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SLC10A1
receptor: FXRTier 1
CAMIP causal chains
FXR
Reduced FXR binding would weaken FXR-driven SHP induction; with SHP-mediated repression relieved, SLC10A1/NTCP expression would rise, thus increasing the hepatic clearance of NTCP substrates.
Affected substrate drugs (PharmGKB): rosuvastatin
Scored variants near SLC10A1
chr14:69,675,415..69,897,241, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr14_69685917_G_A | chr14:69685917 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685885_T_G | chr14:69685885 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685888_G_C | chr14:69685888 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685888_G_A | chr14:69685888 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685844_A_C | chr14:69685844 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685844_A_T | chr14:69685844 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685913_A_C | chr14:69685913 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685862_T_A | chr14:69685862 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685899_G_T | chr14:69685899 | 1.000 | 0.390 | 0.474 | — |
| chr14_69685905_A_C | chr14:69685905 | -1.000 | -0.942 | -1.000 | — |
| chr14_69685939_C_T | chr14:69685939 | -1.000 | -0.899 | -1.000 | — |
| chr14_69685937_G_C | chr14:69685937 | -1.000 | -0.834 | -1.000 | — |
| chr14_69685866_T_C | chr14:69685866 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685939_C_A | chr14:69685939 | -1.000 | -0.859 | -1.000 | — |
| chr14_69685862_T_G | chr14:69685862 | 1.000 | 1.000 | 1.000 | — |
| chr14_69685937_G_A | chr14:69685937 | -1.000 | -0.811 | -1.000 | — |
| chr14_69685939_C_G | chr14:69685939 | -1.000 | -0.887 | -1.000 | — |
| chr14_69685872_G_C | chr14:69685872 | 1.000 | 1.000 | 0.971 | — |
| chr14_69685938_C_T | chr14:69685938 | -1.000 | -0.655 | -1.000 | — |
| chr14_69685871_T_G | chr14:69685871 | 1.000 | 1.000 | 0.760 | — |
| chr14_69685938_C_A | chr14:69685938 | -1.000 | -0.650 | -1.000 | — |
| chr14_69685930_G_T | chr14:69685930 | -1.000 | -0.567 | -1.000 | — |
| chr14_69685899_G_C | chr14:69685899 | 1.000 | 0.804 | 0.988 | — |
| chr14_69685885_T_A | chr14:69685885 | 1.000 | 0.872 | 0.924 | — |
| chr14_69685929_G_T | chr14:69685929 | -1.000 | -0.597 | -1.000 | — |
| chr14_69685941_G_C | chr14:69685941 | -1.000 | -0.567 | -0.901 | — |
| chr14_69685929_G_A | chr14:69685929 | -1.000 | -0.592 | -1.000 | — |
| chr14_69685931_C_T | chr14:69685931 | -1.000 | -0.549 | -0.924 | — |
| chr14_69685930_G_A | chr14:69685930 | -1.000 | -0.494 | -1.000 | — |
| chr14_69685929_G_C | chr14:69685929 | -1.000 | -0.635 | -1.000 | — |
| chr14_69685930_G_C | chr14:69685930 | -1.000 | -0.494 | -0.959 | — |
| chr14_69685895_C_T | chr14:69685895 | 1.000 | 0.814 | 0.842 | — |
| chr14_69685888_G_T | chr14:69685888 | 1.000 | 0.786 | 0.883 | — |
| chr14_69685931_C_G | chr14:69685931 | -1.000 | -0.458 | -0.860 | — |
