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NR0B2
receptor: FXRTier 1
CAMIP causal chains
FXR
Blunted receptor-mediated induction of NR0B2 expression, weakening the downstream transcriptional feedback inhibition of hepatic bile acid synthesis pathways.
Affected substrate drugs (PharmGKB): none in routine clinical use, endogenous or bile acid pathway
Scored variants near NR0B2
chr1:26,811,488..27,013,975, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr1_26864748_G_C | chr1:26864748 | 31,744 | 1,184 | -1,280 | — |
| chr1_26864772_T_A | chr1:26864772 | -9,984 | -1,792 | -3,328 | — |
| chr1_26864722_G_C | chr1:26864722 | 8,832 | 448 | 4,096 | — |
| chr1_26864722_G_A | chr1:26864722 | 8,320 | 416 | 1,024 | — |
| chr1_26864798_A_T | chr1:26864798 | 8,064 | -1,760 | 4,352 | — |
| chr1_26864720_T_C | chr1:26864720 | 7,808 | 128 | 1,536 | — |
| chr1_26864722_G_T | chr1:26864722 | 7,808 | 448 | 1,280 | — |
| chr1_26864820_C_G | chr1:26864820 | -7,680 | -1,504 | -4,864 | — |
| chr1_26864760_C_G | chr1:26864760 | -7,296 | -768 | -4,864 | 6.2e-4 |
| chr1_26864721_G_C | chr1:26864721 | 7,168 | 192 | 4,864 | — |
| chr1_26864734_C_T | chr1:26864734 | -7,168 | -320 | -4,864 | — |
| chr1_26864813_T_A | chr1:26864813 | -7,168 | -224 | -5,632 | — |
| chr1_26864758_A_G | chr1:26864758 | 6,912 | 1,184 | 8,960 | — |
| chr1_26864719_G_C | chr1:26864719 | 6,912 | 64 | -1,024 | — |
| chr1_26864781_C_T | chr1:26864781 | 6,784 | 1,888 | 4,096 | 6.6e-6 |
| chr1_26864811_A_C | chr1:26864811 | 6,784 | 864 | 3,328 | — |
| chr1_26864789_T_G | chr1:26864789 | -6,528 | -448 | -8,448 | — |
| chr1_26864755_T_G | chr1:26864755 | -6,528 | -96 | -3,072 | — |
| chr1_26864721_G_A | chr1:26864721 | 6,400 | 224 | 1,792 | — |
| chr1_26864769_A_G | chr1:26864769 | -6,272 | -2,656 | -1,024 | — |
| chr1_26864720_T_A | chr1:26864720 | 6,144 | 192 | -768 | — |
| chr1_26864771_A_T | chr1:26864771 | -6,144 | -2,208 | -1,792 | — |
| chr1_26864792_G_T | chr1:26864792 | 6,144 | -768 | 4,608 | — |
| chr1_26864831_A_C | chr1:26864831 | -6,144 | -1,600 | -5,376 | — |
| chr1_26864738_A_G | chr1:26864738 | -6,016 | -704 | -5,632 | 1.3e-5 |
| chr1_26864792_G_A | chr1:26864792 | 6,016 | -1,024 | 768 | — |
| chr1_26864793_A_C | chr1:26864793 | 6,016 | -1,472 | 5,376 | — |
| chr1_26864747_A_C | chr1:26864747 | 5,888 | 224 | 3,072 | — |
| chr1_26864772_T_G | chr1:26864772 | -5,888 | -1,408 | -512 | — |
| chr1_26864794_T_C | chr1:26864794 | 5,760 | -1,280 | 6,400 | — |
| chr1_26864796_T_A | chr1:26864796 | -5,760 | 3,552 | -6,400 | — |
| chr1_26864734_C_G | chr1:26864734 | -5,632 | -192 | -8,448 | — |
| chr1_26864797_A_T | chr1:26864797 | 5,632 | -832 | 3,840 | — |
| chr1_26864766_A_C | chr1:26864766 | 5,504 | -64 | 5,632 | — |
