Home / Gene
UGT1A4
receptor: PXRTier 1
CAMIP Tier 1: peak-anchored panel
PXR
Submitted decision (verbatim): 接受
Reviewer notes (verbatim)
Blunted PXR-mediated induction of UGT1A4 may attenuate induction-related increases in substrate glucuronidation and clearance, resulting in higher exposure to substrates such as lamotrigine.
Prior explanatory context
Retained explanatory context, not the pharmacist's submitted wording. The submitted review above takes precedence; this context is not a replacement for the reviewer's revision or notes.
- Inducer
- Rifampicin
- Regulatory element
- at promoter -22 bp
- Predicted consequence
- Blunted receptor-mediated induction of UGT1A4, leading to attenuated clearance and increased systemic exposure of its clinical substrates such as lamotrigine.
- Prior narrative
- Blunted receptor-mediated induction of UGT1A4, leading to attenuated clearance and increased systemic exposure of its clinical substrates such as lamotrigine.
- Drug context
- lamotrigine; tamoxifen; ABT-751; anastrozole; testosterone
Scored variants near UGT1A4
chr2:233,618,735..233,873,300, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr2_233718647_A_T | chr2:233718647 | 1.000 | 1.000 | 1.000 | — |
| chr2_233718667_T_G | chr2:233718667 | -1.000 | -1.000 | -1.000 | — |
| chr2_233691696_G_T | chr2:233691696 | 1.000 | 0.716 | 1.000 | — |
| chr2_233718674_T_G | chr2:233718674 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718675_A_T | chr2:233718675 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718658_G_C | chr2:233718658 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718677_T_G | chr2:233718677 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718674_T_C | chr2:233718674 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718681_T_A | chr2:233718681 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718675_A_C | chr2:233718675 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718621_T_G | chr2:233718621 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718557_G_C | chr2:233718557 | 1.000 | 0.975 | 0.818 | — |
| chr2_233718666_T_A | chr2:233718666 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718681_T_G | chr2:233718681 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718665_A_C | chr2:233718665 | -1.000 | -0.984 | -1.000 | — |
| chr2_233718659_T_C | chr2:233718659 | -1.000 | -0.992 | -1.000 | — |
| chr2_233718682_A_C | chr2:233718682 | -1.000 | -1.000 | -1.000 | — |
| chr2_233718670_T_G | chr2:233718670 | -0.965 | -0.959 | -1.000 | — |
| chr2_233718659_T_G | chr2:233718659 | -0.963 | -0.956 | -1.000 | — |
| chr2_233718647_A_G | chr2:233718647 | 0.937 | 0.769 | 0.812 | — |
| chr2_233718674_T_A | chr2:233718674 | -0.927 | -0.935 | -1.000 | — |
| chr2_233718662_T_A | chr2:233718662 | 0.925 | 1.000 | 0.771 | — |
| chr2_233718644_C_G | chr2:233718644 | 0.910 | 0.680 | 0.976 | — |
| chr2_233718677_T_A | chr2:233718677 | -0.907 | -0.997 | -1.000 | — |
| chr2_233718649_C_A | chr2:233718649 | -0.903 | -0.764 | -1.000 | — |
| chr2_233718667_T_A | chr2:233718667 | -0.890 | -0.951 | -0.959 | — |
