Home / Gene
SLC51A
receptor: FXRTier 1
Prior gene annotation
Retained explanatory context, not the pharmacist's submitted wording; submitted reviews below take precedence.
Drug substrates (prior annotation)
none in routine clinical use, endogenous or bile acid pathway
refs: 16269519
CAMIP Tier 1: peak-anchored panel
FXR
Submitted decision (verbatim): 需修訂
Reviewer revision (verbatim)
Blunted receptor-mediated induction of SLC51A expression may impair bile salt export from enterocytes and the inducible basolateral bile salt efflux route in hepatocytes under increased intracellular bile salt load.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Obeticholic acid; Experimental GW4064
- Regulatory element
- at promoter +1088 bp
- Predicted consequence
- Blunted receptor-mediated induction of SLC51A expression, reducing heteromeric basolateral bile acid efflux capacity in hepatocytes and enterocytes.
- Prior narrative
- Blunted receptor-mediated induction of SLC51A expression, reducing heteromeric basolateral bile acid efflux capacity in hepatocytes and enterocytes.
- Drug context
- none in routine clinical use, endogenous or bile acid pathway
- Prior references
- 16269519
Scored variants near SLC51A
chr3:196,116,533..196,333,427, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr3_196163875_C_G | chr3:196163875 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163869_T_A | chr3:196163869 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163877_C_G | chr3:196163877 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163875_C_T | chr3:196163875 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163877_C_T | chr3:196163877 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163847_C_T | chr3:196163847 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163875_C_A | chr3:196163875 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163876_C_G | chr3:196163876 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163876_C_A | chr3:196163876 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163874_C_G | chr3:196163874 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163869_T_G | chr3:196163869 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163872_A_T | chr3:196163872 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163874_C_T | chr3:196163874 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163876_C_T | chr3:196163876 | 1.000 | 0.942 | 1.000 | — |
| chr3_196163873_G_A | chr3:196163873 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163873_G_C | chr3:196163873 | 1.000 | 1.000 | 1.000 | — |
| chr3_196163878_C_A | chr3:196163878 | 0.877 | 0.881 | 1.000 | — |
| chr3_196163872_A_C | chr3:196163872 | 0.990 | 0.990 | 1.000 | — |
| chr3_196160291_C_G | chr3:196160291 | 0.860 | 0.586 | 1.000 | — |
| chr3_196163878_C_G | chr3:196163878 | 0.817 | 0.838 | 1.000 | — |
| chr3_196163897_T_G | chr3:196163897 | -0.517 | -0.695 | -1.000 | — |
| chr3_196163895_C_G | chr3:196163895 | -0.386 | -0.560 | -1.000 | — |
| chr3_196163898_A_T | chr3:196163898 | -0.536 | -0.692 | -1.000 | — |
| chr3_196163894_G_C | chr3:196163894 | -0.398 | -0.543 | -1.000 | — |