| chr1_26864771_A_G | chr1:26864771 | 5,504 | 1,344 | 5,376 | — |
| chr1_26864774_G_T | chr1:26864774 | -5,504 | -832 | -5,120 | — |
| chr1_26864794_T_A | chr1:26864794 | 5,504 | -1,408 | 256 | — |
| chr1_26864721_G_T | chr1:26864721 | 5,376 | -96 | 1,280 | — |
| chr1_26864723_G_T | chr1:26864723 | 5,376 | 256 | 512 | — |
| chr1_26864743_G_A | chr1:26864743 | -5,376 | -640 | -3,328 | — |
| chr1_26864795_C_A | chr1:26864795 | 5,376 | -1,120 | 3,328 | — |
| chr1_26864839_T_A | chr1:26864839 | 5,376 | 128 | 2,560 | — |
| chr1_26864805_C_A | chr1:26864805 | -5,248 | -224 | -4,352 | — |
| chr1_26864798_A_C | chr1:26864798 | 5,120 | -1,152 | 5,632 | — |
| chr1_26864793_A_G | chr1:26864793 | 5,120 | -1,664 | 4,864 | — |
| chr1_26864794_T_G | chr1:26864794 | 5,120 | -1,728 | 5,120 | — |
| chr1_26864719_G_T | chr1:26864719 | 4,992 | -448 | -768 | — |
| chr1_26864781_C_A | chr1:26864781 | 4,992 | 800 | 4,864 | 6.6e-6 |
| chr1_26864861_C_A | chr1:26864861 | 4,992 | 320 | 0 | — |
| chr1_26864806_G_C | chr1:26864806 | -4,864 | -448 | -5,120 | — |
| chr1_26864763_G_A | chr1:26864763 | 4,864 | 512 | 2,048 | 6.6e-6 |
| chr1_26864718_A_G | chr1:26864718 | -4,736 | -832 | -9,216 | — |
| chr1_26864822_G_C | chr1:26864822 | 4,736 | 896 | 6,656 | — |
| chr1_26864770_A_C | chr1:26864770 | -4,736 | -2,240 | 1,024 | — |
| chr1_26864820_C_T | chr1:26864820 | -4,736 | -160 | -3,072 | — |
| chr1_26864846_G_C | chr1:26864846 | 4,736 | -512 | 3,584 | — |
| chr1_26864874_C_T | chr1:26864874 | 4,736 | 192 | -512 | — |
| chr1_26864806_G_A | chr1:26864806 | -4,608 | -768 | -4,352 | — |
| chr1_26864810_C_A | chr1:26864810 | -4,608 | -704 | -3,328 | — |
| chr1_26864835_G_C | chr1:26864835 | -4,608 | -416 | -256 | — |
| chr1_26864832_C_T | chr1:26864832 | -4,480 | -1,024 | -7,936 | 1.3e-5 |
| chr1_26864719_G_A | chr1:26864719 | 4,480 | -64 | 0 | — |
| chr1_26864770_A_G | chr1:26864770 | -4,480 | -2,528 | -2,816 | — |
| chr1_26864805_C_G | chr1:26864805 | -4,480 | -384 | -1,536 | — |
| chr1_26864843_G_T | chr1:26864843 | 4,480 | 928 | -3,328 | — |
| chr1_26864806_G_T | chr1:26864806 | -4,352 | -576 | -4,608 | — |
| chr1_26864728_A_G | chr1:26864728 | 4,352 | 32 | 1,280 | — |
| chr1_26864790_G_C | chr1:26864790 | 4,352 | -96 | 2,560 | — |
| chr1_26864805_C_T | chr1:26864805 | -4,352 | -160 | 512 | — |
| chr1_26864807_C_T | chr1:26864807 | -4,352 | -480 | -1,536 | — |
| chr1_26864813_T_G | chr1:26864813 | -4,352 | -320 | -2,304 | — |
| chr1_26864864_G_A | chr1:26864864 | -4,352 | 224 | -3,584 | 6.6e-6 |
| chr1_26864765_C_G | chr1:26864765 | -4,224 | -928 | -1,024 | — |
| chr1_26864781_C_G | chr1:26864781 | -4,096 | -1,248 | 6,144 | — |
| chr1_26864710_G_C | chr1:26864710 | 4,096 | 480 | 4,864 | — |
| chr1_26864765_C_A | chr1:26864765 | -4,096 | -1,824 | -3,072 | — |
