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NR0B2
receptor: FXRTier 1
CAMIP Tier 1: peak-anchored panel
FXR
Submitted decision (verbatim): 接受
No revision text or notes were submitted.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Obeticholic acid; Experimental GW4064
- Regulatory element
- overlapping TSS
- Predicted consequence
- Blunted receptor-mediated induction of NR0B2 expression, weakening the downstream transcriptional feedback inhibition of hepatic bile acid synthesis pathways.
- Prior narrative
- Blunted receptor-mediated induction of NR0B2 expression, weakening the downstream transcriptional feedback inhibition of hepatic bile acid synthesis pathways.
- Drug context
- none in routine clinical use, endogenous or bile acid pathway
Scored variants near NR0B2
chr1:26,811,488..27,013,975, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr1_26864748_G_C | chr1:26864748 | 0.825 | 0.094 | -0.059 | — |
| chr1_26827461_T_C | chr1:26827461 | -0.079 | -0.044 | -0.459 | — |
| chr1_26864772_T_A | chr1:26864772 | -0.260 | -0.142 | -0.153 | — |
| chr1_26827451_T_C | chr1:26827451 | -0.072 | -0.079 | -0.453 | — |
| chr1_26864718_A_G | chr1:26864718 | -0.123 | -0.066 | -0.424 | — |
| chr1_26864782_T_A | chr1:26864782 | 0.083 | 0.178 | 0.424 | — |
| chr1_26864833_C_G | chr1:26864833 | 0.057 | 0.013 | 0.424 | — |
| chr1_26864758_A_G | chr1:26864758 | 0.180 | 0.094 | 0.412 | — |
| chr1_26864722_G_C | chr1:26864722 | 0.230 | 0.036 | 0.188 | — |
| chr1_26827486_T_C | chr1:26827486 | -0.061 | -0.072 | -0.400 | — |
| chr1_26864734_C_G | chr1:26864734 | -0.146 | -0.015 | -0.388 | — |
| chr1_26864789_T_G | chr1:26864789 | -0.170 | -0.036 | -0.388 | — |
| chr1_26864722_G_A | chr1:26864722 | 0.216 | 0.033 | 0.047 | — |
| chr1_26827523_T_C | chr1:26827523 | -0.076 | -0.032 | -0.376 | — |
| chr1_26864713_A_G | chr1:26864713 | 0.000 | 0.041 | -0.376 | — |
| chr1_26864798_A_T | chr1:26864798 | 0.210 | -0.140 | 0.200 | — |
| chr1_26864716_T_G | chr1:26864716 | -0.013 | -0.020 | -0.365 | — |
| chr1_26864778_A_C | chr1:26864778 | -0.030 | 0.216 | 0.365 | — |
| chr1_26864832_C_T | chr1:26864832 | -0.116 | -0.081 | -0.365 | 0.0013% |
| chr1_26827470_C_G | chr1:26827470 | 0.042 | 0.051 | 0.359 | — |
| chr1_26864720_T_C | chr1:26864720 | 0.203 | 0.010 | 0.071 | — |
| chr1_26864722_G_T | chr1:26864722 | 0.203 | 0.036 | 0.059 | — |
| chr1_26864741_C_A | chr1:26864741 | 0.080 | 0.074 | 0.353 | — |
| chr1_26864820_C_G | chr1:26864820 | -0.200 | -0.119 | -0.224 | — |
| chr1_26827464_A_C | chr1:26827464 | -0.033 | -0.056 | -0.335 | — |
| chr1_26864760_C_G | chr1:26864760 | -0.190 | -0.061 | -0.224 | 0.062% |
| chr1_26827529_T_C | chr1:26827529 | -0.071 | -0.100 | -0.329 | — |
| chr1_26864721_G_C | chr1:26864721 | 0.186 | 0.015 | 0.224 | — |
| chr1_26864734_C_T | chr1:26864734 | -0.186 | -0.025 | -0.224 | — |
| chr1_26864813_T_A | chr1:26864813 | -0.186 | -0.018 | -0.259 | — |
