Home / Gene
SLC51B
receptor: FXRTier 1
Prior gene annotation
Retained explanatory context, not the pharmacist's submitted wording; submitted reviews below take precedence.
Drug substrates (prior annotation)
none in routine clinical use, endogenous or bile acid pathway
refs: 16269519
CAMIP Tier 1: peak-anchored panel
FXR
Submitted decision (verbatim): 需修訂
Reviewer revision (verbatim)
Blunted receptor-mediated induction of SLC51B expression may impair bile salt export from enterocytes and the inducible basolateral bile salt efflux route in hepatocytes under increased intracellular bile salt load.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Obeticholic acid; Experimental GW4064
- Regulatory element
- overlapping TSS
- Predicted consequence
- Blunted receptor-mediated induction of SLC51B expression, reducing heteromeric basolateral bile acid efflux capacity in hepatocytes and enterocytes.
- Prior narrative
- Blunted receptor-mediated induction of SLC51B expression, reducing heteromeric basolateral bile acid efflux capacity in hepatocytes and enterocytes.
- Drug context
- none in routine clinical use, endogenous or bile acid pathway
- Prior references
- 16269519
Scored variants near SLC51B
chr15:64,945,386..65,153,397, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr15_64982020_C_A | chr15:64982020 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982024_G_A | chr15:64982024 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982022_A_C | chr15:64982022 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982022_A_T | chr15:64982022 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982024_G_C | chr15:64982024 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982020_C_G | chr15:64982020 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982022_A_G | chr15:64982022 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr15_64982021_A_T | chr15:64982021 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982027_C_A | chr15:64982027 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982027_C_G | chr15:64982027 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982028_A_C | chr15:64982028 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982024_G_T | chr15:64982024 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982025_T_A | chr15:64982025 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982025_T_C | chr15:64982025 | -1.000 | -1.000 | -1.000 | <0.001% |
| chr15_64982026_C_G | chr15:64982026 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982020_C_T | chr15:64982020 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982023_A_C | chr15:64982023 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982023_A_T | chr15:64982023 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982025_T_G | chr15:64982025 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982027_C_T | chr15:64982027 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982044_T_G | chr15:64982044 | 1.000 | 1.000 | 0.941 | — |
