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SLC51B
receptor: FXRTier 1
CAMIP causal chains
FXR
Blunted receptor-mediated induction of SLC51B expression, reducing heteromeric basolateral bile acid efflux capacity in hepatocytes and enterocytes.
Affected substrate drugs (PharmGKB): none in routine clinical use, endogenous or bile acid pathway
Scored variants near SLC51B
chr15:64,945,386..65,153,397, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr15_64982020_C_A | chr15:64982020 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982024_G_A | chr15:64982024 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982022_A_C | chr15:64982022 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982022_A_T | chr15:64982022 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982024_G_C | chr15:64982024 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982020_C_G | chr15:64982020 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982022_A_G | chr15:64982022 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr15_64982021_A_T | chr15:64982021 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982027_C_A | chr15:64982027 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982027_C_G | chr15:64982027 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982028_A_C | chr15:64982028 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982024_G_T | chr15:64982024 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982025_T_A | chr15:64982025 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982025_T_C | chr15:64982025 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr15_64982026_C_G | chr15:64982026 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982020_C_T | chr15:64982020 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982023_A_C | chr15:64982023 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982023_A_T | chr15:64982023 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982025_T_G | chr15:64982025 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982027_C_T | chr15:64982027 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982044_T_G | chr15:64982044 | 1.000 | 1.000 | 0.899 | — |
| chr15_64982026_C_A | chr15:64982026 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982028_A_T | chr15:64982028 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982018_G_C | chr15:64982018 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982023_A_G | chr15:64982023 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982007_A_C | chr15:64982007 | 1.000 | 1.000 | 0.933 | — |
| chr15_64981991_A_G | chr15:64981991 | 1.000 | 1.000 | 1.000 | — |
| chr15_64982021_A_G | chr15:64982021 | -1.000 | -1.000 | -1.000 | — |
| chr15_64981991_A_C | chr15:64981991 | 1.000 | 1.000 | 0.876 | — |
| chr15_64981989_G_A | chr15:64981989 | 1.000 | 1.000 | 0.753 | — |
| chr15_64981985_A_T | chr15:64981985 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982017_A_G | chr15:64982017 | 1.000 | 1.000 | 0.865 | — |
