Home / Gene
GSTA1
CAMIP Tier 2: reviewed literature reference panel
These records are literature references, not evidence of a receptor-bound element in this ChIP-seq panel.
PXR
Submitted decision (verbatim): 需修訂
Reviewer notes (verbatim)
A common African haplotype in one of these enhancers in the GSTA locus was found to exhibit potential rifampin hypersensitivity (PMID: 25275310).
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Drug context
- busulfan; chlorambucil; electrophile detoxification
- Nearest peak (bp)
- 57917
- Panel context
- GSTA1 is predominantly Nrf2(ARE)- and AhR-controlled; the PXR contribution is minor, so the absence of a proximal PXR peak is consistent with Nrf2/AhR-dominant regulation.
- Claim type
- clinical_reference_no_binding_claim
Scored variants near GSTA1
chr6:52,691,370..52,903,816, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr6_52745891_G_T | chr6:52745891 | 1.000 | 1.000 | 0.906 | — |
| chr6_52745894_T_G | chr6:52745894 | 0.948 | 0.680 | 0.547 | — |
| chr6_52745832_A_T | chr6:52745832 | 0.815 | 0.807 | 0.488 | — |
| chr6_52745891_G_C | chr6:52745891 | 0.774 | 0.881 | 0.635 | — |
| chr6_52745875_C_G | chr6:52745875 | 0.742 | 0.845 | 0.403 | — |
| chr6_52745830_A_T | chr6:52745830 | 0.684 | 0.431 | 0.253 | — |
| chr6_52745818_A_C | chr6:52745818 | 0.677 | 0.680 | 0.394 | — |
| chr6_52745815_A_T | chr6:52745815 | 0.641 | 0.609 | 0.521 | — |
| chr6_52745831_A_C | chr6:52745831 | 0.582 | 0.541 | 0.385 | — |
| chr6_52745845_G_T | chr6:52745845 | -0.567 | -0.546 | -0.497 | — |
| chr6_52745778_G_T | chr6:52745778 | 0.547 | 0.617 | 0.374 | — |
| chr6_52745777_T_C | chr6:52745777 | 0.546 | 0.607 | 0.406 | — |
| chr6_52745842_C_G | chr6:52745842 | -0.524 | -0.533 | -0.438 | — |
| chr6_52745862_C_A | chr6:52745862 | -0.507 | -0.482 | -0.347 | — |
| chr6_52745781_A_G | chr6:52745781 | 0.501 | 0.510 | 0.409 | — |
| chr6_52745799_C_G | chr6:52745799 | -0.498 | -0.538 | -0.374 | — |
| chr6_52745832_A_G | chr6:52745832 | 0.488 | 0.503 | 0.324 | 72.1% |
| chr6_52745844_A_C | chr6:52745844 | -0.471 | -0.424 | -0.332 | — |
| chr6_52745864_T_G | chr6:52745864 | -0.463 | -0.444 | -0.300 | — |
| chr6_52745867_C_T | chr6:52745867 | -0.454 | -0.439 | -0.397 | 0.0039% |
| chr6_52745799_C_A | chr6:52745799 | -0.453 | -0.505 | -0.374 | — |
| chr6_52745842_C_A | chr6:52745842 | -0.449 | -0.485 | -0.412 | — |
| chr6_52745895_G_T | chr6:52745895 | -0.449 | -0.444 | -0.315 | — |
| chr6_52745892_T_C | chr6:52745892 | -0.448 | -0.421 | -0.303 | — |
| chr6_52745863_T_A | chr6:52745863 | 0.439 | 0.619 | 0.306 | — |
| chr6_52745797_G_C | chr6:52745797 | -0.428 | -0.485 | -0.376 | — |
| chr6_52745833_G_T | chr6:52745833 | -0.428 | -0.416 | -0.356 | — |
| chr6_52745789_T_G | chr6:52745789 | 0.426 | 0.485 | 0.279 | — |
| chr6_52745843_C_G | chr6:52745843 | -0.424 | -0.414 | -0.382 | — |
| chr6_52745867_C_G | chr6:52745867 | -0.424 | -0.409 | -0.344 | — |
