Home / Gene
SLC10A1
receptor: FXRTier 1
CAMIP Tier 1: peak-anchored panel
FXR
Submitted decision (verbatim): 需修訂
Reviewer revision (verbatim)
Reduced FXR binding would weaken FXR-driven SHP induction; with SHP-mediated repression relieved, SLC10A1/NTCP expression would rise, thus increasing the hepatic clearance of NTCP substrates.
Reviewer notes (verbatim)
Rosuvastatin 不在 PharmGKB 臨床註釋
Polymorphisms in SLC10A1 had minimal effects on the plasma concentration of rosuvastatin in Chinese patients with hypercholesterolemia (PMID: 23930675).
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Obeticholic acid; Experimental GW4064
- Regulatory element
- in distal enhancer +11900 bp
- Predicted consequence
- Reduced FXR binding would weaken FXR-driven SHP induction; with SHP-mediated repression relieved, SLC10A1/NTCP expression would rise, thus increasing the hepatic clearance of NTCP substrates.
- Prior narrative
- Reduced FXR binding would weaken FXR-driven SHP induction; with SHP-mediated repression relieved, SLC10A1/NTCP expression would rise, thus increasing the hepatic clearance of NTCP substrates.
Scored variants near SLC10A1
chr14:69,675,415..69,897,241, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr14_69685917_G_A | chr14:69685917 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685885_T_G | chr14:69685885 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685888_G_C | chr14:69685888 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685888_G_A | chr14:69685888 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685844_A_C | chr14:69685844 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685844_A_T | chr14:69685844 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685913_A_C | chr14:69685913 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685862_T_A | chr14:69685862 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685899_G_T | chr14:69685899 | 1.000 | 0.393 | 0.476 | — |
| chr14_69685905_A_C | chr14:69685905 | -1.000 | -0.949 | -1.000 | — |
| chr14_69685939_C_T | chr14:69685939 | -1.000 | -0.906 | -1.000 | — |
| chr14_69685937_G_C | chr14:69685937 | -1.000 | -0.840 | -1.000 | — |
| chr14_69685866_T_C | chr14:69685866 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685939_C_A | chr14:69685939 | -1.000 | -0.865 | -1.000 | — |
| chr14_69685862_T_G | chr14:69685862 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685937_G_A | chr14:69685937 | -1.000 | -0.817 | -1.000 | — |
| chr14_69685939_C_G | chr14:69685939 | -1.000 | -0.893 | -1.000 | — |
| chr14_69685872_G_C | chr14:69685872 | 1.000 | 1.000 | 0.976 | — |
| chr14_69685938_C_T | chr14:69685938 | -1.000 | -0.660 | -1.000 | — |
| chr14_69685871_T_G | chr14:69685871 | 1.000 | 1.000 | 0.765 | — |
| chr14_69685938_C_A | chr14:69685938 | -1.000 | -0.655 | -1.000 | — |
| chr14_69685930_G_T | chr14:69685930 | -1.000 | -0.571 | -1.000 | — |
| chr14_69685899_G_C | chr14:69685899 | 1.000 | 0.810 | 0.994 | — |
| chr14_69685885_T_A | chr14:69685885 | 1.000 | 0.878 | 0.929 | — |
| chr14_69685929_G_T | chr14:69685929 | -1.000 | -0.602 | -1.000 | — |