| chr3_196163895_C_A | chr3:196163895 | -0.364 | -0.524 | -1.000 | — |
| chr3_196163899_A_C | chr3:196163899 | -0.518 | -0.737 | -1.000 | — |
| chr3_196163899_A_T | chr3:196163899 | -0.457 | -0.680 | -1.000 | — |
| chr3_196163895_C_T | chr3:196163895 | -0.384 | -0.516 | -1.000 | — |
| chr3_196163898_A_G | chr3:196163898 | -0.372 | -0.442 | -1.000 | — |
| chr3_196163893_T_C | chr3:196163893 | -0.401 | -0.544 | -1.000 | — |
| chr3_196163893_T_A | chr3:196163893 | -0.432 | -0.571 | -1.000 | — |
| chr3_196163899_A_G | chr3:196163899 | -0.466 | -0.692 | -1.000 | — |
| chr3_196163893_T_G | chr3:196163893 | -0.418 | -0.522 | -1.000 | — |
| chr3_196163907_G_C | chr3:196163907 | 0.443 | 0.119 | 1.000 | — |
| chr3_196160362_T_C | chr3:196160362 | 0.724 | 0.782 | 1.000 | — |
| chr3_196163897_T_A | chr3:196163897 | -0.483 | -0.617 | -1.000 | — |
| chr3_196163909_T_A | chr3:196163909 | -0.476 | -0.635 | -1.000 | — |
| chr3_196163896_A_T | chr3:196163896 | -0.374 | -0.496 | -1.000 | — |
| chr3_196163909_T_G | chr3:196163909 | -0.497 | -0.627 | -1.000 | — |
| chr3_196163912_G_T | chr3:196163912 | 0.426 | 0.426 | 1.000 | — |
| chr3_196163909_T_C | chr3:196163909 | -0.481 | -0.668 | -1.000 | — |
| chr3_196160243_C_A | chr3:196160243 | 0.280 | 0.424 | 1.000 | — |
| chr3_196163906_A_G | chr3:196163906 | -0.349 | -0.371 | -1.000 | — |
| chr3_196163870_G_T | chr3:196163870 | 0.519 | 0.607 | 1.000 | — |
| chr3_196163911_A_C | chr3:196163911 | -0.310 | -0.485 | -1.000 | — |
| chr3_196163879_G_C | chr3:196163879 | -0.396 | -0.482 | -1.000 | — |
| chr3_196163872_A_G | chr3:196163872 | 0.572 | 0.569 | 1.000 | — |
| chr3_196163859_A_G | chr3:196163859 | -0.448 | -0.470 | -1.000 | — |
| chr3_196163911_A_T | chr3:196163911 | -0.320 | -0.463 | -1.000 | — |
| chr3_196163894_G_T | chr3:196163894 | -0.350 | -0.439 | -1.000 | — |
| chr3_196163896_A_G | chr3:196163896 | 0.504 | 0.596 | 1.000 | — |
| chr3_196163877_C_A | chr3:196163877 | 0.622 | 0.541 | 0.929 | — |
| chr3_196160292_C_G | chr3:196160292 | 0.389 | 0.426 | 1.000 | — |
| chr3_196163851_A_G | chr3:196163851 | 0.461 | 0.678 | 1.000 | — |
| chr3_196160291_C_T | chr3:196160291 | 0.449 | 0.353 | 1.000 | — |
| chr3_196163896_A_C | chr3:196163896 | -0.371 | -0.504 | -1.000 | — |
| chr3_196160361_T_G | chr3:196160361 | 0.587 | 0.591 | 0.994 | — |
| chr3_196163892_T_G | chr3:196163892 | -0.245 | -0.312 | -1.000 | — |
| chr3_196163906_A_T | chr3:196163906 | -0.439 | -0.596 | -1.000 | — |
| chr3_196163870_G_C | chr3:196163870 | 0.499 | 0.551 | 1.000 | — |
| chr3_196163880_G_C | chr3:196163880 | 0.541 | 0.515 | 1.000 | — |
| chr3_196163898_A_C | chr3:196163898 | -0.562 | -0.325 | 0.429 | — |
| chr3_196163863_G_C | chr3:196163863 | 0.384 | 0.437 | 0.988 | — |
| chr3_196163928_T_G | chr3:196163928 | 0.502 | 0.740 | 0.988 | — |
| chr3_196163891_G_T | chr3:196163891 | -0.235 | -0.335 | -0.982 | — |
| chr3_196163892_T_A | chr3:196163892 | -0.205 | -0.354 | -0.959 | — |
| chr3_196163910_C_T | chr3:196163910 | -0.306 | -0.406 | -0.953 | — |
| chr3_196163874_C_A | chr3:196163874 | -0.358 | -0.376 | -0.941 | — |
