Home / Gene
UGT2B7
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated modulation of UGT2B7, altering the adaptive clearance rate of heavily utilized opioid and immunosuppressant substrates.
Affected substrate drugs (PharmGKB): lamotrigine; valproic acid; morphine; oxcarbazepine; fentanyl; zidovudine
Scored variants near UGT2B7
chr4:68,951,263..69,212,987, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr4_69020518_C_A | chr4:69020518 | -1.000 | -1.000 | -1.000 | — |
| chr4_69020518_C_G | chr4:69020518 | -1.000 | -1.000 | -1.000 | — |
| chr4_69020536_T_A | chr4:69020536 | -1.000 | -1.000 | -1.000 | 0.0013% |
| chr4_69020540_T_A | chr4:69020540 | -1.000 | -1.000 | -0.876 | — |
| chr4_69020536_T_G | chr4:69020536 | -1.000 | -1.000 | -0.944 | — |
| chr4_69020540_T_C | chr4:69020540 | -1.000 | -1.000 | -0.821 | — |
| chr4_69020534_C_T | chr4:69020534 | -1.000 | -1.000 | -0.882 | — |
| chr4_69020518_C_T | chr4:69020518 | -1.000 | -1.000 | -0.934 | — |
| chr4_69020534_C_G | chr4:69020534 | -1.000 | -1.000 | -0.811 | — |
| chr4_69020541_A_T | chr4:69020541 | -1.000 | -1.000 | -0.817 | — |
| chr4_69020541_A_C | chr4:69020541 | -1.000 | -1.000 | -0.773 | — |
| chr4_69020537_A_T | chr4:69020537 | -1.000 | -1.000 | -0.853 | — |
| chr4_69020538_T_A | chr4:69020538 | -1.000 | -1.000 | -0.682 | — |
| chr4_69020520_A_C | chr4:69020520 | -0.992 | -1.000 | -0.818 | — |
| chr4_69020528_T_G | chr4:69020528 | -0.992 | -1.000 | -0.869 | — |
| chr4_69020525_C_A | chr4:69020525 | -0.982 | -1.000 | -0.805 | — |
| chr4_69020528_T_C | chr4:69020528 | -0.974 | -1.000 | -0.837 | — |
| chr4_69020578_T_G | chr4:69020578 | 0.968 | 0.748 | 0.392 | — |
| chr4_69020529_T_A | chr4:69020529 | -0.964 | -1.000 | -0.869 | — |
| chr4_69020520_A_T | chr4:69020520 | -0.951 | -1.000 | -0.791 | — |
| chr4_69020528_T_A | chr4:69020528 | -0.937 | -1.000 | -0.824 | — |
| chr4_69020492_T_A | chr4:69020492 | 0.921 | 0.943 | 0.624 | — |
| chr4_69020530_A_C | chr4:69020530 | -0.894 | -1.000 | -0.736 | — |
| chr4_69020525_C_G | chr4:69020525 | -0.884 | -1.000 | -0.695 | — |
| chr4_69020522_G_T | chr4:69020522 | -0.863 | -1.000 | -0.615 | — |
| chr4_69020522_G_A | chr4:69020522 | -0.856 | -1.000 | -0.608 | 0.0020% |
| chr4_69020537_A_C | chr4:69020537 | -0.852 | -1.000 | -0.689 | — |
| chr4_69020494_C_T | chr4:69020494 | -0.844 | -1.000 | -0.621 | — |
| chr4_69020538_T_C | chr4:69020538 | -0.832 | -1.000 | -0.519 | — |
| chr4_69020492_T_C | chr4:69020492 | 0.830 | 0.836 | 0.603 | — |
| chr4_69020542_C_A | chr4:69020542 | -0.815 | -0.904 | -0.513 | — |
| chr4_69020536_T_C | chr4:69020536 | -0.763 | -0.922 | -0.540 | — |
| chr4_69020538_T_G | chr4:69020538 | -0.743 | -0.904 | -0.447 | — |
| chr4_69020525_C_T | chr4:69020525 | -0.732 | -0.966 | -0.557 | 15.4% |
| chr4_69020542_C_G | chr4:69020542 | -0.732 | -0.922 | -0.493 | — |