| chr15_64982050_T_A | chr15:64982050 | -1.000 | -1.000 | -1.000 | — |
| chr15_64981933_G_A | chr15:64981933 | 1.000 | 1.000 | 0.618 | — |
| chr15_64982060_C_A | chr15:64982060 | 1.000 | 1.000 | 0.534 | — |
| chr15_64982021_A_C | chr15:64982021 | -1.000 | -1.000 | -0.989 | — |
| chr15_64981985_A_C | chr15:64981985 | -0.985 | -1.000 | -0.831 | — |
| chr15_64982017_A_C | chr15:64982017 | -0.961 | -1.000 | -0.989 | — |
| chr15_64982011_G_A | chr15:64982011 | 0.918 | 0.970 | 0.719 | — |
| chr15_64981996_T_G | chr15:64981996 | 0.900 | 1.000 | 0.702 | — |
| chr15_64982044_T_A | chr15:64982044 | 0.900 | 1.000 | 0.551 | — |
| chr15_64981970_A_C | chr15:64981970 | -0.895 | -0.879 | -0.629 | — |
| chr15_64982008_A_T | chr15:64982008 | -0.880 | -1.000 | -0.770 | — |
| chr15_64982049_T_A | chr15:64982049 | -0.875 | -1.000 | -0.978 | — |
| chr15_64982004_G_T | chr15:64982004 | -0.868 | -0.929 | -0.579 | — |
| chr15_64982051_G_A | chr15:64982051 | -0.866 | -1.000 | -0.843 | — |
| chr15_64982050_T_G | chr15:64982050 | -0.864 | -0.967 | -0.742 | — |
| chr15_64981942_T_C | chr15:64981942 | -0.862 | -0.756 | -0.511 | — |
| chr15_64982026_C_T | chr15:64982026 | -0.862 | -0.874 | -0.781 | — |
| chr15_64982018_G_A | chr15:64982018 | -0.845 | -0.914 | -0.758 | — |
| chr15_64982016_A_C | chr15:64982016 | -0.826 | -0.942 | -0.657 | — |
| chr15_64981958_G_T | chr15:64981958 | -0.803 | -0.819 | -0.500 | — |
| chr15_64981963_T_G | chr15:64981963 | -0.793 | -0.914 | -0.893 | — |
| chr15_64982018_G_T | chr15:64982018 | -0.786 | -0.861 | -0.770 | — |
| chr15_64982017_A_T | chr15:64982017 | -0.770 | -0.846 | -0.764 | — |
| chr15_64982048_T_C | chr15:64982048 | -0.767 | -0.922 | -0.640 | — |
| chr15_64981956_C_T | chr15:64981956 | -0.761 | -0.693 | -0.416 | — |
| chr15_64981960_G_A | chr15:64981960 | 0.754 | 0.063 | 0.309 | — |
| chr15_64982051_G_T | chr15:64982051 | -0.744 | -0.897 | -0.680 | — |
| chr15_64981983_T_G | chr15:64981983 | -0.734 | -0.841 | -0.584 | — |
| chr15_64982033_G_T | chr15:64982033 | -0.732 | -0.839 | -0.792 | — |
| chr15_64982053_A_G | chr15:64982053 | -0.731 | -0.952 | -0.635 | — |
| chr15_64982008_A_C | chr15:64982008 | -0.711 | -0.778 | -0.618 | — |
| chr15_64981988_G_A | chr15:64981988 | -0.707 | -0.768 | -0.584 | — |
| chr15_64982051_G_C | chr15:64982051 | -0.706 | -0.856 | -0.556 | — |
| chr15_64982011_G_T | chr15:64982011 | 0.703 | 0.738 | 0.551 | — |
| chr15_64982008_A_G | chr15:64982008 | -0.698 | -0.768 | -0.607 | — |
| chr15_64982060_C_T | chr15:64982060 | -0.698 | -0.839 | -0.618 | — |
| chr15_64982045_C_T | chr15:64982045 | -0.680 | -0.824 | -0.652 | — |
| chr15_64982006_T_A | chr15:64982006 | -0.674 | -0.574 | -0.449 | — |
| chr15_64981955_T_C | chr15:64981955 | 0.672 | 0.285 | 0.433 | — |
| chr15_64982038_A_T | chr15:64982038 | -0.666 | -0.668 | -0.506 | — |
| chr15_64981962_G_A | chr15:64981962 | -0.666 | -0.688 | -0.461 | <0.001% |
| chr15_64981980_G_C | chr15:64981980 | -0.666 | -0.861 | -0.376 | — |
