Home / Gene
SULT2A1
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of SULT2A1, reducing the inducible sulfonation capacity for hydroxysteroids and clinical substrates such as budesonide.
Affected substrate drugs (PharmGKB): DHEA; budesonide
Scored variants near SULT2A1
chr19:47,770,466..47,986,315, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr19_47778454_C_G | chr19:47778454 | -0.681 | -1.000 | -1.000 | — |
| chr19_47778453_C_A | chr19:47778453 | -0.712 | -1.000 | -1.000 | — |
| chr19_47778453_C_G | chr19:47778453 | -0.704 | -1.000 | -1.000 | — |
| chr19_47778454_C_A | chr19:47778454 | -0.587 | -1.000 | -1.000 | — |
| chr19_47778455_A_T | chr19:47778455 | -0.307 | -1.000 | -1.000 | — |
| chr19_47778452_A_G | chr19:47778452 | -0.454 | -0.912 | -1.000 | — |
| chr19_47778455_A_C | chr19:47778455 | -0.276 | -1.000 | -1.000 | — |
| chr19_47778450_G_T | chr19:47778450 | -0.358 | -0.806 | -1.000 | — |
| chr19_47778446_G_A | chr19:47778446 | -0.531 | -0.771 | -1.000 | — |
| chr19_47778452_A_C | chr19:47778452 | -0.348 | -0.859 | -1.000 | — |
| chr19_47778455_A_G | chr19:47778455 | -0.116 | -0.936 | -1.000 | — |
| chr19_47778454_C_T | chr19:47778454 | -0.129 | -0.738 | -1.000 | — |
| chr19_47778453_C_T | chr19:47778453 | -0.016 | -0.874 | -1.000 | — |
| chr19_47778446_G_T | chr19:47778446 | -0.333 | -0.607 | -1.000 | — |
| chr19_47778452_A_T | chr19:47778452 | -0.092 | -0.627 | -1.000 | — |
| chr19_47778446_G_C | chr19:47778446 | -0.192 | -0.501 | -1.000 | — |
| chr19_47778450_G_C | chr19:47778450 | -0.084 | -0.479 | -1.000 | — |
| chr19_47778448_C_G | chr19:47778448 | -0.156 | -0.489 | -1.000 | — |
| chr19_47778444_T_G | chr19:47778444 | -0.161 | -0.325 | -1.000 | — |
| chr19_47778456_T_G | chr19:47778456 | 0.112 | -0.408 | -1.000 | — |
| chr19_47778428_T_G | chr19:47778428 | 0.229 | 0.320 | 0.944 | — |
| chr19_47778445_G_C | chr19:47778445 | 0.030 | -0.307 | -0.921 | — |
| chr19_47778402_C_G | chr19:47778402 | -0.257 | -0.207 | -0.787 | — |
| chr19_47778402_C_T | chr19:47778402 | -0.175 | -0.151 | -0.708 | — |
| chr19_47778400_T_A | chr19:47778400 | -0.108 | -0.166 | -0.685 | — |
| chr19_47778448_C_T | chr19:47778448 | -0.027 | -0.224 | -0.652 | — |
| chr19_47778402_C_A | chr19:47778402 | -0.248 | -0.136 | -0.629 | — |
| chr19_47778403_G_T | chr19:47778403 | -0.102 | -0.176 | -0.629 | — |
| chr19_47778400_T_G | chr19:47778400 | -0.125 | -0.169 | -0.618 | — |
| chr19_47778436_C_A | chr19:47778436 | -0.123 | -0.118 | -0.618 | — |
| chr19_47778445_G_T | chr19:47778445 | 0.028 | -0.212 | -0.607 | — |
| chr19_47778451_T_G | chr19:47778451 | 0.180 | -0.327 | -0.584 | — |
| chr19_47778445_G_A | chr19:47778445 | 0.087 | -0.204 | -0.562 | — |
| chr19_47778286_T_C | chr19:47778286 | -0.030 | -0.151 | -0.539 | — |
| chr19_47778477_A_G | chr19:47778477 | -0.104 | 0.000 | -0.539 | — |
| chr19_47778294_T_C | chr19:47778294 | -0.051 | -0.098 | -0.528 | — |