| chr4_69020522_G_C | chr4:69020522 | -0.729 | -0.990 | -0.527 | — |
| chr4_69020491_A_G | chr4:69020491 | 0.724 | 0.878 | 0.612 | — |
| chr4_69020492_T_G | chr4:69020492 | 0.721 | 0.618 | 0.415 | — |
| chr4_69020521_A_T | chr4:69020521 | -0.719 | -0.930 | -0.624 | 0.0013% |
| chr4_69020519_A_T | chr4:69020519 | -0.717 | -0.966 | -0.649 | — |
| chr4_69020535_A_T | chr4:69020535 | -0.715 | -0.948 | -0.644 | — |
| chr4_69020544_C_A | chr4:69020544 | -0.699 | -0.849 | -0.518 | — |
| chr4_69020545_A_C | chr4:69020545 | -0.697 | -0.787 | -0.513 | — |
| chr4_69020531_C_A | chr4:69020531 | -0.690 | -0.881 | -0.631 | — |
| chr4_69020424_A_T | chr4:69020424 | 0.685 | 0.901 | 0.421 | — |
| chr4_69020520_A_G | chr4:69020520 | -0.685 | -0.922 | -0.537 | 0.0046% |
| chr4_69020519_A_G | chr4:69020519 | -0.685 | -0.943 | -0.595 | — |
| chr4_69020529_T_G | chr4:69020529 | -0.673 | -0.977 | -0.485 | — |
| chr4_69020519_A_C | chr4:69020519 | -0.669 | -0.899 | -0.586 | — |
| chr4_69020493_C_G | chr4:69020493 | 0.667 | 0.668 | 0.516 | — |
| chr4_69020521_A_C | chr4:69020521 | -0.664 | -0.878 | -0.551 | — |
| chr4_69020529_T_C | chr4:69020529 | -0.657 | -0.855 | -0.557 | — |
| chr4_69020479_C_G | chr4:69020479 | 0.652 | 0.855 | 0.447 | — |
| chr4_69020526_G_C | chr4:69020526 | -0.644 | -0.919 | -0.461 | — |
| chr4_69020482_T_G | chr4:69020482 | 0.643 | 0.745 | 0.374 | — |
| chr4_69020487_G_A | chr4:69020487 | 0.642 | 0.868 | 0.492 | 0.0013% |
| chr4_69020515_A_G | chr4:69020515 | 0.632 | 0.743 | 0.328 | — |
| chr4_69020551_G_T | chr4:69020551 | -0.632 | -0.808 | -0.547 | — |
| chr4_69020531_C_T | chr4:69020531 | -0.619 | -0.834 | -0.577 | — |
| chr4_69020539_T_A | chr4:69020539 | -0.618 | -0.727 | -0.574 | — |
| chr4_69020535_A_G | chr4:69020535 | -0.606 | -0.829 | -0.534 | <0.001% |
| chr4_69020470_A_T | chr4:69020470 | -0.604 | -0.800 | -0.382 | — |
| chr4_69020487_G_C | chr4:69020487 | 0.603 | 0.787 | 0.479 | — |
| chr4_69020488_A_G | chr4:69020488 | 0.597 | 0.642 | 0.427 | — |
| chr4_69020438_C_G | chr4:69020438 | -0.593 | -0.758 | -0.319 | 0.0033% |
| chr4_69020462_T_G | chr4:69020462 | 0.588 | 0.823 | 0.224 | — |
| chr4_69020527_A_T | chr4:69020527 | -0.587 | -0.881 | -0.547 | — |
| chr4_69020501_C_T | chr4:69020501 | -0.583 | -0.712 | -0.450 | — |
| chr4_69020469_A_G | chr4:69020469 | -0.582 | -0.777 | -0.421 | — |
| chr4_69020495_T_A | chr4:69020495 | 0.581 | 0.717 | 0.388 | — |
| chr4_69020496_G_T | chr4:69020496 | -0.577 | -0.779 | -0.414 | — |
| chr4_69020472_G_T | chr4:69020472 | -0.567 | -0.688 | -0.414 | — |
| chr4_69020450_A_G | chr4:69020450 | -0.565 | -0.834 | -0.377 | — |
| chr4_69020438_C_A | chr4:69020438 | -0.564 | -0.691 | -0.318 | 0.0013% |
| chr4_69020539_T_C | chr4:69020539 | -0.562 | -0.686 | -0.518 | — |
| chr4_69020489_G_C | chr4:69020489 | 0.562 | 0.587 | 0.383 | — |