| chr1_26864814_A_T | chr1:26864814 | -4,096 | -480 | -4,096 | — |
| chr1_26864850_C_G | chr1:26864850 | -4,096 | -448 | -3,328 | — |
| chr1_26864801_A_T | chr1:26864801 | 3,968 | 448 | 6,144 | — |
| chr1_26864712_G_C | chr1:26864712 | 3,968 | 512 | 5,888 | — |
| chr1_26864860_T_G | chr1:26864860 | 3,968 | 64 | 4,352 | — |
| chr1_26864751_C_T | chr1:26864751 | -3,968 | -128 | -1,280 | — |
| chr1_26864769_A_C | chr1:26864769 | -3,968 | -2,144 | 512 | — |
| chr1_26864772_T_C | chr1:26864772 | -3,968 | -480 | -1,024 | 6.6e-6 |
| chr1_26864773_A_C | chr1:26864773 | -3,968 | -608 | 0 | 6.6e-6 |
| chr1_26864803_A_C | chr1:26864803 | -3,968 | -384 | -256 | — |
| chr1_26864803_A_T | chr1:26864803 | -3,968 | 384 | -1,792 | — |
| chr1_26864835_G_A | chr1:26864835 | -3,968 | -128 | -2,304 | — |
| chr1_26864862_A_C | chr1:26864862 | 3,968 | -352 | 1,536 | — |
| chr1_26864802_C_A | chr1:26864802 | -3,840 | -416 | -5,888 | — |
| chr1_26864775_T_G | chr1:26864775 | 3,840 | -864 | 4,864 | — |
| chr1_26864735_G_C | chr1:26864735 | 3,840 | 224 | -1,024 | — |
| chr1_26864737_G_A | chr1:26864737 | 3,840 | 576 | 1,280 | — |
| chr1_26864760_C_A | chr1:26864760 | -3,840 | -672 | -1,536 | — |
| chr1_26864773_A_T | chr1:26864773 | -3,840 | 32 | -1,792 | — |
| chr1_26864791_A_C | chr1:26864791 | 3,840 | -576 | 3,328 | — |
| chr1_26864797_A_C | chr1:26864797 | 3,840 | -1,248 | 2,304 | — |
| chr1_26864705_C_A | chr1:26864705 | -3,712 | -864 | -3,584 | — |
| chr1_26864739_G_T | chr1:26864739 | -3,712 | -704 | -1,792 | — |
| chr1_26864755_T_A | chr1:26864755 | -3,712 | -416 | -768 | — |
| chr1_26864766_A_G | chr1:26864766 | -3,712 | -1,952 | 0 | — |
| chr1_26864767_G_C | chr1:26864767 | -3,712 | -2,016 | 1,280 | — |
| chr1_26864808_C_T | chr1:26864808 | -3,712 | -512 | -3,584 | — |
| chr1_26864854_G_C | chr1:26864854 | -3,712 | -416 | -1,024 | — |
| chr1_26864716_T_A | chr1:26864716 | 3,584 | -512 | -3,840 | — |
| chr1_26864737_G_T | chr1:26864737 | 3,584 | 800 | 0 | — |
| chr1_26864751_C_G | chr1:26864751 | -3,584 | -160 | -1,536 | — |
| chr1_26864746_G_A | chr1:26864746 | -3,456 | -288 | -5,888 | 6.6e-6 |
| chr1_26864827_G_T | chr1:26864827 | -3,328 | -416 | -3,840 | — |
| chr1_26864782_T_A | chr1:26864782 | 3,200 | 2,240 | 9,216 | — |
| chr1_26864741_C_A | chr1:26864741 | 3,072 | 928 | 7,680 | — |
| chr1_26864802_C_G | chr1:26864802 | -3,072 | -256 | -4,608 | — |
| chr1_26827461_T_C | chr1:26827461 | -3,040 | -552 | -9,984 | — |
| chr1_26827523_T_C | chr1:26827523 | -2,912 | -408 | -8,192 | — |
| chr1_26864724_A_G | chr1:26864724 | -2,816 | -384 | -6,400 | — |
| chr1_26864820_C_A | chr1:26864820 | -2,816 | -448 | -4,864 | — |
| chr1_26864743_G_C | chr1:26864743 | -2,816 | -384 | -3,584 | — |