| chr19_47778400_T_C | chr19:47778400 | -0.097 | -0.166 | -0.517 | — |
| chr19_47778403_G_C | chr19:47778403 | -0.100 | -0.202 | -0.517 | — |
| chr19_47778416_A_G | chr19:47778416 | -0.090 | -0.156 | -0.506 | — |
| chr19_47778480_G_T | chr19:47778480 | 0.084 | 0.227 | 0.506 | — |
| chr19_47778386_C_G | chr19:47778386 | 0.290 | 0.149 | 0.045 | — |
| chr19_47778436_C_T | chr19:47778436 | -0.102 | -0.091 | -0.494 | — |
| chr19_47778468_G_T | chr19:47778468 | 0.143 | 0.196 | 0.494 | — |
| chr19_47778483_C_T | chr19:47778483 | -0.023 | -0.141 | -0.494 | — |
| chr19_47778352_G_C | chr19:47778352 | -0.009 | -0.108 | -0.483 | — |
| chr19_47778354_G_C | chr19:47778354 | -0.005 | -0.091 | -0.472 | — |
| chr19_47778406_T_A | chr19:47778406 | -0.054 | -0.033 | -0.472 | — |
| chr19_47778444_T_A | chr19:47778444 | 0.014 | -0.123 | -0.472 | — |
| chr19_47778296_G_C | chr19:47778296 | 0.080 | -0.076 | -0.461 | — |
| chr19_47778401_C_G | chr19:47778401 | -0.149 | -0.171 | -0.461 | — |
| chr19_47778382_A_G | chr19:47778382 | 0.168 | 0.234 | 0.449 | — |
| chr19_47778401_C_T | chr19:47778401 | -0.152 | -0.171 | -0.449 | — |
| chr19_47778403_G_A | chr19:47778403 | -0.103 | -0.136 | -0.449 | — |
| chr19_47778449_C_G | chr19:47778449 | 0.106 | -0.275 | -0.449 | — |
| chr19_47778450_G_A | chr19:47778450 | 0.024 | -0.184 | -0.449 | — |
| chr19_47778490_A_G | chr19:47778490 | -0.029 | -0.008 | -0.449 | — |
| chr19_47778541_A_T | chr19:47778541 | -0.108 | 0.030 | -0.449 | — |
| chr19_47778398_A_C | chr19:47778398 | 0.103 | 0.280 | 0.438 | — |
| chr19_47778432_T_G | chr19:47778432 | 0.175 | 0.103 | 0.438 | — |
| chr19_47778386_C_A | chr19:47778386 | 0.254 | 0.149 | -0.315 | — |
| chr19_47778369_A_C | chr19:47778369 | -0.033 | -0.076 | -0.427 | — |
| chr19_47778401_C_A | chr19:47778401 | -0.157 | -0.149 | -0.427 | — |
| chr19_47778447_G_T | chr19:47778447 | 0.029 | -0.159 | -0.427 | — |
| chr19_47778435_C_T | chr19:47778435 | -0.008 | -0.156 | -0.416 | — |
| chr19_47778482_A_G | chr19:47778482 | -0.085 | -0.101 | -0.416 | — |
| chr19_47778385_A_T | chr19:47778385 | 0.238 | 0.144 | -0.056 | — |
| chr19_47778385_A_G | chr19:47778385 | 0.237 | 0.194 | 0.000 | — |
| chr19_47778288_G_C | chr19:47778288 | -0.017 | -0.023 | -0.404 | — |
| chr19_47778382_A_T | chr19:47778382 | 0.128 | 0.229 | 0.393 | — |
| chr19_47778383_C_T | chr19:47778383 | 0.230 | 0.207 | 0.247 | — |
| chr19_47778419_G_A | chr19:47778419 | -0.031 | -0.008 | -0.393 | — |
| chr19_47778476_G_A | chr19:47778476 | 0.041 | 0.118 | 0.393 | — |
| chr19_47778438_C_A | chr19:47778438 | 0.021 | -0.123 | -0.382 | — |
| chr19_47778462_C_G | chr19:47778462 | -0.024 | -0.101 | -0.382 | — |
| chr19_47778465_G_T | chr19:47778465 | 0.108 | 0.040 | 0.382 | — |
| chr19_47778384_C_T | chr19:47778384 | 0.222 | 0.264 | 0.169 | — |
| chr19_47778399_T_C | chr19:47778399 | -0.113 | -0.098 | -0.371 | — |