| chr2_233718683_A_T | chr2:233718683 | -0.890 | -0.911 | -1.000 | — |
| chr2_233691675_A_C | chr2:233691675 | 0.888 | 0.744 | 1.000 | — |
| chr2_233718681_T_C | chr2:233718681 | -0.885 | -0.959 | -1.000 | — |
| chr2_233718675_A_G | chr2:233718675 | -0.882 | -0.905 | -1.000 | — |
| chr2_233718663_A_T | chr2:233718663 | 0.865 | 0.536 | 0.788 | — |
| chr2_233718710_T_G | chr2:233718710 | 0.830 | 0.797 | 0.941 | — |
| chr2_233718672_G_C | chr2:233718672 | -0.810 | -0.871 | -0.953 | — |
| chr2_233718649_C_G | chr2:233718649 | -0.805 | -0.760 | -1.000 | — |
| chr2_233718601_G_A | chr2:233718601 | 0.802 | 0.772 | 0.594 | — |
| chr2_233718682_A_G | chr2:233718682 | -0.795 | -0.840 | -1.000 | — |
| chr2_233718704_T_C | chr2:233718704 | 0.792 | 0.805 | 0.753 | — |
| chr2_233718703_C_G | chr2:233718703 | 0.769 | 0.627 | 0.759 | — |
| chr2_233718555_G_C | chr2:233718555 | 0.755 | 0.754 | 0.635 | — |
| chr2_233718625_T_A | chr2:233718625 | 0.755 | 0.706 | 0.682 | — |
| chr2_233718659_T_A | chr2:233718659 | -0.749 | -0.786 | -1.000 | — |
| chr2_233718658_G_A | chr2:233718658 | -0.740 | -0.753 | -0.835 | — |
| chr2_233718677_T_C | chr2:233718677 | -0.730 | -0.753 | -0.994 | — |
| chr2_233718683_A_C | chr2:233718683 | -0.725 | -0.778 | -1.000 | — |
| chr2_233718682_A_T | chr2:233718682 | -0.709 | -0.721 | -0.953 | — |
| chr2_233718575_C_T | chr2:233718575 | 0.705 | 0.533 | 0.441 | — |
| chr2_233718665_A_G | chr2:233718665 | -0.705 | -0.688 | -0.753 | — |
| chr2_233718684_C_T | chr2:233718684 | -0.697 | -0.801 | -1.000 | — |
| chr2_233718710_T_C | chr2:233718710 | 0.691 | 0.657 | 0.776 | — |
| chr2_233718676_A_G | chr2:233718676 | -0.684 | -0.774 | -1.000 | — |
| chr2_233718696_A_T | chr2:233718696 | -0.684 | -0.666 | -0.835 | — |
| chr2_233718666_T_C | chr2:233718666 | -0.682 | -0.764 | -0.759 | — |
| chr2_233718658_G_T | chr2:233718658 | -0.679 | -0.703 | -0.788 | — |
| chr2_233718663_A_C | chr2:233718663 | 0.676 | 0.376 | 0.724 | — |
| chr2_233718668_A_T | chr2:233718668 | -0.654 | -0.612 | -0.806 | — |
| chr2_233718676_A_C | chr2:233718676 | -0.637 | -0.641 | -0.988 | — |
| chr2_233718602_C_G | chr2:233718602 | 0.629 | 0.602 | 0.465 | — |
| chr2_233718666_T_G | chr2:233718666 | -0.627 | -0.701 | -0.682 | — |
| chr2_233691757_C_A | chr2:233691757 | 0.621 | 0.317 | 0.924 | — |
| chr2_233718691_A_G | chr2:233718691 | -0.617 | -0.618 | -0.700 | — |
| chr2_233718684_C_A | chr2:233718684 | -0.612 | -0.717 | -1.000 | — |
| chr2_233718709_A_G | chr2:233718709 | 0.602 | 0.668 | 0.688 | — |
| chr2_233718671_G_A | chr2:233718671 | 0.596 | 0.459 | 0.388 | — |
| chr2_233718544_A_T | chr2:233718544 | 0.589 | 0.525 | 0.465 | — |
| chr2_233718621_T_A | chr2:233718621 | -0.586 | -0.533 | -0.676 | — |
| chr2_233718678_A_T | chr2:233718678 | -0.577 | -0.652 | -0.882 | — |
| chr2_233718694_G_C | chr2:233718694 | -0.577 | -0.566 | -0.629 | — |
| chr2_233718707_C_T | chr2:233718707 | -0.577 | -0.598 | -0.706 | — |
| chr2_233718683_A_G | chr2:233718683 | -0.576 | -0.582 | -0.776 | — |