| chr6_52745887_T_C | chr6:52745887 | 0.421 | 0.249 | 0.191 | — |
| chr6_52745798_T_A | chr6:52745798 | -0.418 | -0.503 | -0.306 | — |
| chr6_52745797_G_A | chr6:52745797 | -0.416 | -0.470 | -0.394 | — |
| chr6_52745831_A_T | chr6:52745831 | 0.414 | 0.348 | 0.259 | — |
| chr6_52745843_C_A | chr6:52745843 | -0.414 | -0.419 | -0.415 | — |
| chr6_52745798_T_G | chr6:52745798 | -0.408 | -0.472 | -0.279 | — |
| chr6_52745839_T_G | chr6:52745839 | 0.408 | 0.421 | 0.344 | — |
| chr6_52745777_T_A | chr6:52745777 | -0.399 | -0.442 | -0.350 | — |
| chr6_52745841_T_C | chr6:52745841 | -0.399 | -0.409 | -0.329 | — |
| chr6_52745843_C_T | chr6:52745843 | -0.399 | -0.409 | -0.424 | — |
| chr6_52745858_C_G | chr6:52745858 | 0.398 | 0.388 | 0.268 | — |
| chr6_52745833_G_A | chr6:52745833 | -0.396 | -0.388 | -0.338 | 0.0013% |
| chr6_52745833_G_C | chr6:52745833 | -0.394 | -0.365 | -0.291 | — |
| chr6_52745845_G_C | chr6:52745845 | -0.393 | -0.373 | -0.338 | — |
| chr6_52745890_T_A | chr6:52745890 | -0.393 | -0.371 | -0.271 | — |
| chr6_52745892_T_G | chr6:52745892 | -0.391 | -0.353 | -0.259 | — |
| chr6_52745864_T_A | chr6:52745864 | -0.388 | -0.343 | -0.232 | — |
| chr6_52745799_C_T | chr6:52745799 | -0.384 | -0.444 | -0.324 | <0.001% |
| chr6_52745889_A_T | chr6:52745889 | -0.384 | -0.409 | -0.300 | — |
| chr6_52745890_T_G | chr6:52745890 | -0.383 | -0.355 | -0.282 | — |
| chr6_52745842_C_T | chr6:52745842 | -0.381 | -0.388 | -0.315 | — |
| chr6_52745844_A_T | chr6:52745844 | -0.381 | -0.320 | -0.297 | — |
| chr6_52745797_G_T | chr6:52745797 | -0.379 | -0.431 | -0.371 | — |
| chr6_52745780_C_T | chr6:52745780 | -0.378 | -0.437 | -0.315 | — |
| chr6_52745861_A_T | chr6:52745861 | -0.378 | -0.381 | -0.294 | — |
| chr6_52745864_T_C | chr6:52745864 | -0.378 | -0.353 | -0.226 | — |
| chr6_52745840_G_C | chr6:52745840 | -0.373 | -0.378 | -0.321 | — |
| chr6_52745800_A_C | chr6:52745800 | -0.368 | -0.464 | -0.256 | — |
| chr6_52745876_A_C | chr6:52745876 | -0.368 | -0.355 | -0.241 | — |
| chr6_52745796_G_A | chr6:52745796 | -0.363 | -0.424 | -0.300 | — |
| chr6_52745835_C_T | chr6:52745835 | -0.361 | -0.393 | -0.315 | — |
| chr6_52745824_T_C | chr6:52745824 | -0.359 | -0.365 | -0.271 | <0.001% |
| chr6_52745800_A_T | chr6:52745800 | -0.354 | -0.449 | -0.262 | — |
| chr6_52745818_A_T | chr6:52745818 | 0.354 | 0.335 | 0.191 | — |
| chr6_52745862_C_T | chr6:52745862 | -0.354 | -0.353 | -0.215 | — |
| chr6_52745780_C_G | chr6:52745780 | -0.351 | -0.401 | -0.253 | — |
| chr6_52745798_T_C | chr6:52745798 | -0.348 | -0.419 | -0.197 | — |
| chr6_52745841_T_A | chr6:52745841 | -0.348 | -0.345 | -0.312 | — |
| chr6_52745893_T_A | chr6:52745893 | -0.348 | -0.381 | -0.285 | — |
| chr6_52745776_G_T | chr6:52745776 | -0.344 | -0.365 | -0.265 | — |
| chr6_52745827_T_G | chr6:52745827 | 0.344 | 0.404 | 0.282 | — |
| chr6_52745890_T_C | chr6:52745890 | 0.333 | 0.292 | 0.253 | — |
| chr6_52745896_C_A | chr6:52745896 | -0.331 | -0.345 | -0.221 | — |
