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chr15_64356290_C_T

chr15:64356290 · GRCh38C → Trs1345364183gnomAD AF 0.0053%ATAC_only
nearest gene · CSNK1G1 · 117 bp

For a non-coding regulatory variant the nearest gene by distance is frequently not the regulated gene.

Receptor variant-effect scores

PXR
0.070Neutral
FXR
0.051Neutral
AhR
0.261GoF
-1 LoF0+1 GoF

Strongest effect: AhR GoF at p99-scaled 0.261. Impact is moderate on the receptor-specific p99 scale.

The p99-scaled score divides the raw delta by the receptor-specific 99th percentile of |delta| in the reference peak population, then clips to −1 to 1. It is a comparable effect scale, not a percentile rank. AhR is exploratory, from a single replicate.

Cross-annotations

No external database record for this variant. It is a scored in silico saturation SNV.

Mirrored from ClinVar, GTEx, GWAS Catalog, JASPAR/FIMO, gnomAD and phyloP. See Databases.

Region confidence

In receptor peaks: none