| chr15_64982026_C_A | chr15:64982026 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982028_A_T | chr15:64982028 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982018_G_C | chr15:64982018 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982023_A_G | chr15:64982023 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982007_A_C | chr15:64982007 | 1.000 | 1.000 | 0.976 | — |
| chr15_64981991_A_G | chr15:64981991 | 1.000 | 1.000 | 1.000 | — |
| chr15_64982021_A_G | chr15:64982021 | -1.000 | -1.000 | -1.000 | — |
| chr15_64981991_A_C | chr15:64981991 | 1.000 | 1.000 | 0.918 | — |
| chr15_64981989_G_A | chr15:64981989 | 1.000 | 1.000 | 0.788 | — |
| chr15_64981985_A_T | chr15:64981985 | -1.000 | -1.000 | -1.000 | — |
| chr15_64982017_A_G | chr15:64982017 | 1.000 | 1.000 | 0.906 | — |
| chr15_64982050_T_A | chr15:64982050 | -1.000 | -1.000 | -1.000 | — |
| chr15_64981933_G_A | chr15:64981933 | 1.000 | 1.000 | 0.647 | — |
| chr15_64982060_C_A | chr15:64982060 | 1.000 | 1.000 | 0.559 | — |
| chr15_64982021_A_C | chr15:64982021 | -1.000 | -1.000 | -1.000 | — |
| chr15_64981985_A_C | chr15:64981985 | -1.000 | -1.000 | -0.871 | — |
| chr15_64982017_A_C | chr15:64982017 | -0.976 | -1.000 | -1.000 | — |
| chr15_64982011_G_A | chr15:64982011 | 0.932 | 0.977 | 0.753 | — |
| chr15_64981996_T_G | chr15:64981996 | 0.913 | 1.000 | 0.735 | — |
| chr15_64982044_T_A | chr15:64982044 | 0.913 | 1.000 | 0.576 | — |
| chr15_64981970_A_C | chr15:64981970 | -0.908 | -0.886 | -0.659 | — |
| chr15_64982008_A_T | chr15:64982008 | -0.894 | -1.000 | -0.806 | — |
| chr15_64982049_T_A | chr15:64982049 | -0.889 | -1.000 | -1.000 | — |
| chr15_64982004_G_T | chr15:64982004 | -0.881 | -0.937 | -0.606 | — |
| chr15_64982051_G_A | chr15:64982051 | -0.879 | -1.000 | -0.882 | — |
| chr15_64982050_T_G | chr15:64982050 | -0.877 | -0.975 | -0.776 | — |
| chr15_64981942_T_C | chr15:64981942 | -0.875 | -0.761 | -0.535 | — |
| chr15_64982026_C_T | chr15:64982026 | -0.875 | -0.881 | -0.818 | — |
| chr15_64982018_G_A | chr15:64982018 | -0.858 | -0.921 | -0.794 | — |
| chr15_64982016_A_C | chr15:64982016 | -0.839 | -0.949 | -0.688 | — |
| chr15_64981958_G_T | chr15:64981958 | -0.815 | -0.825 | -0.524 | — |
| chr15_64981963_T_G | chr15:64981963 | -0.805 | -0.921 | -0.935 | — |
| chr15_64982018_G_T | chr15:64982018 | -0.798 | -0.868 | -0.806 | — |
| chr15_64982017_A_T | chr15:64982017 | -0.782 | -0.853 | -0.800 | — |
| chr15_64982048_T_C | chr15:64982048 | -0.779 | -0.929 | -0.671 | — |
| chr15_64981956_C_T | chr15:64981956 | -0.772 | -0.698 | -0.435 | — |
| chr15_64981960_G_A | chr15:64981960 | 0.765 | 0.063 | 0.324 | — |
| chr15_64982051_G_T | chr15:64982051 | -0.755 | -0.904 | -0.712 | — |
| chr15_64981983_T_G | chr15:64981983 | -0.745 | -0.848 | -0.612 | — |
| chr15_64982033_G_T | chr15:64982033 | -0.743 | -0.845 | -0.829 | — |
| chr15_64982053_A_G | chr15:64982053 | -0.742 | -0.959 | -0.665 | — |
| chr15_64982008_A_C | chr15:64982008 | -0.721 | -0.784 | -0.647 | — |
| chr15_64981988_G_A | chr15:64981988 | -0.718 | -0.774 | -0.612 | — |
| chr15_64982051_G_C | chr15:64982051 | -0.716 | -0.863 | -0.582 | — |
| chr15_64982011_G_T | chr15:64982011 | 0.714 | 0.744 | 0.576 | — |
| chr15_64982008_A_G | chr15:64982008 | -0.709 | -0.774 | -0.635 | — |