| chr3_196160287_G_C | chr3:196160287 | 0.526 | 0.487 | 0.900 | — |
| chr3_196163892_T_C | chr3:196163892 | -0.234 | -0.350 | -0.929 | — |
| chr3_196163905_G_C | chr3:196163905 | -0.383 | -0.426 | -0.912 | — |
| chr3_196163905_G_A | chr3:196163905 | -0.290 | -0.244 | -0.894 | — |
| chr3_196163911_A_G | chr3:196163911 | -0.274 | -0.416 | -0.888 | — |
| chr3_196163942_C_G | chr3:196163942 | 0.426 | 0.548 | 0.882 | — |
| chr3_196160360_A_G | chr3:196160360 | 0.463 | 0.530 | 0.876 | — |
| chr3_196163902_C_G | chr3:196163902 | 0.343 | 0.135 | 0.859 | — |
| chr3_196160351_A_G | chr3:196160351 | 0.483 | 0.464 | 0.706 | — |
| chr3_196163906_A_C | chr3:196163906 | -0.371 | -0.528 | -0.853 | — |
| chr3_196160367_G_C | chr3:196160367 | -0.481 | -0.497 | -0.829 | — |
| chr3_196163861_C_A | chr3:196163861 | -0.273 | -0.340 | -0.841 | — |
| chr3_196163881_G_C | chr3:196163881 | -0.363 | -0.447 | -0.841 | — |
| chr3_196160357_A_T | chr3:196160357 | -0.383 | -0.365 | -0.829 | — |
| chr3_196160357_A_C | chr3:196160357 | -0.423 | -0.398 | -0.824 | — |
| chr3_196160367_G_A | chr3:196160367 | -0.421 | -0.457 | -0.824 | — |
| chr3_196163866_C_T | chr3:196163866 | 0.203 | 0.241 | 0.818 | — |
| chr3_196160355_A_T | chr3:196160355 | -0.378 | -0.332 | -0.806 | — |
| chr3_196163946_G_A | chr3:196163946 | 0.113 | 0.155 | 0.800 | — |
| chr3_196160325_C_A | chr3:196160325 | -0.449 | -0.168 | -0.529 | — |
| chr3_196163878_C_T | chr3:196163878 | 0.396 | 0.386 | 0.794 | — |
| chr3_196160332_A_T | chr3:196160332 | 0.303 | 0.437 | 0.788 | — |
| chr3_196160338_A_T | chr3:196160338 | 0.441 | 0.508 | 0.694 | — |
| chr3_196160269_C_A | chr3:196160269 | -0.424 | -0.426 | -0.776 | — |
| chr3_196160282_G_T | chr3:196160282 | 0.439 | 0.188 | 0.465 | — |
| chr3_196160270_T_A | chr3:196160270 | -0.300 | -0.404 | -0.741 | — |
| chr3_196163840_G_C | chr3:196163840 | -0.251 | -0.299 | -0.741 | — |
| chr3_196163873_G_T | chr3:196163873 | 0.419 | 0.360 | 0.741 | — |
| chr3_196163939_C_G | chr3:196163939 | 0.418 | 0.414 | 0.741 | — |
| chr3_196160293_C_G | chr3:196160293 | 0.314 | 0.340 | 0.735 | — |
| chr3_196163910_C_G | chr3:196163910 | -0.274 | -0.332 | -0.735 | — |
| chr3_196163949_G_T | chr3:196163949 | -0.188 | -0.254 | -0.735 | — |
| chr3_196163855_T_G | chr3:196163855 | -0.223 | -0.298 | -0.718 | — |
| chr3_196163904_T_C | chr3:196163904 | -0.243 | -0.277 | -0.718 | — |
| chr3_196160263_C_A | chr3:196160263 | -0.371 | -0.419 | -0.706 | — |
| chr3_196160269_C_T | chr3:196160269 | -0.388 | -0.378 | -0.706 | — |
| chr3_196160356_C_A | chr3:196160356 | -0.348 | -0.355 | -0.706 | — |
| chr3_196160289_C_A | chr3:196160289 | -0.371 | -0.365 | -0.700 | — |
| chr3_196163908_G_T | chr3:196163908 | -0.211 | -0.325 | -0.700 | — |
| chr3_196163931_C_T | chr3:196163931 | 0.324 | 0.424 | 0.694 | — |
| chr3_196160269_C_G | chr3:196160269 | -0.386 | -0.396 | -0.688 | — |
| chr3_196163841_G_C | chr3:196163841 | 0.389 | 0.249 | 0.459 | — |
| chr3_196163894_G_A | chr3:196163894 | -0.149 | -0.178 | -0.688 | — |
| chr3_196163907_G_A | chr3:196163907 | -0.349 | -0.437 | -0.688 | — |