| chr1_26864719_G_C | chr1:26864719 | 0.180 | 0.005 | -0.047 | — |
| chr1_26827469_C_G | chr1:26827469 | 0.047 | 0.051 | 0.312 | — |
| chr1_26864781_C_T | chr1:26864781 | 0.176 | 0.150 | 0.188 | <0.001% |
| chr1_26864811_A_C | chr1:26864811 | 0.176 | 0.069 | 0.153 | — |
| chr1_26864732_C_G | chr1:26864732 | -0.030 | -0.015 | -0.306 | — |
| chr1_26864822_G_C | chr1:26864822 | 0.123 | 0.071 | 0.306 | — |
| chr1_26864755_T_G | chr1:26864755 | -0.170 | -0.008 | -0.141 | — |
| chr1_26864721_G_A | chr1:26864721 | 0.166 | 0.018 | 0.082 | — |
| chr1_26864724_A_G | chr1:26864724 | -0.073 | -0.030 | -0.294 | — |
| chr1_26864794_T_C | chr1:26864794 | 0.150 | -0.102 | 0.294 | — |
| chr1_26864796_T_A | chr1:26864796 | -0.150 | 0.282 | -0.294 | — |
| chr1_26827459_C_G | chr1:26827459 | 0.037 | 0.036 | 0.288 | — |
| chr1_26864769_A_G | chr1:26864769 | -0.163 | -0.211 | -0.047 | — |
| chr1_26864720_T_A | chr1:26864720 | 0.160 | 0.015 | -0.035 | — |
| chr1_26864771_A_T | chr1:26864771 | -0.160 | -0.175 | -0.082 | — |
| chr1_26864781_C_G | chr1:26864781 | -0.106 | -0.099 | 0.282 | — |
| chr1_26864792_G_T | chr1:26864792 | 0.160 | -0.061 | 0.212 | — |
| chr1_26864801_A_T | chr1:26864801 | 0.103 | 0.036 | 0.282 | — |
| chr1_26864831_A_C | chr1:26864831 | -0.160 | -0.127 | -0.247 | — |
| chr1_26827477_T_C | chr1:26827477 | -0.038 | -0.053 | -0.276 | — |
| chr1_26864738_A_G | chr1:26864738 | -0.156 | -0.056 | -0.259 | 0.0013% |
| chr1_26864792_G_A | chr1:26864792 | 0.156 | -0.081 | 0.035 | — |
| chr1_26864793_A_C | chr1:26864793 | 0.156 | -0.117 | 0.247 | — |
| chr1_26864712_G_C | chr1:26864712 | 0.103 | 0.041 | 0.271 | — |
| chr1_26864746_G_A | chr1:26864746 | -0.090 | -0.023 | -0.271 | <0.001% |
| chr1_26864747_A_C | chr1:26864747 | 0.153 | 0.018 | 0.141 | — |
| chr1_26864772_T_G | chr1:26864772 | -0.153 | -0.112 | -0.024 | — |
| chr1_26864802_C_A | chr1:26864802 | -0.100 | -0.033 | -0.271 | — |
| chr1_26827472_C_G | chr1:26827472 | 0.058 | 0.037 | 0.265 | — |
| chr1_26827466_G_C | chr1:26827466 | -0.040 | -0.041 | -0.259 | — |
| chr1_26864766_A_C | chr1:26864766 | 0.143 | -0.005 | 0.259 | — |
| chr1_26864797_A_T | chr1:26864797 | 0.146 | -0.066 | 0.176 | — |
| chr1_26864798_A_C | chr1:26864798 | 0.133 | -0.091 | 0.259 | — |
| chr1_26827456_G_C | chr1:26827456 | -0.023 | -0.037 | -0.253 | — |
| chr1_26827470_C_A | chr1:26827470 | 0.042 | 0.039 | 0.253 | — |
| chr1_26827557_A_C | chr1:26827557 | -0.042 | -0.022 | -0.253 | — |
| chr1_26864771_A_G | chr1:26864771 | 0.143 | 0.107 | 0.247 | — |
| chr1_26864774_G_T | chr1:26864774 | -0.143 | -0.066 | -0.235 | — |
| chr1_26864794_T_A | chr1:26864794 | 0.143 | -0.112 | 0.012 | — |
| chr1_26827471_C_G | chr1:26827471 | 0.032 | 0.014 | 0.247 | — |
| chr1_26827479_G_C | chr1:26827479 | -0.025 | -0.038 | -0.247 | — |
| chr1_26864720_T_G | chr1:26864720 | 0.063 | 0.015 | -0.247 | — |
| chr1_26864721_G_T | chr1:26864721 | 0.140 | -0.008 | 0.059 | — |