| chr1_26827451_T_C | chr1:26827451 | -2,752 | -1,000 | -9,856 | — |
| chr1_26827529_T_C | chr1:26827529 | -2,720 | -1,256 | -7,168 | — |
| chr1_26864709_G_C | chr1:26864709 | 2,688 | 32 | 4,864 | 6.6e-6 |
| chr1_26864796_T_G | chr1:26864796 | 2,688 | -736 | 4,352 | — |
| chr1_26864774_G_A | chr1:26864774 | -2,688 | -544 | -4,096 | — |
| chr1_26864745_C_G | chr1:26864745 | -2,560 | -704 | -4,864 | — |
| chr1_26864752_T_A | chr1:26864752 | -2,560 | 288 | 4,864 | 6.6e-6 |
| chr1_26864747_A_T | chr1:26864747 | 2,560 | 832 | 4,352 | — |
| chr1_26864727_C_G | chr1:26864727 | 2,560 | 64 | 3,840 | — |
| chr1_26864720_T_G | chr1:26864720 | 2,432 | 192 | -5,376 | — |
| chr1_26827486_T_C | chr1:26827486 | -2,336 | -912 | -8,704 | — |
| chr1_26864863_A_C | chr1:26864863 | 2,304 | 480 | 5,376 | — |
| chr1_26827472_C_G | chr1:26827472 | 2,240 | 472 | 5,760 | — |
| chr1_26864833_C_G | chr1:26864833 | 2,176 | 160 | 9,216 | — |
| chr1_26827561_C_G | chr1:26827561 | 2,176 | 496 | 4,480 | — |
| chr1_26864711_G_C | chr1:26864711 | 2,048 | -32 | 4,608 | 6.6e-5 |
| chr1_26864743_G_T | chr1:26864743 | -2,048 | -32 | -4,096 | — |
| chr1_26864859_A_G | chr1:26864859 | 1,920 | -128 | 4,352 | — |
| chr1_26827469_C_G | chr1:26827469 | 1,824 | 640 | 6,784 | — |
| chr1_26827469_C_A | chr1:26827469 | 1,792 | 592 | 4,864 | — |
| chr1_26827474_T_C | chr1:26827474 | -1,760 | -448 | -4,864 | — |
| chr1_26864851_A_T | chr1:26864851 | -1,664 | -864 | -4,096 | — |
| chr1_26827470_C_G | chr1:26827470 | 1,632 | 648 | 7,808 | — |
| chr1_26827557_A_C | chr1:26827557 | -1,632 | -272 | -5,504 | — |
| chr1_26827470_C_A | chr1:26827470 | 1,600 | 488 | 5,504 | — |
| chr1_26827556_A_C | chr1:26827556 | -1,600 | -448 | -4,224 | — |
| chr1_26827522_C_G | chr1:26827522 | 1,600 | 256 | 3,840 | — |
| chr1_26827459_C_T | chr1:26827459 | 1,600 | 368 | 3,584 | 3.3e-5 |
| chr1_26827466_G_C | chr1:26827466 | -1,536 | -520 | -5,632 | — |
| chr1_26864855_T_G | chr1:26864855 | 1,536 | 1,280 | 4,096 | — |
| chr1_26864744_A_T | chr1:26864744 | -1,536 | -224 | -3,840 | — |
| chr1_26827471_C_T | chr1:26827471 | 1,504 | 376 | 3,584 | 3.3e-5 |
| chr1_26827477_T_C | chr1:26827477 | -1,472 | -664 | -6,016 | — |
| chr1_26827536_T_C | chr1:26827536 | -1,440 | -480 | -4,608 | — |
| chr1_26827459_C_G | chr1:26827459 | 1,408 | 456 | 6,272 | — |
| chr1_26864745_C_A | chr1:26864745 | -1,408 | -480 | -4,352 | — |
| chr1_26864875_T_C | chr1:26864875 | 1,408 | -640 | 4,096 | — |
| chr1_26827470_C_T | chr1:26827470 | 1,376 | 240 | 4,224 | — |
| chr1_26827560_C_G | chr1:26827560 | 1,344 | 320 | 4,224 | — |
| chr1_26827459_C_A | chr1:26827459 | 1,312 | 408 | 3,584 | — |
| chr1_26827464_A_C | chr1:26827464 | -1,280 | -704 | -7,296 | — |
