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SLC51A
receptor: FXRTier 1
CAMIP causal chains
FXR
Blunted receptor-mediated induction of SLC51A expression, reducing heteromeric basolateral bile acid efflux capacity in hepatocytes and enterocytes.
Affected substrate drugs (PharmGKB): none in routine clinical use, endogenous or bile acid pathway
Scored variants near SLC51A
chr3:196,116,533..196,333,427, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr3_196163875_C_G | chr3:196163875 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163869_T_A | chr3:196163869 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163877_C_G | chr3:196163877 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163875_C_T | chr3:196163875 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163877_C_T | chr3:196163877 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163847_C_T | chr3:196163847 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163875_C_A | chr3:196163875 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163876_C_G | chr3:196163876 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163876_C_A | chr3:196163876 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163874_C_G | chr3:196163874 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163869_T_G | chr3:196163869 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163872_A_T | chr3:196163872 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163874_C_T | chr3:196163874 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163876_C_T | chr3:196163876 | 1.000 | 0.964 | 1.000 | — |
| chr3_196163873_G_A | chr3:196163873 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163873_G_C | chr3:196163873 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163878_C_A | chr3:196163878 | 0.901 | 0.901 | 1.000 | — |
| chr3_196163872_A_C | chr3:196163872 | 1.000 | 1.000 | 1.000 | — |
| chr3_196160291_C_G | chr3:196160291 | 0.884 | 0.600 | 1.000 | — |
| chr3_196163878_C_G | chr3:196163878 | 0.839 | 0.857 | 1.000 | — |
| chr3_196163897_T_G | chr3:196163897 | -0.532 | -0.712 | -1.000 | — |
| chr3_196163895_C_G | chr3:196163895 | -0.397 | -0.573 | -1.000 | — |
| chr3_196163898_A_T | chr3:196163898 | -0.550 | -0.708 | -1.000 | — |
| chr3_196163894_G_C | chr3:196163894 | -0.409 | -0.556 | -1.000 | — |
| chr3_196163895_C_A | chr3:196163895 | -0.374 | -0.536 | -1.000 | — |
| chr3_196163899_A_C | chr3:196163899 | -0.532 | -0.755 | -1.000 | — |
| chr3_196163899_A_T | chr3:196163899 | -0.469 | -0.696 | -1.000 | — |
| chr3_196163895_C_T | chr3:196163895 | -0.395 | -0.529 | -1.000 | — |
| chr3_196163898_A_G | chr3:196163898 | -0.382 | -0.452 | -1.000 | — |
| chr3_196163893_T_C | chr3:196163893 | -0.412 | -0.557 | -1.000 | — |
| chr3_196163893_T_A | chr3:196163893 | -0.444 | -0.584 | -1.000 | — |
| chr3_196163899_A_G | chr3:196163899 | -0.479 | -0.708 | -1.000 | — |
| chr3_196163893_T_G | chr3:196163893 | -0.430 | -0.534 | -1.000 | — |
