.003	0.041	—
chr1_171206479_T_A	chr1:171206479	0.040	0.008	0.012	—
chr1_171206510_T_C	chr1:171206510	-0.027	0.003	0.071	—
chr1_171206492_G_T	chr1:171206492	0.039	0.013	-0.003	—
chr1_171206549_T_A	chr1:171206549	-0.037	-0.020	-0.047	—
chr1_171206453_G_C	chr1:171206453	0.034	0.008	0.065	—
chr1_171206463_G_T	chr1:171206463	0.010	0.020	-0.065	—
chr1_171206467_A_C	chr1:171206467	0.001	-0.025	0.065	—
chr1_171206532_A_C	chr1:171206532	0.037	0.000	0.038	—
chr1_171206468_G_C	chr1:171206468	0.036	-0.010	-0.026	—
chr1_171206536_T_A	chr1:171206536	-0.036	-0.005	-0.003	—
chr1_171206552_G_A	chr1:171206552	0.036	0.015	0.018	—
chr1_171206439_A_C	chr1:171206439	-0.007	-0.025	0.062	—
chr1_171206456_A_C	chr1:171206456	0.001	-0.005	0.062	—
chr1_171206474_A_C	chr1:171206474	0.035	-0.013	0.050	—
chr1_171206471_A_T	chr1:171206471	0.034	-0.013	0.021	—
chr1_171206514_A_G	chr1:171206514	0.034	-0.003	0.024	—
chr1_171206431_A_G	chr1:171206431	0.016	-0.038	0.059	—
chr1_171206478_T_G	chr1:171206478	0.033	-0.003	0.059	—
chr1_171206512_T_G	chr1:171206512	0.033	-0.013	0.021	—
chr1_171206516_A_T	chr1:171206516	-0.033	-0.015	0.000	—
chr1_171206436_T_C	chr1:171206436	0.032	-0.020	0.026	—
chr1_171206440_G_T	chr1:171206440	0.032	-0.018	0.003	—
chr1_171206474_A_G	chr1:171206474	0.032	-0.015	0.050	—
chr1_171206458_A_C	chr1:171206458	-0.002	-0.003	0.056	—
chr1_171206459_G_T	chr1:171206459	0.032	0.013	0.009	—
chr1_171206478_T_A	chr1:171206478	-0.013	0.015	0.056	—
chr1_171206499_C_A	chr1:171206499	-0.032	0.015	0.012	—
chr1_171206520_G_T	chr1:171206520	-0.025	-0.018	-0.056	—
chr1_171206528_G_T	chr1:171206528	0.032	0.010	0.006	—
chr1_171206543_T_C	chr1:171206543	-0.032	0.010	0.015	—
chr1_171206538_T_G	chr1:171206538	0.031	0.000	0.041	—
chr1_171206545_T_C	chr1:171206545	-0.031	-0.008	0.006	—
chr1_171206457_G_T	chr1:171206457	0.030	0.005	0.012	—
chr1_171206478_T_C	chr1:171206478	0.030	-0.005	0.021	—
chr1_171206507_T_G	chr1:171206507	-0.030	-0.005	-0.021	—
chr1_171206540_A_C	chr1:171206540	0.028	0.018	0.053	—
chr1_171206543_T_G	chr1:171206543	0.028	0.003	0.053	—
chr1_171206469_C_G	chr1:171206469	0.029	-0.003	0.000	—
chr1_171206479_T_G	chr1:171206479	0.029	-0.003	0.018	—
chr1_171206492_G_C	chr1:171206492	0.029	-0.003	0.006	—
chr1_171206542_T_G	chr1:171206542	0.029	0.000	0.032	—
chr1_171206441_C_T	chr1:171206441	0.028	0.003	0.009	—
chr1_171206446_C_T	chr1:171206446	-0.028	-0.003	-0.029	—
chr1_171206447_G_A	chr1:171206447	-0.007	-0.003	-0.050	—
chr1_171206456_A_G	chr1:171206456	0.002	-0.018	0.050	—
chr1_171206469_C_A	chr1:171206469	0.028	0.003	-0.018	—
chr1_171206504_G_A	chr1:171206504	0.028	0.005	-0.018	—
chr1_171206533_G_T	chr1:171206533	0.010	-0.005	-0.050	—
chr1_171206537_A_G	chr1:171206537	0.007	0.010	0.050	—
chr1_171206550_C_G	chr1:171206550	-0.028	-0.008	-0.009	—
chr1_171206437_A_C	chr1:171206437	-0.027	-0.010	-0.006	—