| chr6_52745834_G_A | chr6:52745834 | -0.329 | -0.327 | -0.265 | — |
| chr6_52745844_A_G | chr6:52745844 | -0.328 | -0.277 | -0.215 | 0.0053% |
| chr6_52745852_C_A | chr6:52745852 | 0.328 | 0.348 | 0.200 | — |
| chr6_52745859_A_C | chr6:52745859 | 0.324 | 0.330 | 0.315 | — |
| chr6_52745860_A_T | chr6:52745860 | -0.316 | -0.305 | -0.215 | — |
| chr6_52745778_G_C | chr6:52745778 | -0.314 | -0.378 | -0.221 | — |
| chr6_52745860_A_C | chr6:52745860 | -0.311 | -0.249 | -0.150 | — |
| chr6_52745778_G_A | chr6:52745778 | -0.309 | -0.376 | -0.232 | — |
| chr6_52745837_T_G | chr6:52745837 | 0.306 | 0.096 | 0.165 | — |
| chr6_52745795_A_T | chr6:52745795 | -0.304 | -0.368 | -0.279 | — |
| chr6_52745795_A_C | chr6:52745795 | -0.303 | -0.360 | -0.259 | — |
| chr6_52745875_C_A | chr6:52745875 | 0.301 | 0.368 | 0.162 | — |
| chr6_52745796_G_T | chr6:52745796 | -0.296 | -0.358 | -0.215 | — |
| chr6_52745874_T_G | chr6:52745874 | -0.291 | -0.320 | -0.150 | — |
| chr6_52745865_G_A | chr6:52745865 | -0.290 | -0.269 | -0.250 | — |
| chr6_52745793_A_G | chr6:52745793 | -0.288 | -0.340 | -0.194 | — |
| chr6_52745840_G_A | chr6:52745840 | -0.286 | -0.305 | -0.271 | — |
| chr6_52745830_A_C | chr6:52745830 | 0.283 | 0.261 | 0.194 | — |
| chr6_52745855_G_C | chr6:52745855 | -0.283 | -0.299 | -0.244 | <0.001% |
| chr6_52745762_T_C | chr6:52745762 | 0.281 | 0.335 | 0.256 | — |
| chr6_52745848_A_T | chr6:52745848 | -0.281 | -0.327 | -0.244 | — |
| chr6_52745850_T_C | chr6:52745850 | -0.281 | -0.234 | -0.262 | — |
| chr6_52745839_T_A | chr6:52745839 | 0.280 | 0.277 | 0.171 | — |
| chr6_52745877_C_A | chr6:52745877 | 0.280 | 0.099 | 0.138 | — |
| chr6_52745777_T_G | chr6:52745777 | -0.278 | -0.312 | -0.232 | — |
| chr6_52745801_T_A | chr6:52745801 | 0.275 | 0.244 | 0.162 | <0.001% |
| chr6_52745783_A_G | chr6:52745783 | -0.273 | -0.274 | -0.191 | — |
| chr6_52745819_A_C | chr6:52745819 | 0.273 | 0.256 | 0.209 | — |
| chr6_52745817_A_C | chr6:52745817 | 0.271 | 0.241 | 0.185 | — |
| chr6_52745783_A_T | chr6:52745783 | -0.266 | -0.297 | -0.206 | — |
| chr6_52745782_C_A | chr6:52745782 | -0.265 | -0.284 | -0.206 | — |
| chr6_52745793_A_C | chr6:52745793 | -0.265 | -0.322 | -0.194 | — |
| chr6_52745809_T_G | chr6:52745809 | 0.265 | 0.274 | 0.176 | — |
| chr6_52745781_A_C | chr6:52745781 | -0.263 | -0.294 | -0.218 | — |
| chr6_52745876_A_T | chr6:52745876 | -0.260 | -0.277 | -0.191 | — |
| chr6_52745788_T_G | chr6:52745788 | 0.258 | 0.272 | 0.212 | — |
| chr6_52745791_A_G | chr6:52745791 | -0.258 | -0.180 | -0.085 | — |
| chr6_52745898_G_C | chr6:52745898 | 0.258 | 0.266 | 0.165 | — |
| chr6_52745821_T_A | chr6:52745821 | 0.253 | 0.254 | 0.168 | — |
| chr6_52745863_T_C | chr6:52745863 | -0.253 | -0.195 | -0.103 | — |
| chr6_52745857_T_G | chr6:52745857 | 0.251 | 0.305 | 0.156 | — |
| chr6_52745878_C_A | chr6:52745878 | -0.250 | -0.289 | -0.168 | — |