| chr4_69020484_T_C | chr4:69020484 | 0.555 | 0.618 | 0.324 | — |
| chr4_69020535_A_C | chr4:69020535 | -0.553 | -0.725 | -0.472 | — |
| chr4_69020543_T_G | chr4:69020543 | 0.543 | 0.745 | 0.516 | — |
| chr4_69020551_G_A | chr4:69020551 | -0.543 | -0.709 | -0.444 | — |
| chr4_69020473_T_G | chr4:69020473 | -0.540 | -0.636 | -0.395 | — |
| chr4_69020477_T_C | chr4:69020477 | 0.540 | 0.647 | 0.339 | — |
| chr4_69020473_T_A | chr4:69020473 | -0.536 | -0.613 | -0.414 | — |
| chr4_69020491_A_C | chr4:69020491 | 0.536 | 0.623 | 0.426 | — |
| chr4_69020438_C_T | chr4:69020438 | -0.535 | -0.683 | -0.295 | — |
| chr4_69020544_C_G | chr4:69020544 | -0.531 | -0.621 | -0.363 | — |
| chr4_69020424_A_C | chr4:69020424 | 0.530 | 0.626 | 0.260 | — |
| chr4_69020539_T_G | chr4:69020539 | -0.529 | -0.691 | -0.490 | — |
| chr4_69020489_G_T | chr4:69020489 | 0.524 | 0.642 | 0.426 | — |
| chr4_69020476_A_G | chr4:69020476 | -0.521 | -0.675 | -0.258 | — |
| chr4_69020445_G_A | chr4:69020445 | -0.513 | -0.696 | -0.330 | — |
| chr4_69020445_G_C | chr4:69020445 | -0.511 | -0.714 | -0.330 | — |
| chr4_69020516_G_A | chr4:69020516 | -0.503 | -0.574 | -0.311 | — |
| chr4_69020469_A_C | chr4:69020469 | -0.502 | -0.652 | -0.344 | — |
| chr4_69020471_A_C | chr4:69020471 | -0.501 | -0.727 | -0.434 | — |
| chr4_69020521_A_G | chr4:69020521 | -0.499 | -0.629 | -0.373 | — |
| chr4_69020490_C_T | chr4:69020490 | 0.497 | 0.506 | 0.293 | — |
| chr4_69020501_C_G | chr4:69020501 | -0.492 | -0.587 | -0.374 | — |
| chr4_69020555_G_T | chr4:69020555 | -0.482 | -0.675 | -0.409 | — |
| chr4_69020452_C_T | chr4:69020452 | 0.475 | 0.444 | 0.098 | — |
| chr4_69020460_C_G | chr4:69020460 | 0.475 | 0.605 | 0.255 | — |
| chr4_69020446_T_A | chr4:69020446 | -0.472 | -0.709 | -0.305 | — |
| chr4_69020445_G_T | chr4:69020445 | -0.470 | -0.642 | -0.293 | — |
| chr4_69020553_T_A | chr4:69020553 | -0.468 | -0.610 | -0.318 | — |
| chr4_69020461_T_G | chr4:69020461 | 0.463 | 0.621 | 0.256 | — |
| chr4_69020562_C_G | chr4:69020562 | 0.457 | 0.436 | 0.389 | — |
| chr4_69020523_T_C | chr4:69020523 | -0.456 | -0.642 | -0.409 | — |
| chr4_69020550_T_A | chr4:69020550 | -0.455 | -0.527 | -0.240 | — |
| chr4_69020468_C_T | chr4:69020468 | -0.451 | -0.574 | -0.330 | — |
| chr4_69020565_T_A | chr4:69020565 | -0.450 | -0.600 | -0.325 | — |
| chr4_69020475_A_T | chr4:69020475 | -0.449 | -0.605 | -0.398 | — |
| chr4_69020550_T_G | chr4:69020550 | -0.449 | -0.574 | -0.179 | — |
| chr4_69020561_T_C | chr4:69020561 | 0.440 | 0.475 | 0.301 | — |
| chr4_69020437_T_C | chr4:69020437 | -0.439 | -0.535 | -0.267 | — |
| chr4_69020470_A_C | chr4:69020470 | -0.439 | -0.553 | -0.250 | — |
| chr4_69020437_T_A | chr4:69020437 | -0.438 | -0.514 | -0.264 | 0.0039% |
| chr4_69020474_A_G | chr4:69020474 | -0.437 | -0.553 | -0.252 | — |
| chr4_69020477_T_G | chr4:69020477 | -0.436 | -0.592 | -0.253 | — |