| chr3_196160349_A_T | chr3:196160349 | -0.381 | -0.338 | -0.682 | — |
| chr3_196160356_C_G | chr3:196160356 | -0.381 | -0.353 | -0.682 | — |
| chr3_196163900_C_A | chr3:196163900 | -0.260 | -0.387 | -0.682 | — |
| chr3_196163974_C_G | chr3:196163974 | 0.255 | 0.275 | 0.682 | — |
| chr3_196160338_A_G | chr3:196160338 | 0.130 | 0.228 | 0.676 | — |
| chr3_196163847_C_G | chr3:196163847 | 0.304 | 0.378 | 0.676 | — |
| chr3_196163912_G_A | chr3:196163912 | -0.141 | -0.152 | -0.676 | — |
| chr3_196160317_C_G | chr3:196160317 | -0.381 | -0.261 | -0.518 | — |
| chr3_196163975_A_C | chr3:196163975 | -0.157 | -0.209 | -0.659 | — |
| chr3_196160349_A_C | chr3:196160349 | -0.369 | -0.299 | -0.547 | — |
| chr3_196160357_A_G | chr3:196160357 | -0.356 | -0.289 | -0.653 | — |
| chr3_196160364_A_C | chr3:196160364 | 0.245 | 0.305 | 0.635 | — |
| chr3_196163942_C_A | chr3:196163942 | 0.318 | 0.381 | 0.635 | — |
| chr3_196163950_C_G | chr3:196163950 | 0.331 | 0.264 | 0.635 | — |
| chr3_196163871_C_A | chr3:196163871 | -0.295 | -0.234 | -0.629 | — |
| chr3_196160353_A_T | chr3:196160353 | -0.353 | -0.315 | -0.624 | — |
| chr3_196160354_A_T | chr3:196160354 | -0.278 | -0.264 | -0.624 | — |
| chr3_196160367_G_T | chr3:196160367 | -0.331 | -0.348 | -0.624 | — |
| chr3_196163973_C_T | chr3:196163973 | 0.281 | 0.322 | 0.624 | — |
| chr3_196163842_C_G | chr3:196163842 | -0.105 | -0.053 | -0.600 | — |
| chr3_196163972_C_G | chr3:196163972 | 0.138 | 0.183 | 0.600 | — |
| chr3_196163879_G_T | chr3:196163879 | -0.183 | -0.259 | -0.576 | — |
| chr3_196163903_A_T | chr3:196163903 | -0.131 | -0.041 | -0.576 | — |
| chr3_196163947_G_C | chr3:196163947 | 0.218 | 0.251 | 0.576 | — |
| chr3_196163969_G_T | chr3:196163969 | 0.285 | 0.477 | 0.576 | — |
| chr3_196163975_A_T | chr3:196163975 | -0.148 | -0.189 | -0.576 | — |
| chr3_196160329_G_T | chr3:196160329 | -0.316 | -0.305 | -0.571 | — |
| chr3_196160351_A_T | chr3:196160351 | -0.313 | -0.292 | -0.565 | — |
| chr3_196160355_A_G | chr3:196160355 | -0.301 | -0.254 | -0.559 | — |
| chr3_196163908_G_A | chr3:196163908 | -0.249 | -0.345 | -0.559 | — |
| chr3_196160368_G_C | chr3:196160368 | -0.313 | -0.335 | -0.529 | — |
| chr3_196163959_A_C | chr3:196163959 | 0.308 | 0.487 | 0.553 | — |
| chr3_196160341_G_C | chr3:196160341 | 0.210 | 0.264 | 0.547 | — |
| chr3_196160353_A_G | chr3:196160353 | -0.288 | -0.246 | -0.547 | — |
| chr3_196163847_C_A | chr3:196163847 | 0.184 | 0.236 | 0.547 | — |
| chr3_196163842_C_T | chr3:196163842 | -0.309 | -0.190 | -0.512 | — |
| chr3_196163910_C_A | chr3:196163910 | -0.308 | -0.284 | -0.206 | — |
| chr3_196160327_C_A | chr3:196160327 | -0.306 | -0.284 | -0.335 | — |
| chr3_196160354_A_G | chr3:196160354 | -0.268 | -0.231 | -0.541 | — |
| chr3_196163905_G_T | chr3:196163905 | -0.171 | -0.185 | -0.541 | — |
| chr3_196163970_G_C | chr3:196163970 | 0.037 | 0.198 | 0.541 | — |
| chr3_196160325_C_G | chr3:196160325 | -0.290 | -0.218 | -0.535 | — |
| chr3_196160361_T_C | chr3:196160361 | 0.303 | 0.294 | 0.512 | — |
| chr3_196163844_G_C | chr3:196163844 | 0.303 | 0.294 | 0.518 | — |