| chr1_26864723_G_T | chr1:26864723 | 0.140 | 0.020 | 0.024 | — |
| chr1_26864743_G_A | chr1:26864743 | -0.140 | -0.051 | -0.153 | — |
| chr1_26864787_C_G | chr1:26864787 | 0.020 | -0.058 | -0.247 | — |
| chr1_26864795_C_A | chr1:26864795 | 0.140 | -0.089 | 0.153 | — |
| chr1_26864839_T_A | chr1:26864839 | 0.140 | 0.010 | 0.118 | — |
| chr1_26864863_A_C | chr1:26864863 | 0.060 | 0.038 | 0.247 | — |
| chr1_26864863_A_T | chr1:26864863 | 0.017 | 0.020 | 0.247 | — |
| chr1_26827458_C_G | chr1:26827458 | 0.028 | 0.030 | 0.241 | — |
| chr1_26827467_G_C | chr1:26827467 | -0.030 | -0.030 | -0.241 | <0.001% |
| chr1_26864805_C_A | chr1:26864805 | -0.136 | -0.018 | -0.200 | — |
| chr1_26864793_A_G | chr1:26864793 | 0.133 | -0.132 | 0.224 | — |
| chr1_26864794_T_G | chr1:26864794 | 0.133 | -0.137 | 0.235 | — |
| chr1_26864806_G_C | chr1:26864806 | -0.126 | -0.036 | -0.235 | — |
| chr1_26864719_G_T | chr1:26864719 | 0.130 | -0.036 | -0.035 | — |
| chr1_26864781_C_A | chr1:26864781 | 0.130 | 0.063 | 0.224 | <0.001% |
| chr1_26864861_C_A | chr1:26864861 | 0.130 | 0.025 | 0.000 | — |
| chr1_26827469_C_A | chr1:26827469 | 0.047 | 0.047 | 0.224 | — |
| chr1_26827474_T_C | chr1:26827474 | -0.046 | -0.036 | -0.224 | — |
| chr1_26864709_G_C | chr1:26864709 | 0.070 | 0.003 | 0.224 | <0.001% |
| chr1_26864710_G_C | chr1:26864710 | 0.106 | 0.038 | 0.224 | — |
| chr1_26864745_C_G | chr1:26864745 | -0.067 | -0.056 | -0.224 | — |
| chr1_26864752_T_A | chr1:26864752 | -0.067 | 0.023 | 0.224 | <0.001% |
| chr1_26864763_G_A | chr1:26864763 | 0.126 | 0.041 | 0.094 | <0.001% |
| chr1_26864775_T_G | chr1:26864775 | 0.100 | -0.069 | 0.224 | — |
| chr1_26864820_C_A | chr1:26864820 | -0.073 | -0.036 | -0.224 | — |
| chr1_26827468_C_G | chr1:26827468 | 0.022 | 0.023 | 0.218 | — |
| chr1_26864770_A_C | chr1:26864770 | -0.123 | -0.178 | 0.047 | — |
| chr1_26864820_C_T | chr1:26864820 | -0.123 | -0.013 | -0.141 | — |
| chr1_26864846_G_C | chr1:26864846 | 0.123 | -0.041 | 0.165 | — |
| chr1_26864874_C_T | chr1:26864874 | 0.123 | 0.015 | -0.024 | — |
| chr1_26827521_C_G | chr1:26827521 | 0.027 | 0.023 | 0.212 | — |
| chr1_26827536_T_C | chr1:26827536 | -0.037 | -0.038 | -0.212 | — |
| chr1_26864711_G_C | chr1:26864711 | 0.053 | -0.003 | 0.212 | 0.0066% |
| chr1_26864745_C_T | chr1:26864745 | -0.030 | -0.046 | -0.212 | — |
| chr1_26864802_C_G | chr1:26864802 | -0.080 | -0.020 | -0.212 | — |
| chr1_26864806_G_A | chr1:26864806 | -0.120 | -0.061 | -0.200 | — |
| chr1_26864806_G_T | chr1:26864806 | -0.113 | -0.046 | -0.212 | — |
| chr1_26864810_C_A | chr1:26864810 | -0.120 | -0.056 | -0.153 | — |
| chr1_26864835_G_C | chr1:26864835 | -0.120 | -0.033 | -0.012 | — |
| chr1_26827561_C_G | chr1:26827561 | 0.057 | 0.039 | 0.206 | — |
| chr1_26864719_G_A | chr1:26864719 | 0.116 | -0.005 | 0.000 | — |
| chr1_26864770_A_G | chr1:26864770 | -0.116 | -0.201 | -0.129 | — |