| chr19_47778405_G_A | chr19:47778405 | 0.010 | -0.035 | -0.371 | — |
| chr19_47778405_G_C | chr19:47778405 | -0.043 | -0.063 | -0.371 | — |
| chr19_47778419_G_T | chr19:47778419 | -0.088 | 0.045 | -0.371 | — |
| chr19_47778436_C_G | chr19:47778436 | -0.078 | -0.053 | -0.371 | — |
| chr19_47778428_T_C | chr19:47778428 | 0.123 | 0.050 | 0.348 | — |
| chr19_47778480_G_C | chr19:47778480 | 0.040 | 0.101 | 0.348 | — |
| chr19_47778384_C_A | chr19:47778384 | 0.202 | 0.239 | 0.225 | — |
| chr19_47778465_G_C | chr19:47778465 | 0.110 | 0.025 | 0.337 | — |
| chr19_47778466_G_A | chr19:47778466 | 0.145 | 0.028 | 0.337 | — |
| chr19_47778481_G_C | chr19:47778481 | 0.002 | 0.043 | 0.337 | — |
| chr19_47778414_G_T | chr19:47778414 | -0.065 | 0.008 | -0.326 | — |
| chr19_47778385_A_C | chr19:47778385 | -0.040 | 0.005 | -0.315 | — |
| chr19_47778381_G_C | chr19:47778381 | 0.179 | 0.194 | 0.135 | — |
| chr19_47778433_C_A | chr19:47778433 | 0.179 | 0.023 | 0.112 | — |
| chr19_47778292_C_G | chr19:47778292 | 0.080 | 0.045 | 0.303 | — |
| chr19_47778386_C_T | chr19:47778386 | 0.177 | 0.033 | -0.067 | — |
| chr19_47778431_A_G | chr19:47778431 | 0.093 | -0.005 | 0.303 | — |
| chr19_47778493_G_C | chr19:47778493 | 0.045 | 0.071 | 0.303 | — |
| chr19_47778542_G_C | chr19:47778542 | 0.013 | 0.063 | 0.303 | — |
| chr19_47778399_T_G | chr19:47778399 | -0.107 | -0.128 | -0.292 | — |
| chr19_47778411_C_G | chr19:47778411 | -0.051 | -0.078 | -0.292 | — |
| chr19_47778423_A_T | chr19:47778423 | 0.060 | 0.101 | 0.292 | — |
| chr19_47778434_A_C | chr19:47778434 | 0.119 | 0.111 | 0.292 | — |
| chr19_47778435_C_G | chr19:47778435 | 0.005 | -0.136 | -0.292 | — |
| chr19_47778465_G_A | chr19:47778465 | 0.095 | 0.033 | 0.292 | — |
| chr19_47778290_C_G | chr19:47778290 | 0.019 | 0.025 | 0.281 | — |
| chr19_47778405_G_T | chr19:47778405 | 0.003 | 0.010 | -0.281 | — |
| chr19_47778406_T_C | chr19:47778406 | -0.025 | 0.005 | -0.281 | — |
| chr19_47778406_T_G | chr19:47778406 | -0.033 | -0.035 | -0.281 | — |
| chr19_47778407_C_A | chr19:47778407 | -0.039 | 0.010 | -0.281 | — |
| chr19_47778416_A_C | chr19:47778416 | 0.022 | 0.020 | 0.281 | — |
| chr19_47778429_A_G | chr19:47778429 | 0.088 | 0.078 | 0.281 | — |
| chr19_47778487_C_G | chr19:47778487 | 0.034 | -0.055 | -0.281 | — |
| chr19_47778398_A_T | chr19:47778398 | 0.041 | 0.159 | 0.270 | — |
| chr19_47778433_C_G | chr19:47778433 | 0.120 | 0.045 | 0.270 | — |
| chr19_47778435_C_A | chr19:47778435 | -0.018 | -0.091 | -0.270 | — |
| chr19_47778447_G_C | chr19:47778447 | 0.053 | -0.108 | -0.270 | — |
| chr19_47778463_C_G | chr19:47778463 | -0.046 | 0.053 | -0.270 | — |
| chr19_47778468_G_C | chr19:47778468 | 0.120 | 0.060 | 0.270 | — |
| chr19_47778484_G_A | chr19:47778484 | 0.013 | 0.113 | 0.270 | — |
| chr19_47778380_A_T | chr19:47778380 | 0.116 | 0.154 | 0.258 | — |