| chr14_69685941_G_C | chr14:69685941 | -1.000 | -0.571 | -0.906 | — |
| chr14_69685929_G_A | chr14:69685929 | -1.000 | -0.596 | -1.000 | — |
| chr14_69685931_C_T | chr14:69685931 | -1.000 | -0.553 | -0.929 | — |
| chr14_69685930_G_A | chr14:69685930 | -1.000 | -0.497 | -1.000 | — |
| chr14_69685929_G_C | chr14:69685929 | -1.000 | -0.640 | -1.000 | — |
| chr14_69685930_G_C | chr14:69685930 | -1.000 | -0.497 | -0.965 | — |
| chr14_69685895_C_T | chr14:69685895 | 1.000 | 0.820 | 0.847 | — |
| chr14_69685888_G_T | chr14:69685888 | 1.000 | 0.792 | 0.888 | — |
| chr14_69685931_C_G | chr14:69685931 | -1.000 | -0.462 | -0.865 | — |
| chr14_69685915_C_G | chr14:69685915 | -1.000 | -0.759 | -1.000 | — |
| chr14_69685914_G_C | chr14:69685914 | 1.000 | 0.751 | 0.571 | — |
| chr14_69685907_C_G | chr14:69685907 | -1.000 | -0.690 | -0.741 | — |
| chr14_69685920_G_T | chr14:69685920 | -1.000 | -0.640 | -1.000 | — |
| chr14_69685928_T_C | chr14:69685928 | -1.000 | -0.579 | -0.982 | — |
| chr14_69685862_T_C | chr14:69685862 | 1.000 | 0.843 | 0.741 | — |
| chr14_69685940_A_T | chr14:69685940 | -1.000 | -0.579 | -0.947 | — |
| chr14_69685941_G_T | chr14:69685941 | -1.000 | -0.528 | -0.791 | — |
| chr14_69685937_G_T | chr14:69685937 | -1.000 | -0.602 | -0.912 | — |
| chr14_69685938_C_G | chr14:69685938 | -1.000 | -0.510 | -0.832 | — |
| chr14_69685962_G_T | chr14:69685962 | -0.985 | -0.457 | -0.879 | — |
| chr14_69685950_A_C | chr14:69685950 | -0.973 | -0.398 | -0.791 | — |
| chr14_69685907_C_T | chr14:69685907 | -0.968 | -0.695 | -0.776 | — |
| chr14_69685940_A_G | chr14:69685940 | -0.958 | -0.680 | -0.976 | — |
| chr14_69685928_T_A | chr14:69685928 | -0.935 | -0.523 | -0.915 | — |
| chr14_69685880_A_T | chr14:69685880 | -0.928 | -0.746 | -0.932 | — |
| chr14_69685849_C_G | chr14:69685849 | -0.920 | -0.766 | -1.000 | — |
| chr14_69685877_T_A | chr14:69685877 | -0.885 | -0.673 | -0.735 | — |
| chr14_69685928_T_G | chr14:69685928 | -0.880 | -0.541 | -0.929 | — |
| chr14_69685874_A_C | chr14:69685874 | 0.877 | 0.843 | 0.900 | — |
| chr14_69685886_G_T | chr14:69685886 | -0.870 | -0.668 | -0.900 | — |
| chr14_69685878_G_A | chr14:69685878 | -0.867 | -0.604 | -0.868 | — |
| chr14_69685882_T_A | chr14:69685882 | -0.867 | -0.599 | -0.741 | — |
| chr14_69685884_T_A | chr14:69685884 | -0.855 | -0.657 | -0.800 | — |
| chr14_69685878_G_C | chr14:69685878 | -0.849 | -0.579 | -0.832 | — |
| chr14_69685877_T_G | chr14:69685877 | -0.845 | -0.665 | -0.732 | — |
| chr14_69685879_G_C | chr14:69685879 | -0.835 | -0.749 | -0.694 | — |
| chr14_69685927_G_T | chr14:69685927 | 0.832 | 0.434 | 0.682 | — |
| chr14_69685886_G_A | chr14:69685886 | -0.810 | -0.596 | -0.665 | — |
| chr14_69685881_C_G | chr14:69685881 | -0.797 | -0.690 | -0.815 | — |
| chr14_69685882_T_C | chr14:69685882 | 0.797 | 0.675 | 0.671 | — |
| chr14_69685880_A_G | chr14:69685880 | -0.792 | -0.675 | -0.815 | — |
| chr14_69685910_T_G | chr14:69685910 | 0.789 | 0.739 | 1.000 | — |
| chr14_69685861_C_G | chr14:69685861 | 0.787 | 0.703 | 0.665 | <0.001% |
| chr14_69685879_G_T | chr14:69685879 | -0.777 | -0.599 | -0.856 | — |