| chr14_69685915_C_G | chr14:69685915 | -1.000 | -0.753 | -1.000 | — |
| chr14_69685914_G_C | chr14:69685914 | 1.000 | 0.746 | 0.567 | — |
| chr14_69685907_C_G | chr14:69685907 | -1.000 | -0.685 | -0.737 | — |
| chr14_69685920_G_T | chr14:69685920 | -1.000 | -0.635 | -1.000 | — |
| chr14_69685928_T_C | chr14:69685928 | -1.000 | -0.574 | -0.977 | — |
| chr14_69685862_T_C | chr14:69685862 | 1.000 | 0.836 | 0.737 | — |
| chr14_69685940_A_T | chr14:69685940 | -1.000 | -0.574 | -0.942 | — |
| chr14_69685941_G_T | chr14:69685941 | -1.000 | -0.524 | -0.787 | — |
| chr14_69685937_G_T | chr14:69685937 | -0.997 | -0.597 | -0.906 | — |
| chr14_69685938_C_G | chr14:69685938 | -0.995 | -0.506 | -0.827 | — |
| chr14_69685962_G_T | chr14:69685962 | -0.980 | -0.453 | -0.874 | — |
| chr14_69685950_A_C | chr14:69685950 | -0.969 | -0.395 | -0.787 | — |
| chr14_69685907_C_T | chr14:69685907 | -0.964 | -0.690 | -0.772 | — |
| chr14_69685940_A_G | chr14:69685940 | -0.954 | -0.675 | -0.971 | — |
| chr14_69685928_T_A | chr14:69685928 | -0.930 | -0.519 | -0.909 | — |
| chr14_69685880_A_T | chr14:69685880 | -0.924 | -0.741 | -0.927 | — |
| chr14_69685849_C_G | chr14:69685849 | -0.916 | -0.761 | -1.000 | — |
| chr14_69685877_T_A | chr14:69685877 | -0.881 | -0.668 | -0.731 | — |
| chr14_69685928_T_G | chr14:69685928 | -0.876 | -0.537 | -0.924 | — |
| chr14_69685874_A_C | chr14:69685874 | 0.873 | 0.836 | 0.895 | — |
| chr14_69685886_G_T | chr14:69685886 | -0.866 | -0.662 | -0.895 | — |
| chr14_69685878_G_A | chr14:69685878 | -0.863 | -0.599 | -0.863 | — |
| chr14_69685882_T_A | chr14:69685882 | -0.863 | -0.594 | -0.737 | — |
| chr14_69685884_T_A | chr14:69685884 | -0.851 | -0.652 | -0.795 | — |
| chr14_69685878_G_C | chr14:69685878 | -0.844 | -0.574 | -0.827 | — |
| chr14_69685877_T_G | chr14:69685877 | -0.841 | -0.660 | -0.728 | — |
| chr14_69685879_G_C | chr14:69685879 | -0.831 | -0.743 | -0.690 | — |
| chr14_69685927_G_T | chr14:69685927 | 0.828 | 0.431 | 0.678 | — |
| chr14_69685886_G_A | chr14:69685886 | -0.806 | -0.592 | -0.661 | — |
| chr14_69685881_C_G | chr14:69685881 | -0.793 | -0.685 | -0.810 | — |
| chr14_69685882_T_C | chr14:69685882 | 0.793 | 0.670 | 0.667 | — |
| chr14_69685880_A_G | chr14:69685880 | -0.788 | -0.670 | -0.810 | — |
| chr14_69685910_T_G | chr14:69685910 | 0.785 | 0.733 | 1.000 | — |
| chr14_69685861_C_G | chr14:69685861 | 0.783 | 0.698 | 0.661 | <0.001% |
| chr14_69685879_G_T | chr14:69685879 | -0.773 | -0.594 | -0.851 | — |
| chr14_69685860_C_T | chr14:69685860 | -0.770 | -0.617 | -0.731 | — |
| chr14_69685907_C_A | chr14:69685907 | -0.760 | -0.418 | -0.544 | — |
| chr14_69685927_G_C | chr14:69685927 | 0.752 | 0.290 | 0.690 | — |
| chr14_69685915_C_A | chr14:69685915 | -0.750 | -0.526 | -0.749 | — |
| chr14_69685940_A_C | chr14:69685940 | -0.750 | -0.426 | -0.635 | — |
| chr14_69685878_G_T | chr14:69685878 | -0.740 | -0.524 | -0.766 | — |
| chr14_69685886_G_C | chr14:69685886 | -0.737 | -0.599 | -0.716 | — |