| chr15_64982060_C_T | chr15:64982060 | -0.709 | -0.845 | -0.647 | — |
| chr15_64982045_C_T | chr15:64982045 | -0.690 | -0.830 | -0.682 | — |
| chr15_64982006_T_A | chr15:64982006 | -0.684 | -0.579 | -0.471 | — |
| chr15_64981955_T_C | chr15:64981955 | 0.682 | 0.287 | 0.453 | — |
| chr15_64982038_A_T | chr15:64982038 | -0.676 | -0.673 | -0.529 | — |
| chr15_64981962_G_A | chr15:64981962 | -0.676 | -0.693 | -0.482 | <0.001% |
| chr15_64981980_G_C | chr15:64981980 | -0.676 | -0.868 | -0.394 | — |
| chr15_64981988_G_T | chr15:64981988 | 0.671 | 0.706 | 0.447 | — |
| chr15_64981957_T_G | chr15:64981957 | -0.665 | -0.688 | -0.518 | — |
| chr15_64981993_C_G | chr15:64981993 | 0.662 | 0.703 | 0.600 | — |
| chr15_64982045_C_A | chr15:64982045 | 0.653 | 0.931 | 0.547 | — |
| chr15_64982047_C_T | chr15:64982047 | -0.650 | -0.812 | -0.718 | — |
| chr15_64982048_T_A | chr15:64982048 | -0.644 | -0.855 | -0.576 | — |
| chr15_64982084_T_A | chr15:64982084 | 0.641 | 0.759 | 0.471 | — |
| chr15_64982050_T_C | chr15:64982050 | -0.640 | -0.766 | -0.482 | — |
| chr15_64981961_G_A | chr15:64981961 | -0.635 | -0.652 | -0.594 | — |
| chr15_64982058_C_G | chr15:64982058 | 0.635 | 0.675 | 0.476 | — |
| chr15_64981968_G_T | chr15:64981968 | -0.629 | -0.546 | -0.482 | — |
| chr15_64981964_G_C | chr15:64981964 | -0.626 | -0.383 | -0.353 | 0.0013% |
| chr15_64982040_C_G | chr15:64982040 | -0.626 | -0.650 | -0.559 | — |
| chr15_64982053_A_T | chr15:64982053 | -0.618 | -0.805 | -0.524 | — |
| chr15_64982052_G_C | chr15:64982052 | -0.613 | -0.787 | -0.453 | — |
| chr15_64981958_G_A | chr15:64981958 | -0.612 | -0.665 | -0.459 | — |
| chr15_64982019_G_A | chr15:64982019 | -0.611 | -0.607 | -0.606 | 0.0020% |
| chr15_64981980_G_T | chr15:64981980 | -0.607 | -0.774 | -0.347 | — |
| chr15_64981978_C_G | chr15:64981978 | -0.606 | -0.660 | -0.412 | — |
| chr15_64981994_A_C | chr15:64981994 | -0.596 | -0.569 | -0.388 | — |
| chr15_64981959_T_G | chr15:64981959 | -0.583 | -0.538 | -0.506 | — |
| chr15_64982016_A_T | chr15:64982016 | -0.583 | -0.675 | -0.512 | — |
| chr15_64982064_T_A | chr15:64982064 | -0.573 | -0.787 | -0.453 | — |
| chr15_64981964_G_A | chr15:64981964 | -0.564 | -0.442 | -0.371 | — |
| chr15_64982042_G_C | chr15:64982042 | -0.562 | -0.596 | -0.476 | — |
| chr15_64982002_C_A | chr15:64982002 | -0.560 | -0.548 | -0.459 | — |
| chr15_64981972_A_C | chr15:64981972 | -0.559 | -0.480 | -0.224 | — |
| chr15_64981984_C_A | chr15:64981984 | -0.551 | -0.739 | -0.382 | 0.0020% |
| chr15_64981987_T_A | chr15:64981987 | -0.550 | -0.591 | -0.482 | — |
| chr15_64982004_G_C | chr15:64982004 | -0.542 | -0.566 | -0.376 | — |
| chr15_64982003_A_G | chr15:64982003 | -0.542 | -0.558 | -0.471 | — |
| chr15_64982085_C_A | chr15:64982085 | -0.541 | -0.660 | -0.535 | — |
| chr15_64982042_G_A | chr15:64982042 | -0.540 | -0.640 | -0.565 | — |
| chr15_64982062_G_A | chr15:64982062 | -0.529 | -0.680 | -0.488 | 0.0013% |
| chr15_64981994_A_T | chr15:64981994 | -0.527 | -0.538 | -0.376 | — |
| chr15_64982055_T_A | chr15:64982055 | -0.511 | -0.635 | -0.565 | — |
| chr15_64982006_T_G | chr15:64982006 | -0.509 | -0.434 | -0.371 | — |
| chr15_64981949_T_C | chr15:64981949 | 0.504 | 0.373 | 0.353 | — |