| chr6_52745839_T_C | chr6:52745839 | 0.246 | 0.277 | 0.194 | — |
| chr6_52745879_C_A | chr6:52745879 | -0.246 | -0.279 | -0.171 | — |
| chr6_52745807_C_A | chr6:52745807 | -0.245 | -0.261 | -0.226 | <0.001% |
| chr6_52745896_C_G | chr6:52745896 | -0.245 | -0.261 | -0.115 | — |
| chr6_52745802_C_A | chr6:52745802 | -0.243 | -0.256 | -0.182 | — |
| chr6_52745779_A_C | chr6:52745779 | -0.241 | -0.264 | -0.197 | — |
| chr6_52745821_T_C | chr6:52745821 | 0.241 | 0.272 | 0.226 | 0.018% |
| chr6_52745828_G_T | chr6:52745828 | -0.238 | -0.259 | -0.206 | — |
| chr6_52745882_G_A | chr6:52745882 | -0.238 | -0.241 | -0.144 | — |
| chr6_52745835_C_A | chr6:52745835 | -0.236 | -0.218 | -0.244 | — |
| chr6_52745894_T_A | chr6:52745894 | -0.236 | -0.239 | -0.141 | — |
| chr6_52745792_C_A | chr6:52745792 | -0.231 | -0.279 | -0.174 | — |
| chr6_52745861_A_G | chr6:52745861 | -0.231 | -0.234 | -0.153 | — |
| chr6_52745775_T_C | chr6:52745775 | -0.230 | -0.226 | -0.162 | — |
| chr6_52745788_T_A | chr6:52745788 | 0.228 | 0.175 | 0.126 | — |
| chr6_52745896_C_T | chr6:52745896 | -0.225 | -0.244 | -0.121 | — |
| chr6_52745874_T_C | chr6:52745874 | 0.220 | -0.023 | 0.112 | — |
| chr6_52745779_A_G | chr6:52745779 | -0.218 | -0.249 | -0.171 | — |
| chr6_52745793_A_T | chr6:52745793 | -0.218 | -0.266 | -0.153 | — |
| chr6_52745886_T_A | chr6:52745886 | -0.218 | -0.234 | -0.138 | — |
| chr6_52745887_T_A | chr6:52745887 | -0.218 | -0.254 | -0.218 | — |
| chr6_52745891_G_A | chr6:52745891 | 0.218 | 0.228 | 0.265 | — |
| chr6_52745858_C_A | chr6:52745858 | -0.216 | -0.188 | -0.159 | — |
| chr6_52745855_G_T | chr6:52745855 | -0.211 | -0.218 | -0.191 | — |
| chr6_52745811_T_A | chr6:52745811 | -0.210 | -0.226 | -0.221 | — |
| chr6_52745845_G_A | chr6:52745845 | 0.210 | 0.241 | 0.165 | — |
| chr6_52745792_C_T | chr6:52745792 | -0.206 | -0.251 | -0.153 | — |
| chr6_52745865_G_C | chr6:52745865 | -0.206 | -0.198 | -0.162 | — |
| chr6_52745787_T_G | chr6:52745787 | 0.205 | 0.185 | 0.159 | — |
| chr6_52745858_C_T | chr6:52745858 | 0.205 | 0.292 | 0.097 | — |
| chr6_52745871_G_T | chr6:52745871 | -0.205 | -0.203 | -0.135 | — |
| chr6_52745852_C_G | chr6:52745852 | 0.203 | 0.211 | 0.203 | 0.0020% |
| chr6_52745894_T_C | chr6:52745894 | -0.203 | -0.173 | -0.059 | — |
| chr6_52745795_A_G | chr6:52745795 | -0.201 | -0.223 | -0.168 | — |
| chr6_52745878_C_T | chr6:52745878 | -0.201 | -0.234 | -0.156 | — |
| chr6_52745810_T_G | chr6:52745810 | 0.200 | 0.201 | 0.188 | — |
| chr6_52745857_T_C | chr6:52745857 | -0.200 | -0.206 | -0.135 | — |
| chr6_52745878_C_G | chr6:52745878 | -0.200 | -0.239 | -0.097 | — |
| chr6_52745773_G_A | chr6:52745773 | 0.198 | 0.206 | 0.103 | — |
| chr6_52745800_A_G | chr6:52745800 | -0.198 | -0.234 | -0.076 | — |
| chr6_52745884_T_C | chr6:52745884 | 0.196 | 0.165 | 0.126 | — |
| chr6_52745773_G_T | chr6:52745773 | -0.195 | -0.208 | -0.176 | — |
| chr6_52745823_C_G | chr6:52745823 | 0.195 | 0.170 | 0.135 | — |