| chr3_196163907_G_C | chr3:196163907 | 0.455 | 0.122 | 1.000 | — |
| chr3_196160362_T_C | chr3:196160362 | 0.744 | 0.800 | 1.000 | — |
| chr3_196163897_T_A | chr3:196163897 | -0.497 | -0.631 | -1.000 | — |
| chr3_196163909_T_A | chr3:196163909 | -0.489 | -0.649 | -1.000 | — |
| chr3_196163896_A_T | chr3:196163896 | -0.384 | -0.508 | -1.000 | — |
| chr3_196163909_T_G | chr3:196163909 | -0.510 | -0.642 | -1.000 | — |
| chr3_196163912_G_T | chr3:196163912 | 0.438 | 0.436 | 1.000 | — |
| chr3_196163909_T_C | chr3:196163909 | -0.494 | -0.683 | -1.000 | — |
| chr3_196160243_C_A | chr3:196160243 | 0.287 | 0.434 | 1.000 | — |
| chr3_196163906_A_G | chr3:196163906 | -0.359 | -0.379 | -1.000 | — |
| chr3_196163870_G_T | chr3:196163870 | 0.533 | 0.621 | 1.000 | — |
| chr3_196163911_A_C | chr3:196163911 | -0.319 | -0.496 | -1.000 | — |
| chr3_196163879_G_C | chr3:196163879 | -0.407 | -0.494 | -1.000 | — |
| chr3_196163872_A_G | chr3:196163872 | 0.588 | 0.582 | 1.000 | — |
| chr3_196163859_A_G | chr3:196163859 | -0.460 | -0.481 | -1.000 | — |
| chr3_196163911_A_T | chr3:196163911 | -0.329 | -0.474 | -1.000 | — |
| chr3_196163894_G_T | chr3:196163894 | -0.360 | -0.449 | -1.000 | — |
| chr3_196163896_A_G | chr3:196163896 | 0.518 | 0.610 | 1.000 | — |
| chr3_196163877_C_A | chr3:196163877 | 0.639 | 0.553 | 0.965 | — |
| chr3_196160292_C_G | chr3:196160292 | 0.400 | 0.436 | 1.000 | — |
| chr3_196163851_A_G | chr3:196163851 | 0.474 | 0.694 | 1.000 | — |
| chr3_196160291_C_T | chr3:196160291 | 0.462 | 0.361 | 1.000 | — |
| chr3_196163896_A_C | chr3:196163896 | -0.381 | -0.516 | -1.000 | — |
| chr3_196160361_T_G | chr3:196160361 | 0.603 | 0.605 | 1.000 | — |
| chr3_196163892_T_G | chr3:196163892 | -0.251 | -0.319 | -1.000 | — |
| chr3_196163906_A_T | chr3:196163906 | -0.451 | -0.610 | -1.000 | — |
| chr3_196163870_G_C | chr3:196163870 | 0.513 | 0.564 | 1.000 | — |
| chr3_196163880_G_C | chr3:196163880 | 0.556 | 0.527 | 1.000 | — |
| chr3_196163898_A_C | chr3:196163898 | -0.577 | -0.332 | 0.446 | — |
| chr3_196163863_G_C | chr3:196163863 | 0.395 | 0.447 | 1.000 | — |
| chr3_196163928_T_G | chr3:196163928 | 0.516 | 0.757 | 1.000 | — |
| chr3_196163891_G_T | chr3:196163891 | -0.241 | -0.343 | -1.000 | — |
| chr3_196163892_T_A | chr3:196163892 | -0.210 | -0.362 | -0.995 | — |
| chr3_196163910_C_T | chr3:196163910 | -0.315 | -0.416 | -0.989 | — |
| chr3_196163874_C_A | chr3:196163874 | -0.368 | -0.384 | -0.977 | — |
| chr3_196160287_G_C | chr3:196160287 | 0.540 | 0.499 | 0.934 | — |
| chr3_196163892_T_C | chr3:196163892 | -0.240 | -0.358 | -0.965 | — |
| chr3_196163905_G_C | chr3:196163905 | -0.393 | -0.436 | -0.947 | — |
| chr3_196163905_G_A | chr3:196163905 | -0.297 | -0.249 | -0.928 | — |
| chr3_196163911_A_G | chr3:196163911 | -0.281 | -0.426 | -0.922 | — |
| chr3_196163942_C_G | chr3:196163942 | 0.438 | 0.561 | 0.916 | — |
| chr3_196160360_A_G | chr3:196160360 | 0.475 | 0.543 | 0.910 | — |