| chr19_47778384_C_G | chr19:47778384 | 0.074 | 0.149 | 0.258 | — |
| chr19_47778413_G_C | chr19:47778413 | 0.041 | 0.060 | 0.258 | — |
| chr19_47778426_C_A | chr19:47778426 | -0.038 | -0.071 | -0.258 | — |
| chr19_47778472_C_G | chr19:47778472 | -0.014 | -0.015 | -0.258 | — |
| chr19_47778476_G_C | chr19:47778476 | 0.015 | 0.108 | 0.258 | — |
| chr19_47778478_G_C | chr19:47778478 | 0.005 | 0.076 | 0.258 | — |
| chr19_47778516_T_A | chr19:47778516 | -0.022 | -0.121 | -0.258 | — |
| chr19_47778549_A_G | chr19:47778549 | 0.080 | -0.023 | -0.258 | — |
| chr19_47778467_G_A | chr19:47778467 | 0.148 | 0.013 | 0.135 | — |
| chr19_47778467_G_C | chr19:47778467 | 0.148 | -0.035 | 0.157 | — |
| chr19_47778468_G_A | chr19:47778468 | 0.148 | -0.005 | 0.045 | — |
| chr19_47778466_G_C | chr19:47778466 | 0.146 | -0.040 | 0.247 | — |
| chr19_47778424_G_T | chr19:47778424 | 0.084 | 0.076 | 0.247 | — |
| chr19_47778427_G_A | chr19:47778427 | -0.085 | -0.098 | -0.247 | — |
| chr19_47778449_C_A | chr19:47778449 | 0.050 | -0.139 | -0.247 | — |
| chr19_47778451_T_C | chr19:47778451 | 0.122 | -0.229 | -0.247 | — |
| chr19_47778383_C_G | chr19:47778383 | 0.139 | 0.214 | 0.135 | — |
| chr19_47778318_G_A | chr19:47778318 | 0.013 | -0.033 | -0.236 | — |
| chr19_47778318_G_T | chr19:47778318 | 0.025 | -0.020 | -0.236 | — |
| chr19_47778319_A_G | chr19:47778319 | -0.002 | 0.028 | 0.236 | — |
| chr19_47778383_C_A | chr19:47778383 | 0.138 | 0.196 | 0.011 | — |
| chr19_47778430_A_G | chr19:47778430 | 0.080 | 0.055 | 0.236 | — |
| chr19_47778438_C_G | chr19:47778438 | 0.030 | -0.071 | -0.236 | — |
| chr19_47778480_G_A | chr19:47778480 | 0.064 | 0.113 | 0.236 | — |
| chr19_47778429_A_C | chr19:47778429 | -0.137 | 0.025 | -0.213 | — |
| chr19_47778467_G_T | chr19:47778467 | 0.135 | -0.010 | 0.225 | — |
| chr19_47778428_T_A | chr19:47778428 | 0.134 | 0.050 | 0.202 | — |
| chr19_47778399_T_A | chr19:47778399 | -0.041 | -0.086 | -0.225 | — |
| chr19_47778407_C_G | chr19:47778407 | 0.002 | 0.035 | -0.225 | — |
| chr19_47778456_T_A | chr19:47778456 | 0.057 | -0.073 | -0.225 | — |
| chr19_47778457_T_C | chr19:47778457 | 0.044 | -0.108 | -0.225 | — |
| chr19_47778470_A_T | chr19:47778470 | -0.034 | -0.068 | -0.225 | — |
| chr19_47778537_C_T | chr19:47778537 | 0.121 | 0.023 | -0.225 | — |
| chr19_47778543_G_A | chr19:47778543 | 0.002 | 0.055 | 0.225 | — |
| chr19_47778544_A_C | chr19:47778544 | 0.004 | 0.040 | 0.225 | — |
| chr19_47778432_T_C | chr19:47778432 | 0.130 | 0.063 | 0.202 | — |
| chr19_47778464_G_T | chr19:47778464 | 0.128 | -0.058 | -0.056 | — |
| chr19_47778509_G_T | chr19:47778509 | 0.127 | 0.134 | -0.090 | — |
| chr19_47778432_T_A | chr19:47778432 | 0.126 | 0.043 | 0.124 | — |
| chr19_47778316_G_T | chr19:47778316 | 0.033 | -0.028 | -0.213 | — |
| chr19_47778350_C_G | chr19:47778350 | -0.022 | -0.040 | -0.213 | — |