| chr4_69020485_A_G | chr4:69020485 | 0.436 | 0.525 | 0.284 | <0.001% |
| chr4_69020493_C_A | chr4:69020493 | 0.435 | 0.455 | 0.322 | — |
| chr4_69020446_T_G | chr4:69020446 | -0.430 | -0.634 | -0.218 | — |
| chr4_69020601_T_G | chr4:69020601 | -0.426 | -0.582 | -0.307 | — |
| chr4_69020478_A_G | chr4:69020478 | -0.421 | -0.577 | -0.198 | 0.0020% |
| chr4_69020547_G_C | chr4:69020547 | 0.421 | 0.553 | 0.418 | <0.001% |
| chr4_69020567_A_C | chr4:69020567 | 0.416 | 0.561 | 0.310 | — |
| chr4_69020500_A_T | chr4:69020500 | 0.415 | 0.561 | 0.188 | — |
| chr4_69020446_T_C | chr4:69020446 | -0.415 | -0.603 | -0.241 | — |
| chr4_69020490_C_A | chr4:69020490 | 0.415 | 0.457 | 0.250 | — |
| chr4_69020527_A_G | chr4:69020527 | -0.412 | -0.603 | -0.385 | — |
| chr4_69020448_A_G | chr4:69020448 | -0.410 | -0.558 | -0.232 | — |
| chr4_69020565_T_C | chr4:69020565 | 0.410 | 0.400 | 0.229 | — |
| chr4_69020576_T_A | chr4:69020576 | -0.410 | -0.512 | -0.247 | — |
| chr4_69020440_A_C | chr4:69020440 | -0.407 | -0.525 | -0.241 | — |
| chr4_69020440_A_T | chr4:69020440 | -0.403 | -0.499 | -0.227 | — |
| chr4_69020449_A_T | chr4:69020449 | -0.402 | -0.519 | -0.279 | — |
| chr4_69020526_G_T | chr4:69020526 | -0.399 | -0.512 | -0.273 | — |
| chr4_69020524_T_G | chr4:69020524 | -0.398 | -0.527 | -0.247 | — |
| chr4_69020569_G_T | chr4:69020569 | -0.398 | -0.395 | -0.249 | — |
| chr4_69020598_T_C | chr4:69020598 | 0.397 | 0.626 | 0.060 | — |
| chr4_69020421_T_G | chr4:69020421 | 0.395 | 0.465 | 0.253 | — |
| chr4_69020574_T_A | chr4:69020574 | -0.395 | -0.481 | -0.258 | — |
| chr4_69020548_A_C | chr4:69020548 | 0.393 | 0.506 | 0.373 | — |
| chr4_69020456_A_C | chr4:69020456 | -0.391 | -0.558 | -0.273 | 0.262% |
| chr4_69020436_A_T | chr4:69020436 | -0.390 | -0.514 | -0.160 | — |
| chr4_69020440_A_G | chr4:69020440 | -0.388 | -0.483 | -0.195 | — |
| chr4_69020494_C_G | chr4:69020494 | 0.387 | 0.444 | 0.356 | <0.001% |
| chr4_69020545_A_G | chr4:69020545 | -0.383 | -0.413 | -0.253 | — |
| chr4_69020447_T_G | chr4:69020447 | -0.377 | -0.532 | -0.255 | — |
| chr4_69020456_A_T | chr4:69020456 | -0.377 | -0.532 | -0.252 | — |
| chr4_69020509_G_T | chr4:69020509 | -0.377 | -0.442 | -0.379 | 0.044% |
| chr4_69020524_T_A | chr4:69020524 | -0.377 | -0.499 | -0.261 | — |
| chr4_69020444_A_T | chr4:69020444 | -0.375 | -0.473 | -0.194 | — |
| chr4_69020542_C_T | chr4:69020542 | -0.375 | -0.444 | -0.200 | — |
| chr4_69020517_A_C | chr4:69020517 | -0.370 | -0.577 | -0.082 | — |
| chr4_69020437_T_G | chr4:69020437 | -0.364 | -0.449 | -0.189 | — |
| chr4_69020579_G_T | chr4:69020579 | -0.363 | -0.475 | -0.296 | — |
| chr4_69020602_G_T | chr4:69020602 | -0.363 | -0.418 | -0.182 | — |
| chr4_69020444_A_C | chr4:69020444 | -0.362 | -0.457 | -0.150 | — |
| chr4_69020651_G_C | chr4:69020651 | 0.360 | 0.491 | 0.258 | — |