| chr3_196163902_C_G | chr3:196163902 | 0.352 | 0.138 | 0.892 | — |
| chr3_196160351_A_G | chr3:196160351 | 0.496 | 0.475 | 0.733 | — |
| chr3_196163906_A_C | chr3:196163906 | -0.381 | -0.540 | -0.885 | — |
| chr3_196160367_G_C | chr3:196160367 | -0.494 | -0.509 | -0.861 | — |
| chr3_196163861_C_A | chr3:196163861 | -0.280 | -0.348 | -0.873 | — |
| chr3_196163881_G_C | chr3:196163881 | -0.373 | -0.457 | -0.873 | — |
| chr3_196160357_A_T | chr3:196160357 | -0.393 | -0.374 | -0.861 | — |
| chr3_196160357_A_C | chr3:196160357 | -0.434 | -0.408 | -0.855 | — |
| chr3_196160367_G_A | chr3:196160367 | -0.432 | -0.468 | -0.855 | — |
| chr3_196163866_C_T | chr3:196163866 | 0.209 | 0.247 | 0.849 | — |
| chr3_196160355_A_T | chr3:196160355 | -0.388 | -0.340 | -0.837 | — |
| chr3_196163946_G_A | chr3:196163946 | 0.116 | 0.158 | 0.831 | — |
| chr3_196160325_C_A | chr3:196160325 | -0.462 | -0.171 | -0.550 | — |
| chr3_196163878_C_T | chr3:196163878 | 0.407 | 0.395 | 0.824 | — |
| chr3_196160332_A_T | chr3:196160332 | 0.311 | 0.447 | 0.818 | — |
| chr3_196160338_A_T | chr3:196160338 | 0.453 | 0.519 | 0.721 | — |
| chr3_196160269_C_A | chr3:196160269 | -0.436 | -0.436 | -0.806 | — |
| chr3_196160282_G_T | chr3:196160282 | 0.451 | 0.192 | 0.482 | — |
| chr3_196160270_T_A | chr3:196160270 | -0.308 | -0.413 | -0.769 | — |
| chr3_196163840_G_C | chr3:196163840 | -0.258 | -0.306 | -0.769 | — |
| chr3_196163873_G_T | chr3:196163873 | 0.431 | 0.369 | 0.769 | — |
| chr3_196163939_C_G | chr3:196163939 | 0.429 | 0.423 | 0.769 | — |
| chr3_196160293_C_G | chr3:196160293 | 0.323 | 0.348 | 0.763 | — |
| chr3_196163910_C_G | chr3:196163910 | -0.281 | -0.340 | -0.763 | — |
| chr3_196163949_G_T | chr3:196163949 | -0.193 | -0.260 | -0.763 | — |
| chr3_196163855_T_G | chr3:196163855 | -0.229 | -0.305 | -0.745 | — |
| chr3_196163904_T_C | chr3:196163904 | -0.250 | -0.283 | -0.745 | — |
| chr3_196160263_C_A | chr3:196160263 | -0.381 | -0.429 | -0.733 | — |
| chr3_196160269_C_T | chr3:196160269 | -0.398 | -0.387 | -0.733 | — |
| chr3_196160356_C_A | chr3:196160356 | -0.357 | -0.364 | -0.733 | — |
| chr3_196160289_C_A | chr3:196160289 | -0.381 | -0.374 | -0.727 | — |
| chr3_196163908_G_T | chr3:196163908 | -0.217 | -0.332 | -0.727 | — |
| chr3_196163931_C_T | chr3:196163931 | 0.333 | 0.434 | 0.721 | — |
| chr3_196160269_C_G | chr3:196160269 | -0.397 | -0.405 | -0.715 | — |
| chr3_196163841_G_C | chr3:196163841 | 0.400 | 0.255 | 0.476 | — |
| chr3_196163894_G_A | chr3:196163894 | -0.153 | -0.182 | -0.715 | — |
| chr3_196163907_G_A | chr3:196163907 | -0.359 | -0.447 | -0.715 | — |
| chr3_196160349_A_T | chr3:196160349 | -0.391 | -0.345 | -0.708 | — |
| chr3_196160356_C_G | chr3:196160356 | -0.391 | -0.361 | -0.708 | — |
| chr3_196163900_C_A | chr3:196163900 | -0.267 | -0.396 | -0.708 | — |
| chr3_196163974_C_G | chr3:196163974 | 0.262 | 0.282 | 0.708 | — |
| chr3_196160338_A_G | chr3:196160338 | 0.133 | 0.234 | 0.702 | — |