| chr14_69685860_C_T | chr14:69685860 | -0.774 | -0.622 | -0.735 | — |
| chr14_69685907_C_A | chr14:69685907 | -0.764 | -0.421 | -0.547 | — |
| chr14_69685927_G_C | chr14:69685927 | 0.755 | 0.292 | 0.694 | — |
| chr14_69685915_C_A | chr14:69685915 | -0.754 | -0.530 | -0.753 | — |
| chr14_69685940_A_C | chr14:69685940 | -0.754 | -0.429 | -0.638 | — |
| chr14_69685878_G_T | chr14:69685878 | -0.744 | -0.528 | -0.771 | — |
| chr14_69685886_G_C | chr14:69685886 | -0.740 | -0.604 | -0.721 | — |
| chr14_69685845_T_C | chr14:69685845 | 0.735 | 0.629 | 0.694 | — |
| chr14_69685852_C_A | chr14:69685852 | 0.732 | 0.523 | 0.524 | — |
| chr14_69685881_C_T | chr14:69685881 | -0.732 | -0.624 | -0.853 | — |
| chr14_69685971_G_T | chr14:69685971 | -0.720 | -0.289 | -0.671 | — |
| chr14_69685913_A_T | chr14:69685913 | 0.715 | 0.510 | 0.629 | — |
| chr14_69685877_T_C | chr14:69685877 | -0.702 | -0.571 | -0.565 | — |
| chr14_69685908_T_C | chr14:69685908 | -0.694 | -0.490 | -0.744 | — |
| chr14_69685889_C_G | chr14:69685889 | -0.684 | -0.538 | -0.632 | — |
| chr14_69685884_T_G | chr14:69685884 | -0.671 | -0.533 | -0.594 | — |
| chr14_69685828_C_G | chr14:69685828 | -0.661 | -0.609 | -0.718 | — |
| chr14_69685851_C_T | chr14:69685851 | -0.656 | -0.520 | -0.618 | 0.0020% |
| chr14_69685876_T_A | chr14:69685876 | -0.656 | -0.472 | -0.597 | — |
| chr14_69685853_C_G | chr14:69685853 | 0.652 | 0.508 | 0.718 | — |
| chr14_69685825_G_A | chr14:69685825 | -0.651 | -0.558 | -0.694 | — |
| chr14_69685898_A_G | chr14:69685898 | 0.644 | 0.472 | 0.541 | — |
| chr14_69685828_C_A | chr14:69685828 | -0.632 | -0.556 | -0.788 | — |
| chr14_69685835_A_C | chr14:69685835 | 0.632 | 0.464 | 0.447 | — |
| chr14_69685847_G_C | chr14:69685847 | -0.629 | -0.500 | -0.765 | — |
| chr14_69685883_T_G | chr14:69685883 | -0.624 | -0.546 | -0.518 | — |
| chr14_69685891_G_T | chr14:69685891 | -0.619 | -0.401 | -0.535 | — |
| chr14_69685887_T_A | chr14:69685887 | 0.617 | 0.480 | 0.547 | — |
| chr14_69685858_T_G | chr14:69685858 | 0.614 | 0.459 | 0.418 | — |
| chr14_69685894_G_T | chr14:69685894 | -0.609 | -0.439 | -0.644 | — |
| chr14_69685843_A_G | chr14:69685843 | -0.606 | -0.376 | -0.776 | <0.001% |
| chr14_69685933_G_T | chr14:69685933 | -0.606 | -0.185 | -0.221 | — |
| chr14_69685829_T_G | chr14:69685829 | -0.604 | -0.500 | -0.518 | — |
| chr14_69685898_A_T | chr14:69685898 | 0.602 | 0.477 | 0.541 | — |
| chr14_69685889_C_A | chr14:69685889 | -0.592 | -0.490 | -0.538 | — |
| chr14_69685832_G_C | chr14:69685832 | -0.591 | -0.221 | -0.253 | — |
| chr14_69685882_T_G | chr14:69685882 | -0.589 | -0.477 | -0.406 | — |
| chr14_69685915_C_T | chr14:69685915 | -0.587 | -0.426 | -0.559 | — |
| chr14_69685859_G_T | chr14:69685859 | -0.571 | -0.381 | -0.347 | — |
| chr14_69685936_T_C | chr14:69685936 | -0.571 | -0.358 | -0.447 | — |
| chr14_69685819_C_G | chr14:69685819 | -0.569 | -0.602 | -0.682 | — |
| chr14_69685829_T_A | chr14:69685829 | -0.564 | -0.477 | -0.535 | — |
| chr14_69685914_G_T | chr14:69685914 | 0.559 | 0.459 | 0.324 | — |
| chr14_69685883_T_A | chr14:69685883 | -0.556 | -0.495 | -0.494 | — |