| chr19_47778368_C_A | chr19:47778368 | 0.020 | 0.003 | -0.213 | — |
| chr19_47778397_G_C | chr19:47778397 | -0.067 | -0.063 | -0.213 | — |
| chr19_47778477_A_T | chr19:47778477 | 0.008 | -0.101 | -0.213 | — |
| chr19_47778478_G_A | chr19:47778478 | -0.004 | 0.068 | 0.213 | — |
| chr19_47778503_G_T | chr19:47778503 | -0.032 | 0.028 | 0.213 | — |
| chr19_47778526_C_G | chr19:47778526 | 0.038 | 0.073 | 0.213 | — |
| chr19_47778543_G_C | chr19:47778543 | -0.007 | 0.035 | 0.213 | — |
| chr19_47778381_G_A | chr19:47778381 | 0.120 | 0.146 | 0.056 | — |
| chr19_47778457_T_G | chr19:47778457 | 0.119 | -0.131 | -0.112 | — |
| chr19_47778291_C_G | chr19:47778291 | -0.008 | -0.005 | 0.202 | — |
| chr19_47778296_G_T | chr19:47778296 | 0.005 | -0.010 | -0.202 | — |
| chr19_47778311_G_A | chr19:47778311 | -0.007 | -0.040 | -0.202 | — |
| chr19_47778321_T_G | chr19:47778321 | -0.003 | 0.003 | 0.202 | — |
| chr19_47778345_C_A | chr19:47778345 | 0.018 | -0.013 | -0.202 | — |
| chr19_47778345_C_T | chr19:47778345 | -0.025 | -0.018 | -0.202 | — |
| chr19_47778346_C_T | chr19:47778346 | 0.002 | -0.020 | -0.202 | — |
| chr19_47778357_G_C | chr19:47778357 | -0.021 | -0.060 | -0.202 | — |
| chr19_47778408_C_A | chr19:47778408 | 0.020 | 0.096 | 0.202 | — |
| chr19_47778420_G_C | chr19:47778420 | -0.034 | -0.028 | -0.202 | — |
| chr19_47778441_C_A | chr19:47778441 | -0.052 | 0.020 | 0.202 | — |
| chr19_47778449_C_T | chr19:47778449 | 0.005 | -0.091 | -0.202 | — |
| chr19_47778451_T_A | chr19:47778451 | 0.111 | -0.149 | -0.202 | — |
| chr19_47778471_C_G | chr19:47778471 | 0.004 | 0.005 | -0.202 | — |
| chr19_47778473_T_G | chr19:47778473 | -0.011 | -0.023 | -0.202 | — |
| chr19_47778475_G_C | chr19:47778475 | -0.018 | 0.096 | 0.202 | — |
| chr19_47778483_C_G | chr19:47778483 | 0.007 | -0.043 | -0.202 | — |
| chr19_47778494_C_G | chr19:47778494 | 0.032 | 0.043 | -0.202 | — |
| chr19_47778497_C_G | chr19:47778497 | 0.027 | 0.045 | 0.202 | — |
| chr19_47778543_G_T | chr19:47778543 | -0.008 | 0.081 | 0.202 | — |
| chr19_47778548_G_C | chr19:47778548 | 0.006 | 0.081 | 0.202 | — |
| chr19_47778457_T_A | chr19:47778457 | 0.117 | -0.088 | -0.112 | — |
| chr19_47778381_G_T | chr19:47778381 | 0.112 | 0.166 | 0.067 | — |
| chr19_47778293_C_G | chr19:47778293 | 0.064 | 0.033 | 0.191 | — |
| chr19_47778323_A_G | chr19:47778323 | 0.005 | 0.000 | 0.191 | — |
| chr19_47778368_C_G | chr19:47778368 | 0.050 | 0.000 | -0.191 | — |
| chr19_47778371_G_T | chr19:47778371 | -0.020 | -0.038 | -0.191 | — |
| chr19_47778379_A_C | chr19:47778379 | 0.074 | 0.088 | 0.191 | — |
| chr19_47778390_T_G | chr19:47778390 | -0.019 | -0.053 | -0.191 | — |
| chr19_47778404_G_C | chr19:47778404 | -0.069 | -0.081 | -0.191 | — |
| chr19_47778412_T_C | chr19:47778412 | 0.056 | 0.048 | 0.191 | — |
| chr19_47778426_C_T | chr19:47778426 | 0.010 | -0.043 | -0.191 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.