| chr1_26864805_C_G | chr1:26864805 | -0.116 | -0.030 | -0.071 | — |
| chr1_26864843_G_T | chr1:26864843 | 0.116 | 0.074 | -0.153 | — |
| chr1_26864728_A_G | chr1:26864728 | 0.113 | 0.003 | 0.059 | — |
| chr1_26864733_G_T | chr1:26864733 | -0.013 | -0.018 | -0.200 | — |
| chr1_26864745_C_A | chr1:26864745 | -0.037 | -0.038 | -0.200 | — |
| chr1_26864747_A_T | chr1:26864747 | 0.067 | 0.066 | 0.200 | — |
| chr1_26864790_G_C | chr1:26864790 | 0.113 | -0.008 | 0.118 | — |
| chr1_26864796_T_G | chr1:26864796 | 0.070 | -0.058 | 0.200 | — |
| chr1_26864805_C_T | chr1:26864805 | -0.113 | -0.013 | 0.024 | — |
| chr1_26864807_C_T | chr1:26864807 | -0.113 | -0.038 | -0.071 | — |
| chr1_26864813_T_G | chr1:26864813 | -0.113 | -0.025 | -0.106 | — |
| chr1_26864830_C_A | chr1:26864830 | 0.003 | -0.020 | -0.200 | — |
| chr1_26864847_G_A | chr1:26864847 | -0.013 | -0.015 | 0.200 | — |
| chr1_26864859_A_G | chr1:26864859 | 0.050 | -0.010 | 0.200 | — |
| chr1_26864860_T_G | chr1:26864860 | 0.103 | 0.005 | 0.200 | — |
| chr1_26864864_G_A | chr1:26864864 | -0.113 | 0.018 | -0.165 | <0.001% |
| chr1_26827470_C_T | chr1:26827470 | 0.036 | 0.019 | 0.194 | — |
| chr1_26827471_C_A | chr1:26827471 | 0.029 | 0.028 | 0.194 | — |
| chr1_26827556_A_C | chr1:26827556 | -0.042 | -0.036 | -0.194 | — |
| chr1_26827560_C_G | chr1:26827560 | 0.035 | 0.025 | 0.194 | — |
| chr1_26864765_C_G | chr1:26864765 | -0.110 | -0.074 | -0.047 | — |
| chr1_26827474_T_G | chr1:26827474 | 0.009 | 0.013 | 0.188 | — |
| chr1_26827559_C_G | chr1:26827559 | 0.029 | 0.028 | 0.188 | — |
| chr1_26864734_C_A | chr1:26864734 | -0.023 | -0.023 | -0.188 | <0.001% |
| chr1_26864743_G_T | chr1:26864743 | -0.053 | -0.003 | -0.188 | — |
| chr1_26864765_C_A | chr1:26864765 | -0.106 | -0.145 | -0.141 | — |
| chr1_26864774_G_A | chr1:26864774 | -0.070 | -0.043 | -0.188 | — |
| chr1_26864814_A_T | chr1:26864814 | -0.106 | -0.038 | -0.188 | — |
| chr1_26864824_A_T | chr1:26864824 | -0.027 | -0.041 | -0.188 | — |
| chr1_26864850_C_G | chr1:26864850 | -0.106 | -0.036 | -0.153 | — |
| chr1_26864851_A_T | chr1:26864851 | -0.043 | -0.069 | -0.188 | — |
| chr1_26864855_T_G | chr1:26864855 | 0.040 | 0.102 | 0.188 | — |
| chr1_26864875_T_C | chr1:26864875 | 0.037 | -0.051 | 0.188 | — |
| chr1_26864892_G_A | chr1:26864892 | -0.013 | -0.018 | -0.188 | — |
| chr1_26827444_A_C | chr1:26827444 | -0.027 | -0.025 | -0.182 | — |
| chr1_26864751_C_T | chr1:26864751 | -0.103 | -0.010 | -0.059 | — |
| chr1_26864769_A_C | chr1:26864769 | -0.103 | -0.170 | 0.024 | — |
| chr1_26864772_T_C | chr1:26864772 | -0.103 | -0.038 | -0.047 | <0.001% |
| chr1_26864773_A_C | chr1:26864773 | -0.103 | -0.048 | 0.000 | <0.001% |
| chr1_26864803_A_C | chr1:26864803 | -0.103 | -0.030 | -0.012 | — |
| chr1_26864803_A_T | chr1:26864803 | -0.103 | 0.030 | -0.082 | — |
| chr1_26864835_G_A | chr1:26864835 | -0.103 | -0.010 | -0.106 | — |
| chr1_26864862_A_C | chr1:26864862 | 0.103 | -0.028 | 0.071 | — |