| chr15_64981988_G_T | chr15:64981988 | 0.661 | 0.700 | 0.427 | — |
| chr15_64981957_T_G | chr15:64981957 | -0.655 | -0.683 | -0.494 | — |
| chr15_64981993_C_G | chr15:64981993 | 0.652 | 0.698 | 0.573 | — |
| chr15_64982045_C_A | chr15:64982045 | 0.643 | 0.924 | 0.522 | — |
| chr15_64982047_C_T | chr15:64982047 | -0.640 | -0.806 | -0.685 | — |
| chr15_64982048_T_A | chr15:64982048 | -0.634 | -0.849 | -0.551 | — |
| chr15_64982084_T_A | chr15:64982084 | 0.631 | 0.753 | 0.449 | — |
| chr15_64982050_T_C | chr15:64982050 | -0.630 | -0.761 | -0.461 | — |
| chr15_64981961_G_A | chr15:64981961 | -0.625 | -0.647 | -0.567 | — |
| chr15_64982058_C_G | chr15:64982058 | 0.625 | 0.670 | 0.455 | — |
| chr15_64981968_G_T | chr15:64981968 | -0.620 | -0.542 | -0.461 | — |
| chr15_64981964_G_C | chr15:64981964 | -0.616 | -0.380 | -0.337 | 0.0013% |
| chr15_64982040_C_G | chr15:64982040 | -0.616 | -0.645 | -0.534 | — |
| chr15_64982053_A_T | chr15:64982053 | -0.609 | -0.798 | -0.500 | — |
| chr15_64982052_G_C | chr15:64982052 | -0.604 | -0.781 | -0.433 | — |
| chr15_64981958_G_A | chr15:64981958 | -0.603 | -0.660 | -0.438 | — |
| chr15_64982019_G_A | chr15:64982019 | -0.602 | -0.602 | -0.579 | 0.0020% |
| chr15_64981980_G_T | chr15:64981980 | -0.598 | -0.768 | -0.331 | — |
| chr15_64981978_C_G | chr15:64981978 | -0.597 | -0.655 | -0.393 | — |
| chr15_64981994_A_C | chr15:64981994 | -0.587 | -0.564 | -0.371 | — |
| chr15_64981959_T_G | chr15:64981959 | -0.575 | -0.534 | -0.483 | — |
| chr15_64982016_A_T | chr15:64982016 | -0.575 | -0.670 | -0.489 | — |
| chr15_64982064_T_A | chr15:64982064 | -0.565 | -0.781 | -0.433 | — |
| chr15_64981964_G_A | chr15:64981964 | -0.556 | -0.438 | -0.354 | — |
| chr15_64982042_G_C | chr15:64982042 | -0.553 | -0.592 | -0.455 | — |
| chr15_64982002_C_A | chr15:64982002 | -0.552 | -0.544 | -0.438 | — |
| chr15_64981972_A_C | chr15:64981972 | -0.551 | -0.476 | -0.213 | — |
| chr15_64981984_C_A | chr15:64981984 | -0.543 | -0.733 | -0.365 | 0.0020% |
| chr15_64981987_T_A | chr15:64981987 | -0.542 | -0.587 | -0.461 | — |
| chr15_64982004_G_C | chr15:64982004 | -0.534 | -0.562 | -0.360 | — |
| chr15_64982003_A_G | chr15:64982003 | -0.534 | -0.554 | -0.449 | — |
| chr15_64982085_C_A | chr15:64982085 | -0.533 | -0.655 | -0.511 | — |
| chr15_64982042_G_A | chr15:64982042 | -0.532 | -0.635 | -0.539 | — |
| chr15_64982062_G_A | chr15:64982062 | -0.521 | -0.675 | -0.466 | 0.0013% |
| chr15_64981994_A_T | chr15:64981994 | -0.520 | -0.534 | -0.360 | — |
| chr15_64982055_T_A | chr15:64982055 | -0.503 | -0.630 | -0.539 | — |
| chr15_64982006_T_G | chr15:64982006 | -0.502 | -0.431 | -0.354 | — |
| chr15_64981949_T_C | chr15:64981949 | 0.497 | 0.370 | 0.337 | — |
| chr15_64981987_T_G | chr15:64981987 | -0.492 | -0.476 | -0.360 | — |
| chr15_64982072_G_C | chr15:64982072 | 0.489 | 0.607 | 0.348 | — |
| chr15_64981990_C_G | chr15:64981990 | 0.487 | 0.599 | 0.326 | — |
| chr15_64981960_G_C | chr15:64981960 | -0.485 | -0.413 | -0.247 | — |