| chr14_69685970_A_C | chr14:69685970 | -0.554 | -0.206 | -0.385 | — |
| chr14_69685818_A_C | chr14:69685818 | -0.549 | -0.452 | -0.529 | — |
| chr14_69685875_T_C | chr14:69685875 | 0.546 | 0.525 | 0.394 | — |
| chr14_69685967_G_C | chr14:69685967 | -0.542 | -0.228 | -0.494 | — |
| chr14_69685872_G_T | chr14:69685872 | -0.541 | -0.406 | -0.656 | — |
| chr14_69685884_T_C | chr14:69685884 | -0.541 | -0.459 | -0.441 | — |
| chr14_69685831_T_A | chr14:69685831 | -0.539 | -0.373 | -0.476 | — |
| chr14_69685923_A_T | chr14:69685923 | 0.531 | 0.244 | 0.482 | — |
| chr14_69685820_A_C | chr14:69685820 | -0.529 | -0.480 | -0.518 | — |
| chr14_69685895_C_G | chr14:69685895 | -0.527 | -0.173 | -0.312 | — |
| chr14_69685900_A_C | chr14:69685900 | 0.527 | 0.398 | 0.447 | — |
| chr14_69685860_C_A | chr14:69685860 | 0.524 | 0.396 | 0.329 | — |
| chr14_69685948_G_T | chr14:69685948 | -0.521 | -0.254 | -0.550 | — |
| chr14_69685847_G_A | chr14:69685847 | -0.519 | -0.424 | -0.676 | — |
| chr14_69685973_T_C | chr14:69685973 | -0.519 | -0.244 | -0.471 | — |
| chr14_69685969_C_A | chr14:69685969 | -0.517 | -0.236 | -0.450 | — |
| chr14_69685887_T_G | chr14:69685887 | 0.509 | 0.348 | 0.424 | — |
| chr14_69685842_A_G | chr14:69685842 | -0.507 | -0.378 | -0.676 | — |
| chr14_69685931_C_A | chr14:69685931 | -0.506 | -0.213 | -0.400 | — |
| chr14_69685867_G_C | chr14:69685867 | -0.502 | -0.414 | -0.541 | — |
| chr14_69685855_G_T | chr14:69685855 | -0.499 | -0.365 | -0.441 | — |
| chr14_69685847_G_T | chr14:69685847 | -0.496 | -0.409 | -0.676 | — |
| chr14_69741167_T_A | chr14:69741167 | -0.494 | -0.424 | -0.791 | — |
| chr14_69685880_A_C | chr14:69685880 | -0.493 | -0.470 | -0.388 | — |
| chr14_69685819_C_A | chr14:69685819 | -0.488 | -0.581 | -0.612 | — |
| chr14_69685920_G_A | chr14:69685920 | 0.486 | 0.383 | 0.565 | 0.0020% |
| chr14_69685971_G_C | chr14:69685971 | -0.484 | -0.076 | -0.371 | <0.001% |
| chr14_69685866_T_G | chr14:69685866 | -0.483 | -0.315 | -0.424 | — |
| chr14_69685853_C_A | chr14:69685853 | 0.479 | 0.358 | 0.494 | — |
| chr14_69685871_T_A | chr14:69685871 | 0.478 | 0.360 | 0.229 | — |
| chr14_69685887_T_C | chr14:69685887 | 0.478 | 0.381 | 0.559 | — |
| chr14_69685897_G_A | chr14:69685897 | -0.476 | -0.419 | -0.447 | — |
| chr14_69685838_T_C | chr14:69685838 | 0.474 | 0.330 | 0.482 | — |
| chr14_69685889_C_T | chr14:69685889 | -0.474 | -0.378 | -0.400 | — |
| chr14_69685824_T_G | chr14:69685824 | -0.469 | -0.510 | -0.547 | — |
| chr14_69685869_A_T | chr14:69685869 | -0.468 | -0.419 | -0.494 | — |
| chr14_69685871_T_C | chr14:69685871 | 0.464 | 0.332 | 0.465 | — |
| chr14_69685818_A_T | chr14:69685818 | -0.461 | -0.391 | -0.447 | — |
| chr14_69685855_G_A | chr14:69685855 | -0.461 | -0.287 | -0.435 | <0.001% |
| chr14_69685866_T_A | chr14:69685866 | -0.459 | -0.277 | -0.359 | — |
| chr14_69685872_G_A | chr14:69685872 | -0.456 | -0.261 | -0.382 | — |
| chr14_69685913_A_G | chr14:69685913 | 0.454 | 0.294 | 0.371 | — |
| chr14_69685964_C_A | chr14:69685964 | -0.453 | -0.168 | -0.438 | — |