chr1_171206508_T_C	chr1:171206508	0.027	0.003	0.029	—
chr1_171206433_T_G	chr1:171206433	0.027	-0.033	0.044	—
chr1_171206434_G_T	chr1:171206434	0.002	-0.008	-0.047	—
chr1_171206460_A_C	chr1:171206460	0.002	-0.005	0.047	—
chr1_171206463_G_A	chr1:171206463	-0.027	-0.005	-0.038	—
chr1_171206508_T_G	chr1:171206508	-0.027	-0.003	0.015	—
chr1_171206511_G_T	chr1:171206511	-0.001	-0.010	-0.047	—
chr1_171206453_G_T	chr1:171206453	0.026	0.013	0.021	—
chr1_171206500_A_C	chr1:171206500	0.026	-0.005	-0.012	—
chr1_171206501_C_A	chr1:171206501	-0.026	-0.005	-0.012	—
chr1_171206504_G_T	chr1:171206504	0.026	0.020	0.003	—
chr1_171206434_G_A	chr1:171206434	-0.003	-0.005	-0.044	—
chr1_171206436_T_A	chr1:171206436	0.007	-0.008	0.044	—
chr1_171206439_A_G	chr1:171206439	0.004	-0.013	0.044	—
chr1_171206452_A_C	chr1:171206452	0.010	0.015	0.044	—
chr1_171206505_A_C	chr1:171206505	0.007	0.003	0.044	—
chr1_171206505_A_G	chr1:171206505	0.007	0.003	0.044	—
chr1_171206509_T_G	chr1:171206509	-0.016	0.015	0.044	—
chr1_171206534_A_G	chr1:171206534	-0.025	0.000	0.029	—
chr1_171206561_A_C	chr1:171206561	0.025	0.005	0.029	—
chr1_171206449_A_G	chr1:171206449	-0.024	-0.015	-0.021	—
chr1_171206539_A_G	chr1:171206539	0.024	0.003	0.038	—
chr1_171206562_A_G	chr1:171206562	0.024	0.005	0.009	—
chr1_171206433_T_A	chr1:171206433	0.023	-0.003	-0.009	—
chr1_171206436_T_G	chr1:171206436	0.017	-0.051	0.041	—
chr1_171206438_G_A	chr1:171206438	-0.005	0.008	0.041	—
chr1_171206458_A_G	chr1:171206458	-0.001	-0.018	0.041	—
chr1_171206462_A_C	chr1:171206462	-0.008	-0.018	0.041	—
chr1_171206462_A_G	chr1:171206462	0.003	-0.003	0.041	—
chr1_171206465_T_G	chr1:171206465	0.007	-0.018	0.041	—
chr1_171206466_G_C	chr1:171206466	0.023	0.005	0.024	—
chr1_171206488_A_T	chr1:171206488	0.023	0.005	0.009	—
chr1_171206490_G_T	chr1:171206490	0.017	0.010	-0.041	—
chr1_171206491_A_C	chr1:171206491	0.004	-0.010	0.041	—
chr1_171206494_C_T	chr1:171206494	0.023	0.005	-0.035	—
chr1_171206495_A_C	chr1:171206495	-0.007	-0.020	-0.041	—
chr1_171206502_A_G	chr1:171206502	0.012	-0.015	0.041	—
chr1_171206507_T_A	chr1:171206507	-0.023	-0.005	-0.024	—
chr1_171206509_T_A	chr1:171206509	0.013	0.025	0.041	—
chr1_171206517_C_A	chr1:171206517	-0.014	-0.013	-0.041	—
chr1_171206530_T_A	chr1:171206530	0.023	0.015	0.015	—
chr1_171206530_T_G	chr1:171206530	0.023	0.003	0.029	—
chr1_171206547_G_T	chr1:171206547	0.001	-0.003	-0.041	—
chr1_171206558_C_G	chr1:171206558	-0.021	0.013	0.041	—
chr1_171206559_C_G	chr1:171206559	0.010	0.003	0.041	—
chr1_171206440_G_A	chr1:171206440	0.022	-0.018	-0.009	—
chr1_171206470_C_G	chr1:171206470	0.022	-0.003	0.009	—
chr1_171206512_T_C	chr1:171206512	-0.022	-0.008	0.021	—
chr1_171206518_A_C	chr1:171206518	0.022	0.003	0.032	—
chr1_171206550_C_T	chr1:171206550	-0.022	-0.010	-0.038	—
chr1_171206556_T_A	chr1:171206556	0.022	0.013	0.009	—
chr1_171206556_T_G	chr1:171206556	0.022	0.008	0.026	—