| chr15_64981987_T_G | chr15:64981987 | -0.499 | -0.480 | -0.376 | — |
| chr15_64982072_G_C | chr15:64982072 | 0.497 | 0.612 | 0.365 | — |
| chr15_64981990_C_G | chr15:64981990 | 0.494 | 0.604 | 0.341 | — |
| chr15_64981960_G_C | chr15:64981960 | -0.493 | -0.416 | -0.259 | — |
| chr15_64981971_C_A | chr15:64981971 | 0.484 | 0.579 | 0.329 | — |
| chr15_64982071_T_G | chr15:64982071 | 0.483 | 0.607 | 0.447 | — |
| chr15_64981951_T_C | chr15:64981951 | 0.483 | 0.152 | 0.353 | <0.001% |
| chr15_64981940_A_T | chr15:64981940 | -0.478 | -0.401 | -0.294 | — |
| chr15_64982040_C_T | chr15:64982040 | -0.476 | -0.551 | -0.459 | — |
| chr15_64982001_G_T | chr15:64982001 | 0.472 | 0.416 | 0.265 | — |
| chr15_64982066_A_T | chr15:64982066 | -0.471 | -0.596 | -0.412 | — |
| chr15_64981973_C_T | chr15:64981973 | 0.468 | 0.665 | 0.271 | — |
| chr15_64982069_G_T | chr15:64982069 | -0.468 | -0.569 | -0.471 | — |
| chr15_64982019_G_T | chr15:64982019 | 0.460 | 0.520 | 0.312 | <0.001% |
| chr15_64981985_A_G | chr15:64981985 | -0.458 | -0.548 | -0.253 | — |
| chr15_64982007_A_G | chr15:64982007 | -0.453 | -0.503 | -0.500 | — |
| chr15_64982047_C_A | chr15:64982047 | -0.450 | -0.584 | -0.482 | — |
| chr15_64982059_A_T | chr15:64982059 | -0.449 | -0.480 | -0.429 | — |
| chr15_64982080_T_G | chr15:64982080 | 0.448 | 0.355 | 0.241 | <0.001% |
| chr15_64981991_A_T | chr15:64981991 | 0.444 | 0.563 | 0.371 | — |
| chr15_64982071_T_C | chr15:64982071 | 0.443 | 0.505 | 0.435 | — |
| chr15_64982117_C_G | chr15:64982117 | 0.443 | 0.475 | 0.412 | — |
| chr15_64982065_C_A | chr15:64982065 | -0.441 | -0.619 | -0.429 | — |
| chr15_64981966_C_G | chr15:64981966 | -0.439 | -0.322 | -0.335 | — |
| chr15_64981983_T_A | chr15:64981983 | -0.436 | -0.602 | -0.341 | — |
| chr15_64981959_T_A | chr15:64981959 | -0.434 | -0.442 | -0.365 | — |
| chr15_64981995_C_A | chr15:64981995 | 0.430 | 0.452 | 0.365 | — |
| chr15_64982035_C_T | chr15:64982035 | -0.428 | -0.449 | -0.465 | — |
| chr15_64982033_G_A | chr15:64982033 | -0.423 | -0.447 | -0.429 | — |
| chr15_64982032_A_G | chr15:64982032 | -0.420 | -0.365 | -0.335 | — |
| chr15_64981984_C_G | chr15:64981984 | -0.418 | -0.548 | -0.141 | — |
| chr15_64982010_T_C | chr15:64982010 | 0.418 | 0.515 | 0.347 | <0.001% |
| chr15_64982036_C_A | chr15:64982036 | -0.418 | -0.429 | -0.312 | — |
| chr15_64981970_A_G | chr15:64981970 | -0.416 | -0.444 | -0.218 | — |
| chr15_64982070_A_C | chr15:64982070 | 0.416 | 0.447 | 0.282 | — |
| chr15_64982080_T_C | chr15:64982080 | 0.416 | 0.376 | 0.347 | — |
| chr15_64982072_G_T | chr15:64982072 | 0.409 | 0.449 | 0.253 | — |
| chr15_64981929_C_G | chr15:64981929 | -0.408 | -0.393 | -0.300 | — |
| chr15_64982054_C_T | chr15:64982054 | -0.408 | -0.574 | -0.265 | — |
| chr15_64981982_G_A | chr15:64981982 | -0.406 | -0.594 | -0.300 | 0.0013% |
| chr15_64981998_G_C | chr15:64981998 | 0.404 | 0.480 | 0.329 | — |
| chr15_64982065_C_T | chr15:64982065 | -0.403 | -0.563 | -0.447 | — |
| chr15_64982032_A_C | chr15:64982032 | 0.400 | 0.424 | 0.418 | — |
| chr15_64982096_G_C | chr15:64982096 | -0.396 | -0.449 | -0.412 | — |