| chr2_233718575_C_G | chr2:233718575 | 0.572 | 0.310 | 0.359 | — |
| chr2_233718710_T_A | chr2:233718710 | 0.571 | 0.431 | 0.700 | — |
| chr2_233718594_C_A | chr2:233718594 | -0.569 | -0.566 | -0.612 | — |
| chr2_233718591_G_T | chr2:233718591 | -0.567 | -0.546 | -0.600 | — |
| chr2_233718619_G_A | chr2:233718619 | -0.564 | -0.522 | -0.588 | — |
| chr2_233718605_T_A | chr2:233718605 | 0.562 | 0.363 | 0.371 | — |
| chr2_233718705_T_G | chr2:233718705 | 0.562 | 0.434 | 0.512 | — |
| chr2_233718638_T_G | chr2:233718638 | -0.556 | -0.472 | -0.629 | — |
| chr2_233718673_G_T | chr2:233718673 | 0.556 | 0.259 | 0.276 | — |
| chr2_233718601_G_C | chr2:233718601 | 0.546 | 0.662 | 0.576 | — |
| chr2_233718650_G_C | chr2:233718650 | 0.544 | 0.553 | 0.441 | — |
| chr2_233718667_T_C | chr2:233718667 | -0.544 | -0.734 | -0.606 | — |
| chr2_233718697_C_A | chr2:233718697 | -0.544 | -0.548 | -0.600 | — |
| chr2_233718696_A_C | chr2:233718696 | -0.542 | -0.503 | -0.629 | — |
| chr2_233718684_C_G | chr2:233718684 | -0.534 | -0.584 | -0.841 | — |
| chr2_233718693_G_T | chr2:233718693 | 0.534 | 0.596 | 0.494 | — |
| chr2_233718711_T_C | chr2:233718711 | 0.531 | 0.602 | 0.653 | — |
| chr2_233718593_T_G | chr2:233718593 | -0.524 | -0.566 | -0.559 | — |
| chr2_233718591_G_C | chr2:233718591 | -0.519 | -0.477 | -0.535 | — |
| chr2_233718649_C_T | chr2:233718649 | -0.511 | -0.495 | -0.682 | — |
| chr2_233718597_A_G | chr2:233718597 | 0.509 | 0.556 | 0.529 | — |
| chr2_233718670_T_A | chr2:233718670 | -0.507 | -0.452 | -0.535 | — |
| chr2_233718665_A_T | chr2:233718665 | -0.502 | -0.317 | -0.582 | — |
| chr2_233718643_C_A | chr2:233718643 | 0.501 | 0.350 | 0.382 | — |
| chr2_233718656_C_A | chr2:233718656 | -0.493 | -0.439 | -0.612 | — |
| chr2_233718672_G_A | chr2:233718672 | -0.486 | -0.518 | -0.553 | — |
| chr2_233718622_T_G | chr2:233718622 | -0.484 | -0.470 | -0.565 | — |
| chr2_233718695_C_G | chr2:233718695 | 0.484 | 0.566 | 0.576 | — |
| chr2_233718577_C_A | chr2:233718577 | -0.483 | -0.434 | -0.459 | — |
| chr2_233718646_T_A | chr2:233718646 | 0.479 | 0.457 | 0.524 | — |
| chr2_233718713_C_T | chr2:233718713 | -0.479 | -0.537 | -0.618 | — |
| chr2_233718595_A_T | chr2:233718595 | -0.474 | -0.492 | -0.594 | — |
| chr2_233718591_G_A | chr2:233718591 | -0.473 | -0.454 | -0.518 | — |
| chr2_233718661_A_C | chr2:233718661 | -0.468 | -0.459 | -0.588 | — |
| chr2_233718706_C_G | chr2:233718706 | 0.468 | 0.363 | 0.182 | — |
| chr2_233718569_A_C | chr2:233718569 | 0.463 | 0.401 | 0.394 | — |
| chr2_233718672_G_T | chr2:233718672 | -0.461 | -0.447 | -0.524 | — |
| chr2_233718645_A_G | chr2:233718645 | 0.459 | 0.378 | 0.488 | — |
| chr2_233718567_G_C | chr2:233718567 | -0.449 | -0.416 | -0.376 | — |
| chr2_233718593_T_A | chr2:233718593 | -0.449 | -0.487 | -0.512 | — |
| chr2_233718668_A_C | chr2:233718668 | -0.448 | -0.501 | -0.553 | — |
| chr2_233718545_T_A | chr2:233718545 | 0.446 | 0.475 | 0.447 | — |
| chr2_233718595_A_G | chr2:233718595 | -0.441 | -0.439 | -0.441 | — |
| chr2_233718696_A_G | chr2:233718696 | -0.441 | -0.462 | -0.529 | — |