| chr14_69685864_T_A | chr14:69685864 | -0.449 | -0.338 | -0.488 | — |
| chr14_69685922_G_A | chr14:69685922 | -0.446 | -0.249 | -0.276 | — |
| chr14_69685985_G_T | chr14:69685985 | -0.444 | -0.162 | -0.359 | — |
| chr14_69685819_C_T | chr14:69685819 | -0.443 | -0.482 | -0.518 | — |
| chr14_69685841_T_C | chr14:69685841 | -0.441 | -0.289 | -0.494 | — |
| chr14_69685870_A_T | chr14:69685870 | 0.438 | 0.297 | 0.365 | — |
| chr14_69685941_G_A | chr14:69685941 | 0.433 | 0.241 | 0.176 | — |
| chr14_69685864_T_C | chr14:69685864 | -0.431 | -0.338 | -0.488 | — |
| chr14_69685909_C_A | chr14:69685909 | 0.429 | 0.315 | 0.447 | — |
| chr14_69685924_G_C | chr14:69685924 | 0.429 | 0.355 | 0.576 | — |
| chr14_69685850_A_G | chr14:69685850 | -0.428 | -0.381 | -0.471 | — |
| chr14_69685840_G_C | chr14:69685840 | -0.426 | -0.363 | -0.688 | — |
| chr14_69719739_T_A | chr14:69719739 | 0.078 | 0.178 | 0.753 | — |
| chr14_69685865_G_T | chr14:69685865 | -0.423 | -0.325 | -0.512 | — |
| chr14_69685870_A_C | chr14:69685870 | 0.418 | 0.274 | 0.329 | — |
| chr14_69685855_G_C | chr14:69685855 | -0.416 | -0.297 | -0.382 | — |
| chr14_69685921_T_G | chr14:69685921 | 0.416 | 0.239 | 0.182 | — |
| chr14_69685952_A_C | chr14:69685952 | -0.413 | -0.104 | -0.288 | — |
| chr14_69685963_C_G | chr14:69685963 | 0.411 | 0.076 | 0.247 | — |
| chr14_69685826_T_C | chr14:69685826 | -0.409 | -0.350 | -0.406 | — |
| chr14_69685869_A_G | chr14:69685869 | -0.409 | -0.226 | -0.271 | 0.0013% |
| chr14_69685958_A_G | chr14:69685958 | 0.408 | 0.272 | 0.412 | — |
| chr14_69685970_A_G | chr14:69685970 | -0.406 | -0.190 | -0.329 | — |
| chr14_69685897_G_C | chr14:69685897 | 0.401 | 0.279 | 0.282 | — |
| chr14_69685894_G_C | chr14:69685894 | -0.398 | -0.114 | -0.288 | — |
| chr14_69685881_C_A | chr14:69685881 | -0.394 | -0.299 | -0.153 | — |
| chr14_69685896_T_C | chr14:69685896 | 0.394 | 0.239 | 0.288 | — |
| chr14_69685843_A_T | chr14:69685843 | -0.393 | -0.277 | -0.606 | — |
| chr14_69685900_A_T | chr14:69685900 | 0.393 | 0.315 | 0.535 | — |
| chr14_69685865_G_C | chr14:69685865 | -0.391 | -0.320 | -0.465 | — |
| chr14_69685825_G_C | chr14:69685825 | -0.389 | -0.409 | -0.412 | — |
| chr14_69685863_T_A | chr14:69685863 | -0.389 | -0.289 | -0.259 | — |
| chr14_69685841_T_G | chr14:69685841 | -0.388 | -0.287 | -0.488 | — |
| chr14_69685921_T_A | chr14:69685921 | 0.388 | 0.231 | 0.188 | — |
| chr14_69685981_T_G | chr14:69685981 | 0.388 | 0.015 | 0.276 | — |
| chr14_69685828_C_T | chr14:69685828 | -0.386 | -0.411 | -0.506 | — |
| chr14_69685846_T_A | chr14:69685846 | 0.386 | 0.261 | 0.265 | — |
| chr14_69685856_A_T | chr14:69685856 | 0.381 | 0.322 | 0.418 | — |
| chr14_69685919_C_G | chr14:69685919 | 0.381 | 0.365 | 0.288 | — |
| chr14_69685977_T_G | chr14:69685977 | -0.379 | -0.051 | -0.124 | — |
| chr14_69685918_T_G | chr14:69685918 | 0.378 | 0.302 | 0.376 | — |
| chr14_69685970_A_T | chr14:69685970 | -0.378 | -0.140 | -0.300 | — |
| chr14_69685902_A_C | chr14:69685902 | 0.376 | 0.381 | 0.353 | — |
| chr14_69685914_G_A | chr14:69685914 | 0.376 | 0.363 | 0.282 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.