| chr15_64982061_A_T | chr15:64982061 | -0.395 | -0.546 | -0.382 | — |
| chr15_64982071_T_A | chr15:64982071 | 0.386 | 0.508 | 0.365 | — |
| chr15_64982110_T_C | chr15:64982110 | -0.384 | -0.388 | -0.371 | — |
| chr15_64981965_G_A | chr15:64981965 | -0.381 | -0.322 | -0.212 | — |
| chr15_64981983_T_C | chr15:64981983 | -0.381 | -0.515 | -0.229 | — |
| chr15_64981968_G_C | chr15:64981968 | -0.376 | -0.297 | -0.206 | — |
| chr15_64981961_G_C | chr15:64981961 | -0.374 | -0.340 | -0.176 | — |
| chr15_64982054_C_G | chr15:64982054 | -0.372 | -0.444 | -0.294 | — |
| chr15_64981939_G_A | chr15:64981939 | 0.371 | 0.457 | 0.235 | — |
| chr15_64982084_T_G | chr15:64982084 | 0.362 | 0.406 | 0.318 | — |
| chr15_64981960_G_T | chr15:64981960 | -0.361 | -0.371 | -0.229 | — |
| chr15_64981961_G_T | chr15:64981961 | -0.360 | -0.345 | -0.229 | — |
| chr15_64981980_G_A | chr15:64981980 | 0.359 | 0.340 | 0.200 | — |
| chr15_64981996_T_A | chr15:64981996 | -0.359 | -0.325 | -0.194 | — |
| chr15_64982029_G_C | chr15:64982029 | 0.359 | 0.353 | 0.312 | — |
| chr15_64981952_C_G | chr15:64981952 | -0.358 | -0.264 | -0.241 | — |
| chr15_64981988_G_C | chr15:64981988 | -0.358 | -0.338 | -0.276 | — |
| chr15_64982055_T_C | chr15:64982055 | -0.358 | -0.437 | -0.371 | — |
| chr15_64981977_C_A | chr15:64981977 | 0.356 | 0.404 | 0.335 | — |
| chr15_64982006_T_C | chr15:64982006 | -0.356 | -0.322 | -0.265 | — |
| chr15_64982046_C_T | chr15:64982046 | -0.356 | -0.475 | -0.324 | 0.0013% |
| chr15_64981956_C_A | chr15:64981956 | -0.354 | -0.277 | -0.212 | — |
| chr15_64981973_C_G | chr15:64981973 | 0.354 | 0.338 | 0.241 | — |
| chr15_64981987_T_C | chr15:64981987 | -0.354 | -0.371 | -0.276 | — |
| chr15_64982112_T_C | chr15:64982112 | 0.354 | 0.472 | 0.335 | — |
| chr15_64982015_C_T | chr15:64982015 | -0.353 | -0.409 | -0.394 | — |
| chr15_64982085_C_G | chr15:64982085 | -0.349 | -0.358 | -0.271 | — |
| chr15_64981997_A_G | chr15:64981997 | 0.345 | 0.409 | 0.294 | — |
| chr15_64981963_T_C | chr15:64981963 | 0.341 | 0.492 | 0.294 | — |
| chr15_64981999_G_C | chr15:64981999 | 0.339 | 0.332 | 0.282 | 0.0013% |
| chr15_64982086_T_G | chr15:64982086 | 0.333 | 0.343 | 0.365 | — |
| chr15_64982015_C_G | chr15:64982015 | -0.332 | -0.376 | -0.312 | <0.001% |
| chr15_64982049_T_C | chr15:64982049 | -0.331 | -0.462 | -0.324 | <0.001% |
| chr15_64982005_A_C | chr15:64982005 | -0.325 | -0.332 | -0.241 | — |
| chr15_64982029_G_A | chr15:64982029 | 0.325 | 0.409 | 0.247 | — |
| chr15_64981951_T_G | chr15:64981951 | -0.324 | -0.317 | -0.253 | — |
| chr15_64982066_A_C | chr15:64982066 | -0.323 | -0.452 | -0.224 | — |
| chr15_64981940_A_G | chr15:64981940 | -0.321 | -0.256 | -0.124 | — |
| chr15_64982028_A_G | chr15:64982028 | -0.321 | -0.297 | -0.176 | — |
| chr15_64982049_T_G | chr15:64982049 | -0.321 | -0.462 | -0.294 | — |
| chr15_64982070_A_G | chr15:64982070 | 0.321 | 0.404 | 0.247 | — |
| chr15_64982005_A_T | chr15:64982005 | -0.320 | -0.315 | -0.247 | — |
| chr15_64982053_A_C | chr15:64982053 | -0.320 | -0.444 | -0.224 | — |
| chr15_64982041_A_C | chr15:64982041 | 0.319 | 0.358 | 0.300 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.