chr1_171206461_G_C	chr1:171206461	-0.022	0.008	0.006	—
chr1_171206465_T_A	chr1:171206465	-0.022	-0.015	-0.003	—
chr1_171206482_A_G	chr1:171206482	0.005	-0.010	-0.038	—
chr1_171206503_G_C	chr1:171206503	0.020	0.008	0.038	—
chr1_171206536_T_G	chr1:171206536	-0.015	0.003	0.038	—
chr1_171206537_A_C	chr1:171206537	0.017	-0.003	0.038	—
chr1_171206549_T_C	chr1:171206549	-0.022	-0.013	-0.018	—
chr1_171206551_A_T	chr1:171206551	-0.022	0.000	-0.018	—
chr1_171206444_G_C	chr1:171206444	0.021	-0.036	-0.012	—
chr1_171206504_G_C	chr1:171206504	0.021	0.008	0.026	—
chr1_171206521_C_A	chr1:171206521	0.021	0.005	0.000	—
chr1_171206523_A_C	chr1:171206523	-0.021	-0.018	-0.026	—
chr1_171206540_A_T	chr1:171206540	0.021	-0.003	0.000	—
chr1_171206542_T_A	chr1:171206542	0.021	-0.008	-0.012	—
chr1_171206558_C_T	chr1:171206558	-0.021	0.005	-0.006	—
chr1_171206567_G_C	chr1:171206567	0.021	0.008	0.032	—
chr1_171206460_A_G	chr1:171206460	0.013	-0.013	0.035	—
chr1_171206461_G_T	chr1:171206461	0.020	0.010	0.009	—
chr1_171206470_C_T	chr1:171206470	0.010	0.013	-0.035	—
chr1_171206479_T_C	chr1:171206479	0.018	-0.003	0.035	—
chr1_171206482_A_C	chr1:171206482	-0.003	0.003	0.035	—
chr1_171206488_A_C	chr1:171206488	0.007	0.003	0.035	—
chr1_171206491_A_T	chr1:171206491	0.017	0.003	0.035	—
chr1_171206498_A_T	chr1:171206498	-0.005	-0.023	-0.035	—
chr1_171206514_A_C	chr1:171206514	0.017	0.000	0.035	—
chr1_171206527_A_C	chr1:171206527	-0.002	-0.003	0.035	—
chr1_171206528_G_C	chr1:171206528	0.020	0.000	0.012	—
chr1_171206534_A_C	chr1:171206534	-0.003	-0.003	0.035	—
chr1_171206543_T_A	chr1:171206543	0.020	-0.008	0.006	—
chr1_171206546_A_G	chr1:171206546	0.002	0.008	0.035	—
chr1_171206550_C_A	chr1:171206550	-0.016	-0.008	-0.035	—
chr1_171206557_T_G	chr1:171206557	0.004	0.005	0.035	—
chr1_171206560_C_G	chr1:171206560	0.014	-0.005	0.035	—
chr1_171206568_G_A	chr1:171206568	-0.018	-0.003	-0.035	—
chr1_171206444_G_A	chr1:171206444	0.019	-0.020	-0.012	—
chr1_171206468_G_T	chr1:171206468	-0.019	0.000	-0.018	—
chr1_171206489_G_C	chr1:171206489	0.019	0.015	0.026	—
chr1_171206509_T_C	chr1:171206509	0.019	0.013	0.021	—
chr1_171206532_A_T	chr1:171206532	0.019	0.000	0.015	—
chr1_171206552_G_T	chr1:171206552	-0.019	-0.008	-0.024	—
chr1_171206553_T_G	chr1:171206553	0.019	-0.003	0.032	—
chr1_171206437_A_G	chr1:171206437	-0.018	-0.008	-0.018	—
chr1_171206440_G_C	chr1:171206440	0.018	-0.008	-0.024	—
chr1_171206447_G_C	chr1:171206447	0.012	0.000	-0.032	—
chr1_171206452_A_G	chr1:171206452	0.018	-0.013	0.000	—
chr1_171206473_T_C	chr1:171206473	0.010	0.003	0.032	—
chr1_171206484_A_C	chr1:171206484	0.005	0.003	0.032	—
chr1_171206488_A_G	chr1:171206488	0.018	-0.003	0.024	—
chr1_171206507_T_C	chr1:171206507	0.017	-0.003	0.032	—
chr1_171206518_A_G	chr1:171206518	0.011	-0.003	0.032	—

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