| chr3_196160263_C_T | chr3:196160263 | -0.285 | -0.302 | -0.529 | — |
| chr3_196160293_C_A | chr3:196160293 | 0.195 | 0.241 | 0.529 | — |
| chr3_196160345_A_G | chr3:196160345 | 0.300 | 0.203 | 0.247 | — |
| chr3_196163904_T_A | chr3:196163904 | -0.136 | -0.066 | -0.529 | — |
| chr3_196163972_C_A | chr3:196163972 | 0.115 | 0.180 | 0.529 | — |
| chr3_196160267_T_C | chr3:196160267 | -0.191 | -0.221 | -0.524 | — |
| chr3_196160251_T_G | chr3:196160251 | 0.218 | 0.266 | 0.518 | — |
| chr3_196160337_A_G | chr3:196160337 | 0.188 | 0.211 | 0.518 | — |
| chr3_196163853_A_T | chr3:196163853 | -0.138 | -0.203 | -0.512 | — |
| chr3_196160267_T_G | chr3:196160267 | 0.251 | 0.246 | 0.506 | — |
| chr3_196163865_T_C | chr3:196163865 | -0.218 | -0.135 | -0.506 | — |
| chr3_196163963_C_G | chr3:196163963 | 0.022 | 0.150 | 0.506 | — |
| chr3_196160324_A_C | chr3:196160324 | -0.266 | -0.259 | -0.500 | — |
| chr3_196163840_G_A | chr3:196163840 | -0.185 | -0.213 | -0.500 | — |
| chr3_196160268_C_T | chr3:196160268 | -0.165 | -0.266 | -0.494 | — |
| chr3_196160352_T_G | chr3:196160352 | -0.225 | -0.236 | -0.494 | — |
| chr3_196163891_G_A | chr3:196163891 | 0.186 | 0.180 | 0.494 | — |
| chr3_196160343_G_T | chr3:196160343 | -0.278 | -0.213 | -0.388 | — |
| chr3_196160356_C_T | chr3:196160356 | -0.201 | -0.211 | -0.488 | — |
| chr3_196163925_C_A | chr3:196163925 | 0.101 | 0.142 | 0.488 | — |
| chr3_196163935_C_A | chr3:196163935 | -0.190 | -0.169 | -0.488 | — |
| chr3_196160270_T_G | chr3:196160270 | -0.231 | -0.338 | -0.482 | — |
| chr3_196163853_A_G | chr3:196163853 | -0.165 | -0.277 | -0.482 | — |
| chr3_196160292_C_T | chr3:196160292 | 0.176 | 0.150 | 0.476 | — |
| chr3_196163862_T_C | chr3:196163862 | -0.007 | 0.005 | 0.476 | — |
| chr3_196163903_A_C | chr3:196163903 | -0.100 | 0.000 | -0.476 | — |
| chr3_196160303_G_T | chr3:196160303 | -0.230 | -0.178 | -0.471 | — |
| chr3_196160355_A_C | chr3:196160355 | -0.266 | -0.041 | -0.376 | — |
| chr3_196163880_G_T | chr3:196163880 | 0.218 | 0.203 | 0.471 | — |
| chr3_196163946_G_T | chr3:196163946 | 0.048 | 0.074 | 0.471 | — |
| chr3_196163973_C_A | chr3:196163973 | 0.178 | 0.239 | 0.471 | — |
| chr3_196160366_A_T | chr3:196160366 | -0.238 | -0.287 | -0.465 | — |
| chr3_196163924_G_T | chr3:196163924 | 0.138 | 0.211 | 0.465 | — |
| chr3_196160321_G_T | chr3:196160321 | -0.260 | -0.221 | -0.388 | — |
| chr3_196160346_A_G | chr3:196160346 | 0.126 | 0.297 | 0.459 | — |
| chr3_196163913_C_G | chr3:196163913 | -0.136 | -0.168 | -0.459 | — |
| chr3_196163961_C_T | chr3:196163961 | 0.033 | 0.076 | 0.459 | — |
| chr3_196163972_C_T | chr3:196163972 | 0.176 | 0.193 | 0.459 | — |
| chr3_196160311_G_C | chr3:196160311 | -0.210 | -0.180 | -0.453 | — |
| chr3_196163839_A_C | chr3:196163839 | -0.183 | -0.195 | -0.453 | — |
| chr3_196163840_G_T | chr3:196163840 | -0.178 | -0.213 | -0.453 | — |
| chr3_196163879_G_A | chr3:196163879 | -0.228 | -0.234 | -0.453 | — |
| chr3_196163908_G_C | chr3:196163908 | -0.213 | -0.348 | -0.453 | — |
| chr3_196160321_G_A | chr3:196160321 | -0.255 | -0.226 | -0.400 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.