| chr3_196163847_C_G | chr3:196163847 | 0.312 | 0.387 | 0.702 | — |
| chr3_196163912_G_A | chr3:196163912 | -0.145 | -0.156 | -0.702 | — |
| chr3_196160317_C_G | chr3:196160317 | -0.391 | -0.268 | -0.537 | — |
| chr3_196163975_A_C | chr3:196163975 | -0.162 | -0.214 | -0.684 | — |
| chr3_196160349_A_C | chr3:196160349 | -0.379 | -0.306 | -0.568 | — |
| chr3_196160357_A_G | chr3:196160357 | -0.366 | -0.296 | -0.678 | — |
| chr3_196160364_A_C | chr3:196160364 | 0.251 | 0.312 | 0.660 | — |
| chr3_196163942_C_A | chr3:196163942 | 0.326 | 0.390 | 0.660 | — |
| chr3_196163950_C_G | chr3:196163950 | 0.340 | 0.270 | 0.660 | — |
| chr3_196163871_C_A | chr3:196163871 | -0.303 | -0.239 | -0.653 | — |
| chr3_196160353_A_T | chr3:196160353 | -0.362 | -0.322 | -0.647 | — |
| chr3_196160354_A_T | chr3:196160354 | -0.285 | -0.270 | -0.647 | — |
| chr3_196160367_G_T | chr3:196160367 | -0.340 | -0.356 | -0.647 | — |
| chr3_196163973_C_T | chr3:196163973 | 0.289 | 0.330 | 0.647 | — |
| chr3_196163842_C_G | chr3:196163842 | -0.108 | -0.055 | -0.623 | — |
| chr3_196163972_C_G | chr3:196163972 | 0.142 | 0.187 | 0.623 | — |
| chr3_196163879_G_T | chr3:196163879 | -0.188 | -0.265 | -0.598 | — |
| chr3_196163903_A_T | chr3:196163903 | -0.135 | -0.042 | -0.598 | — |
| chr3_196163947_G_C | chr3:196163947 | 0.224 | 0.257 | 0.598 | — |
| chr3_196163969_G_T | chr3:196163969 | 0.292 | 0.488 | 0.598 | — |
| chr3_196163975_A_T | chr3:196163975 | -0.152 | -0.194 | -0.598 | — |
| chr3_196160329_G_T | chr3:196160329 | -0.325 | -0.312 | -0.592 | — |
| chr3_196160351_A_T | chr3:196160351 | -0.321 | -0.299 | -0.586 | — |
| chr3_196160355_A_G | chr3:196160355 | -0.309 | -0.260 | -0.580 | — |
| chr3_196163908_G_A | chr3:196163908 | -0.256 | -0.353 | -0.580 | — |
| chr3_196160368_G_C | chr3:196160368 | -0.321 | -0.343 | -0.550 | — |
| chr3_196163959_A_C | chr3:196163959 | 0.316 | 0.499 | 0.574 | — |
| chr3_196160341_G_C | chr3:196160341 | 0.215 | 0.270 | 0.568 | — |
| chr3_196160353_A_G | chr3:196160353 | -0.296 | -0.252 | -0.568 | — |
| chr3_196163847_C_A | chr3:196163847 | 0.189 | 0.242 | 0.568 | — |
| chr3_196163842_C_T | chr3:196163842 | -0.317 | -0.195 | -0.531 | — |
| chr3_196163910_C_A | chr3:196163910 | -0.316 | -0.291 | -0.214 | — |
| chr3_196160327_C_A | chr3:196160327 | -0.315 | -0.291 | -0.348 | — |
| chr3_196160354_A_G | chr3:196160354 | -0.275 | -0.236 | -0.562 | — |
| chr3_196163905_G_T | chr3:196163905 | -0.176 | -0.190 | -0.562 | — |
| chr3_196163970_G_C | chr3:196163970 | 0.038 | 0.203 | 0.562 | — |
| chr3_196160325_C_G | chr3:196160325 | -0.297 | -0.223 | -0.556 | — |
| chr3_196160361_T_C | chr3:196160361 | 0.311 | 0.301 | 0.531 | — |
| chr3_196163844_G_C | chr3:196163844 | 0.311 | 0.301 | 0.537 | — |
| chr3_196160263_C_T | chr3:196160263 | -0.292 | -0.309 | -0.550 | — |
| chr3_196160293_C_A | chr3:196160293 | 0.200 | 0.247 | 0.550 | — |
| chr3_196160345_A_G | chr3:196160345 | 0.308 | 0.208 | 0.256 | — |