| chr15_64981971_C_A | chr15:64981971 | 0.477 | 0.574 | 0.315 | — |
| chr15_64982071_T_G | chr15:64982071 | 0.476 | 0.602 | 0.427 | — |
| chr15_64981951_T_C | chr15:64981951 | 0.475 | 0.151 | 0.337 | <0.001% |
| chr15_64981940_A_T | chr15:64981940 | -0.470 | -0.398 | -0.281 | — |
| chr15_64982040_C_T | chr15:64982040 | -0.469 | -0.547 | -0.438 | — |
| chr15_64982001_G_T | chr15:64982001 | 0.465 | 0.413 | 0.253 | — |
| chr15_64982066_A_T | chr15:64982066 | -0.464 | -0.592 | -0.393 | — |
| chr15_64981973_C_T | chr15:64981973 | 0.461 | 0.660 | 0.258 | — |
| chr15_64982069_G_T | chr15:64982069 | -0.461 | -0.564 | -0.449 | — |
| chr15_64982019_G_T | chr15:64982019 | 0.453 | 0.516 | 0.298 | <0.001% |
| chr15_64981985_A_G | chr15:64981985 | -0.452 | -0.544 | -0.242 | — |
| chr15_64982007_A_G | chr15:64982007 | -0.447 | -0.499 | -0.478 | — |
| chr15_64982047_C_A | chr15:64982047 | -0.443 | -0.579 | -0.461 | — |
| chr15_64982059_A_T | chr15:64982059 | -0.443 | -0.476 | -0.410 | — |
| chr15_64982080_T_G | chr15:64982080 | 0.441 | 0.353 | 0.230 | <0.001% |
| chr15_64981991_A_T | chr15:64981991 | 0.438 | 0.559 | 0.354 | — |
| chr15_64982071_T_C | chr15:64982071 | 0.436 | 0.501 | 0.416 | — |
| chr15_64982117_C_G | chr15:64982117 | 0.436 | 0.471 | 0.393 | — |
| chr15_64982065_C_A | chr15:64982065 | -0.434 | -0.615 | -0.410 | — |
| chr15_64981966_C_G | chr15:64981966 | -0.433 | -0.320 | -0.320 | — |
| chr15_64981983_T_A | chr15:64981983 | -0.430 | -0.597 | -0.326 | — |
| chr15_64981959_T_A | chr15:64981959 | -0.428 | -0.438 | -0.348 | — |
| chr15_64981995_C_A | chr15:64981995 | 0.424 | 0.448 | 0.348 | — |
| chr15_64982035_C_T | chr15:64982035 | -0.421 | -0.446 | -0.444 | — |
| chr15_64982033_G_A | chr15:64982033 | -0.417 | -0.443 | -0.410 | — |
| chr15_64982032_A_G | chr15:64982032 | -0.414 | -0.363 | -0.320 | — |
| chr15_64981984_C_G | chr15:64981984 | -0.411 | -0.544 | -0.135 | — |
| chr15_64982010_T_C | chr15:64982010 | 0.411 | 0.511 | 0.331 | <0.001% |
| chr15_64982036_C_A | chr15:64982036 | -0.411 | -0.426 | -0.298 | — |
| chr15_64981970_A_G | chr15:64981970 | -0.410 | -0.441 | -0.208 | — |
| chr15_64982070_A_C | chr15:64982070 | 0.410 | 0.443 | 0.270 | — |
| chr15_64982080_T_C | chr15:64982080 | 0.410 | 0.373 | 0.331 | — |
| chr15_64982072_G_T | chr15:64982072 | 0.403 | 0.446 | 0.242 | — |
| chr15_64981929_C_G | chr15:64981929 | -0.402 | -0.390 | -0.287 | — |
| chr15_64982054_C_T | chr15:64982054 | -0.402 | -0.569 | -0.253 | — |
| chr15_64981982_G_A | chr15:64981982 | -0.400 | -0.589 | -0.287 | 0.0013% |
| chr15_64981998_G_C | chr15:64981998 | 0.398 | 0.476 | 0.315 | — |
| chr15_64982065_C_T | chr15:64982065 | -0.398 | -0.559 | -0.427 | — |
| chr15_64982032_A_C | chr15:64982032 | 0.394 | 0.421 | 0.399 | — |
| chr15_64982096_G_C | chr15:64982096 | -0.390 | -0.446 | -0.393 | — |
| chr15_64982061_A_T | chr15:64982061 | -0.389 | -0.542 | -0.365 | — |
| chr15_64982071_T_A | chr15:64982071 | 0.380 | 0.504 | 0.348 | — |