| chr14_69685845_T_C | chr14:69685845 | 0.732 | 0.625 | 0.690 | — |
| chr14_69685852_C_A | chr14:69685852 | 0.728 | 0.519 | 0.520 | — |
| chr14_69685881_C_T | chr14:69685881 | -0.728 | -0.620 | -0.848 | — |
| chr14_69685971_G_T | chr14:69685971 | -0.717 | -0.287 | -0.667 | — |
| chr14_69685913_A_T | chr14:69685913 | 0.712 | 0.506 | 0.626 | — |
| chr14_69685877_T_C | chr14:69685877 | -0.699 | -0.567 | -0.561 | — |
| chr14_69685908_T_C | chr14:69685908 | -0.690 | -0.486 | -0.740 | — |
| chr14_69685889_C_G | chr14:69685889 | -0.680 | -0.534 | -0.629 | — |
| chr14_69685884_T_G | chr14:69685884 | -0.667 | -0.529 | -0.591 | — |
| chr14_69685828_C_G | chr14:69685828 | -0.657 | -0.605 | -0.713 | — |
| chr14_69685851_C_T | chr14:69685851 | -0.652 | -0.516 | -0.614 | 0.0020% |
| chr14_69685876_T_A | chr14:69685876 | -0.652 | -0.469 | -0.594 | — |
| chr14_69685853_C_G | chr14:69685853 | 0.649 | 0.504 | 0.713 | — |
| chr14_69685825_G_A | chr14:69685825 | -0.647 | -0.554 | -0.690 | — |
| chr14_69685898_A_G | chr14:69685898 | 0.641 | 0.469 | 0.538 | — |
| chr14_69685828_C_A | chr14:69685828 | -0.629 | -0.552 | -0.784 | — |
| chr14_69685835_A_C | chr14:69685835 | 0.629 | 0.461 | 0.444 | — |
| chr14_69685847_G_C | chr14:69685847 | -0.626 | -0.496 | -0.760 | — |
| chr14_69685883_T_G | chr14:69685883 | -0.621 | -0.542 | -0.515 | — |
| chr14_69685891_G_T | chr14:69685891 | -0.616 | -0.398 | -0.532 | — |
| chr14_69685887_T_A | chr14:69685887 | 0.614 | 0.476 | 0.544 | — |
| chr14_69685858_T_G | chr14:69685858 | 0.611 | 0.456 | 0.415 | — |
| chr14_69685894_G_T | chr14:69685894 | -0.606 | -0.436 | -0.640 | — |
| chr14_69685843_A_G | chr14:69685843 | -0.603 | -0.373 | -0.772 | <0.001% |
| chr14_69685933_G_T | chr14:69685933 | -0.603 | -0.184 | -0.219 | — |
| chr14_69685829_T_G | chr14:69685829 | -0.601 | -0.496 | -0.515 | — |
| chr14_69685898_A_T | chr14:69685898 | 0.599 | 0.474 | 0.538 | — |
| chr14_69685889_C_A | chr14:69685889 | -0.589 | -0.486 | -0.535 | — |
| chr14_69685832_G_C | chr14:69685832 | -0.588 | -0.219 | -0.251 | — |
| chr14_69685882_T_G | chr14:69685882 | -0.586 | -0.474 | -0.404 | — |
| chr14_69685915_C_T | chr14:69685915 | -0.584 | -0.423 | -0.556 | — |
| chr14_69685859_G_T | chr14:69685859 | -0.568 | -0.378 | -0.345 | — |
| chr14_69685936_T_C | chr14:69685936 | -0.568 | -0.355 | -0.444 | — |
| chr14_69685819_C_G | chr14:69685819 | -0.566 | -0.597 | -0.678 | — |
| chr14_69685829_T_A | chr14:69685829 | -0.561 | -0.474 | -0.532 | — |
| chr14_69685914_G_T | chr14:69685914 | 0.556 | 0.456 | 0.322 | — |
| chr14_69685883_T_A | chr14:69685883 | -0.553 | -0.491 | -0.491 | — |
| chr14_69685970_A_C | chr14:69685970 | -0.551 | -0.204 | -0.383 | — |
| chr14_69685818_A_C | chr14:69685818 | -0.546 | -0.448 | -0.526 | — |
| chr14_69685875_T_C | chr14:69685875 | 0.543 | 0.521 | 0.392 | — |
| chr14_69685967_G_C | chr14:69685967 | -0.540 | -0.227 | -0.491 | — |