| chr6_52745841_T_G | chr6:52745841 | 0.195 | 0.193 | 0.174 | — |
| chr6_52745861_A_C | chr6:52745861 | 0.195 | 0.320 | 0.094 | — |
| chr6_52745813_A_C | chr6:52745813 | 0.193 | 0.226 | 0.194 | — |
| chr6_52745848_A_C | chr6:52745848 | 0.193 | 0.152 | 0.159 | — |
| chr6_52745863_T_G | chr6:52745863 | -0.193 | -0.114 | -0.056 | — |
| chr6_52745785_C_A | chr6:52745785 | -0.191 | -0.195 | -0.156 | — |
| chr6_52745814_C_A | chr6:52745814 | 0.191 | 0.198 | 0.112 | — |
| chr6_52745834_G_C | chr6:52745834 | -0.191 | -0.178 | -0.162 | — |
| chr6_52745838_C_A | chr6:52745838 | -0.191 | -0.206 | -0.168 | — |
| chr6_52745893_T_C | chr6:52745893 | -0.191 | -0.239 | -0.126 | 0.0013% |
| chr6_52745895_G_A | chr6:52745895 | -0.191 | -0.190 | -0.129 | — |
| chr6_52745884_T_G | chr6:52745884 | 0.190 | 0.188 | 0.159 | — |
| chr6_52745807_C_T | chr6:52745807 | -0.185 | -0.188 | -0.147 | <0.001% |
| chr6_52745816_A_C | chr6:52745816 | 0.185 | 0.178 | 0.156 | — |
| chr6_52745865_G_T | chr6:52745865 | -0.185 | -0.165 | -0.153 | — |
| chr6_52745827_T_A | chr6:52745827 | 0.183 | 0.162 | 0.091 | — |
| chr6_52745827_T_C | chr6:52745827 | 0.183 | 0.178 | 0.156 | 0.0020% |
| chr6_52745877_C_G | chr6:52745877 | 0.183 | 0.046 | 0.097 | — |
| chr6_52745786_T_A | chr6:52745786 | 0.180 | 0.211 | 0.135 | — |
| chr6_52745882_G_C | chr6:52745882 | -0.180 | -0.195 | -0.138 | — |
| chr6_52745850_T_G | chr6:52745850 | 0.178 | 0.188 | 0.197 | — |
| chr6_52745794_A_T | chr6:52745794 | -0.175 | -0.188 | -0.115 | — |
| chr6_52745782_C_G | chr6:52745782 | -0.173 | -0.183 | -0.103 | — |
| chr6_52745832_A_C | chr6:52745832 | -0.173 | -0.173 | -0.074 | — |
| chr6_52745786_T_C | chr6:52745786 | 0.171 | 0.221 | 0.132 | 72.1% |
| chr6_52745803_A_C | chr6:52745803 | 0.168 | 0.142 | 0.132 | — |
| chr6_52745872_T_A | chr6:52745872 | 0.168 | 0.178 | 0.076 | — |
| chr6_52745808_C_A | chr6:52745808 | -0.166 | -0.223 | -0.159 | — |
| chr6_52745856_T_C | chr6:52745856 | -0.166 | -0.231 | -0.109 | <0.001% |
| chr6_52745866_G_C | chr6:52745866 | -0.166 | -0.020 | -0.100 | — |
| chr6_52745815_A_C | chr6:52745815 | 0.165 | 0.178 | 0.182 | <0.001% |
| chr6_52745860_A_G | chr6:52745860 | -0.165 | -0.152 | -0.100 | — |
| chr6_52745790_C_G | chr6:52745790 | 0.163 | 0.165 | 0.129 | — |
| chr6_52745866_G_T | chr6:52745866 | -0.163 | -0.025 | -0.065 | 0.0039% |
| chr6_52745781_A_T | chr6:52745781 | -0.161 | -0.251 | -0.153 | — |
| chr6_52745808_C_T | chr6:52745808 | -0.161 | -0.198 | -0.150 | — |
| chr6_52745872_T_C | chr6:52745872 | 0.161 | 0.117 | 0.200 | — |
| chr6_52745846_C_G | chr6:52745846 | 0.160 | 0.289 | 0.124 | — |
| chr6_52745847_A_G | chr6:52745847 | -0.158 | -0.117 | -0.056 | — |
| chr6_52745879_C_G | chr6:52745879 | -0.158 | -0.180 | -0.082 | — |
| chr6_52745828_G_C | chr6:52745828 | -0.156 | -0.173 | -0.144 | — |
| chr6_52745824_T_A | chr6:52745824 | -0.153 | -0.119 | 0.003 | 0.0020% |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.