| chr1_26827560_C_A | chr1:26827560 | 1,280 | 288 | 3,712 | 2.0e-5 |
| chr1_26827522_C_A | chr1:26827522 | 1,280 | 264 | 3,584 | — |
| chr1_26827560_C_T | chr1:26827560 | 1,280 | 288 | 3,584 | — |
| chr1_26827471_C_G | chr1:26827471 | 1,248 | 176 | 5,376 | — |
| chr1_26827559_C_A | chr1:26827559 | 1,248 | 368 | 3,584 | 1.3e-5 |
| chr1_26827448_G_C | chr1:26827448 | -1,216 | -328 | -3,840 | — |
| chr1_26827531_A_C | chr1:26827531 | -1,216 | -376 | -3,712 | — |
| chr1_26827460_C_G | chr1:26827460 | 1,184 | 280 | 3,840 | — |
| chr1_26864778_A_C | chr1:26864778 | -1,152 | 2,720 | 7,936 | — |
| chr1_26864732_C_G | chr1:26864732 | -1,152 | -192 | -6,656 | — |
| chr1_26827467_G_C | chr1:26827467 | -1,152 | -384 | -5,248 | 6.6e-6 |
| chr1_26864745_C_T | chr1:26864745 | -1,152 | -576 | -4,608 | — |
| chr1_26864750_T_G | chr1:26864750 | -1,152 | -160 | 3,840 | — |
| chr1_26827518_G_C | chr1:26827518 | -1,152 | -144 | -3,584 | — |
| chr1_26827471_C_A | chr1:26827471 | 1,120 | 352 | 4,224 | — |
| chr1_26827559_C_G | chr1:26827559 | 1,120 | 352 | 4,096 | — |
| chr1_26827458_C_G | chr1:26827458 | 1,088 | 376 | 5,248 | — |
| chr1_26827444_A_C | chr1:26827444 | -1,056 | -312 | -3,968 | — |
| chr1_26827521_C_G | chr1:26827521 | 1,024 | 288 | 4,608 | — |
| chr1_26864824_A_T | chr1:26864824 | -1,024 | -512 | -4,096 | — |
| chr1_26827482_G_C | chr1:26827482 | -992 | -424 | -3,712 | — |
| chr1_26827479_G_C | chr1:26827479 | -960 | -480 | -5,376 | — |
| chr1_26827533_C_G | chr1:26827533 | 960 | 32 | 3,840 | — |
| chr1_26827456_G_C | chr1:26827456 | -896 | -472 | -5,504 | — |
| chr1_26864734_C_A | chr1:26864734 | -896 | -288 | -4,096 | 6.6e-6 |
| chr1_26864708_A_G | chr1:26864708 | 896 | 576 | -3,584 | — |
| chr1_26827468_C_G | chr1:26827468 | 864 | 296 | 4,736 | — |
| chr1_26864787_C_G | chr1:26864787 | 768 | -736 | -5,376 | — |
| chr1_26864863_A_T | chr1:26864863 | 640 | 256 | 5,376 | — |
| chr1_26864847_G_C | chr1:26864847 | -640 | -96 | 3,840 | — |
| chr1_26864716_T_G | chr1:26864716 | -512 | -256 | -7,936 | — |
| chr1_26864733_G_T | chr1:26864733 | -512 | -224 | -4,352 | — |
| chr1_26864847_G_A | chr1:26864847 | -512 | -192 | 4,352 | — |
| chr1_26864892_G_A | chr1:26864892 | -512 | -224 | -4,096 | — |
| chr1_26864732_C_A | chr1:26864732 | -512 | -448 | -3,840 | — |
| chr1_26827473_A_G | chr1:26827473 | 448 | 192 | 3,840 | — |
| chr1_26827474_T_G | chr1:26827474 | 352 | 168 | 4,096 | — |
| chr1_26827464_A_G | chr1:26827464 | 288 | 104 | 3,584 | — |
| chr1_26864830_C_A | chr1:26864830 | 128 | -256 | -4,352 | — |
| chr1_26864821_G_T | chr1:26864821 | 128 | -160 | -3,840 | — |
| chr1_26827495_C_G | chr1:26827495 | 64 | 112 | 3,584 | — |
| chr1_26864713_A_G | chr1:26864713 | 0 | 512 | -8,192 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.