| chr14_69685872_G_T | chr14:69685872 | -0.538 | -0.403 | -0.652 | — |
| chr14_69685884_T_C | chr14:69685884 | -0.538 | -0.456 | -0.439 | — |
| chr14_69685831_T_A | chr14:69685831 | -0.536 | -0.370 | -0.474 | — |
| chr14_69685923_A_T | chr14:69685923 | 0.528 | 0.242 | 0.480 | — |
| chr14_69685820_A_C | chr14:69685820 | -0.526 | -0.476 | -0.515 | — |
| chr14_69685895_C_G | chr14:69685895 | -0.525 | -0.171 | -0.310 | — |
| chr14_69685900_A_C | chr14:69685900 | 0.525 | 0.395 | 0.444 | — |
| chr14_69685860_C_A | chr14:69685860 | 0.522 | 0.393 | 0.327 | — |
| chr14_69685948_G_T | chr14:69685948 | -0.518 | -0.252 | -0.547 | — |
| chr14_69685847_G_A | chr14:69685847 | -0.517 | -0.421 | -0.673 | — |
| chr14_69685973_T_C | chr14:69685973 | -0.517 | -0.242 | -0.468 | — |
| chr14_69685969_C_A | chr14:69685969 | -0.515 | -0.234 | -0.447 | — |
| chr14_69685887_T_G | chr14:69685887 | 0.507 | 0.345 | 0.421 | — |
| chr14_69685842_A_G | chr14:69685842 | -0.505 | -0.375 | -0.673 | — |
| chr14_69685931_C_A | chr14:69685931 | -0.503 | -0.212 | -0.398 | — |
| chr14_69685867_G_C | chr14:69685867 | -0.500 | -0.411 | -0.538 | — |
| chr14_69685855_G_T | chr14:69685855 | -0.497 | -0.363 | -0.439 | — |
| chr14_69685847_G_T | chr14:69685847 | -0.493 | -0.406 | -0.673 | — |
| chr14_69741167_T_A | chr14:69741167 | -0.492 | -0.421 | -0.787 | — |
| chr14_69685880_A_C | chr14:69685880 | -0.490 | -0.466 | -0.386 | — |
| chr14_69685819_C_A | chr14:69685819 | -0.485 | -0.577 | -0.608 | — |
| chr14_69685920_G_A | chr14:69685920 | 0.483 | 0.380 | 0.561 | 0.0020% |
| chr14_69685971_G_C | chr14:69685971 | -0.482 | -0.076 | -0.368 | <0.001% |
| chr14_69685866_T_G | chr14:69685866 | -0.480 | -0.312 | -0.421 | — |
| chr14_69685853_C_A | chr14:69685853 | 0.477 | 0.355 | 0.491 | — |
| chr14_69685871_T_A | chr14:69685871 | 0.475 | 0.358 | 0.228 | — |
| chr14_69685887_T_C | chr14:69685887 | 0.475 | 0.378 | 0.556 | — |
| chr14_69685897_G_A | chr14:69685897 | -0.474 | -0.416 | -0.444 | — |
| chr14_69685838_T_C | chr14:69685838 | 0.472 | 0.327 | 0.480 | — |
| chr14_69685889_C_T | chr14:69685889 | -0.472 | -0.375 | -0.398 | — |
| chr14_69685824_T_G | chr14:69685824 | -0.467 | -0.506 | -0.544 | — |
| chr14_69685869_A_T | chr14:69685869 | -0.465 | -0.416 | -0.491 | — |
| chr14_69685871_T_C | chr14:69685871 | 0.462 | 0.330 | 0.462 | — |
| chr14_69685818_A_T | chr14:69685818 | -0.459 | -0.388 | -0.444 | — |
| chr14_69685855_G_A | chr14:69685855 | -0.459 | -0.285 | -0.433 | <0.001% |
| chr14_69685866_T_A | chr14:69685866 | -0.457 | -0.275 | -0.357 | — |
| chr14_69685872_G_A | chr14:69685872 | -0.454 | -0.259 | -0.380 | — |
| chr14_69685913_A_G | chr14:69685913 | 0.452 | 0.292 | 0.368 | — |
| chr14_69685964_C_A | chr14:69685964 | -0.450 | -0.166 | -0.436 | — |
| chr14_69685864_T_A | chr14:69685864 | -0.447 | -0.335 | -0.485 | — |
| chr14_69685922_G_A | chr14:69685922 | -0.444 | -0.247 | -0.275 | — |
| chr14_69685985_G_T | chr14:69685985 | -0.442 | -0.161 | -0.357 | — |