| chr4_69020433_A_T | chr4:69020433 | -0.359 | -0.462 | -0.237 | 66.6% |
| chr4_69020447_T_A | chr4:69020447 | -0.358 | -0.504 | -0.256 | — |
| chr4_69020556_A_C | chr4:69020556 | 0.358 | 0.306 | 0.357 | — |
| chr4_69020570_T_A | chr4:69020570 | -0.358 | -0.514 | -0.176 | — |
| chr4_69020491_A_T | chr4:69020491 | 0.357 | 0.395 | 0.250 | — |
| chr4_69020493_C_T | chr4:69020493 | 0.357 | 0.343 | 0.249 | — |
| chr4_69020543_T_A | chr4:69020543 | 0.357 | 0.468 | 0.272 | — |
| chr4_69020490_C_G | chr4:69020490 | 0.351 | 0.340 | 0.194 | — |
| chr4_69020577_T_C | chr4:69020577 | -0.350 | -0.460 | -0.264 | — |
| chr4_69020471_A_T | chr4:69020471 | -0.350 | -0.525 | -0.331 | — |
| chr4_69020442_C_A | chr4:69020442 | 0.349 | 0.325 | 0.099 | — |
| chr4_69020498_G_A | chr4:69020498 | -0.349 | -0.423 | -0.269 | — |
| chr4_69020436_A_C | chr4:69020436 | -0.345 | -0.449 | -0.139 | — |
| chr4_69020456_A_G | chr4:69020456 | -0.344 | -0.473 | -0.223 | — |
| chr4_69020485_A_C | chr4:69020485 | 0.343 | 0.408 | 0.136 | — |
| chr4_69020425_T_A | chr4:69020425 | 0.342 | 0.465 | 0.290 | — |
| chr4_69020448_A_T | chr4:69020448 | -0.342 | -0.465 | -0.208 | — |
| chr4_69020527_A_C | chr4:69020527 | -0.342 | -0.535 | -0.302 | — |
| chr4_69020530_A_G | chr4:69020530 | 0.342 | 0.400 | 0.176 | — |
| chr4_69020569_G_A | chr4:69020569 | -0.338 | -0.364 | -0.229 | — |
| chr4_69020524_T_C | chr4:69020524 | 0.338 | 0.291 | 0.089 | — |
| chr4_69020454_T_G | chr4:69020454 | -0.337 | -0.470 | -0.202 | — |
| chr4_69020457_C_T | chr4:69020457 | -0.335 | -0.410 | -0.278 | — |
| chr4_69020439_A_C | chr4:69020439 | -0.334 | -0.478 | -0.261 | — |
| chr4_69020474_A_T | chr4:69020474 | 0.334 | 0.483 | 0.327 | — |
| chr4_69020450_A_T | chr4:69020450 | 0.333 | 0.322 | 0.067 | — |
| chr4_69020514_G_T | chr4:69020514 | -0.332 | -0.408 | -0.307 | — |
| chr4_69020574_T_G | chr4:69020574 | -0.332 | -0.439 | -0.227 | — |
| chr4_69020476_A_T | chr4:69020476 | -0.328 | -0.387 | -0.110 | — |
| chr4_69020559_T_C | chr4:69020559 | -0.326 | -0.481 | -0.226 | — |
| chr4_69020621_T_G | chr4:69020621 | 0.325 | 0.395 | 0.151 | — |
| chr4_69020510_C_T | chr4:69020510 | -0.323 | -0.351 | -0.353 | — |
| chr4_69020409_C_G | chr4:69020409 | 0.320 | 0.364 | 0.183 | — |
| chr4_69020424_A_G | chr4:69020424 | 0.318 | 0.364 | 0.186 | — |
| chr4_69020480_A_C | chr4:69020480 | 0.315 | 0.304 | 0.200 | — |
| chr4_69020462_T_A | chr4:69020462 | 0.314 | 0.452 | 0.098 | — |
| chr4_69020436_A_G | chr4:69020436 | -0.313 | -0.423 | -0.159 | — |
| chr4_69020579_G_C | chr4:69020579 | -0.312 | -0.410 | -0.224 | — |
| chr4_69020450_A_C | chr4:69020450 | -0.311 | -0.465 | -0.232 | — |
| chr4_69020564_T_G | chr4:69020564 | 0.310 | 0.351 | 0.243 | — |
| chr4_69020439_A_T | chr4:69020439 | -0.309 | -0.429 | -0.234 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.