| chr1_26827448_G_C | chr1:26827448 | -0.032 | -0.026 | -0.176 | — |
| chr1_26827460_C_G | chr1:26827460 | 0.031 | 0.022 | 0.176 | — |
| chr1_26827473_A_G | chr1:26827473 | 0.012 | 0.015 | 0.176 | — |
| chr1_26827522_C_G | chr1:26827522 | 0.042 | 0.020 | 0.176 | — |
| chr1_26827533_C_G | chr1:26827533 | 0.025 | 0.003 | 0.176 | — |
| chr1_26864716_T_A | chr1:26864716 | 0.093 | -0.041 | -0.176 | — |
| chr1_26864727_C_G | chr1:26864727 | 0.067 | 0.005 | 0.176 | — |
| chr1_26864732_C_A | chr1:26864732 | -0.013 | -0.036 | -0.176 | — |
| chr1_26864735_G_C | chr1:26864735 | 0.100 | 0.018 | -0.047 | — |
| chr1_26864737_G_A | chr1:26864737 | 0.100 | 0.046 | 0.059 | — |
| chr1_26864744_A_T | chr1:26864744 | -0.040 | -0.018 | -0.176 | — |
| chr1_26864750_T_G | chr1:26864750 | -0.030 | -0.013 | 0.176 | — |
| chr1_26864760_C_A | chr1:26864760 | -0.100 | -0.053 | -0.071 | — |
| chr1_26864773_A_T | chr1:26864773 | -0.100 | 0.003 | -0.082 | — |
| chr1_26864791_A_C | chr1:26864791 | 0.100 | -0.046 | 0.153 | — |
| chr1_26864797_A_C | chr1:26864797 | 0.100 | -0.099 | 0.106 | — |
| chr1_26864821_G_T | chr1:26864821 | 0.003 | -0.013 | -0.176 | — |
| chr1_26864827_G_T | chr1:26864827 | -0.087 | -0.033 | -0.176 | — |
| chr1_26864847_G_C | chr1:26864847 | -0.017 | -0.008 | 0.176 | — |
| chr1_26827482_G_C | chr1:26827482 | -0.026 | -0.034 | -0.171 | — |
| chr1_26827531_A_C | chr1:26827531 | -0.032 | -0.030 | -0.171 | — |
| chr1_26827560_C_A | chr1:26827560 | 0.033 | 0.023 | 0.171 | 0.0020% |
| chr1_26864705_C_A | chr1:26864705 | -0.097 | -0.069 | -0.165 | — |
| chr1_26864739_G_T | chr1:26864739 | -0.097 | -0.056 | -0.082 | — |
| chr1_26864755_T_A | chr1:26864755 | -0.097 | -0.033 | -0.035 | — |
| chr1_26864766_A_G | chr1:26864766 | -0.097 | -0.155 | 0.000 | — |
| chr1_26864767_G_C | chr1:26864767 | -0.097 | -0.160 | 0.059 | — |
| chr1_26864808_C_T | chr1:26864808 | -0.097 | -0.041 | -0.165 | — |
| chr1_26864854_G_C | chr1:26864854 | -0.097 | -0.033 | -0.047 | — |
| chr1_26827459_C_A | chr1:26827459 | 0.034 | 0.032 | 0.165 | — |
| chr1_26827459_C_T | chr1:26827459 | 0.042 | 0.029 | 0.165 | 0.0033% |
| chr1_26827464_A_G | chr1:26827464 | 0.007 | 0.008 | 0.165 | — |
| chr1_26827471_C_T | chr1:26827471 | 0.039 | 0.030 | 0.165 | 0.0033% |
| chr1_26827495_C_G | chr1:26827495 | 0.002 | 0.009 | 0.165 | — |
| chr1_26827518_G_C | chr1:26827518 | -0.030 | -0.011 | -0.165 | — |
| chr1_26827522_C_A | chr1:26827522 | 0.033 | 0.021 | 0.165 | — |
| chr1_26827559_C_A | chr1:26827559 | 0.032 | 0.029 | 0.165 | 0.0013% |
| chr1_26827560_C_T | chr1:26827560 | 0.033 | 0.023 | 0.165 | — |
| chr1_26864708_A_G | chr1:26864708 | 0.023 | 0.046 | -0.165 | — |
| chr1_26864737_G_T | chr1:26864737 | 0.093 | 0.063 | 0.000 | — |
| chr1_26864743_G_C | chr1:26864743 | -0.073 | -0.030 | -0.165 | — |
| chr1_26864751_C_G | chr1:26864751 | -0.093 | -0.013 | -0.071 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.