| chr14_69685819_C_T | chr14:69685819 | -0.440 | -0.479 | -0.515 | — |
| chr14_69685841_T_C | chr14:69685841 | -0.439 | -0.287 | -0.491 | — |
| chr14_69685870_A_T | chr14:69685870 | 0.435 | 0.295 | 0.363 | — |
| chr14_69685941_G_A | chr14:69685941 | 0.430 | 0.239 | 0.175 | — |
| chr14_69685864_T_C | chr14:69685864 | -0.429 | -0.335 | -0.485 | — |
| chr14_69685909_C_A | chr14:69685909 | 0.427 | 0.312 | 0.444 | — |
| chr14_69685924_G_C | chr14:69685924 | 0.427 | 0.353 | 0.573 | — |
| chr14_69685850_A_G | chr14:69685850 | -0.425 | -0.378 | -0.468 | — |
| chr14_69685840_G_C | chr14:69685840 | -0.424 | -0.360 | -0.684 | — |
| chr14_69719739_T_A | chr14:69719739 | 0.078 | 0.176 | 0.749 | — |
| chr14_69685865_G_T | chr14:69685865 | -0.421 | -0.322 | -0.509 | — |
| chr14_69685870_A_C | chr14:69685870 | 0.416 | 0.272 | 0.327 | — |
| chr14_69685855_G_C | chr14:69685855 | -0.414 | -0.295 | -0.380 | — |
| chr14_69685921_T_G | chr14:69685921 | 0.414 | 0.237 | 0.181 | — |
| chr14_69685952_A_C | chr14:69685952 | -0.411 | -0.103 | -0.287 | — |
| chr14_69685963_C_G | chr14:69685963 | 0.409 | 0.076 | 0.246 | — |
| chr14_69685826_T_C | chr14:69685826 | -0.407 | -0.348 | -0.404 | — |
| chr14_69685869_A_G | chr14:69685869 | -0.407 | -0.224 | -0.269 | 0.0013% |
| chr14_69685958_A_G | chr14:69685958 | 0.406 | 0.270 | 0.409 | — |
| chr14_69685970_A_G | chr14:69685970 | -0.404 | -0.189 | -0.327 | — |
| chr14_69685897_G_C | chr14:69685897 | 0.399 | 0.277 | 0.281 | — |
| chr14_69685894_G_C | chr14:69685894 | -0.396 | -0.113 | -0.287 | — |
| chr14_69685881_C_A | chr14:69685881 | -0.392 | -0.297 | -0.152 | — |
| chr14_69685896_T_C | chr14:69685896 | 0.392 | 0.237 | 0.287 | — |
| chr14_69685843_A_T | chr14:69685843 | -0.391 | -0.275 | -0.602 | — |
| chr14_69685900_A_T | chr14:69685900 | 0.391 | 0.312 | 0.532 | — |
| chr14_69685865_G_C | chr14:69685865 | -0.389 | -0.317 | -0.462 | — |
| chr14_69685825_G_C | chr14:69685825 | -0.387 | -0.406 | -0.409 | — |
| chr14_69685863_T_A | chr14:69685863 | -0.387 | -0.287 | -0.257 | — |
| chr14_69685841_T_G | chr14:69685841 | -0.386 | -0.285 | -0.485 | — |
| chr14_69685921_T_A | chr14:69685921 | 0.386 | 0.229 | 0.187 | — |
| chr14_69685981_T_G | chr14:69685981 | 0.386 | 0.015 | 0.275 | — |
| chr14_69685828_C_T | chr14:69685828 | -0.384 | -0.408 | -0.503 | — |
| chr14_69685846_T_A | chr14:69685846 | 0.384 | 0.259 | 0.263 | — |
| chr14_69685856_A_T | chr14:69685856 | 0.379 | 0.320 | 0.415 | — |
| chr14_69685919_C_G | chr14:69685919 | 0.379 | 0.363 | 0.287 | — |
| chr14_69685977_T_G | chr14:69685977 | -0.377 | -0.050 | -0.123 | — |
| chr14_69685918_T_G | chr14:69685918 | 0.376 | 0.300 | 0.374 | — |
| chr14_69685970_A_T | chr14:69685970 | -0.376 | -0.139 | -0.298 | — |
| chr14_69685902_A_C | chr14:69685902 | 0.374 | 0.378 | 0.351 | — |
| chr14_69685914_G_A | chr14:69685914 | 0.374 | 0.360 | 0.281 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.