| chr2_233718680_G_C | chr2:233718680 | -0.434 | -0.437 | -0.594 | — |
| chr2_233718686_G_A | chr2:233718686 | 0.431 | 0.378 | 0.418 | — |
| chr2_233718712_A_G | chr2:233718712 | 0.424 | 0.412 | 0.506 | — |
| chr2_233718711_T_G | chr2:233718711 | 0.423 | 0.358 | 0.494 | — |
| chr2_233718565_T_A | chr2:233718565 | -0.421 | -0.447 | -0.429 | — |
| chr2_233718579_G_T | chr2:233718579 | -0.421 | -0.414 | -0.435 | — |
| chr2_233718661_A_T | chr2:233718661 | -0.421 | -0.371 | -0.576 | — |
| chr2_233718655_G_T | chr2:233718655 | 0.416 | 0.442 | 0.347 | — |
| chr2_233718577_C_T | chr2:233718577 | -0.411 | -0.416 | -0.512 | — |
| chr2_233691687_C_G | chr2:233691687 | 0.410 | 0.404 | 0.665 | — |
| chr2_233718651_A_T | chr2:233718651 | -0.406 | -0.421 | -0.435 | — |
| chr2_233718669_A_G | chr2:233718669 | -0.406 | -0.576 | -0.412 | — |
| chr2_233718596_G_C | chr2:233718596 | 0.401 | 0.464 | 0.459 | — |
| chr2_233718574_C_G | chr2:233718574 | 0.399 | 0.358 | 0.300 | — |
| chr2_233718620_A_T | chr2:233718620 | 0.399 | 0.409 | 0.229 | — |
| chr2_233718637_T_A | chr2:233718637 | -0.399 | -0.393 | -0.453 | — |
| chr2_233718654_G_T | chr2:233718654 | -0.399 | -0.393 | -0.488 | — |
| chr2_233718605_T_C | chr2:233718605 | -0.398 | -0.393 | -0.382 | — |
| chr2_233718646_T_G | chr2:233718646 | 0.394 | 0.376 | 0.382 | — |
| chr2_233718685_T_G | chr2:233718685 | -0.393 | -0.431 | -0.388 | — |
| chr2_233718695_C_A | chr2:233718695 | 0.391 | 0.416 | 0.412 | — |
| chr2_233718567_G_A | chr2:233718567 | -0.379 | -0.363 | -0.388 | — |
| chr2_233718629_T_A | chr2:233718629 | -0.378 | -0.350 | -0.429 | — |
| chr2_233718643_C_T | chr2:233718643 | 0.378 | 0.325 | 0.259 | — |
| chr2_233718663_A_G | chr2:233718663 | -0.378 | -0.363 | -0.400 | — |
| chr2_233718547_A_T | chr2:233718547 | 0.373 | 0.388 | 0.371 | — |
| chr2_233718553_A_C | chr2:233718553 | 0.371 | 0.327 | 0.324 | — |
| chr2_233718641_G_C | chr2:233718641 | 0.368 | 0.317 | 0.288 | — |
| chr2_233718669_A_C | chr2:233718669 | -0.366 | -0.500 | -0.306 | — |
| chr2_233718673_G_C | chr2:233718673 | 0.364 | 0.236 | 0.276 | — |
| chr2_233718678_A_C | chr2:233718678 | 0.363 | 0.298 | 0.488 | — |
| chr2_233718623_G_C | chr2:233718623 | -0.359 | -0.266 | -0.435 | — |
| chr2_233718592_G_T | chr2:233718592 | -0.354 | -0.363 | -0.400 | — |
| chr2_233718697_C_T | chr2:233718697 | -0.353 | -0.393 | -0.371 | — |
| chr2_233718709_A_C | chr2:233718709 | 0.348 | 0.404 | 0.494 | — |
| chr2_233718611_A_G | chr2:233718611 | 0.338 | 0.376 | 0.482 | — |
| chr2_233718712_A_C | chr2:233718712 | 0.338 | 0.278 | 0.465 | — |
| chr2_233718671_G_C | chr2:233718671 | 0.333 | 0.269 | 0.306 | — |
| chr2_233718713_C_G | chr2:233718713 | -0.331 | -0.400 | -0.465 | — |
| chr2_233718594_C_G | chr2:233718594 | -0.329 | -0.358 | -0.365 | — |
| chr2_233718650_G_T | chr2:233718650 | -0.328 | -0.269 | -0.459 | — |
| chr2_233718679_A_C | chr2:233718679 | -0.326 | -0.294 | -0.359 | — |
| chr2_233718685_T_A | chr2:233718685 | -0.326 | -0.325 | -0.424 | — |
| chr2_233718563_A_T | chr2:233718563 | -0.319 | -0.302 | -0.347 | — |