| chr3_196163904_T_A | chr3:196163904 | -0.140 | -0.068 | -0.550 | — |
| chr3_196163972_C_A | chr3:196163972 | 0.118 | 0.184 | 0.550 | — |
| chr3_196160267_T_C | chr3:196160267 | -0.197 | -0.226 | -0.544 | — |
| chr3_196160251_T_G | chr3:196160251 | 0.224 | 0.273 | 0.537 | — |
| chr3_196160337_A_G | chr3:196160337 | 0.193 | 0.216 | 0.537 | — |
| chr3_196163853_A_T | chr3:196163853 | -0.142 | -0.208 | -0.531 | — |
| chr3_196160267_T_G | chr3:196160267 | 0.258 | 0.252 | 0.525 | — |
| chr3_196163865_T_C | chr3:196163865 | -0.224 | -0.138 | -0.525 | — |
| chr3_196163963_C_G | chr3:196163963 | 0.022 | 0.153 | 0.525 | — |
| chr3_196160324_A_C | chr3:196160324 | -0.274 | -0.265 | -0.519 | — |
| chr3_196163840_G_A | chr3:196163840 | -0.190 | -0.218 | -0.519 | — |
| chr3_196160268_C_T | chr3:196160268 | -0.169 | -0.273 | -0.513 | — |
| chr3_196160352_T_G | chr3:196160352 | -0.231 | -0.242 | -0.513 | — |
| chr3_196163891_G_A | chr3:196163891 | 0.191 | 0.184 | 0.513 | — |
| chr3_196160343_G_T | chr3:196160343 | -0.285 | -0.218 | -0.403 | — |
| chr3_196160356_C_T | chr3:196160356 | -0.207 | -0.216 | -0.507 | — |
| chr3_196163925_C_A | chr3:196163925 | 0.104 | 0.145 | 0.507 | — |
| chr3_196163935_C_A | chr3:196163935 | -0.195 | -0.173 | -0.507 | — |
| chr3_196160270_T_G | chr3:196160270 | -0.238 | -0.345 | -0.501 | — |
| chr3_196163853_A_G | chr3:196163853 | -0.169 | -0.283 | -0.501 | — |
| chr3_196160292_C_T | chr3:196160292 | 0.181 | 0.153 | 0.495 | — |
| chr3_196163862_T_C | chr3:196163862 | -0.007 | 0.005 | 0.495 | — |
| chr3_196163903_A_C | chr3:196163903 | -0.103 | 0.000 | -0.495 | — |
| chr3_196160303_G_T | chr3:196160303 | -0.236 | -0.182 | -0.489 | — |
| chr3_196160355_A_C | chr3:196160355 | -0.274 | -0.042 | -0.391 | — |
| chr3_196163880_G_T | chr3:196163880 | 0.224 | 0.208 | 0.489 | — |
| chr3_196163946_G_T | chr3:196163946 | 0.050 | 0.075 | 0.489 | — |
| chr3_196163973_C_A | chr3:196163973 | 0.183 | 0.244 | 0.489 | — |
| chr3_196160366_A_T | chr3:196160366 | -0.244 | -0.294 | -0.482 | — |
| chr3_196163924_G_T | chr3:196163924 | 0.142 | 0.216 | 0.482 | — |
| chr3_196160321_G_T | chr3:196160321 | -0.267 | -0.226 | -0.403 | — |
| chr3_196160346_A_G | chr3:196160346 | 0.130 | 0.304 | 0.476 | — |
| chr3_196163913_C_G | chr3:196163913 | -0.140 | -0.171 | -0.476 | — |
| chr3_196163961_C_T | chr3:196163961 | 0.034 | 0.078 | 0.476 | — |
| chr3_196163972_C_T | chr3:196163972 | 0.181 | 0.197 | 0.476 | — |
| chr3_196160311_G_C | chr3:196160311 | -0.215 | -0.184 | -0.470 | — |
| chr3_196163839_A_C | chr3:196163839 | -0.188 | -0.200 | -0.470 | — |
| chr3_196163840_G_T | chr3:196163840 | -0.183 | -0.218 | -0.470 | — |
| chr3_196163879_G_A | chr3:196163879 | -0.234 | -0.239 | -0.470 | — |
| chr3_196163908_G_C | chr3:196163908 | -0.219 | -0.356 | -0.470 | — |
| chr3_196160321_G_A | chr3:196160321 | -0.262 | -0.231 | -0.415 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.