| chr15_64982110_T_C | chr15:64982110 | -0.379 | -0.385 | -0.354 | — |
| chr15_64981965_G_A | chr15:64981965 | -0.375 | -0.320 | -0.202 | — |
| chr15_64981983_T_C | chr15:64981983 | -0.375 | -0.511 | -0.219 | — |
| chr15_64981968_G_C | chr15:64981968 | -0.370 | -0.295 | -0.197 | — |
| chr15_64981961_G_C | chr15:64981961 | -0.368 | -0.338 | -0.169 | — |
| chr15_64982054_C_G | chr15:64982054 | -0.366 | -0.441 | -0.281 | — |
| chr15_64981939_G_A | chr15:64981939 | 0.366 | 0.453 | 0.225 | — |
| chr15_64982084_T_G | chr15:64982084 | 0.357 | 0.403 | 0.303 | — |
| chr15_64981960_G_T | chr15:64981960 | -0.356 | -0.368 | -0.219 | — |
| chr15_64981961_G_T | chr15:64981961 | -0.355 | -0.343 | -0.219 | — |
| chr15_64981980_G_A | chr15:64981980 | 0.354 | 0.338 | 0.191 | — |
| chr15_64981996_T_A | chr15:64981996 | -0.353 | -0.322 | -0.185 | — |
| chr15_64982029_G_C | chr15:64982029 | 0.353 | 0.350 | 0.298 | — |
| chr15_64981952_C_G | chr15:64981952 | -0.352 | -0.262 | -0.230 | — |
| chr15_64981988_G_C | chr15:64981988 | -0.352 | -0.335 | -0.264 | — |
| chr15_64982055_T_C | chr15:64982055 | -0.352 | -0.433 | -0.354 | — |
| chr15_64981977_C_A | chr15:64981977 | 0.351 | 0.401 | 0.320 | — |
| chr15_64982006_T_C | chr15:64982006 | -0.351 | -0.320 | -0.253 | — |
| chr15_64982046_C_T | chr15:64982046 | -0.351 | -0.471 | -0.309 | 0.0013% |
| chr15_64981956_C_A | chr15:64981956 | -0.349 | -0.275 | -0.202 | — |
| chr15_64981973_C_G | chr15:64981973 | 0.349 | 0.335 | 0.230 | — |
| chr15_64981987_T_C | chr15:64981987 | -0.349 | -0.368 | -0.264 | — |
| chr15_64982112_T_C | chr15:64982112 | 0.349 | 0.469 | 0.320 | — |
| chr15_64982015_C_T | chr15:64982015 | -0.348 | -0.406 | -0.376 | — |
| chr15_64982085_C_G | chr15:64982085 | -0.344 | -0.355 | -0.258 | — |
| chr15_64981997_A_G | chr15:64981997 | 0.340 | 0.406 | 0.281 | — |
| chr15_64981963_T_C | chr15:64981963 | 0.336 | 0.489 | 0.281 | — |
| chr15_64981999_G_C | chr15:64981999 | 0.334 | 0.330 | 0.270 | 0.0013% |
| chr15_64982086_T_G | chr15:64982086 | 0.328 | 0.340 | 0.348 | — |
| chr15_64982015_C_G | chr15:64982015 | -0.327 | -0.373 | -0.298 | <0.001% |
| chr15_64982049_T_C | chr15:64982049 | -0.326 | -0.458 | -0.309 | <0.001% |
| chr15_64982005_A_C | chr15:64982005 | -0.320 | -0.330 | -0.230 | — |
| chr15_64982029_G_A | chr15:64982029 | 0.320 | 0.406 | 0.236 | — |
| chr15_64981951_T_G | chr15:64981951 | -0.319 | -0.315 | -0.242 | — |
| chr15_64982066_A_C | chr15:64982066 | -0.318 | -0.448 | -0.213 | — |
| chr15_64981940_A_G | chr15:64981940 | -0.316 | -0.254 | -0.118 | — |
| chr15_64982028_A_G | chr15:64982028 | -0.316 | -0.295 | -0.169 | — |
| chr15_64982049_T_G | chr15:64982049 | -0.316 | -0.458 | -0.281 | — |
| chr15_64982070_A_G | chr15:64982070 | 0.316 | 0.401 | 0.236 | — |
| chr15_64982005_A_T | chr15:64982005 | -0.316 | -0.312 | -0.236 | — |
| chr15_64982053_A_C | chr15:64982053 | -0.316 | -0.441 | -0.213 | — |
| chr15_64982041_A_C | chr15:64982041 | 0.314 | 0.355 | 0.287 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.