| chr2_233718644_C_T | chr2:233718644 | -0.319 | -0.353 | -0.329 | — |
| chr2_233718630_C_G | chr2:233718630 | 0.318 | 0.213 | 0.335 | — |
| chr2_233718708_A_T | chr2:233718708 | 0.318 | 0.283 | 0.441 | — |
| chr2_233718691_A_T | chr2:233718691 | -0.316 | -0.353 | -0.365 | — |
| chr2_233718711_T_A | chr2:233718711 | 0.316 | 0.236 | 0.347 | — |
| chr2_233718573_T_G | chr2:233718573 | 0.313 | 0.287 | 0.288 | — |
| chr2_233718606_T_C | chr2:233718606 | 0.313 | 0.269 | 0.218 | — |
| chr2_233718699_T_A | chr2:233718699 | -0.313 | -0.345 | -0.376 | — |
| chr2_233718592_G_A | chr2:233718592 | -0.311 | -0.292 | -0.365 | — |
| chr2_233718577_C_G | chr2:233718577 | -0.309 | -0.256 | -0.212 | — |
| chr2_233718553_A_T | chr2:233718553 | 0.308 | 0.261 | 0.265 | — |
| chr2_233718594_C_T | chr2:233718594 | -0.308 | -0.350 | -0.347 | — |
| chr2_233718600_A_C | chr2:233718600 | -0.306 | -0.345 | -0.247 | — |
| chr2_233718639_G_T | chr2:233718639 | 0.306 | 0.183 | 0.188 | — |
| chr2_233718601_G_T | chr2:233718601 | 0.303 | 0.335 | 0.265 | — |
| chr2_233718629_T_C | chr2:233718629 | -0.301 | -0.279 | -0.312 | — |
| chr2_233718631_C_G | chr2:233718631 | -0.301 | -0.282 | -0.335 | — |
| chr2_233691648_T_A | chr2:233691648 | -0.245 | -0.292 | -0.526 | — |
| chr2_233718618_T_A | chr2:233718618 | -0.298 | -0.279 | -0.318 | — |
| chr2_233718687_G_A | chr2:233718687 | -0.291 | -0.277 | -0.247 | — |
| chr2_233718608_A_G | chr2:233718608 | 0.286 | 0.208 | 0.306 | — |
| chr2_233718653_A_C | chr2:233718653 | 0.286 | 0.213 | 0.282 | — |
| chr2_233718662_T_C | chr2:233718662 | 0.286 | 0.401 | 0.294 | — |
| chr2_233718679_A_G | chr2:233718679 | -0.286 | -0.232 | -0.276 | — |
| chr2_233718626_C_T | chr2:233718626 | 0.285 | 0.307 | 0.241 | — |
| chr2_233718566_T_A | chr2:233718566 | -0.283 | -0.292 | -0.318 | — |
| chr2_233691723_C_G | chr2:233691723 | -0.220 | -0.241 | -0.497 | — |
| chr2_233691682_T_G | chr2:233691682 | 0.105 | 0.137 | 0.491 | — |
| chr2_233718588_C_G | chr2:233718588 | -0.278 | -0.312 | -0.324 | — |
| chr2_233718616_C_T | chr2:233718616 | -0.278 | -0.287 | -0.400 | — |
| chr2_233691696_G_C | chr2:233691696 | 0.180 | 0.140 | 0.488 | — |
| chr2_233718590_G_A | chr2:233718590 | 0.276 | 0.231 | 0.241 | — |
| chr2_233718595_A_C | chr2:233718595 | -0.276 | -0.279 | -0.188 | — |
| chr2_233718597_A_C | chr2:233718597 | 0.276 | 0.272 | 0.276 | — |
| chr2_233718680_G_A | chr2:233718680 | -0.276 | -0.334 | -0.435 | — |
| chr2_233718599_G_A | chr2:233718599 | 0.273 | 0.190 | 0.165 | — |
| chr2_233718679_A_T | chr2:233718679 | -0.273 | -0.195 | -0.288 | — |
| chr2_233718631_C_T | chr2:233718631 | -0.270 | -0.244 | -0.341 | — |
| chr2_233691664_G_T | chr2:233691664 | -0.215 | -0.211 | -0.474 | — |
| chr2_233718618_T_C | chr2:233718618 | -0.268 | -0.305 | -0.206 | — |
| chr2_233718702_T_G | chr2:233718702 | 0.268 | 0.287 | 0.276 | — |
| chr2_233718633_A_C | chr2:233718633 | 0.266 | 0.343 | 0.259 | — |
| chr2_233718680_G_T | chr2:233718680 | 0.266 | 0.142 | 0.282 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.